ライフサイエンスコーパス: determinant

1 ion protein of 45 kD) as a crucial targeting determinant.

2 to substrate specificity but is not the sole determinant.

3 6) is a known potent virulence and antigenic determinant.

4 the endocytosis and activity of this apical determinant.

5 the context of metabolic disease than a key determinant.

6 the ACh binding domain, the E loop, is a key determinant.

7 to identify the hierarchies among potential determinants.

8 lized by adjacently encoded cognate immunity determinants.

9 ies on the correct partitioning of cell fate determinants.

10 binant bacteria carrying specific resistance determinants.

11 ory is determined by intracortical molecular determinants.

12 rect and rapid detection of other resistance determinants.

13 s the heterogeneity among polio transmission determinants.

14 ola (TDE) and one of its principal virulence determinants.

15 cell shape and also represent key antigenic determinants.

16 In this study, we explored the molecular determinants and potential mechanism for this difference

17 But its determinants and their relative importance are still a m

18 To estimate the baseline prevalence, trends, determinants, and costs of antiemetic overuse from Janua

19 The prevalence, determinants, and implications of relative bradycardia (

20 uestions, we studied the prevalence, genomic determinants, and selective forces shaping cis-regulator

21 for investigating E faecalis wound infection determinants, and suggest that both immune modulation an

22 However, the mechanism by which these determinants are delivered and positioned is poorly unde

23 hat programmes addressing socioenvironmental determinants are essential to achieve thriving populatio

24 ic regression analyses were used to identify determinants associated with anorectal chlamydia and gon

25 argeted coexpression of sT and the cell fate-determinant atonal bHLH transcription factor 1 (ATOH1) l

26 o referred to as cross-reactive carbohydrate determinants (CCDs), can share significant structural ho

27 acin (n = 1) in addition to known resistance determinants, collectively termed the "secondary resisto

28 The identification of molecular determinants composing such network is hence fundamental

29 t upstream social, political, and structural determinants contribute more to health inequities than d

30 ry factor 4 (IRF4) was a key transcriptional determinant controlling T cell responses during transpla

31 tains a translation-dependent, coding region determinant (CRD) of instability that limits its express

32 -specific leucine zipper protein, a rod fate determinant during photoreceptor development.

33 ed blood pressure) and societal level health determinants (eg, health systems, health policies, and b

34 st invariably precedes disease, the critical determinants enabling pneumococcal progression from this

35 iate the planar polarization of apical-basal determinants, ensuring asymmetric division into daughter

36 -7 critical amino acids within the antigenic determinant (epitope), the whole proteome can be represe

37 er on the distribution of unmeasured outcome determinants, even when the causal network linking varia

38 eptors in the postsynaptic area is a crucial determinant for the expression of inhibitory synaptic pl

39 NA via inducing repressed chromatin and is a determinant for the Pol III repertoire.

40 of genes inside the nucleus is an important determinant for their function.

41 Here, we investigated sex-specific determinants for facial wrinkles.

42 ehensive genome-wide analysis of the fitness determinants for growth in vitro and in vivo of a highly

43 stable, and an understanding of the sequence determinants for improved protein solubility is highly d

44 The molecular determinants for substrate recognition by DASS remain ob

45 and lower activity conformations, structural determinants for the different conformations have remain

46 we validated known and identified additional determinants for wrinkling.

47 cellular zDHHC enzymes and mapped molecular determinants governing this selectivity.

48 ltiple regression models, socioenvironmental determinants had coefficients of 0.00-0.43 SD and 22 of

49 bute to brain morphology results in Jacobian determinant images that represent local brain shape and

50 rthologs, additional sequence and structural determinants impact their ability to act as functional r

51 lted from mislocalization of DivIVA, a major determinant in facilitating polar elongation in mycobact

52 ve or unresolved inflammation is the primary determinant in heart failure pathology post-MI.

