ライフサイエンスコーパス: detrimental

1 tions, and translation errors are not always detrimental.

2 enlargement of the windows have proven to be detrimental.

3 rowth, suggesting that excessive PEX1 can be detrimental.

4 berrant neural activity that is behaviorally detrimental.

5 reased availability of one splice variant is detrimental.

6 feminization and masculinization are equally detrimental.

7 environment, microglia can be beneficial or detrimental.

8 ndogenous RNA through loss of specificity is detrimental.

9 , with respect to increasing yield, or is it detrimental?

10 Therefore, blocking detrimental activity of both receptor types could be the

11 Tropospheric ozone is considered the most detrimental air pollutant for vegetation at the global s

12 iately after checkpoint blockade can be both detrimental and beneficial for patients with cancer.

13 lly, hyperactivity in the hippocampus may be detrimental and could be one factor that drives Abeta de

14 Airway remodeling is a detrimental and refractory process showing age-dependent

15 However, in the injured nerve it was detrimental and resulted in delayed repair and functiona

16 translated mRNAs in the Fmr1(-/y) brain are detrimental, and some may be candidates for enhancement

17 n the selection and persistence of otherwise detrimental APOL1 kidney disease variants.

18 d be proimmunogenic while apoptosis would be detrimental, as has previously been reported in the cont

19 w consider the beneficial (as opposed to the detrimental) aspects of microbes.

20 acemaker implantation may have a significant detrimental association with patients' prognosis.

21 rds, the impacts of cyclones are known to be detrimental at breeding colonies, but impacts on the ann

22 However, tryptophan substitutions were detrimental at two sites.

23 In its presence, ACQOS causes detrimental autoimmunity, thereby reducing osmotolerance

24 CaMKII as a possible downstream mediator of detrimental beta-AR signaling in HF.

25 ms that can lead to short-term and long-term detrimental cardiomyopathies but differences between rod

26 bifunctional Noyori-type catalysts leads to detrimental catalytic activity.

27 (+)/IL-2(+)/TNF-alpha(+) CD8(+) T cells) and detrimental (CD107a(+)/IFN-gamma(+)/IL-2(-)/TNF-alpha(-)

28 ey drive macrophages toward an alternate and detrimental cell fate of necroptosis.

29 n discussion of prognosis is associated with detrimental changes in measures of the strength of the p

30 ane conductance regulator (CFTR), leading to detrimental changes to protein stability and function.

31 a novel therapeutic strategy to minimize the detrimental clinical outcomes of prolonged cold IRI duri

32 iviral therapy to prevent the development of detrimental clinical outcomes.

33 to ensure that sleep is not initiated during detrimental conditions.

34 with allergic and autoimmune conditions and detrimental consequences in patients with tuberculosis a

35 al AD-associated pathologies, as well as the detrimental consequences of LC degeneration during disea

36 present a widespread target for limiting the detrimental consequences of polymicrobial catheter colon

37 By demonstrating the detrimental consequences of prolonged cellular activatio

38 by which bacteria can potentially bypass the detrimental consequences of toxic amyloid intermediates.

39 that prolonged TNFalpha exposure could have detrimental consequences to endothelial cells by causing

40 Stringent evidence of the direct detrimental contribution of exposure to bullying in chil

41 o which observed associations reflect direct detrimental contributions of exposure to bullying to men

42 In the cerebellum, both compensatory and detrimental contributions seem to occur.

43 Poorly supported management can have detrimental, costly or irreversible impacts on the envir

44 nockdown((-/-)()) mice were rescued from the detrimental CVB3-mediated effects as shown by a reduced

45 ediated encroachment of euchromatin leads to detrimental decondensation of germline chromatin and ger

46 lar proteins in marine organisms against the detrimental denaturing effects of another naturally occu

47 distinguish patient-protective from patient-detrimental desmoplasia and foretell tumor recurrences,

48 ased ability to undergo metabolism and cause detrimental drug-drug interactions.

49 Extreme heat was detrimental during overwintering periods and beneficial

50 programming, generating mutant hiPSCs with a detrimental effect in their differentiated progeny.

