ライフサイエンスコーパス: deubiquitinating enzyme

1 the first verified protein target of the EBV deubiquitinating enzyme.

2 lso requires the action of CYLD, a RIPK1 K63 deubiquitinating enzyme.

3 two different mutations in a gene encoding a deubiquitinating enzyme.

4 ssemble substrates, shuttling factors, and a deubiquitinating enzyme.

5 ations in USP9X, encoding a highly conserved deubiquitinating enzyme.

6 by the enzymatic activity of the EBV-encoded deubiquitinating enzyme.

7 eins, IKK, NF-kappaB, ubiquitin ligases, and deubiquitinating enzymes.

8 ng a short hairpin RNA library against known deubiquitinating enzymes.

9 tin and Uch37, one of the proteasome's three deubiquitinating enzymes.

10 umor (OTU) domain class of cysteine protease deubiquitinating enzymes.

11 tor protein may regulate a subclass of human deubiquitinating enzymes.

12 g process that is mediated by p97-associated deubiquitinating enzymes.

13 eins and recruits both ubiquitin ligases and deubiquitinating enzymes.

14 iquitin ligase BRAP2/IMP, and a subfamily of deubiquitinating enzymes.

15 ding member of a previously unknown class of deubiquitinating enzymes.

16 and is distinct from that observed in other deubiquitinating enzymes.

17 jugation is a reversible process mediated by deubiquitinating enzymes.

18 opts a fold closely resembling that of known deubiquitinating enzymes.

19 asome and one of three proteasome-associated deubiquitinating enzymes.

20 These include E3 ubiquitin ligases and deubiquitinating enzymes.

21 ubiquitin ligases (E3s) and removed through deubiquitinating enzymes.

22 n tumor domain (OTU)-containing subfamily of deubiquitinating enzymes.

23 alpha-helical hairpin that is unusual among deubiquitinating enzymes.

24 Deubiquitinating enzyme A (DUBA), an ovarian tumor domai

25 Deubiquitinating enzyme A (DUBA), which selectively clea

26 Deubiquitinating enzymes, a class of proteases capable o

27 s 63-linked ubiquitination of TRAF6, and the deubiquitinating enzyme A20 was found to be significantl

28 dislocation of MHCI heavy chains did require deubiquitinating enzyme activity and rapid proteasome-me

29 In vitro reconstitution of USP1 deubiquitinating enzyme activity, using either ubiquitin

30 The deubiquitinating enzyme AMSH has been implicated in the

31 n of receptors and was also regulated by two deubiquitinating enzymes, AMSH and UBPY, which localized

32 trate that USP53 is a catalytically inactive deubiquitinating enzyme and a novel component of tight j

33 Itch interacts with the deubiquitinating enzyme and is required for deubiquitina

34 , we performed a siRNA screening to identify deubiquitinating enzymes and found that USP36 acts as an

35 and ENY2 orchestrate activities of multiple deubiquitinating enzymes and that imbalances in these ac

36 spatial arrangement of ubiquitin receptors, deubiquitinating enzymes and the protein unfolding machi

37 ins may also form complexes with other human deubiquitinating enzymes and thereby regulate their acti

38 perativity between an ubiquitin ligase and a deubiquitinating enzyme, and establish a role for USP7 i

39 We previously identified PfUCHL3, a deubiquitinating enzyme, and here we characterize its ac

40 ical analysis showed that AMSH1 is an active deubiquitinating enzyme, and that AMSH1 specifically cle

41 ncluding the Stk11 protein kinase, the Usp9x deubiquitinating enzyme, and their substrate kinase MARK

42 n ubiquitin ligases, of JAMM- and USP-domain-deubiquitinating enzymes, and of numerous ubiquitin-bind

43 ubiquitination processes involving the AMSH1 deubiquitinating enzyme are thus involved in both infect

44 Because deubiquitinating enzymes are components of the ubiquitin

45 Deubiquitinating enzymes are essential to the ubiquitin

46 Deubiquitinating enzymes are proteases that reverse this

47 Sem1p and its interacting partner, Ubp6p (a deubiquitinating enzyme), are essential to maintain telo

48 Collectively these results implicate a deubiquitinating enzyme as a regulator of the UPR.

49 Here, we report USP15, a deubiquitinating enzyme, as a regulator of protein-prote

50 The deubiquitinating enzyme associated molecule with the SH3

51 ubiquitin-ligase interacts with ataxin-3, a deubiquitinating enzyme associated with Machado-Joseph d