53 ency of BMP2 could be the primary phenotypic determinant in individuals with predicted truncating var

54 owth rate heterogeneity is the primary shape determinant in Marchantia polymorpha and suggests that t

55 he initially heterogeneous dolomite is a key determinant in producing a two-stage dissolution in the

56 of lipid asymmetry genetic pathway as a key determinant in protecting A. baumannii from the bacteric

57 n lipid homeostasis may represent a critical determinant in the progression of several neurodegenerat

58 e a functional interaction between these two determinants in mediating Pfalciparum erythrocyte invasi

59 le is known about the molecular and cellular determinants in mPFC for stress-associated mental disord

60 this procedure, separated from other outcome determinants including patient and procedural characteri

61 One such prion is [SWI(+) ], whose protein determinant is Swi1, a subunit of the SWI/SNF chromatin-

62 more deeply studied P. aeruginosa virulence determinant is the type III secretion system (T3SS); the

63 When fused to Sup35MC, the [PSI(+) ] determinant lacking its PrD, Swi11-31 and Swi11-32 can a

64 These data unveil the metabolic determinant leading to an increased autoimmunity risk in

65 assess the relationship between the Jacobian determinant, MAL, and FEV1 decline.

66 hild health programmes focused on biomedical determinants might not sufficiently enhance child cognit

67 the infection cell, which organizes polarity determinants necessary for plant cell invasion.

68 intensity of the MAPK pathway is a critical determinant not only in tumour development, but also in

69 ated gene type 1 (hERG1) channels is a major determinant of action potential repolarization in the hu

70 (hypoxia-inducible factor)-1alpha is a major determinant of angiogenesis and induces VEGF transcripti

71 associated with atrial fibrillation and as a determinant of arrhythmia progression.

72 nnel inactivation are emerging as a critical determinant of arrhythmias in heart failure.

73 in FTO is the most important common genetic determinant of body weight.

74 (low O2) is a fundamental microenvironmental determinant of bone marrow (BM) pathophysiology.

75 cells as a population - in turn may become a determinant of cancer progression potential and prognosi

76 at in mammals, for which heart rate is a key determinant of cardiac energy demand, AMPK functions in

77 Since protein glycosylation is an important determinant of cell adhesion, we hypothesized that radia

78 y and qualify this Hippo effector as the key determinant of cell mechanics in response to ECM cues.

79 ZEB1 is also a key determinant of cell plasticity, endowing cells with the

80 The secretory pathway is a major determinant of cellular homoeostasis.

81 A, a histone H3 variant, is a key epigenetic determinant of chromosome domains known as centromeres.

82 Patients' biochemical profiles are a major determinant of clinical outcome for a given treatment.

83 A critical determinant of Cr(VI) generation within soils and sedime

84 rate FBW7 mutational status as a key genetic determinant of CRC response to targeted therapies, and M

85 elop new nodes (development rate) is a major determinant of crop production time, yet the genetic con

86 evealed Nef position 9 as a subtype-specific determinant of differential HLA-A versus HLA-B downregul

87 suggest that higher ePPIX levels are a major determinant of disease severity and risk of liver dysfun

88 analyses revealed tracheid size as the main determinant of earlywood density, while wall dimensions

89 atmosphere mass and energy exchange and is a determinant of ecosystem structure and function.

90 d nitrification, and N input rates are a key determinant of emission rates.

91 Caveolin1 (Cav1) is also an important determinant of endothelial function.

92 y acid synthesis as the primary biosynthetic determinant of Escherichia coli size and present evidenc

93 auxin transport by PIN proteins is a primary determinant of flowering plant branching patterns regula

94 DNA methylation at promoters is an important determinant of gene expression.

95 gest that EGFR likely serves as an important determinant of HCMV tropism for select subsets of hemato

96 teine domain protein P36 as a major parasite determinant of host cell receptor usage.

97 endent, mitogenic conditioning of AECII is a determinant of host susceptibility to infection with IAV

98 Genital inflammation is a key determinant of human immunodeficiency virus (HIV) transm

99 rves as a prognostic biomarker and a crucial determinant of immunosuppressive microenvironment via re

100 strated that the lipid environment is also a determinant of initial protein topology, which is dynami

101 ch the timing of Tsc1 deletion is a critical determinant of its effect on remyelination.