51 A detrimental effect of aging on pseudo-random productions

52 Because this detrimental effect of alpha-synuclein on neurons can be

53 The detrimental effect of high antioxidant amounts on TTB st

54 Thus, the detrimental effect of Panx1 deletion in endothelial and/

55 t affect AD-N LCLs, while it neutralized the detrimental effect of TCAH in Control LCLs and resulted

56 which activates the mitoUPR to mitigate the detrimental effect of these mutations on dopamine neuron

57 on of binder additives, which often render a detrimental effect on electrical transport of the printe

58 s, elites and queens) may have an especially detrimental effect on groups' ability to deal with these

59 Glucocorticoid has a detrimental effect on HBVr in RA patients.

60 Mixing also had a detrimental effect on host populations independent of di

61 However, they generally have a detrimental effect on memory and memory-related processe

62 tion of production, which in turn can have a detrimental effect on quality and well-being of consumer

63 rogression-free survival improvement with no detrimental effect on quality of life in patients with p

64 Choosing a direct HLAi transplant has no detrimental effect on survival, but offers no survival b

65 relaxin was safe and well tolerated, with no detrimental effect on systemic blood pressure or hepatic

66 ing of amplitude-modulated sounds may have a detrimental effect on the ability of SNHL listeners to u

67 ispose of so as to leave no trace, or have a detrimental effect on the environment.

68 indicated that segregation has a consistent, detrimental effect on the health of US-born Hispanics, c

69 , ocean acidification is predicted to have a detrimental effect on the physiology of calcifying organ

70 d that the applied protocol did not have any detrimental effect on the retained activity of immobiliz

71 queous film between the ISM and its SC has a detrimental effect on the sensor performance.

72 data confirmed that crossing the hands has a detrimental effect on TOJ judgments in sighted but not i

73 repair proteins that would otherwise have a detrimental effect on viral replication.IMPORTANCE Tumor

74 Thus, the OM inflammation exerted a detrimental effect, not only on OSNs, but also on OB neu

75 nhances functional recovery by blocking this detrimental effect.

76 orylation or dephosphorylation showed little detrimental effect.

77 es and performance degradation caused by the detrimental effects arising from environmental gases and

78 These new media reduced the detrimental effects caused by light and allowed cells to

79 ase II trial for RP, has both beneficial and detrimental effects in animal models of RP depending on

80 ons by OSA during pregnancy impose long-term detrimental effects manifesting as metabolic dysfunction

81 In conclusion, maternal exercise negates the detrimental effects of a maternal high-fat diet on gluco

82 dic memory and learning, is sensitive to the detrimental effects of ageing at morphological and molec

83 The detrimental effects of aortic stiffening may result in b

84 igh crystal quality, while also reducing the detrimental effects of built-in electric fields.

85 f its less-invasive nature, avoidance of the detrimental effects of cardiopulmonary bypass, and large

86 ld permeate through the fibers, reducing the detrimental effects of concentration polarization and pr

87 also protected neuronal responding from the detrimental effects of distracters presented during the

88 xtra carbon gain that can help cope with the detrimental effects of drought.

89 can permit animals to partially overcome the detrimental effects of early maternal deprivation, which

90 inistration of an HDAC inhibitor rescues the detrimental effects of ELS when applied after the manife

91 can provide insight into thresholds for the detrimental effects of estimated sodium intake (ESI) on

92 is a potentially useful tool to correct the detrimental effects of faulty genes; several RNAi are un

93 ABP2 protease domain, helping to explain the detrimental effects of Glu-221 substitution on HABP2 act

94 Detrimental effects of hyperaccumulation of the aromatic

95 response to control infection and limit the detrimental effects of inflammation.

96 e recombination reaction also means that the detrimental effects of inter-radical exchange and dipola

97 Our study offers the first evidence of detrimental effects of light pollution on the health of

98 In particular, we identify the potentially detrimental effects of markets, and the benefits of a co

99 ning onto an obesogenic diet exaggerated the detrimental effects of maternal diet-induced obesity in

100 rmined ifmaternal exercise could reverse the detrimental effects of maternal high-fat feeding on offs

101 tra centrosomes during mitosis, avoiding the detrimental effects of multipolar divisions.