52 One such protein is the deubiquitinating enzyme ataxin 3, which is widely expres

53 cysteine protease domain found in four human deubiquitinating enzymes: ataxin-3, the ataxin-3-like pr

54 ic deficiency of Cyld, a recently identified deubiquitinating enzyme, attenuates the early wave of ge

55 The identification of the deubiquitinating enzyme BAP1 as a tumor suppressor may l

56 This deubiquitinating enzyme binds BoNT/A light chain directl

57 u tumor suppressor (VHL) protein-interacting deubiquitinating enzyme, binds to the Robo1 receptor, an

58 The deubiquitinating enzyme BRCA1-associated protein 1 (BAP1

59 hibition of RNF168 at telomeres involves the deubiquitinating enzyme BRCC3 and the ubiquitin ligase U

60 We further identify the deubiquitinating enzyme, BRCC3, as a critical regulator

61 ed-coil domain protein CCDC98/Abraxas, and a deubiquitinating enzyme BRCC36.

62 More interestingly, Mib1 is associated with deubiquitinating enzymes, BRCC36 and the mammalian ortho

63 me can be antagonized by proteasome-residing deubiquitinating enzymes, by the binding of polyubiquiti

64 we show that USP14, a proteasome-associated deubiquitinating enzyme, can inhibit the degradation of

65 Here, we show that the chlamydial deubiquitinating enzyme (Cdu) 1 localizes in the inclusi

66 nd Hse1 that recruit ubiquitinated cargo and deubiquitinating enzymes close to each other.

67 )-UAF1 (USP1-associated factor 1) complex, a deubiquitinating enzyme complex for PCNA and FANCD2.

68 sent the isolation of two novel multisubunit deubiquitinating enzyme complexes containing USP12 and U

69 teins that interact with the USP12 and USP46 deubiquitinating enzyme complexes.

70 Incubation with a deubiquitinating enzyme converted the p110:p107 PEPC het

71 Hence, deubiquitinating enzymes could offer novel therapeutic t

72 n-induced and NF-kappaB-driven expression of deubiquitinating enzyme CSN5 leads to PD-L1 stabilizatio

73 The deubiquitinating enzyme CYLD has recently been implicate

74 stigated the role of the recently identified deubiquitinating enzyme CYLD in osteoclastogenesis and f

75 Deubiquitinating enzyme CYLD inhibits NEMO linear ubiqui

76 The deubiquitinating enzyme CYLD is a tumor suppressor prote

77 f Cancer Cell, Nikolaou et al. show that the deubiquitinating enzyme CYLD is critical for controlling

78 Despite recent studies that identify deubiquitinating enzyme cylindromatosis (CYLD) as a key

79 last precursors, Itch bound to TRAF6 and the deubiquitinating enzyme cylindromatosis.

80 ction was replaced by the recruitment of the deubiquitinating enzyme, cylindromatosis, an inhibitor o

81 Determining how deubiquitinating enzymes discriminate between ubiquitin-

82 ry proteins such as Bro1, which recruits the deubiquitinating enzyme Doa4 to remove ubiquitin from ca

83 ion of the protein Rfu1, an inhibitor of the deubiquitinating enzyme Doa4.

84 s together with serial mutagenesis defined a deubiquitinating enzyme domain and a ubiquitin associati

85 mbrane and faces the cytosol with the active deubiquitinating enzyme domain.

