ライフサイエンスコーパス: deubiquitinase

1 PTEN influences its stability through OTUD3 deubiquitinase.

2 ith concomitantly reduced affinity for other deubiquitinases.

3 d function in a protein complex with histone deubiquitinases.

4 the chromatin binding and activities of the deubiquitinases.

5 o form of USP7, which differs from other USP deubiquitinases.

6 ubiquitin-specific protease (USP) family of deubiquitinases.

7 mulation with proinflammatory cytokines, the deubiquitinase A20 inducibly interacts with the regulato

8 pendent, noncatalytic mechanism by which the deubiquitinase A20 inhibits IkappaB kinase and NF-kappaB

9 PTEN, the signaling inhibitor SOCS1 and the deubiquitinase A20.

10 mulation of IKKgamma deubiquitination by the deubiquitinases A20 and CYLD (cylindromatosis).

11 rotease 9X (USP9X) is by far the most active deubiquitinase acting on Ub-PEX5, both in female rat liv

12 described here will be useful in identifying deubiquitinases acting on other ubiquitin conjugates.

13 ors or confer differential susceptibility to deubiquitinase activities associated with each pathway.

14 ying complex possesses acetyltransferase and deubiquitinase activities.

15 e depending on opposing ubiquitin ligase and deubiquitinase activities.

16 r phosphorylation directly regulates VCIP135 deubiquitinase activity and Golgi membrane fusion in the

17 which is accompanied by the recovery of its deubiquitinase activity and Golgi reassembly.

18 rylation of CYLD at serine 418 decreases its deubiquitinase activity and is necessary for IKKepsilon-

19 dies reveal molecular mechanisms whereby A20 deubiquitinase activity and ubiquitin binding, linear ub

20 The PCP domain was shown to have deubiquitinase activity for both RIG-I and TBK-1, whose

21 However, the deubiquitinase activity for stabilizing Tip60 is unknown

22 o underscores the biological significance of deubiquitinase activity in MSC function.

23 y reported effectors, such as the unexpected deubiquitinase activity in Xanthomonas XopD, contributed

24 d's incorporation into the proteasome, Rpn11 deubiquitinase activity is inhibited to prevent unwarran

25 The deubiquitinase activity is involved in the stabilization

26 USP7 deubiquitinase activity is required for the stabilizatio

27 ermore, small-molecule inhibitors of HAUSP's deubiquitinase activity markedly suppress the growth of

28 This interaction allows the deubiquitinase activity of ataxin 3 to protect beclin 1

29 nuclear factor-kappaB activation through its deubiquitinase activity or by degradation of mRNA encodi

30 n this modular complex, Ataxin-7 anchors the deubiquitinase activity to the larger complex.

31 8R) in a case that completely abolished BAP1 deubiquitinase activity was identified.

32 A small-molecule inhibitor of STAMBP deubiquitinase activity, BC-1471, decreases NALP7 protei

33 gative regulator of NF-kappaB signaling with deubiquitinase activity, is highly expressed in label-re

34 GE mobility shift of the protein, blocks its deubiquitinase activity, promotes its dissociation from

35 l kinase inhibitors, directly inhibits Usp9x deubiquitinase activity, resulting in the down-regulatio

36 ds plant chromatin and has enzymatic histone deubiquitinase activity, specific for the H2B histone.

37 bilities, as well as RNase activity, but not deubiquitinase activity, which impaired the inhibitory a

38 uate ubiquitin binding and thus inhibit USP7 deubiquitinase activity.

39 two juxtaposed helices critical to ataxin-3 deubiquitinase activity.

40 H2O2, revealing a new mechanism to regulate deubiquitinase activity.

41 A20 restricts NF-kappaB signals via its deubiquitinase activity.

42 into the proteasome as well as a C-terminal deubiquitinase adaptor (DEUBAD) domain that binds the de

43 head (winged-helix) DNA-binding domain and a deubiquitinase adaptor domain shared with two regulators

44 was examined and it was discovered that some deubiquitinases also possess derubylase activity.