102 We propose that epigenetic drift is a determinant of lifespan in mammals.Caloric restriction h

103 s Pol III activity, and is also an important determinant of longevity.

104 ary, the m(6)A-reader YTHDF2 is an intrinsic determinant of mammalian oocyte competence and early zyg

105 nd surrounding the solid tumor is a critical determinant of metastasis.

106 Recent focus on temperature as a determinant of microrefugia insufficiently accounts for

107 On multivariable analyses, the mean Jacobian determinant of normal voxels within 2 mm of emphysematou

108 suggests that individual surgeon volume is a determinant of not only mitral repair rates, but also fr

109 omatin histone modification state is a major determinant of nuclear blebbing and morphology via its c

110 fy the novel site S267 as being an important determinant of nuclear size.

111 of the upper forest canopy were the dominant determinant of orangutan movement among all age and sex

112 noninvasive assessment of fibrosis, a major determinant of outcome in nonalcoholic fatty liver disea

113 the yield of the lipid pathway as a crucial determinant of overall process yield.

114 For most immune-mediated diseases, the main determinant of patient well-being is not the diagnosis i

115 tested whether glycosylation also acts as a determinant of permissivity for ferret, hamster, and gui

116 hodiesterase acid-like 3B (SMPDL3b) is a key determinant of podocyte injury and a known off target of

117 movement model (radiation) was a significant determinant of poliomyelitis incidence, it did not impro

118 rgin status remains an important independent determinant of postresection survival.

119 studies determined that the major virulence determinant of R. equi is the surface bound virulence as

120 However, tRNA availability is not the sole determinant of rate; rather, interactions between adjace

121 lum Ca(2+) transporting PfATP6 as a putative determinant of resistance to SC81458 and SC83288.

122 h-affinity choline transporter is a critical determinant of signalling by the neurotransmitter acetyl

123 f the population treated in a year was a key determinant of simulated effectiveness, irrespective of

124 a similar role for fatty acids as a positive determinant of size in the Gram-positive bacterium Bacil

125 ngs, showing that pigmentation is a critical determinant of skin aging.

126 Maternal nutritional status is a key determinant of small for gestational age (SGA), but some

127 , a receptor tyrosine kinase (RTK) and major determinant of somatic cell fate.

128 at the P2X7-PANX1 pore complex is a critical determinant of spreading depolarization susceptibility w

129 Our data identify Gag-protease as a major determinant of subtype differences in disease progressio

130 rmly establish that in HIV-1, CA is a strong determinant of susceptibility to Lv2/REAF.

131 the hypothesis that acoustic signalling is a determinant of swarm morphology and present the first co

132 Although an important determinant of T cell efficacy, it has proven difficult

133 kinase kinase beta (CaMKKbeta) emerges as a determinant of the competing roles of cytoplasmic Ca(2+)

134 of hosts that parasites can infect is a key determinant of the emergence and spread of disease.

135 The microbiome has emerged as a major determinant of the functioning of host organisms, affect

136 We show that nuclear confinement is a key determinant of the intra-chromosomal interactions, and c

137 Cub survival is an important determinant of the lifetime reproductive success in leop

138 mans and animals engage in a task is often a determinant of the likelihood of the task's success.

139 surface of endothelial cells (ECs) is a key determinant of the magnitude and duration of angiogenesi

140 ngs identify BAT as a decisive physiological determinant of the onset of metabolic dysregulation in o

141 erity of the CLCNKB mutation is an important determinant of the phenotype in classic BS.

142 Transcript levels are a critical determinant of the proteome and hence cellular function.

143 nical property of the central stalk is a key determinant of the rate of ATP turnover.

144 study of the role of income inequality as a determinant of the use of mental health services reporte

145 nstrate that accessory helicases are a major determinant of this balance.