102 wer bounds of CIs indicated that substantial detrimental effects of prognostic discussion were unlike

103 lasticity while ameliorating the potentially detrimental effects of stochasticity.

104 The beneficial or detrimental effects of stress are largely mediated by th

105 oney to buy time can protect people from the detrimental effects of time pressure on life satisfactio

106 or raising public health awareness about the detrimental effects of tobacco smoke exposure on childre

107 on many axons throughout this period with no detrimental effects on axons.

108 heir composition and biological effects have detrimental effects on cardiovascular health.

109 nalogs to deplete ER Ca(2+) stores and their detrimental effects on cell viability.

110 uggest excessive cholinergic stimulation has detrimental effects on DLPFC representations of task att

111 cerns that high phosphorus intake could have detrimental effects on health.

112 ted that gestational carbofuran exposure has detrimental effects on hippocampal neurogenesis, the gen

113 ctly regulated food contaminants with severe detrimental effects on human and animal health.

114 he risk for neurodevelopmental disability or detrimental effects on other organs.

115 ir use is subject of debate because of their detrimental effects on pollinators.

116 c activity worsened Tau pathology and caused detrimental effects on pre- and post-synaptic markers, s

117 orruption are discussed, and its potentially detrimental effects on social attention, perspective tak

118 In conclusion, Edn2 has detrimental effects on the BRB and Muller cells that inv

119 s of the autophagy machinery, which may have detrimental effects on the expansion of the field.

120 t by OSA during pregnancy can have long-term detrimental effects on the fetus, and lead to persistent

121 mption that prematurity results in long-term detrimental effects on the integrity of the cerebellum.

122 tes to myelin injury may exert beneficial or detrimental effects on the lesion pathology, depending o

123 rnal wellbeing, obesity during pregnancy has detrimental effects on the long-term health of the offsp

124 iety or depressive disorders, which can have detrimental effects on the mother, child, and family.

125 ntroduction of a radioactive nuclide without detrimental effects on the pharmacokinetic and toxicolog

126 ent (2 [1.6%] and 8 [6.2%]) or perceived any detrimental effects on their relationship with their onc

127 zyme L-ACY-1 to balance FACs' beneficial vs. detrimental effects remains unknown.

128 cean acidification' was coined, with limited detrimental effects reported.

129 Here, we summarize the detrimental effects that current employment structures h

130 (mtDNA) transcripts were decreased, without detrimental effects to cell growth.

131 at can eradicate tumours selectively without detrimental effects to healthy cells.

132 Negligible detrimental effects to sponge tissue were observed after

133 Previously undocumented detrimental effects were identified for extreme precipit

134 vestigated with both beneficial and possible detrimental effects, depending on the cytokine.

135 cfDNA might be useful to assess CPB-mediated detrimental effects, including endothelial damage, in ca

136 Incomplete or delayed resolution leads to detrimental effects, including propagated tissue damage

137 Despite its known detrimental effects, iron deficiency remains the most co

138 NDP52) fails to reverse amyloid-beta-induced detrimental effects.

139 ition, emotion regulation via suppression, a detrimental emotional control strategy, was positively c

140 Oxidative stress is one of the most detrimental factors affecting oocyte developmental compe

141 ent stability at pH 3.6, while it was highly detrimental for all anthocyanins at pH 4.6.

142 area of mesopores and total pore volume were detrimental for anthocyanins and colour intensity, while

143 iated with vaginal inflammation which can be detrimental for health.

144 in signal peptidase whose expression appears detrimental for infection.

145 ith both too low and too high mobility being detrimental for its activity.

146 Although decoherence is detrimental for most of the tasks in quantum information

147 Flooding is detrimental for nearly all higher plants, including crop

148 ivo, whereas unregulated duplex unwinding is detrimental for recombination precision.