45 y obstacle in delineating the impact between deubiquitinase and deISGylase activities on viral host e

46 e (PLpro) that has been observed to act as a deubiquitinase and deISGylase to antagonize type I inter

47 ptidase 49 (USP49) as a histone H2B-specific deubiquitinase and demonstrate that H2B deubiquitination

48 A20 contains deubiquitinase and E3 ligase domains and thus has been p

49 RF1 and suggest that the association between deubiquitinase and E3 ligase may serve as a common strat

50 e deISGylase activity but retained wild-type deubiquitinase and peptide cleavage activities.

51 vity with no appreciable impact on its other deubiquitinase and peptide cleavage biochemical properti

52 east, where loss of Ataxin-7 inactivates the deubiquitinase and results in increased H2B ubiquitinati

53 nd implements M2 polarization using both its deubiquitinase and RNase activities that cause sequentia

54 y identifies USP49 as a histone H2B-specific deubiquitinase and uncovers a critical role for H2B deub

55 a synthetic lethal screen with a library of deubiquitinases and identify USP39, which encodes an ess

56 Our work highlights the plasticity of deubiquitinases and indicates that new conformational st

57 Deubiquitinases and the ubiquitin/proteasome components

58 Ovarian tumour deubiquitinases are cysteine proteases that cleave polyu

59 Deubiquitinases are important components of the protein

60 Deubiquitinases are proteases with a wide functional div

61 Here we find that Ubp2 and Ubp3 deubiquitinases are required for the proteasomal degrada

62 Here we show that ovarian tumour deubiquitinases are susceptible to reversible oxidation

63 977 melanoma cases and 754 controls and used deubiquitinase assays, a pedigree analysis, and a histop

64 The two deubiquitinases associate more with Rsp5 upon heat-stres

65 enhancing binding and activity of the USP16 deubiquitinase at transcribed genes.

66 olyglutamine (polyQ) repeat expansion in the deubiquitinase ataxin-3 causes neurodegeneration in Spin

67 re generated in situ by aggregate-associated deubiquitinase ataxin-3.

68 stinct pathways; an important example is the deubiquitinase ataxin3, which collaborates with p97 in e

69 We report that in addition to inhibition of deubiquitinases, b-AP15 inhibits the selenoprotein thior

70 the important tumour suppressor protein, the deubiquitinase BAP1.

71 USP2a is a member of a subfamily of deubiquitinases, called ubiquitin-specific cysteine prot

72 Here we reveal how the deubiquitinase Cezanne (also known as OTUD7B) specifical

73 The deubiquitinase cezanne is a direct target of miR-218 and

74 A compensatory upregulation of Usp24, a deubiquitinase closely related to Usp9x, in Usp9x KD cel

75 establish the druggability of the USP1/UAF1 deubiquitinase complex and its potential as a molecular

76 onally interacted with the constituents of a deubiquitinase complex consisting of USP22, ATXN7, and A

77 s BAP1 and ASXL1 interact to form a polycomb deubiquitinase complex that removes monoubiquitin from h

78 SXL1 is the obligate regulatory subunit of a deubiquitinase complex whose catalytic subunit is BAP1.

79 removed by BRISC, an ABRO1/BRCC36-containing deubiquitinase complex.

80 Ovarian tumour deubiquitinases comprise a family of fourteen human enzy

81 Here, we show that Leon, the Drosophila USP5 deubiquitinase, controls postsynaptic growth.

82 Because high levels of the USP8 deubiquitinase correlated with high levels of FLIP(S) ub

83 uitin chain assembly complex (LUBAC) and the deubiquitinase CYLD (cylindromatosis).

84 The deubiquitinase CYLD acts as a key negative regulator to

85 iquitin-editing enzyme A20 (TNFAIP3) and the deubiquitinase CYLD are central negative regulators of N

86 Here we demonstrate that E3 ligase Itch and deubiquitinase Cyld formed a complex via interaction thr

87 re we report that silencing of the lysine 63 deubiquitinase CYLD increases HIV transcription in an NF

88 Conversely, knockdown of the RIP1 deubiquitinase CYLD inhibited these functions.

89 Here we show that loss of deubiquitinase CYLD led to the development of lung fibro

90 es CARMA1 and is negatively regulated by the deubiquitinase CYLD.

