ライフサイエンスコーパス: detrimental

1 or excessive activation of autophagy can be detrimental.

2 d glucose balance control to paradoxical and detrimental.

3 ect exposure to developing offspring is more detrimental.

4 mber of cells with off-target editing can be detrimental.

5 drive multiple outcomes: both beneficial and detrimental.

6 first antimicrobial order, are frequent and detrimental.

7 xcessive activation of autophagy can also be detrimental.

8 d receptor-ligand interactions could also be detrimental.

9 This overhang must be protected against detrimental activities of nucleases and of the DNA damag

10 th B*18:01 (CD8 T cells, 6.2%; P < .0003), a detrimental allele.

11 the human host have been known to attribute detrimental and beneficial effects on tumor progression.

12 The interplay of these detrimental and beneficial effects remains puzzling. Her

13 slinking of the peptidoglycan polymer can be detrimental and highlight a critical role of the bacteri

14 Loss in Sec61 integrity is detrimental and implicated in the progression of disease

15 ced by exogenous or endogenous agents can be detrimental and, if excessive, can result in organ and t

16 Systemic pathway activation, however, may be detrimental, and agents amenable to tissue targeting for

17 sin system blockade therapies inhibiting the detrimental Ang II/AT(1) receptor axis.

18 , in part because protective and potentially detrimental antibody-mediated mechanisms are the same an

19 n that reveals potentially beneficial versus detrimental aspects of the influenza-associated cytokine

20 Mediation analysis suggested that the detrimental associations of 13 sphingolipids with T2D we

21 Although ANA residues were detrimental at the 5' end of the antisense strand, the s

22 restricted increase in purine nucleotides is detrimental because it severely depletes pRpp and essent

23 ctors but also make the alloys more prone to detrimental bipolar diffusion.

24 These results suggest that detrimental body composition is not directly determined

25 ce lacking this transporter do not have this detrimental brain phenotype.

26 EME and were found beneficial by eliminating detrimental bubble formation.

27 To prevent detrimental Ca(2+) overload, the activity of MCU must be

28 Improper sample preparation leads to detrimental cascades, resulting in loss of precious time

29 interpreted in the light of 'protective' or 'detrimental' CD8(+) T cell responses which are restricte

30 ized in TDM are not strong predictors of the detrimental clinical outcomes of interest.

31 s necessary to reduce the incidence of these detrimental complications.

32 that oculomotor freezing mitigates potential detrimental, concomitant effects of microsaccades and re

33 luscan communities may have been low because detrimental conditions did not devastate the entire Gulf

34 ay be beneficial in one season but result in detrimental conditions in another because life-history s

35 indings suggest that smoking does not have a detrimental consequence on MS susceptibility.

36 Earlier age of puberty has detrimental consequences for many aspects of health.

37 by dopamine replacement therapy, often with detrimental consequences for patients and caregivers.

38 occurs during myocardial infarction has very detrimental consequences for the heart.

39 w available health capacity, with associated detrimental consequences for the wider health, well-bein

40 dedifferentiation do not exclusively reflect detrimental consequences of aging.

41 host cell-polarity barrier would reduce the detrimental consequences of infection by pathogenic bact

42 levels of stress response activation and the detrimental consequences that can occur in the absence o

43 Since new insertions can have detrimental consequences, cells need to efficiently cont

44 he HIT-2000-BIS4 trial aimed to avoid highly detrimental craniospinal irradiation (CSI) in children <

45 Intrinsically, detrimental defects accumulating at the surface and grai

46 ment centres while also avoiding potentially detrimental delays in the delivery of cancer care.

47 se brain infiltration by glioma cells causes detrimental disease progression, but its multicellular c

48 n, which can lead to the persistence of this detrimental DNA adduct.

49 r the RecQ4 helicases in the repair of these detrimental DNA lesions.

50 r DISC1 that may be able to initiate further detrimental downstream events and should thus be conside

51 Aneuploidy is highly detrimental during development yet common in cancers and

52 xcess application of N-rich fertilizers with detrimental economic and environmental impacts.