149 another abundant mRNA modification, is also detrimental for RNA binding, thus revealing a potentiall

150 oinflammatory cytokines, which are otherwise detrimental for survival of the parasite within the infe

151 but the high charge density of this state is detrimental for the prevention of the aqueous layer form

152 hboring non-active synapses is thought to be detrimental for the specificity of memory storage.

153 sdermal sensors, due to the reduction of the detrimental foreign body reaction and of consequent pote

154 These cells exert their detrimental functions by promoting tumor growth, angioge

155 bowel diseases, whereas both beneficial and detrimental functions have been documented in neurodegen

156 ial intracellularly, but extracellularly has detrimental functions.

157 with HCV regardless of fibrosis stage may be detrimental given the increased risk of mortality even f

158 ces in low- and middle-income countries have detrimental health and climate effects; cleaner-burning

159 As such, possible detrimental health effects could be amplified through th

160 One possible approach to reducing the detrimental health effects of cystic fibrosis could be t

161 being protective while chronic heavy use has detrimental health outcomes.

162 ted, cell-autonomous feature that exerts its detrimental, highly aggressive growth potential upon esc

163 ecular patterns that stimulate protective or detrimental host immunity.

164 to alter the cell surface pattern to prevent detrimental host responses.

165 experiments revealed that SOX5/6/21 prevent detrimental hyperproliferation of oncogene expressing SV

166 s, but signaling via this interaction can be detrimental if dysregulated.

167 ority of infected individuals but can become detrimental if not finely tuned.

168 utic and thereby mitigate this key source of detrimental immune recognition, we developed a Pareto op

169 ers in the coordination of the lifesaving or detrimental immune response against infections.

170 , emphasizing the potential for induction of detrimental immune responses and the need to better unde

171 We hypothesized that such detrimental immune responses can be avoided by enhancing

172 a shift could play an important role in the detrimental immunopathology that is seen in aspergillosi

173 loid-derived suppressor cells (MDSCs) induce detrimental immunosuppression, but little is known about

174 lies on efficient DNA repair to mitigate the detrimental impact of DNA damage associated with excessi

175 it may potentially result in a beneficial or detrimental impact on the host.

176 radiotherapy in cancer survivors and have a detrimental impact on their quality of life.

177 nd land management for food production, with detrimental impacts on aquatic ecosystems.

178 e gut microbial community structure can have detrimental impacts on hosts.

179 lant without antibiotics can be used with no detrimental impacts on milk microbiome and bacterial loa

180 olume of polymer wastes and their associated detrimental impacts on the environment, the plastic life

181 ernative hypothesis that forest loss is most detrimental in already fragmented landscapes.

182 IRF5 is detrimental in atherosclerosis by promoting the maintena

183 er dichotomy toward Th2 responses, which are detrimental in cutaneous leishmaniasis but beneficial in

184 l of variability per se that is particularly detrimental in early life.

185 sions, is troublesome, which is particularly detrimental in oncology where rearrangements play diagno

186 Hypermetabolism might be detrimental in other structures in which it is associate

187 Elevated sphingosine 1-phosphate (S1P) is detrimental in Sickle Cell Disease (SCD), but the mechan

188 sion of T-bet, but not Gata3, in T cells was detrimental in TMEV infection.

189 tients' family members can also be extremely detrimental, including financial pressures.

190 SCI patients could be a strategy to prevent detrimental infections.

191 y Clostridium perfringens is one of the most detrimental infectious diseases in poultry.

192 ent in multimodality immunotherapy targeting detrimental inflammation and immunosuppression after SS/

193 to diminish innate protection, POP2 reduces detrimental inflammation while preserving and enhancing

194 mune cells that can drive this excessive and detrimental inflammation.

195 we have found that SCS A-beta deficiency has detrimental influence on neuronal mitochondrial dynamics

196 ain homeostasis and compensate for otherwise-detrimental intestinal inflammation.

197 nstallation and operation are known to cause detrimental loss of the product water quality.