91 We report here that silencing of the deubiquitinase cylindromatosis protein (CYLD), increases

92 t was inserted into the EVG genome encodes a deubiquitinase/deISGylase and potentially suppresses hos

93 tations in the A20 ovarian tumour (OTU)-type deubiquitinase domain or in the zinc finger-4 (ZnF4) ubi

94 requiring MCPIP1's endoribonuclease but not deubiquitinase domain.

95 ch house histone acetyltransferase (HAT) and deubiquitinase (DUB) activities.

96 b-AP15 and its derivatives block proteasome deubiquitinase (DUB) activity and have been developed an

97 vity blocks oogenesis, while loss of the H2B deubiquitinase (DUB) activity does not.

98 Inhibition of deubiquitinase (DUB) activity is a promising strategy fo

99 Interestingly, an MHV68 mutant lacking deubiquitinase (DUB) activity, embedded within the large

100 The deubiquitinase (DUB) and tumor suppressor BAP1 catalyzes

101 A20 possesses both deubiquitinase (DUB) and ubiquitin E3 ligase activities

102 frequently mutated in cancer, functions as a deubiquitinase (DUB) for histone H2A.

103 e [poly(Q)] tract in ATXN7, a subunit of the deubiquitinase (DUB) module (DUBm) in the SAGA complex.

104 atalytic domain of herpes simplex virus UL36 deubiquitinase (DUb) to the N-terminal RING domain of rh

105 The deubiquitinase (DUB) Ubp10 is thought to promote heteroc

106 We identified the deubiquitinase (DUB) Ubp7 as a late-arriving endocytic p

107 Recent evidence suggests that several deubiquitinases (DUB) are overexpressed or activated in

108 in regulation of the UPS involves targeting deubiquitinases (DUB).

109 Mechanistically, we identify a deubiquitinase, DUB3, as a target of CDK4/6; CDK4/6-medi

110 position on substrate, and susceptibility to deubiquitinases (DUBs) affect processing of different su

111 Deubiquitinases (DUBs) are a new class of drug targets,

112 , and both 20S proteasome peptidases and 19S deubiquitinases (DUBs) are becoming attractive targets o

113 Deubiquitinases (DUBs) are key regulators of Ub signalin

114 Deubiquitinases (DUBs) are proteases that regulate vario

115 Recent findings implicate ERAD-associated deubiquitinases (DUBs) as positive and negative regulato

116 ide bond is processed to a similar extent by deubiquitinases (DUBs) as that of a native Nepsilon-Gly-

117 There are approximately 90 deubiquitinases (DUBs) encoded in the human genome, of w

118 Sixteen ovarian tumor (OTU) family deubiquitinases (DUBs) exist in humans, and most members

119 lysines, which can be antagonized by various deubiquitinases (DUBs) including the CYLD tumour suppres

120 hibition of UPS components, particularly key deubiquitinases (DUBs) of the ubiquitin-specific proteas

121 Deubiquitinases (DUBs) play an important role in regulat

122 Deubiquitinases (DUBs) remove ubiquitin conjugates from

123 In eukaryotes, deubiquitinases (DUBs) remove ubiquitin conjugates from

124 Deubiquitinases (DUBs) reverse ubiquitin signals with eq

125 ormations, and ubiquitin-binding domains and deubiquitinases (DUBs) select pre-existing conformations

126 studies is that ubiquitin ligases (E3s) and deubiquitinases (DUBs), enzymes with opposing activities

127 B2 NZF Ub binding domain (UBD), 10 out of 12 deubiquitinases (DUBs), including USP8, USP15 and USP30,

128 e specificities of two proteasome-associated deubiquitinases (DUBs), Rpn11 and Ubp6, and explored the

129 us stages, including through its reversal by deubiquitinases (DUBs).

130 ts are well known, as are a variety of viral deubiquitinases (DUBs).

131 Removal of ubiquitin chains is mediated by deubiquitinases (DUBs).

132 ng catalyzed by a family of enzymes known as deubiquitinases (DUBs).

133 emoval of ubiquitin by ubiquitin ligases and deubiquitinases (DUBs).