53 d resolution of stromal keratitis but had no detrimental effect as assessed by visual outcome at 6 mo

54 We conclude that a general and seemingly detrimental effect of aneuploidy, slowed proliferation,

55 tolysis loop and did not protect against the detrimental effect of CTRC cleavage.

56 ther, our data provide strong evidence for a detrimental effect of FERMT2 underexpression in neurons

57 rein demonstrate that there is a significant detrimental effect of HS on the pathogenesis of E. maxim

58 Overall, these findings elucidate the detrimental effect of hypoxia on mitochondrial-biogenesi

59 Here we show the detrimental effect of hypoxia on mitochondrial-biogenesi

60 These observations highlight a detrimental effect of podocyte-targeted HO-1 overexpress

61 ur study found some evidence of the expected detrimental effect of sucrose on dental caries but no ef

62 ysM(Cre) mice) demonstrated a more prolonged detrimental effect on NMJ reinnervation and worse functi

63 terogeneity within whole blood samples had a detrimental effect on the classification ability of the

64 W mutation appeared to have the most drastic detrimental effect on the structure and organization of

65 Infection with BCG was shown to exert a detrimental effect primarily upon epithelial cells, with

66 We observed detrimental effects across all tested modeling approache

67 regulate these proteins and their downstream detrimental effects are often unknown.

68 her with our increasing understanding of the detrimental effects conferred by broad-spectrum antibiot

69 over with reduced river flow and potentially detrimental effects downstream.

70 e responses by acknowledging their possible, detrimental effects in damaged or stressed tissues.

71 is, a deleterious arm of RAS, unleashing its detrimental effects in diabetes.

72 ol sexual maturation and mitigate associated detrimental effects in fish.

73 Detrimental effects in this and other susceptible animal

74 on with beneficial microbes might reduce the detrimental effects of a Western-style diet.

75 ges at the sites of injury, and suppress the detrimental effects of acute inflammation.

76 tion that cooperative breeding mitigates the detrimental effects of adverse environmental conditions

77 ous system may play a role in mitigating the detrimental effects of aging in this long-lived animal.

78 red as a counter-regulatory mechanism to the detrimental effects of Ang II.

79 While the detrimental effects of anthropogenic stressors on the be

80 s low probability of establishment is due to detrimental effects of antibiotics on resistant cells, c

81 preventative and therapeutic target against detrimental effects of As exposure in children.

82 otential therapeutic interest to address the detrimental effects of both environmental and genetic fa

83 Both beneficial and detrimental effects of C1q as well as contributions to l

84 te its potential benefits, undesired or even detrimental effects of cannabis can limit its use.

85 Detrimental effects of diarrhea on child growth and surv

86 Our results also suggest that the detrimental effects of disadvantaged life course circums

87 a critical period of brain development, the detrimental effects of early adversity are likely to be

88 Results also underscore the potential detrimental effects of Fe(0) and bioaugmentation culture

89 represents a novel approach to mitigate the detrimental effects of hyperinsulinemia on immunoregulat

90 The detrimental effects of low fiber Westernized diets may u

91 Here, we identify a molecular mechanism for detrimental effects of low maternal n-3 PUFA intake on h

92 sing an intraventricular balloon revealed no detrimental effects of mexiletine (1 and 5 uM) on mechan

93 uced biodiversity and ecosystem functioning, detrimental effects of nutrients occurred only at high l

94 classical monocyte function may mitigate the detrimental effects of perinatal liver inflammation.

95 Moreover, we showed that the detrimental effects of PERK inactivation in oligodendroc

96 Given the serious detrimental effects of plastic litter on marine ecosyste

97 in receptor (p75(NTR)) were resistant to the detrimental effects of SD on hippocampal plasticity at b

98 decline by subjecting the population to the detrimental effects of stochastic processes (i.e. low de

99 cker aqueous samples, thereby mitigating the detrimental effects of strong attenuation on detection s

100 The current study found causal detrimental effects of T2DM on several cancers.

101 A MedDiet could counteract the detrimental effects of these metabolites.This trial was

102 ll-inducing vaccine candidates that minimise detrimental effects of viral diversification and at the

103 mHTT reduction may outweigh the potentially detrimental effects of wtHTT loss following non-selectiv

104 urge in corticosterone by itself has delayed detrimental effects on amygdalar structure and function,

105 blebee colony growth, and all treatments had detrimental effects on brood production.