198 tulate that the delayed aversive response to detrimental microbes may provide survival benefits by al

199 Whereas severe stress is detrimental, mild stress can be beneficial for health an

200 smalogens), many peroxisomal defects lead to detrimental mitochondrial abnormalities for unknown reas

201 e base excision repair pathway for discreet, detrimental modifications, and thus, the mechanisms by w

202 communities and their ability to constraint detrimental mutants should be considered to design robus

203 Alzheimer's disease (AD) is a detrimental neurodegenerative disease with no effective

204 n elevation of atmospheric [CO2 ] that it is detrimental not only under future conditions of elevated

205 ween managing beneficial microbes, excluding detrimental ones, and channelling as much energy as is a

206 an influence the outcome of infection, being detrimental or beneficial according to the stage of vira

207 he root-soil interface, that can invade with detrimental or beneficial outcomes.

208 Because neuroinflammation can be detrimental or beneficial, before developing immunomodul

209 lain why grain boundaries may be beneficial, detrimental or benign towards device performance.

210 points need to be correlated with observable detrimental organism changes before a need for risk mana

211 Js), has been considered a key factor in the detrimental outcome of the motor function in amyotrophic

212 nt use of psychostimulant drugs, despite the detrimental outcomes associated with continued drug use,

213 ach can be useful for assessing the possible detrimental outcomes of toxic spills, for example oil sp

214 In these areas, detrimental peri-infarct depolarizations (PIDs) contribu

215 t will yield unprecedented knowledge of this detrimental phenotype.

216 O-mediated cascades have both protective and detrimental potential.

217 immunotherapeutics that potentially limits a detrimental proinflammatory response.

218 While biological noise can sometimes be detrimental, recent studies have provided an increasing

219 vide evidence supporting the hypothesis of a detrimental relationship between straight metalworking f

220 uits during postharvest process, persists as detrimental residue to consumers.

221 zed s.c. infection, IL-10 production plays a detrimental role by facilitating bacterial persistence v

222 Together, these findings suggest a detrimental role for EPCR-binding CIDRalpha1 domains in

223 expression of microRNAs (miRNAs) can have a detrimental role in disease pathogenesis.

224 High nutrient availability may play a detrimental role in drought survival due to preferential

225 entify for the first time that NLRP3 plays a detrimental role later in infection, contributing to IAV

226 Here we show the detrimental role of endogenous fructose production by th

227 In this study, we report a detrimental role of Ly6C(hi) iMOs in visceral leishmania

228 Our findings uncover a detrimental role of T-bet-dependent NKp46(+) ILCs in the

229 iple sclerosis and can assume beneficial and detrimental roles during lesion development.

230 Our study suggests previously unknown detrimental roles for two OPN isoforms in causing the im

231 The beneficial versus detrimental roles of estrogen plus progesterone (E+P) in

232 the beneficial effects while minimizing the detrimental roles of the innate immunity may aid functio

233 Opioid pain medications have detrimental side effects including analgesic tolerance a

234 at the system level are accompanied by some detrimental side effects.

235 y while eliminating transesterification as a detrimental side reaction.

236 therapeutic tool to selectively modulate the detrimental signaling environment that precludes remyeli

237 TGFbeta signals, yet may also contribute to detrimental TGFbeta signaling such as EMT.

238 Moisture uptake and outgassing can be detrimental to a system by altering the chemical and mec

239 overcome the water capillary force which is detrimental to achieving freestanding thin films.

240 ated with actively transcribed chromatin are detrimental to ATXR5 activity.

241 s also induce oxidative stress, which may be detrimental to bacterial growth, it is imperative to und

242 Furthermore, FOSL1 genetic inhibition is detrimental to both KRAS-driven tumour types.

243 that Nep1 inhibition makes dAbeta expression detrimental to both MTM and LTM.

244 coholic beverages is commonly regarded to be detrimental to cardiovascular health, there is a debate

245 In both cases the formation of Ni(I) is detrimental to catalysis, which is proposed to proceed v

246 y for R36C, G175R, R17S, and R17H will prove detrimental to cognitive function and successful aging,

247 ng reproductive development are particularly detrimental to crop fruit/seed production.

248 High temperatures are detrimental to crop yields and could lead to global warm

249 Receiving negative social feedback can be detrimental to emotional, cognitive, and physical well-b

250 rily leads to parochialism and ultimately is detrimental to global cooperation.