134 d is reversed by a class of enzymes known as deubiquitinases (DUBs).

135 is tumor-suppressor protein), a K63-specific deubiquitinase enriched in postsynaptic densities, cleav

136 mplex, comprised of the E3 ligase Nrdp1, the deubiquitinase enzyme USP8, and Clec16a, a mediator of b

137 in-specific peptidase 9, X-linked (USP9X), a deubiquitinase enzyme, binds ERG in VCaP prostate cancer

138 With TLR ligation, the deubiquitinase enzyme, STAM-binding protein (STAMBP) imp

139 It can be reversed by deubiquitinase enzymes (DUBs) that remove ubiquitin moie

140 Deubiquitinase enzymes cleave ubiquitin from substrates

141 an and colleagues identify a sixth family of deubiquitinase enzymes that are highly conserved through

142 Collectively, our results identify CYLD as a deubiquitinase facilitating DNA damage-induced p53 activ

143 iated cellular complexes, and identified the deubiquitinase FAM/USP9X as a novel interacting protein

144 In this study, we identified a member of the deubiquitinases family, ubiquitin-specific protease 18 (

145 direct antagonism between an E3 ligase and a deubiquitinase, Fbw7 and Usp28, in modulating intestinal

146 brary, we have identified USP2 as a specific deubiquitinase for cyclin D1.

147 S holoenzyme, which ultimately activates the deubiquitinase for substrate degradation.

148 study identifies USP12 and USP46 as histone deubiquitinases for H2A and H2B and reveals that USP12 r

149 how here that CYLD, a tumour suppressor with deubiquitinase function, has a pivotal and cell-intrinsi

150 clear which of the several counteracting H2A deubiquitinases functions along with PRC1 to control H2A

151 on by either lysine mutations or fusion of a deubiquitinase hampers NE-derived vesicle formation and

152 nd to the N-terminal TRAF-like region of the deubiquitinase HAUSP (herpesvirus-associated ubiquitin-s

153 ecently, an increasing number of histone H2A deubiquitinases have been identified and characterized.

154 Deubiquitinases hydrolyse ubiquitin modifications from p

155 USP7 is a deubiquitinase implicated in destabilizing the tumor sup

156 n IL-2 signaling and reduced expression of a deubiquitinase important for FOXP3 stability.

157 ene targeting approach to knockout (KO) this deubiquitinase in chicken DT40 cells.

158 The potential inclusion of such a novel deubiquitinase in the emerging anti-inflammatory strateg

159 e activities, revealing K63-linkage-specific deubiquitinases in human pathogens, such as Salmonella,

160 protease 14 (Usp14), a proteasome-associated deubiquitinase, in direct Ag presentation using a ligand

161 it stabilizes c-IAPs in vivo mainly through deubiquitinase-independent mechanisms.

162 related to enhanced expression of the USP22 deubiquitinase induced by c-MYC, leading to reduced SIRT

163 in vitro and in vivo, whereas a gradient of deubiquitinase inhibition promotes axon turning in vitro

164 Treatment with the deubiquitinase inhibitor PR-619 increased caspase-8 ubiq

165 Taken together, our data indicate that the deubiquitinase inhibitor WP1130 increases bacterial kill

166 we found that the partially selective Usp9x deubiquitinase inhibitor WP1130 induced apoptosis and re

167 suggests opportunities for developing other deubiquitinase inhibitors and may be a strategy more bro

168 However, developing selective deubiquitinase inhibitors has been challenging and no co

169 mational dynamics are critical for ubiquitin-deubiquitinase interactions and imply that the fine tuni

170 USP9X is a deubiquitinase involved in multiple signaling and surviv

171 tors is central to Hh signaling, but whether deubiquitinase is involved in this process remains unkno

172 ed; however, it is unknown whether and how a deubiquitinase is involved.

173 The BAP1 nuclear deubiquitinase is known to target histones (together wit

174 egulatory factor 1 (IRF1), suggesting that a deubiquitinase is recruited during gene activation.

175 The BAP1 protein, a nuclear deubiquitinase, is inactivated in 15% of clear cell RCCs

176 tment with a small molecule inhibitor of the deubiquitinase (IU1) increased receptor ubiquitination.