106 all changes on temperature and voltages, had detrimental effects on cells.

107 ebees frequently come into contact with have detrimental effects on colony health and performance and

108 ime under flexible duty-hour policies had no detrimental effects on duty-hour violations or resident

109 xture of gases, the most robust evidence for detrimental effects on health is for fine particulate ma

110 Air pollution is associated with detrimental effects on human health, including decreased

111 nmental pollution has the potential to cause detrimental effects on humans and the environment.

112 retain T-independent properties, leading to detrimental effects on immune responses.

113 fatty acid biosynthesis and the concomitant detrimental effects on membrane integrity.

114 uring aging and suggest that TREM2 may exert detrimental effects on neuronal function.

115 with clopidogrel (n = 3) partly reversed the detrimental effects on SEC injury and therefore provided

116 There were no detrimental effects on severity adjusted mortality, read

117 aring rehabilitation, hearing loss can cause detrimental effects on speech, language, developmental,

118 unction, such as during infection, will have detrimental effects on the success of the pregnancy.

119 lective harvesting of older males could have detrimental effects on the wider elephant society throug

120 r adequate microclimate in fruit zone has no detrimental effects on white wine aroma and hydroxycinna

121 Radiation damage usually leads to detrimental effects such as embrittlement, accelerated c

122 materials are more susceptible to heat, and detrimental effects such as thermally induced degradatio

123 king defects leading to a human disease with detrimental effects to erythropoiesis and neurodevelopme

124 tism is ubiquitous in nature with widespread detrimental effects to hosts, making parasitism a likely

125 variants demonstrated a pleiotropic range of detrimental effects upon protein modeling and in vitro a

126 and vitamins could be reduced by 50% with no detrimental effects, but blastocyst development was impa

127 dial substrate metabolism and its downstream detrimental effects, such as mitochondrial dysfunction,

128 h microorganisms that can have beneficial or detrimental effects.

129 ing mechanism to minimize the aforementioned detrimental effects.

130 clerosis complex 1 KO mice exhibited similar detrimental effects.

131 ecies can become disrupted, with potentially detrimental effects.

132 However, such remedies could have detrimental effects.

133 cAMP-calcium signaling can have a number of detrimental effects: for example, opening nearby K(+) ch

134 predicted here are lattice-matched, show no detrimental electronic instability, and display broken t

135 ET-1 (E6), Abeta and E6 + Abeta rats was not detrimental enough to injure the complete network.

136 eous sites (SAT) has been suspected as a key detrimental event.

137 nisms are triggered to resist Abeta-mediated detrimental events.

138 ential cycling, the oxide layer evolves into detrimental features such as steps and terraces.

139 so provided genetic evidence that ADORA2B is detrimental for age-related SNHL by impairing cochlear m

140 is taurine deficiency that can be especially detrimental for carnivorous fish.

141 in the materials, which are not necessarily detrimental for certain applications.

142 phenomena, where noise, which is considered detrimental for electronic circuits and communication sy

143 ding Lgals3(+) osteogenic cells likely to be detrimental for late-stage atherosclerosis plaque pathog

144 is and indicate that Notch inhibition may be detrimental for patients with low levels of Notch signal

145 semiconductors are frequently considered as detrimental for photogenerated carrier transport, their

146 stion of whether endurance exercise could be detrimental for some individuals.

147 microbials because a loss of its activity is detrimental for survival of many pathogens and no appare

148 sity, alterations in adipokine levels may be detrimental for the cardiovascular system.

149 While bulk defects are detrimental for the device performance by mainly limitin

150 nsequences of dietary Na(+) reduction may be detrimental for the kidney.

151 rly morphogenesis, its sustained activity is detrimental for the mature apical shape.