146 suggesting that immune complexes are a major determinant of this immunization.

147 r findings position p53 as a novel molecular determinant of thymic epithelium function throughout lif

148 e propose transcript length as a further key determinant of translation efficiency.

149 Cough is the major determinant of tuberculosis transmission.

150 gns.Parasitemia has been considered the main determinant of visceral leishmaniasis transmission.

151 Hyperpolarization level is the main determinant of whether the thalamus exhibits trough-max

152 ovides an impetus to better characterize the determinants of (18)F-FDG uptake in various tumors and t

153 om ABHD5 500 million years ago, to identify determinants of ABHD5 lipolysis activation.

154 This analysis draws on the Early Determinants of Adult Health study (2005-2008), a cohort

155 kers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project from 29,765 PSC

156 kers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project sought to inform

157 kers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project were analyzed in

158 Reflecting the Inflammation and Nutritional Determinants of Anemia (BRINDA) project were analyzed in

159 Reflecting the Inflammation and Nutritional Determinants of Anemia (BRINDA) project.

160 tion-burden category to identify independent determinants of anemia (hemoglobin concertation <120 g/L

161 hese findings link immune homeostasis to key determinants of anti-tumoral immunity and escape, reveal

162 This study brings to light important determinants of antigenicity in a clinically relevant xe

163 indings suggest that variables which are key determinants of asthma presence, severity, or control ma

164 conduction slowing, genes encoding molecular determinants of atrial conduction velocity, including Sc

165 ental data about the immunopathology and the determinants of autoantibody formation and keratinocyte

166 The genetic determinants of body fat distribution are poorly underst

167 acy is too recent to have influenced genetic determinants of brain organization.

168 A thorough understanding of the important determinants of cancer evolution under combination thera

169 ttleneck in our understanding of the genetic determinants of cancer.

170 As our findings reveal viral determinants of CHIKV dissemination and pathogenicity, t

171 data improve our understanding of the viral determinants of CHIKV pathogenesis and adaptive changes

172 should prioritise action on community-level determinants of childhood HAZ trajectories.

173 asi-experimental study to explore ecological determinants of clinical burdens from C difficile infect

174 , to a lesser extent, nitrogen, to be strong determinants of community composition.

175 The burden and determinants of complications and comorbidities in conte

176 ibody-positive children in The Environmental Determinants of Diabetes in the Young (TEDDY) study.

177 However, the magnitude and determinants of differences in cis-regulation for regula

178 ine clinical characteristics, genotypes, and determinants of disease severity in a large patient coho

179 me, and DNA methylome analysis to understand determinants of drug response.

180 buminuria, and C reactive protein as non-GFR determinants of eGFRcys.

181 all-cause mortality and investigated non-GFR determinants of eGFRcys.

182 We wish to identify determinants of endothelial lineage.

183 ation and are presumed to be among the major determinants of eukaryotic genome structure.

184 ow that highly polymorphic HLA-A, -B, and -C determinants of fetal origin are selectively exposed in

185 of GA and neovascularization were important determinants of final visual acuity in eyes with the cut

186 tially across regions and are key structural determinants of food and nutrient production that need t

187 sults support recent assertions that the six determinants of gait do not serve to improve walking eco

188 MicroRNAs (miRs) are key determinants of gene and protein expression, and atypica

189 lution-guided approach to define the genetic determinants of genome defense and to reveal the molecul

190 Human papillomavirus prevalence and determinants of genotype-specific concordance were asses

191 ase glutamine catabolism, defining important determinants of glutamine anaplerosis and glutaminase de

192 Our aim was to examine the risk and determinants of HCC in patients cured with DAA.

193 at is, concepts such as the exposome, social determinants of health (SDoH), and citizen science, and

194 After accounting for social determinants of health and risk factors, black men and w

195 clinical and angiographic factors and social determinants of health, including widowhood and insuranc

196 The determinants of helminth resistance are not well underst

197 d population movement patterns are important determinants of historical poliomyelitis incidence in Pa

198 h few studies assessing potential structural determinants of HIV risk.