177 tion affecting the catalytic site within the deubiquitinase JAB1/MPN/Mov34 (JAMM)/MPN domain.

178 ice, we identified cylindromatosis (CYLD), a deubiquitinase known to act directly on RIP1 and promote

179 We report that USP28, a deubiquitinase known to be inhibitable by Ni(II) or hypo

180 ction in euploid cells, and deletion of this deubiquitinase leads to further proteasome-mediated prot

181 Thus, the deubiquitinase Leon maintains ubiquitin homeostasis and

182 biquitinated cyclin D1 as a substrate with a deubiquitinase library, we have identified USP2 as a spe

183 talytic domain related in fold to Ulp family deubiquitinase-like enzymes and a C-terminal PI3P-bindin

184 Here we report that USP30, a deubiquitinase localized to mitochondria, antagonizes mi

185 sease, indicating that ubiquitin ligases and deubiquitinases maintain the delicate balance between ef

186 he Spt-Ada-Gcn5 acetyltransferase (SAGA) H2B deubiquitinase module competes with Bre1 for binding to

187 chanism in vivo, we found that a recombinant deubiquitinase module is active in the absence of Ataxin

188 Deubiquitinase MYSM1 has been shown to play a critical r

189 Immunity, Jiang et al. demonstrate that the deubiquitinase MYSM1 is part of an epigenetic switch tha

190 this study, we revealed that the histone H2A deubiquitinase MYSM1 plays an essential and intrinsic ro

191 on of NK cell development by the histone H2A deubiquitinase MYSM1 through the transcriptional control

192 ) mouse model, we identified the histone H2A deubiquitinase Mysm1, as a critical regulator in DC diff

193 found that mice deficient in the histone H2A deubiquitinase MYSM1, despite their severe defect in B c

194 mpaired in mice deficient in the histone H2A deubiquitinase MYSM1.

195 the protein stability of USP28, a bona fide deubiquitinase of LSD1.

196 iquitin carboxyl-terminal hydrolase (UCH) L5 deubiquitinases of the 19S proteasome that shows antitum

197 e reversal of this reaction by the USP1:UAF1 deubiquitinase only occurs when DNA is disengaged.

198 rulence factors that function as E3 ligases, deubiquitinases or as enzymes that directly attack ubiqu

199 acterial effector proteins with deSUMOylase, deubiquitinase, or, even, acetyltransferase activities.

200 We identify an Arabidopsis otubain-like deubiquitinase OTLD1 which directly interacts with the A

201 Here, we show that an OTU domain deubiquitinase, OTUD4, is a positive regulator of ALKBH2

202 Here we have identified the deubiquitinase OTUD7B as a pivotal regulator of the non-

203 Here, we show that the M1-specific deubiquitinase OTULIN is essential for preventing TNF-as

204 entified that the ovarian tumor (OTU) family deubiquitinase OTULIN specifically disassembles Met1-Ub.

205 naling, and its function is regulated by the deubiquitinases OTULIN and CYLD, which associate with th

206 ngle E3 ligase complex (LUBAC), one specific deubiquitinase (OTULIN) and a very few linear polyubiqui

207 In contrast to other characterized USP deubiquitinases, our results indicate that USP28 has a c

208 Here, we demonstrate that the deubiquitinase ovarian tumor domain containing ubiquitin

209 for the 19S-resident and degradation-coupled deubiquitinase Poh1 in TRIM21 neutralization, signaling,

210 To reveal how the polycomb repressive-deubiquitinase (PR-DUB) complex controls substrate selec

211 The tumour suppressor CYLD is a deubiquitinase previously shown to inhibit NF-kappaB, MA

212 Deubiquitinases reduce polyubiquitin dwell times prefere

213 oncanonical mechanism by which an OTU family deubiquitinase regulates its substrates, and provides mu

214 Here we report that Usp16, a histone H2A deubiquitinase, regulates H2A deubiquitination and gene

215 nctions for this entire group of histone H2A deubiquitinases remain unknown.