152 response and macrophage function and is also detrimental for vaccine responses.

153 t these cells can have beneficial as well as detrimental functions, both innately and as participants

154 hile others are concerned over potential for detrimental health consequences.

155 ects of acute radiation exposure (DEARE) are detrimental health effects that occur after exposure to

156 f aromatic compounds cause air pollution and detrimental health effects.

157 phic relationship is established to overcome detrimental host diets and identify Ap as the bacterium

158 etabolic interactions to become resilient to detrimental host diets.

159 to provide neurotrophic support and inhibit detrimental host immune responses in vivo following tran

160 he CNS, including synaptic pruning, which is detrimental if dysregulated.

161 r gene therapy, but its broad tropism can be detrimental if the transgene being delivered is harmful

162 re mitochondrial dysfunction, but triggers a detrimental imbalance in the mitochondrial redox system,

163 e Ypk1, which repressed Orm2 and prevented a detrimental imbalance of SL metabolism.

164 is required for dissecting protective versus detrimental immunity to pathogens that cause chronic inf

165 We did not find a highly penetrant detrimental impact of lifelong very low levels of LDL ch

166 es in collagen fibers also contribute to the detrimental impact of MIF.

167 Exaggerations of the detrimental impact of recreational drug use on the human

168 Given the detrimental impact of the pandemic on mental health and

169 ical data showed that these complexes have a detrimental impact on cancer outcome, thus raising inter

170 accumulation inhibits target enzymes with a detrimental impact on fitness.

171 lated to cardiovascular disease, but without detrimental impact on liver function.

172 privation during midlife and older age has a detrimental impact on metabolism, may lead to adipose ti

173 STAT3, and low PTEN expression levels have a detrimental impact on patient disease-free survival.

174 This has had a detrimental impact on population health and well-being,

175 were no new safety signals, and SABR had no detrimental impact on QOL.

176 and neurovirulent arbovirus that has severe detrimental impact on the developing human fetal brain.

177 Visual impairment (VI) can have a detrimental impact on vision-related quality of life (VR

178 ake this heterogeneity into account to avoid detrimental implications of a unidimensional focus on hu

179 We predict that mutations are more detrimental in ACE2 than TMPRSS2.

180 on that heterologous immunity is necessarily detrimental in LT and provide an explanation for the ass

181 nts, "high-risk" grafts did not appear to be detrimental in medium MELD patients.

182 The insulating vapor film can be highly detrimental in metallurgical quenching and thermal contr

183 ft uncontrolled, these responses may lead to detrimental inflammation(3).

184 ntracellular delivery, and the triggering of detrimental inflammatory responses following innate immu

185 of stressed gestating mice that may trigger detrimental inflammatory signaling at the maternal-fetal

186 Subsequent case reports highlight the major detrimental interactions of checkpoint inhibitors and th

187 in the short term but paradoxically may have detrimental long-term effects.

188 spiral artery remodeling, and prevention of detrimental maternal immune responses to placental and f

189 How the transmission of detrimental mtDNA mutations is restricted through the ma

190 n of OG:A is crucial to prevent improper and detrimental MutY-mediatedadenine excision from G:A or T:

191 ve therapeutic approaches aimed at resolving detrimental myeloid cell responses in tissues, including

192 Through this mechanism, elesclomol prevented detrimental neurodegenerative changes and improved the s

193 t excising proviral DNA, will likely lead to detrimental neuropathological outcomes during HIV CNS in

194 sted by lowered abundance of proinflammatory detrimental neutrophils.

195 However, such detrimental O(2) effects are targetable by exogenous H(2

196 that dexamethasone treatment can have direct detrimental off-target effects on the cardiovascular sys

197 h-quality structures, whereas it can even be detrimental otherwise.

198 testing CTC-positive preoperatively showed a detrimental outcome despite successful tumor resections.

199 ular matrix helps manifest the beneficial or detrimental outcome mediated by the collective of cells.