199 vides a structural framework to characterize determinants of host/tissue tropism, pathogenicity, and

200 ng of patterns of health, climate, and other determinants of human well-being.

201 rgets, and characterization of the molecular determinants of immunity in wheat.

202 In an attempt to uncover the determinants of immunodominance among several dominant e

203 To reveal determinants of interaction properties, a set of TAL cla

204 ve relaxation and restoring forces are known determinants of left ventricular (LV) diastolic function

205 is are well-described, chronic environmental determinants of leukocyte number are less well understoo

206 e, I review the anatomical and physiological determinants of locomotor economy (e.g., limb length and

207 be needed to fully elucidate the underlying determinants of low vitamin D concentrations in AA popul

208 The viral determinants of Lv2 susceptibility mapped to the HIV-2 e

209 Using prospective data from the Early Determinants of Mammographic Density Study (n = 1,108; 1

210 However, the key determinants of metabolic flexibility among relevant cli

211 e for the characterization of sequence-level determinants of MMP-substrate specificity.

212 tionary processes but also of the underlying determinants of modern proteins' physical, chemical, and

213 Few studies have investigated the viral determinants of mother-to-child transmission.

214 would thus advance our understanding of the determinants of motivated behavior.

215 rithm successfully provided several sequence determinants of N-terminal acetylation for proteins lack

216 quences, attempts to understand the sequence determinants of N-terminal acetylation were conducted in

217 investigation was to identify the structural determinants of NCX1 palmitoylation.

218 ial code of TFs, cell surface molecules, and determinants of neuronal morphology that is differential

219 These studies unveil determinants of neurovirulence and stability in Japanese

220 We identified determinants of new-onset atrial fibrillation and, using

221 etic variation and biological or behavioural determinants of obesity.

222 ol, and avoids autophagy by expressing three determinants of pathogenesis: two secreted phospholipase

223 To investigate the structural and functional determinants of pattern separation we built models of th

224 is revealed a genome-wide map of the genetic determinants of plant root colonization and offers a sta

225 Understanding the determinants of polio transmission and its large-scale e

226 create resource pulses that may be important determinants of pollinator dynamics.

227 clearance <1.0 or <1.5 mm was an independent determinants of postresection survival in certain subgro

228 Among the major determinants of potassium uptake in the model organism S

229 of prometastatic genes, including important determinants of premetastatic niche formation.

230 Here, we investigate mechanisms and determinants of PVEM induction and its potential role in

231 ly relevant model for studying the molecular determinants of radiation-induced intestinal damage and

232 oefficients squared [SPCCs2]) identified key determinants of RE.

233 ion is enabling study of the physicochemical determinants of reactivity.

234 However, discrete genomic determinants of response to cancer immunotherapy, unlike

235 s in understanding the molecular and genomic determinants of response to cancer immunotherapy, with a

236 hysiology of source and sink organs are main determinants of rice productivity.

237 of these 156 proteins might identify genetic determinants of risk-associated circulating factors and

238 However, the determinants of selective binding have remained elusive.

239 re studies should focus on understanding the determinants of sex differences in rehospitalization ris

240 zed to the animal or vegetal pole, including determinants of somatic and germline fates.

241 PR-Cas adaptation system, including sequence determinants of spacer acquisition that are relevant for

242 e extent of structural progression, identify determinants of structural progression, and determine th

243 patterns of viral diversity in wildlife and determinants of successful cross-species transmission, o

244 uency of remission and identify preoperative determinants of successful outcome.

245 Genetic determinants of susceptibility to silver nanoparticle-in

246 e an opportunity to assess the magnitude and determinants of suspected NVSS underreporting.

247 Our data suggest that NCR peptides are host determinants of symbiotic specificity in M. truncatula a

248 responses in gene therapy is still long; the determinants of the balance between tolerance and immuno

249 eal candidate to investigate the allocentric determinants of the brain's cognitive map.

