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1 design process, since aminoglycoside-induced destacking of A1492 and A1493 is thought to be a determi
2 these binding reactions being coupled to the destacking of adenine residues from the terminal G-tetra
3 By contrast, the binding of G418 induces the destacking of base 1492 when either rRNA A site serves a
4 lution as compared to a Tris glycine system, destacking of proteins down to 6.5 kDa, and a 100-fold b
5 ic rRNA A-site being dictated by the coupled destacking of the adenine residues at positions 1492 and
7 the protein binding cavity with concomitant destacking of the opposing complementary 2-Ap nucleotide
8 ational change in the rRNA that involves the destacking of two adenine residues (A1492 and A1493 in E
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