86 omain, lysine 63-ubiquitin (K63-Ub)-specific deubiquitinating enzyme (DUB) and a member of two protei

87 MERS-CoV PL(pro) was recently shown to be a deubiquitinating enzyme (DUB) and to possess deISGylatin

88 ted ring domain protein 1) E3 ligase and the deubiquitinating enzyme (DUB) BRCC36 to MDC1-gammaH2AX-d

89 An in-depth understanding of deubiquitinating enzyme (DUB) catalysis, particularly th

90 While the N-terminal domain of A20 is a deubiquitinating enzyme (DUB) for Lys63-linked polyubiqu

91 BRCC36-deubiquitinating enzyme (DUB) forms two different comple

92 A newly discovered virally encoded deubiquitinating enzyme (DUB) is strictly conserved acro

93 BRCC36 is a Zn(2+)-dependent deubiquitinating enzyme (DUB) that hydrolyzes lysine-63-

94 le with the SH3 domain of STAM3 (AMSH3) is a deubiquitinating enzyme (DUB) that interacts with endoso

95 hus, our results demonstrate that USP25 is a deubiquitinating enzyme (DUB) that negatively regulates

96 These findings establish CYLD as a pivotal deubiquitinating enzyme (DUB) that regulates germ cell a

97 tein BRCA1 along with Abraxas and the BRCC36 deubiquitinating enzyme (DUB) to polyubiquitin structure

98 apid dephosphorylation and activation of the deubiquitinating enzyme (DUB) USP8.

99 the initiator E2, Ube2w, and the specialized deubiquitinating enzyme (DUB), ataxin-3, participate in

100 activity of the TRAF6-interacting the Lys63-deubiquitinating enzyme (DUB), cylindromatosis tumor sup

101 Here, we have identified the deubiquitinating enzyme (DUB), ubiquitin-specific protea

102 ubiquitination is well studied; however, the deubiquitinating enzyme (DUB), which regulates TRAF2 sta

103 Deubiquitinating enzymes (DUB) form a family of cysteine

104 he Hippo pathway via ubiquitination, yet few deubiquitinating enzymes (DUB) have been implicated.

105 port that BITC and PEITC effectively inhibit deubiquitinating enzymes (DUB), including the enzymes US

106 Deubiquitinating enzymes (DUBs) act on ubiquitinated sub

107 ecycle at the apical membranes of CCD cells, deubiquitinating enzymes (DUBs) are likely involved in r

108 ytosed CFTR for degradation in the lysosome, deubiquitinating enzymes (DUBs) are likely to facilitate

109 Deubiquitinating enzymes (DUBs) are negative regulators

110 Deubiquitinating enzymes (DUBs) are proteases that can a

111 Deubiquitinating enzymes (DUBs) are proteases that proce

112 Ubiquitinating as well as deubiquitinating enzymes (DUBs) can regulate these proce

113 Deubiquitinating enzymes (DUBs) control the ubiquitinati

114 Deubiquitinating enzymes (DUBs) function in a variety of

115 Deubiquitinating enzymes (Dubs) function to remove coval

116 Deubiquitinating enzymes (DUBs) have emerged as essentia

117 Deubiquitinating enzymes (DUBs) have emerged as key play

118 By countering protein ubiquitination, deubiquitinating enzymes (DUBs) help control neuronal fa

119 the dynamic removal of this modification by deubiquitinating enzymes (DUBs) impacts genome maintenan

120 are treated with a panel of linkage-specific deubiquitinating enzymes (DUBs) in parallel reactions, f

121 To search for the deubiquitinating enzymes (DUBs) involved in the antivira

122 The functional diversity of deubiquitinating enzymes (DUBs) is not well understood.

123 Deubiquitinating enzymes (DUbs) play important roles in

124 There are approximately 79 active deubiquitinating enzymes (DUBs) predicted in the human g

125 Deubiquitinating enzymes (DUBs) recognize and cleave lin

126 Deubiquitinating enzymes (DUBs) regulate various cellula

127 Deubiquitinating enzymes (DUBs) remove ubiquitin (Ub) fr

128 The discovery of viruses encoding deubiquitinating enzymes (DUBs) suggests they remove ubi

129 However, the proteasome also contains deubiquitinating enzymes (DUBs) that can remove ubiquiti

130 ed proteins is effected by a large number of deubiquitinating enzymes (DUBs) that function as cystein

131 The deubiquitinating enzymes (DUBs) that function in the ner

132 at the stability of ARTs is regulated by the deubiquitinating enzymes (DUBs) Ubp2 and Ubp15.