250 mutagenesis analyses, we delineate sequence determinants of the differential sensitivity of 3' splic

251 Dendrite size and morphology are key determinants of the functional properties of neurons and

252 ostasis and oncogenic signaling are critical determinants of the growth of human liver cancer cells,

253 Here, we report the structural determinants of the interaction between DHTS and HuR and

254 to the Env trimer were found to be important determinants of the potency of activation and entry inhi

255 n (VDBP) in AA and EA women and investigated determinants of the vitamin D-biomarker concentrations i

256 ccharides provide insight into the molecular determinants of their specificity.

257 t kinase evolution along with the structural determinants of these changes.

258 The sequence and structural determinants of these processes are complex and highly c

259 However, the molecular determinants of this essential signaling mechanism still

260 Yet, the underlying determinants of this variability are poorly understood.

261 ion, hindering progress toward understanding determinants of transmission and pathogenesis.

262 biology discussed genetic and environmental determinants of type 1 and type 2 diabetes risk and prog

263 These features, in turn, are major determinants of type-specific neuronal function.

264 Endothelial cells (ECs) are critical determinants of vascular homeostasis and inflammation, b

265 EV) infections are limited and immunological determinants of viral persistence remain largely unexplo

266 Key determinants of water scarcity are found to be the cost

267 An analysis of antigenic determinants on both allergens was performed by site-dir

268 We mapped the binding determinants on each protein, demonstrating that ataxin3

269 ity binding and specificity for carbohydrate determinants on the bacterial surface.

270 Multiple biological, behavioural and genetic determinants or correlates of obesity have been identifi

271 macaques for the identification of virulence determinants or the evaluation of therapeutics, we infec

272 We used numerically exact determinant quantum Monte Carlo calculations to demonstr

273 ave identified p11 in LHb as a key molecular determinant regulating negative emotions, which may help

274 but its in vivo cellular tropism and tropism determinants remain unidentified.

275 The genetic determinants responsible for this canonical case of viru

276 To map the critical determinant, Ser5 mutants bearing C-terminal deletions w

277 h levels of the canonical E-selectin binding determinant sialyl Lewis X (sLe(X)) and display markedly

278 337-343 of AKAP79 is the sole PP2B-anchoring determinant sustaining these diverse topologies.

279 Notably, m(6)A facilitates the master female determinant Sxl, since multiple m(6)A components enhance

280 ernal tyrosine-based sorting motif YXXL as a determinant that can affect the incomplete neutralizatio

281 Here we used mouse models to examine host determinants that affect H. pylori BabA expression.

282 kocyte subset numbers, as well as nongenetic determinants that affect these patterns, thereby providi

283 del, this study describes critical molecular determinants that confer this high resistance to transmi

284 ental and clinical relevance to decipher new determinants that control TEC homeostasis in vivo.

285 To identify structural determinants that distinguish the two conformations and

286 for drug development; however, the molecular determinants that govern the interactions and functions

287 r appreciation of the cellular and molecular determinants that maintain tumor growth, will undoubtedl

288 Here, we consider determinants that may bias isoform-specific effector act

289 cal comparison of these enzymes suggests key determinants that underlie the functional properties of

290 teract with three independent HIV-1 envelope determinants: the CD4 binding site, the membrane-proxima

291 To better understand possible determinants, this prospective case series assesses ging

292 ure associated with antimicrobial resistance determinants through an internationally available databa

293 sis of the contribution of various molecular determinants to the volume changes upon protein unfoldin

294 ng perhaps the most important biomass growth determinant under natural, unstressed conditions.

295 crease in plasma homocysteine as the primary determinant.We provided capsules with free Met to 15 hea

296 pecialized tuning for localized cytoskeletal determinants, whereas dynein activity is less compartmen

297 e stronger association of socioenvironmental determinants with improved cognition suggests present re

298 e the complement of diversity and resistance determinants within endemic M. tuberculosis populations.

299 Key molecular determinants within the Orai N terminus that together wi

300 functional amyloids are often key virulence determinants, yet the structural basis for their activit