216 Deubiquitinases remove ubiquitin from proteins, and thei

217 Deubiquitinases remove ubiquitin from substrates to prev

218 By contrast, the OTUD7B deubiquitinase removes polyubiquitin chains from GbetaL

219 ctional RNAi screen and identified BAP1 as a deubiquitinase required for efficient assembly of the ho

220 D4, which encode a ubiquitin E3 ligase and a deubiquitinase, respectively, were found in three affect

221 6S proteasome, where they are removed by the deubiquitinase Rpn11 during ATP-dependent substrate degr

222 ination at and eviction from chromatin; as a deubiquitinase, specific to the antagonism of ubiquitin

223 Together, these results reveal that the deubiquitinase STAMBPL1 is a key regulator of Tax traffi

224 e presence of A20, an upstream Lys-63-linked deubiquitinase, strongly curtailed the ability of MLK3 t

225 h TIR domain signalosome formation; 2) major deubiquitinases such as A20, CYLD, and DUBA prevent asso

226 o protect polyubiquitin from the activity of deubiquitinases, such as ataxin-3, that are necessary fo

227 ed ubiquitin-specific protease 8 (USP8) as a deubiquitinase that down-regulates Smo ubiquitination.

228 l hydrolase, UCH-L1, is an abundant neuronal deubiquitinase that is associated with Parkinson's disea

229 entify the mechanism of secretion of TssM, a deubiquitinase that plays an integral role in regulating

230 e (RNAi) libraries, we identified USP47 as a deubiquitinase that prevents beta-catenin ubiquitination

231 We recently discovered OTULIN as a deubiquitinase that specifically cleaves Met1-linked pol

232 e encoding A20 to repress expression of this deubiquitinase that suppresses inflammatory NF-kappaB si

233 OTUD4 is a scaffold for USP7 and USP9X, two deubiquitinases that act directly on the AlkB proteins.

234 Ubiquitination is balanced by deubiquitinases that cleave polyubiquitin chains and opp

235 ified USP12 and USP46 as histone H2A and H2B deubiquitinases that regulate Xenopus development.

236 of these sites prevents the binding of USP9x deubiquitinase, thereby promoting the proteasomal degrad

237 Deubiquitinases therefore play an important role in the

238 strated that USP21 acts as a bona fide RIG-I deubiquitinase to down-regulate antiviral response indep

239 finger (NZF1) domain of the K29/K33-specific deubiquitinase TRABID specifically binds K29/K33-linked

240 ve Npl4 Zinc Finger 1 (NZF1) domain from the deubiquitinase TRABID to enrich for chains from human ce

241 llectively called 'Il23' here) involving the deubiquitinase Trabid.

242 K1 in the context of NASH, we identified the deubiquitinase tumor necrosis factor alpha-induced prote

243 We have identified the deubiquitinase Ubiquitin Specific Protease-7 (USP7) as a

244 Rather, we identified the deubiquitinase ubiquitin-specific peptidase 9X (USP9X) a

245 e ubiquitin pathway add (ligases) or remove (deubiquitinases) ubiquitin tags to or from their target

246 Here, we show that disruption of yeast deubiquitinase UBP3 leads to enhanced UV resistance, inc

247 The deubiquitinase Ubp3, which was identified by a genome-wi

248 ontrast, another UBL-containing protein, the deubiquitinase Ubp6, is also anchored by Rpn1, yet it di

249 The Saccharomyces cerevisiae deubiquitinase Ubp7 has been characterized previously as

250 Sumoylation of Smo in turn recruits a deubiquitinase UBPY/USP8 to antagonize Smo ubiquitinatio

251 hanistically, in response to DNA damage, the deubiquitinase UCHL3 is phosphorylated and activated by

252 ermediates, we show that many ovarian tumour deubiquitinases undergo reversible oxidation upon treatm

253 and can be mediated through the loss of the deubiquitinase USP1.