133 ells is likely regulated by a diverse set of deubiquitinating enzymes (DUBs) with distinct ubiquitin

134 the coronaviral enzyme over homologous human deubiquitinating enzymes (DUBs), and no significant cyto

135 Uch37 is one of the three principal deubiquitinating enzymes (DUBs), and the only ubiquitin

136 biquitin-vinylsulfone inhibitor specific for deubiquitinating enzymes (DUBs), we confirmed that, like

137 arian tumor domain-containing superfamily of deubiquitinating enzymes (DUBs), which is capable of inh

138 Deubiquitinating enzymes (DUBs), which reverse the proce

139 Lys(48)-linked chains are resistant to many deubiquitinating enzymes (DUBs).

140 teins, and these are countered by an army of deubiquitinating enzymes (DUBs).

141 ubiquitin chain and binds to 26 S-associated deubiquitinating enzymes (DUBs): in yeast to Ubp6, which

142 lf, the ubiquitin conjugation machinery, and deubiquitinating enzymes enable activity and regulation

143 used by a mutation in Usp53, a member of the deubiquitinating enzyme family.

144 (Slimb), whose action is antagonized by the deubiquitinating enzyme fat facets.

145 entify UCH37 as the first, to our knowledge, deubiquitinating enzyme for E2F1.

146 indicate that UCHL1 promotes metastases as a deubiquitinating enzyme for HIF-1alpha, which justifies

147 quitin specific protease 7 (USP7) is a known deubiquitinating enzyme for tumor suppressor p53 and its

148 Ubiquitin-specific protease 7 (USP7) is a deubiquitinating enzyme found in all eukaryotes that cat

149 polycomb repressor complex 1 (PRC1) and H2A-deubiquitinating enzymes (H2A-DUBs).

150 g that hRpn13 interaction may stabilize this deubiquitinating enzyme in human cells.

151 Here we identify the first deubiquitinating enzyme in P. falciparum, PfUCH54, by it

152 ly binding the promoter region of Tnfaip3, a deubiquitinating enzyme in TLR signaling.

153 but the identities and specific functions of deubiquitinating enzymes in the nervous system are lacki

154 f c-IAPs is inhibited by USP19 and implicate deubiquitinating enzymes in the regulation of IAP stabil

155 get the MM cell in its microenvironment (eg, deubiquitinating enzyme inhibitors; chymotryptic [carfil

156 ted molecule of SH3 domain of STAM (AMSH), a deubiquitinating enzyme, interact with each other in cel

157 These data show how a deubiquitinating enzyme-interacting protein dictates the

158 These results indicate that the EBV deubiquitinating enzyme interacts with, deubiquitinates,

159 Here we report that USP19, a deubiquitinating enzyme, interacts with cellular IAP 1 (

160 dentified that USP2a, a circadian-controlled deubiquitinating enzyme, interacts with CRY1 and enhance

161 Here, we show that the USP7 deubiquitinating enzyme is an integral component of the

162 Ataxin-3, a deubiquitinating enzyme, is the disease protein in spino

163 ubiquitin binding domain (ZnF UBP) from the deubiquitinating enzyme isopeptidase T (IsoT, or USP5) a

164 TRAF6 activity can be impeded by deubiquitinating enzymes like ubiquitin-specific proteas

165 Finally, pharmacologic inhibition of deubiquitinating enzymes markedly enhances sterol-depend

166 d by the opposition of ubiquitin ligases and deubiquitinating enzymes mediates endocytic trafficking

167 The USP19 deubiquitinating enzyme modulates the expression of myog

168 o involves ataxin-3 (atx3), a p97-associated deubiquitinating enzyme mutated in type-3 spinocerebella

169 Here we report the identification of a deubiquitinating enzyme, named ubiquitin-specific protea

170 We report here that USP8/UBPY, a deubiquitinating enzyme not previously implicated in mit

171 th ubiquitin-specific protease 10 (USP10), a deubiquitinating enzyme of p53.