200 t defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic infl

201 Lipid perturbations contribute to detrimental outcomes in obesity.

202 The prevalence of detrimental outcomes of perinatal cannabis exposure is l

203 To mitigate the potentially detrimental outcomes of wildfires, it is imperative that

204 expression changes that lead to adaptive or detrimental phenotypic outcomes.

205 the role of HLA-G+ EVT in the development of detrimental placental inflammatory responses associated

206 R159 function is inhibited, which results in detrimental pleiotropic defects, questioning the purpose

207 Individuals with a detrimental prognosis were identified using various thre

208 es to give rise to macrophages that lack the detrimental proinflammatory gene signature and reduced p

209 CK5-beta-catenin interaction may reverse the detrimental properties of CK5+ breast cancer cells.

210 Despite extensive efforts, detrimental reactivity of lithium metal with electrolyte

211 in efficacy and mitigate unproductive, often detrimental reactivity.

212 otential risk for creating novel variants or detrimental reassortants within pig populations.IMPORTAN

213 essing the GABA shunt activity, avoiding the detrimental reduction in fatty acid biosynthesis and the

214 We demonstrated previously that IRF3 plays a detrimental role in a severe mouse model of sepsis, indu

215 tion and that viral expression of CD80 has a detrimental role in corneal scarring, likely by increasi

216 -24-3p and miR-145-5p are reported to have a detrimental role in ischemia-reperfusion injury.

217 MMP-9 has been shown to play a detrimental role in many metastatic human cancers, inclu

218 The detrimental role of miR-19b in inducing endothelial dysf

219 tulated the phenotype of WMI, supporting the detrimental role of mitochondrial uncoupling in the path

220 These results unravel a possible detrimental role of NETs in the pathophysiology of COVID

221 In contrast to the detrimental role of periostin in CKD, we discovered a pr

222 The detrimental role of platelets in sinusoidal endothelial

223 he resulting degradation products may play a detrimental role, which is still not well understood.

224 They can play either beneficial or detrimental roles in lesion pathogenesis, depending on t

225 everal studies have described beneficial and detrimental roles played by astrocytes in remyelination.

226 velopment of novel strategies for decreasing detrimental rumination-like activity during sleep and fo

227 but have attained limited efficacy with some detrimental side effects.

228 , subcerebral projection neurons might carry detrimental signals to their downstream targets.

229 ostructures, with stronger resilience toward detrimental size-effects.

230 are summarized in 1) the negative impact of detrimental socioeconomic status on oral health changes

231 ntification of several vasculoprotective and detrimental species, which might be considered for thera

232 ess suggests that this protein has a role in detrimental stress responses.

233 ymer hole-injection layer is used to prevent detrimental surface oxidation and resulting degradation

234 on marine ectotherms with the potential for detrimental, synergistic effects; yet, effects of these

235 the latest promising approaches to targeting detrimental T cell memory in the settings of organ trans

236 However, it is unclear which factors drive detrimental TGFbeta1 pathways in the hypertensive pulmon

237 hough neuroinflammation is often depicted as detrimental, there is growing evidence that alternativel

238 ith Asn or Asp, respectively, in A5D is more detrimental to activity than the double substitution whe

239 latent virus (e.g., shock and kill) would be detrimental to astrocyte function and possibly augment t

240 rizability, which can be either favorable or detrimental to biological activity.

241 Alkylation of guanine bases in DNA is detrimental to cells due to its high mutagenic and cytot

242 Saturated lipids are particularly detrimental to cells, but how lipid saturation levels ar

243 he broadly-held view that space radiation is detrimental to cognition.

244 mbination of pathological amyloid and tau is detrimental to cognitive decline in preclinical Alzheime

245 malies (GAs) are tumor-like lesions that are detrimental to colony fitness and are commonly associate

246 While raising pH in acidic soils can be detrimental to ECM tree growth, the exact mechanism for

247 (OA) is unclear, and this lack of clarity is detrimental to efforts to identify therapeutic targets.

248 ate that the epigenetic repercussions may be detrimental to future generations.

249 ed Trp/Glu residue pair in the lower pore is detrimental to gating and selectivity, although this int

250 g bleach cleaning reported herein are likely detrimental to human health.