251 ged disruptions of normal rhythms are highly detrimental to health, deeper knowledge of how our biolo

252 long working hours, are recognized as being detrimental to health.

253 an increase in seasonal fluctuations is more detrimental to high-latitude species adapted to low mean

254 7A1 deficiency owing to genetic mutations is detrimental to human health, whereas 50% of activity ret

255 load required to navigate such a workflow is detrimental to hypothesis generation.

256 important and that overexpression of opaR is detrimental to in vivo fitness.

257 irus' adaptation to its current host will be detrimental to its onward transmission within the host p

258 show that adding a tag to the C-terminus is detrimental to KCC2 function.

259 an increase in the mean temperature is more detrimental to low-latitude species adapted to high mean

260 CT contains potential interferences that are detrimental to MALDI-MSI, while fixation is undesirable

261 M87 proteins, truncated M1 was notably more detrimental to neurite outgrowth than truncated M87, and

262 from cortical neural progenitors in vivo is detrimental to neuronal migration.

263 nses to neuronal injury may be beneficial or detrimental to neuronal recovery, but the mechanisms tha

264 required for absolute quantification was not detrimental to non-targeted data evaluation.

265 nvironments provided by older mothers may be detrimental to offspring cardiovascular health, but that

266 esults indicate that pre-maturation aging is detrimental to oocytes' competence to undergo maturation

267 Radiophobia is detrimental to patients and parents, induces stress, and

268 Notably, these functional alterations are detrimental to performance, and thus, the combination of

269 Salinity of the soil is highly detrimental to plant growth.

270 itionally, masculinization is generally more detrimental to populations than feminization.

271 Avian leukosis virus (ALV) is detrimental to poultry health and causes substantial eco

272 fluorine-18 preparation has been found to be detrimental to reaction yields.

273 ction is a neuropsychiatric disorder that is detrimental to society and currently has no effective tr

274 d oscillations of the mechanical mean values detrimental to the entanglement generation.

275 ncentrations in water supplies is considered detrimental to the environment and human health, and is

276 use of common skin washing techniques may be detrimental to the epidermal antibacterial defense syste

277 onditions caused by heavy sheep grazing were detrimental to the existence of Acrididae, Cicadellidae,

278 While ubiquitous hTetherin expression was detrimental to the growth and survival of mice, restrict

279 Thus, defects in organelle clearance may be detrimental to the health of the cells, contributing to

280 me evolution, but their enhanced activity is detrimental to the host and therefore must be tightly re

281 These cytokines are detrimental to the host during infection by priming leuk

282 Since severe inflammation can be detrimental to the host, we investigated whether targeti

283 ince it enhances bacterial dispersal, but is detrimental to the host.

284 dampening excessive inflammation that may be detrimental to the infected cell.

285 mones can be beneficial to the microbe while detrimental to the insect host.Behavioral manipulation o

286 ovascular responses in cirrhosis that can be detrimental to the LT candidate.

287 ls, and the decrease projected here could be detrimental to the North Atlantic Right Whale and a host

288 sential micronutrient, increased amounts are detrimental to the organism; thus, only a small window e

289 contamination is generally considered to be detrimental to the performance of aprotic lithium-air ba

290 is often a collaborative effort that may be detrimental to the producers.

291 Early and high-level expression of hNIS is detrimental to the recombinant virus, leading to the agg

292 at have residual TLR8 activity, which may be detrimental to the tolerability of the candidate drug.

293 daughter cells, which would be particularly detrimental to the whole organism.

294 lipids favours protein reconstitution but is detrimental to topology and function.

295 es mellitus, a condition that is known to be detrimental to union.

296 however, combination of these traits can be detrimental too, for instance by leading to undesirable

297 hing (on-switching), MINFIELD largely avoids detrimental transitions to higher molecular states.

298 results suggest that IL33 may initiate early detrimental type 2 immune responses after trauma through

299 igate whether this response is protective or detrimental, we generated mice in which the critical aut

300 nisms that induce Allee effects which become detrimental when populations are reduced and maintained