172 YOD1 is a highly conserved deubiquitinating enzyme of the ovarian tumor (otubain) f

173 BRCA1-associated protein-1 (BAP1), a deubiquitinating enzyme of unknown cellular function, is

174 Deubiquitinating enzymes of the ovarian tumour (OTU) fam

175 ellular processes and pathways, and specific deubiquitinating enzymes often play the decisive role of

176 The diverse roles of deubiquitinating enzymes, or DUBs, in determining the fa

177 Finally, ubiquitin chains are trimmed by the deubiquitinating enzyme Otu1p, which is recruited and ac

178 s regulated in a non-canonical manner by the deubiquitinating enzyme, OTUB1 (OTU domain-containing ub

179 onjugating enzyme in the regulation of an E3/deubiquitinating enzyme pair, with important implication

180 -linked ubiquitin chains via the proteasomal deubiquitinating enzyme Poh1.

181 further show that ataxin-3, a p97-associated deubiquitinating enzyme previously implicated in ER-asso

182 chanisms, including ubiquitin E3 ligases and deubiquitinating enzymes, provide great opportunities fo

183 We focus on two of these proteins, the deubiquitinating enzyme Psmd14 and the E3 ligase Fbxw7,

184 ell as the large number and diversity of the deubiquitinating enzymes raise the possibility that sign

185 Deubiquitinating enzymes regulate essential cellular pro

186 he catalytic activity of this disease-linked deubiquitinating enzyme regulates several of its cellula

187 c peptidase 8 (USP8), an endosome-associated deubiquitinating enzyme, regulates the ubiquitination, t

188 unknown interplay between an E3 ligase and a deubiquitinating enzyme regulating TBP levels during cel

189 97/p47 complex-interacting protein, p135), a deubiquitinating enzyme required for p97/p47-mediated po

190 ate binding, preventative modifications, and deubiquitinating enzyme reversal of ubiquitination.

191 Three deubiquitinating enzymes-Rpn11, Usp14, and Uch37-are ass

192 ling pathways might be modulated by specific deubiquitinating enzyme(s).

193 In this report, we find that Usp9x, a deubiquitinating enzyme, stably associates with the SMN

194 The ubiquitination process is reversible via deubiquitinating enzymes, such as ubiquitin-specific pep

195 the most widely studied among the nearly 100 deubiquitinating enzymes, supports cancer by positively

196 The CYLD protein is a deubiquitinating enzyme that acts as a negative regulato

197 a transcriptional co-repressor, as well as a deubiquitinating enzyme that appears to function in cell

198 eoxygenation can be influenced by Cezanne, a deubiquitinating enzyme that cleaves ubiquitin from spec

199 l of aggresomes requires Poh1, a proteasomal deubiquitinating enzyme that cleaves ubiquitinated prote

200 We show that dCYLD encodes a deubiquitinating enzyme that deubiquitinates dTRAF2 and

201 biquitin C-terminal hydrolase L1 (UCH-L1), a deubiquitinating enzyme that functions to regulate cellu

202 e fertility genes include USP8, an essential deubiquitinating enzyme that has a role in acrosome asse

203 USP28 (ubiquitin-specific protease 28) is a deubiquitinating enzyme that has been implicated in the

204 CYLD is a lysine 63-deubiquitinating enzyme that inhibits NF-kappaB and JNK

205 entrosome duplication that requires USP33, a deubiquitinating enzyme that is able to regulate CP110 l

206 Cylindromatosis (CYLD) is a deubiquitinating enzyme that is altered in patients with

207 Rpn11 is a proteasome-associated deubiquitinating enzyme that is essential for viability.

208 quitin C-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is highly expressed in neur

209 Isopeptidase T (IsoT/USP5) is a deubiquitinating enzyme that is largely responsible for

210 quitin C-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is selectively and abundant

211 an ubiquitin-specific protease 7 (USP7) is a deubiquitinating enzyme that prevents protein degradatio

212 USP14 is a proteasome-bound deubiquitinating enzyme that recycles ubiquitin and regu

213 dentification of OTUB1 as a c-IAP-associated deubiquitinating enzyme that regulates c-IAP1 stability.