251 beneficial to interact with cooperators but detrimental to interact with cheaters.

252 ate here that in vitro, hyperexcitability is detrimental to islets whereas underexcitability is prote

253 rescent probes or biotin was not immediately detrimental to larval movement and survival, which died

254 induced oligomerization of Amyloid-beta were detrimental to lifespan and healthspan, we were able to

255 d herbicide drift exposure to weeds could be detrimental to long-term management as numerous weeds ev

256 The recent bust of the Blockchain bubble was detrimental to many projects intended to return control

257 ation and metabolism; their treatment may be detrimental to metabolic outcomes.

258 helminths are protective and their treatment detrimental to metabolic outcomes.

259 trate that loss of functional capillaries is detrimental to muscle function, even in otherwise health

260 t but also will hide the inequities that are detrimental to optimal system performance and assurance

261 COVID-19 pandemic will likely be especially detrimental to patients with AUD/ALD, and actions need t

262 Pulmonary mycoses are difficult to treat and detrimental to patients.

263 isruption of melatonin receptor signaling is detrimental to photoreceptor health.

264 ual cannibalism is likely to be particularly detrimental to population viability.

265 Many viruses are detrimental to pregnancy and negatively affect fetal gro

266 survival of mothers, ultimately this loss is detrimental to progeny survival.

267 ation during the juvenile critical window is detrimental to proper functioning of the prefrontal cort

268 c tool for cancer-associated cachexia and is detrimental to serum 25-hydroxyvitamin D (25(OH)D) conce

269 can produce hormonal imbalances that can be detrimental to sexual and skeletal development.

270 ndicating that commitment to reproduction is detrimental to somatic health.

271 elays in attaining the final native fold are detrimental to the cell, altogether showing that a co-tr

272 ic variation of mosquito populations will be detrimental to the deployment of this technology for pop

273 ile substitution of the adamantyl groups was detrimental to the enantioselectivity, mechanistic infor

274 primary sensory areas is puzzling, as it is detrimental to the exact mapping between stimulus featur

275 overly robust inflammatory response that is detrimental to the host during CDI.

276 road array of functions, both beneficial and detrimental to the host.

277 s described for azithromycin, which could be detrimental to the host.

278 subtilisin/kexin type 9 loss-of-function is detrimental to the juvenile host with septic shock.

279 eeding of the microbiome creates a dysbiosis detrimental to the long-term health of the metazoan host

280 hese gene-silencing events are thought to be detrimental to the pathogen and beneficial to the host.

281 networks and strong selection are generally detrimental to the performance of the random ranking, bu

282 We suggest that increased serum IL-6 may be detrimental to the pig xenograft because it is likely to

283 when disrupted during memory acquisition, is detrimental to the subsequent rapid retrieval of aversiv

284 , the axial-axial conformations, known to be detrimental to the TADF process, are suppressed by linki

285 a guanosine (CpG), indicating that they are detrimental to the virus.

286 , and problems around communication were all detrimental to this process.

287 through a covalent enzyme inhibitor that is detrimental to tumor tissue in its own right, may find u

288 re to LAN alters brain physiology and can be detrimental to well-being in otherwise healthy individua

289 If such a machinery fails to eliminate detrimental topological entanglements, utilization of th

290 Detrimental transitions were considered when transitioni

291 er rGNB or Candida spp. were associated with detrimental transitions.

292 side or a fluoroquinolone) protected against detrimental transitions.

293 ed to determine risk factors associated with detrimental transitions.

294 gnosis with unnecessary laboratory tests and detrimental treatments.

295 h models will fail to reproduce data and how detrimental truncation of a pathway leads to detectable

296 on energy metabolism and efficiency could be detrimental under multiple-stressors exposures and energ

297 ated activity in the STN region was the more detrimental was the effect on response times.

298 es Echinochloa crus-galli is one of the most detrimental weeds in crop fields, especially in rice pad

299 Structured background is particularly detrimental when analyzing single-molecule images for 3-

300 nerally considered beneficial, it can become detrimental when cues from different senses are in confl