254 The deubiquitinase USP10 specifically removes ubiquitination

255 NEMO ubiquitylation is decreased through the deubiquitinase USP10, which interacts with NEMO via MCPI

256 Huwe1 activity on TBP is antagonized by the deubiquitinase USP10, which protects TBP from degradatio

257 ugh Notch/Hey1-induced repression of the PML deubiquitinase USP11 and suggests an important role for

258 ical analyses of an evolutionarily conserved deubiquitinase, USP12, which is activated by two beta-pr

259 Here we report that a deubiquitinase, USP13, regulates DDR by targeting RAP80.

260 of ML364, a small molecule inhibitor of the deubiquitinase USP2 and its use to interrogate the biolo

261 E3 ligase Nedd4 and deubiquitination by the deubiquitinases USP20 and USP33 have been shown to regul

262 ligase, and promoted the dissociation of the deubiquitinases USP20 and USP33.

263 Here we report that the E3 deubiquitinase USP21 prevents the depletion of FOXP3 at

264 Functional comparison of three deubiquitinases (USP21, A20, and CYLD) demonstrated that

265 The deubiquitinase USP28 stabilizes oncogenic factors, inclu

266 encoding the p53-binding protein 53BP1, the deubiquitinase USP28, and the ubiquitin ligase TRIM37.

267 This activity is antagonized by the deubiquitinase Usp28, which is highly expressed in murin

268 Recently, we have identified the deubiquitinase USP37 as a regulator of the cell cycle.

269 We show that the deubiquitinase USP37 binds CDH1 and removes degradative

270 The deubiquitinase USP44 was identified as a key regulator o

271 In this study, we show that the deubiquitinase USP46 stabilizes the expression of both P

272 Here we report that a deubiquitinase, USP49, is a new regulator of the AKT pat

273 ion elongation factor Elongin BC and the H2B deubiquitinase USP7 to modulate transcriptional processe

274 BP1 by accelerating its interaction with the deubiquitinase USP7.

275 ort that PHF8 physically associates with the deubiquitinase USP7.

276 f CHMP5 by inducing its interaction with the deubiquitinase USP8.

277 content and pathological localization of the deubiquitinase Usp8.

278 Drosophila model, unlike knockdown of other deubiquitinases, Usp8 protected from alpha-synuclein-ind

279 our data describe the identification of the deubiquitinase USP9X as a novel mTORC1 and -2 binding pa

280 ere, we define a cell intrinsic role for the deubiquitinase Usp9X during proximal TCR signaling.

281 anner, we found that loss of function in the deubiquitinase USP9X prevented proliferation arrest by t

282 a, the E3 ligases MULE and betaTrCP, and the deubiquitinase USP9x regulate cytokine-mediated MCL-1 pr

283 Here we show that the deubiquitinase USP9X stabilizes MCL1 and thereby promote

284 most commonly mutated gene was the X-linked deubiquitinase Usp9x, which was inactivated in over 50%

285 in early mitosis and deubiquitinated by the deubiquitinase VCIP135 in late mitosis.

286 nsisting of the HECT E3 ligase UBE3C and the deubiquitinase vOTU.

287 s and His box motifs conserved in eukaryotic deubiquitinases, was purified and biochemically characte

288 uggesting that Ub-PEX5 is also a target of a deubiquitinase were also obtained in that work.

289 We identify Dub3 as a bona fide Snail1 deubiquitinase, which interacts with and stabilizes Snai

290 release requires cooperation of Cdc48 with a deubiquitinase, which trims polyubiquitin to an oligoubi

291 s identified Usp16 as one of the histone H2A deubiquitinases, which coordinates with the H2A ubiquiti

292 USP7 is a protein deubiquitinase with an essential role in development.

293 Mysm1 is a recently identified histone H2A deubiquitinase with essential and intrinsic roles for ma

294 on mutations in OTULIN (FAM105B), encoding a deubiquitinase with linear linkage specificity.

295 domain revealed high similarity to mammalian deubiquitinases with a unique alpha-helix close to the s

296 review, we focus on NF-kappaB regulation by deubiquitinases with an emphasis on A20 and CYLD.

297 2c inhibited representative deubiquitinases with micromolar IC50, and its proapoptot

298 nts exhibit increased affinity for the USP14 deubiquitinase, with concomitantly reduced affinity for

299 e processing and is accomplished by Rpn11, a deubiquitinase within the 'lid' sub-complex.

300 enzymatic activities with two mitochondrial deubiquitinases, yeast ScUBP16 and human HsUSP30, which