214 The CYLD gene encodes a deubiquitinating enzyme that removes Lys-63-linked ubiqu

215 It encodes a deubiquitinating enzyme that removes Lys63- or linear-li

216 fic proteases (UBPs) are one large family of deubiquitinating enzymes that bear signature cysteine an

217 target them for proteosomal degradation and deubiquitinating enzymes that promote their stabilizatio

218 We performed an siRNA screen to identify deubiquitinating enzymes that regulate AR; in that scree

219 Less is known, however, about the deubiquitinating enzymes that regulate T cell proliferat

220 remodeling to generate a Poh1-dependent K63-deubiquitinating enzyme to facilitate protein aggregate

221 vities of the ubiquitination machinery and a deubiquitinating enzyme to maintain and modulate the dyn

222 sing a proteomic approach, we identified the deubiquitinating enzyme ubiquitin-specific protease 11 (

223 ionally, an opioid-mediated induction of the deubiquitinating enzyme ubiquitin-specific protease 15 w

224 Employing this method, we identified the deubiquitinating enzyme ubiquitin-specific protease 22 (

225 We previously demonstrated that the deubiquitinating enzyme ubiquitin-specific protease 2a (

226 We now report the discovery that the deubiquitinating enzyme ubiquitin-specific protease 33 (

227 The deubiquitinating enzyme ubiquitin-specific protease 8 (U

228 Here, we show that the deubiquitinating enzyme ubiquitin-specific protease-46 (

229 We show that a deubiquitinating enzyme, ubiquitin C-terminal hydrolase-

230 that this ubiquitination is reversed by two deubiquitinating enzymes, ubiquitin-specific proteases (

231 Here, we characterize a yeast deubiquitinating enzyme, Ubp10, that possesses IDRs flan

232 romyces cerevisiae, Cdh1 associates with the deubiquitinating enzyme Ubp15, but the significance of t

233 iochemical characterization of a multidomain deubiquitinating enzyme, Ubp15, from Saccharomyces cerev

234 ved in numerous processes, and an associated deubiquitinating enzyme, Ubp2, modulates its activity.

235 a core particle (CP) subunit depends on the deubiquitinating enzyme Ubp3, although a regulatory part

236 all integrity is negatively regulated by the deubiquitinating enzyme Ubp3.

237 s/PKA signaling is negatively regulated by a deubiquitinating enzyme, Ubp3.

238 f-function mutation in the gene encoding the deubiquitinating enzyme Ubp6 improves growth rates in fo

239 The proteasome-associated deubiquitinating enzyme Ubp6, which spares ubiquitin fro

240 tin chain disassembly, by binding the UBL of deubiquitinating enzyme Ubp6.

241 subject to disassembly by a proteasome-bound deubiquitinating enzyme, Ubp6.

242 Yeast proteasomes contain two deubiquitinating enzymes, Ubp6 and Rpn11.

243 3 associates with EGFR and combines with the deubiquitinating enzyme UBPY/USP8 to transfer EGFR from

244 at Smo ubiquitination is counteracted by the deubiquitinating enzyme UBPY/USP8.

245 hosphorylated neurofilament H (pNFH) and the deubiquitinating enzyme UCH-L1 in lumbar CSF samples fro

246 m1 and S5a, the ATPase subunit Rpt5, and the deubiquitinating enzyme Uch37 are ubiquitinated in situ

247 5),report crystal structures that define how deubiquitinating enzyme UCH37 is switched on or off by p

248 e cap-associated protein, which recruits the deubiquitinating enzyme UCH37 to the 26S proteasome.

249 inase adaptor (DEUBAD) domain that binds the deubiquitinating enzyme Uch37.

250 in receptor hRpn13/Adrm1 binds and activates deubiquitinating enzyme Uch37/UCHL5 and is targeted by b

251 thermore, BDNF increased the activity of the deubiquitinating enzyme UchL1 in synaptoneurosomes and u

252 r the transcriptional repression of the USP1 deubiquitinating enzyme upon exposure to DNA-damaging ag

253 The deubiquitinating enzyme USP1 (ubiquitin-specific proteas

254 The deubiquitinating enzyme USP1 controls the cellular level

255 We show that the deubiquitinating enzyme USP1 promotes ID protein stabili

256 ns on histones, is actively destroyed by the deubiquitinating enzyme USP1.

257 ts describe a mechanism of regulation of the deubiquitinating enzyme, USP1, and of DNA repair.

258 factor 1) protein binds and stimulates three deubiquitinating enzymes: USP1, USP12, and USP46.

