ライフサイエンスコーパス: desumoylation

1 ype calcium channels, results in rapid FOXP1 deSUMOylation.

2 -phase process is involved in Mre11 and Nbs1 desumoylation.

3 are decreased by SUMOylation and enhanced by deSUMOylation.

4 ost closely related to enzymes that catalyze desumoylation.

5 ing a direct requirement of OsOTS1-dependent deSUMOylation activity in rice nuclei for salt tolerance

6 of c-Jun but is critically dependent on the desumoylation activity of SENP1.

7 yelocytic leukemia but is independent of the desumoylation activity of SuPr-1.

8 Our study suggests that TNFalpha-induced desumoylation and cytoplasmic translocation of HIPK1 are

9 Interestingly, I/R stress leads to desumoylation and translocation of nuclear SIRT1 into th

10 hway homeostasis by promoting target protein desumoylation and/or degradation.

11 SUMOylation and deSUMOylation are dynamic mechanisms regulating a spectr

12 physiologic consequences of SUMOylation and deSUMOylation are not fully understood.

13 nt phosphorylation of LXRs, leading to their deSUMOylation by the SUMO protease SENP3 and release fro

14 -induced-sumoylation stabilizes Smo, whereas desumoylation by Ulp1 destabilizes Smo in a phosphorylat

15 s, perhaps counterintuitively, Ulp1-mediated desumoylation can promote SUMO modification by stabilizi

16 ingly, we showed that TNFalpha induced HIPK1 desumoylation concomitant with a translocation from nucl

17 Desumoylation did not affect the catalytic activity of P

18 Da (Sp110) is SUMO1-modified and undergoes a deSUMOylation-driven release from the PML-NB in the pres

19 highlighting the biological requirement for deSUMOylation dynamics.

20 802-815) demonstrate how a desumoylation enzyme is targeted to the nucleolus for re

21 Furthermore, we demonstrate that the desumoylation enzyme SuPr-1 can be modified by SUMO-1-VS

22 es Smo sumoylation by dissociating it from a desumoylation enzyme Ulp1.

23 RING domain mutants or by coexpression of a desumoylation enzyme.

24 specific protease 1 (SENP1) and 2 may act as deSUMOylation enzymes for MTA1.

25 Disruption of the sumoylation/desumoylation equilibrium is associated with several dis

26 cate a critical role of balanced SUMOylation/deSUMOylation for proper cardiac development, metabolism

27 The physiological importance of desumoylation has been revealed by mutations in either g

28 ) modification of proteins (SUMOylation) and deSUMOylation have emerged as important regulatory mecha

29 to quantitatively image p53 sumoylation and desumoylation in cells and living mice.

30 identify a critical role for SENP1-mediated deSUMOylation in promoting Pin1 function during tumorige

31 are modified by SUMO; however, the effect of desumoylation in regulating nuclear receptor function ha

32 Preventing deSUMOylation in Schizosaccharomyces pombe results in sl

33 view the current knowledge about SUMOylation/deSUMOylation in the heart and provide an integrated pic

34 es provide insights on the potential role of desumoylation in the regulation of nuclear receptor acti

35 A key target for SENP3-mediated deSUMOylation is the GTPase Drp1, which plays a major ro

36 In parallel with IRF8 deSUMOylation, macrophage activation led to the inductio

37 e the possibility that NPC-localized protein desumoylation may be a key regulatory event preventing i

38 t of either cellular sumoylation or cellular desumoylation mechanisms inhibits cell growth in the abs

39 endent transcription is not mediated through desumoylation of AR, but rather through its ability to d

40 DeSUMOylation of Drp1 by the enzyme SENP3 promotes cell

41 r following reoxygenation after OGD allowing deSUMOylation of Drp1, which facilitates Drp1 localizati

42 lly, inflammation-induced SENP1 promotes the deSUMOylation of GATA2 and IkappaBalpha in endothelial c

43 regulate AR-dependent transcription through desumoylation of HDAC1.

44 cogenesis, our studies support the idea that deSUMOylation of Maf1 and induction of its gene targets

45 uggesting that Ad regulates paralog-specific desumoylation of Nbs1.

46 otypes thought to be caused by inappropriate desumoylation of nucleoplasmic targets that are normally

47 SENP1-mediated deSUMOylation of PKC is involved in the kainate-induced

48 entrin-specific peptidase 1 (SENP1)-mediated deSUMOylation of PKC, indicating that the crosstalk betw

49 apamycin complex 1 (TORC1), results in rapid desumoylation of these proteins, which is reflected by l

50 (conjugating enzyme; E2), and ULP1 and ULP2 (desumoylation peptidases) are all doxorubicin resistant,

51 These results demonstrate that deSUMOylation plays a critical role in prostate pathogen

52 MEL-18 facilitated the deSUMOylation process by inhibiting BMI-1/RING1B-mediate

53 Thus, Drp1 deSUMOylation promotes cell death by enhancing Mff-media

54 However, how deSUMOylation recruits Drp1 to the MOM is unknown.

55 Here we show that deSUMOylation selectively promotes Drp1 binding to the M

56 orylation of Bcl11b was coupled to its rapid desumoylation, which was followed by a subsequent cycle

57 Increasing deSUMOylation with sentrin/SUMO-specific protease SENP1