259 Mechanistically, nuclear Ufd1 recruits the deubiquitinating enzyme USP13 to counteract APC/C(Cdh1)-

260 e that Siah2 is subject to regulation by the deubiquitinating enzyme USP13.

261 ch resulted in a decreased expression of the deubiquitinating enzyme USP14 and several presynaptic pr

262 nction mutation in the proteasome-associated deubiquitinating enzyme Usp14, which is required for rec

263 The proteasome-associated deubiquitinating enzyme Usp14/Ubp6 inhibits protein degr

264 0-20% in our preparations) also contains the deubiquitinating enzyme Usp14/Ubp6, which regulates prot

265 roteasome function through inhibition of the deubiquitinating enzymes USP14 and UCHL5.

266 Here we report that the deubiquitinating enzyme, USP15, specifically deubiquitin

267 r direct effectors of ubH2B, we identified a deubiquitinating enzyme, Usp15, through affinity purific

268 removal of ubiquitin from this lysine by the deubiquitinating enzyme USP19.

269 A previously uncharacterized deubiquitinating enzyme, USP29 binds to, cleaves poly-ub

270 Our data identify the deubiquitinating enzyme USP2a as a novel regulator of th

271 eptide that bears sequence similarity to the deubiquitinating enzyme USP2a.

272 We found that the deubiquitinating enzyme USP33 interacts with the Robo1 r

273 Because the deubiquitinating enzyme USP33 is involved in several imp

274 me pathway in human cells, we identified the deubiquitinating enzyme USP44 (ubiquitin-specific protea

275 ng et al. examine mice and cells lacking the deubiquitinating enzyme USP44.

276 The deubiquitinating enzyme USP48 stabilizes TRAF2 and reduc

277 We show that knockdown of the deubiquitinating enzyme USP5 (isopeptidase T) results in

278 x and leads to interaction between FoxM1 and deubiquitinating enzyme USP5, thereby deubiquitination a

279 me in a substoichiometric fashion, e.g., the deubiquitinating enzymes USP5/isopeptidase T and USP7/HA

280 interactions between a 100 kDa, multi-domain deubiquitinating enzyme, USP5 and a diubiquitin substrat

281 w role for vIRF1 through deregulation of the deubiquitinating enzyme USP7 to inhibit p53-mediated ant

282 rence in the expression level of the claspin deubiquitinating enzyme USP7 was detected.

283 Knockdown of the p53 deubiquitinating enzyme USP7/HAUSP also reverses the sup

284 oordinated action of UBE4B, ESCRT-0, and the deubiquitinating enzyme USP8 enable the endosomal sortin

285 B3 ligand neuregulin-1 (NRG1) stabilizes the deubiquitinating enzyme USP8, which in turn stabilizes N

286 ains on the substrate in the presence of the deubiquitinating enzyme USP8.

287 Here we show that in vivo knockdown of the deubiquitinating enzyme USP9X attenuates T-cell prolifer

288 E3 ubiquitin ligase c-Cbl and also with the deubiquitinating enzyme USP9x; moreover, siRNA downregul

289 t that Ets-1 destruction is regulated by the deubiquitinating enzyme, Usp9x, and has major impact on

290 omal degradation by the dominant effect of a deubiquitinating enzyme, VCIP135/VCPIP1.

291 e disassembly of these heterodimers by major deubiquitinating enzymes was examined and it was discove

292 A (DUBA), an ovarian tumor domain-containing deubiquitinating enzyme, was discovered in a small inter

293 encoding the P. falciparum orthologue of the deubiquitinating enzyme were observed.

294 We recently reported that the USP1 deubiquitinating enzyme, which regulates the Fanconi ane

295 However, the deubiquitinating enzymes, which regulate MSH2 remain unk

296 dge, we have identified the first centriolar deubiquitinating enzyme whose expression regulates centr

297 ases (USPs) constitute the largest family of deubiquitinating enzymes, whose catalytic competency is

298 with specificity directed toward pathogenic deubiquitinating enzymes without inhibiting host DUBs.

299 Here, we identified the deubiquitinating enzyme YOD1 (OTUD2) as a novel interact

300 of cofactors including UBXD1, PLAA, and the deubiquitinating enzyme YOD1, which we term ELDR compone