1 effects on the aromatic ring and a secondary
deuterium kinetic isotope effect.
2 on the basis of pH-rate profiles and solvent
deuterium kinetic isotope effects.
3 own to be steady-state ordered using primary
deuterium kinetic isotope effects.
4 y stopped-flow visible spectrophotometry and
deuterium kinetic isotope effects.
5 Primary
deuterium kinetic isotope effects (
1 degrees DKIE) on (k
6 We recently reported abnormal secondary
deuterium kinetic isotope effects (
2 degrees KIEs) for h
7 Cleavage at U exhibits a large 5'
deuterium kinetic isotope effect,
a potential signature
8 alpha-
Deuterium kinetic isotope effects (
alpha-DKIEs) based up
9 cyclopentyl sulfonates, logarithms of alpha-
deuterium kinetic isotope effects (
alpha-KIE) correlate
10 Significant
deuterium kinetic isotope effects and a positive correla
11 The experimentally observed rate law,
deuterium kinetic isotope effects,
and identification of
12 on, very large, weakly temperature dependent
deuterium kinetic isotope effects (
approximately 50) are
13 Both solvent O-H and substrate C-H
deuterium kinetic isotope effects are observed for these
14 Deuterium kinetic isotope effects are widely used in che
15 ntribution to the mechanism by examining the
deuterium kinetic isotope effect associated with the hyd
16 examining the temperature dependence of the
deuterium kinetic isotope effect associated with the tra
17 Solvent
deuterium kinetic isotope effects at pH 5.8, using APADH
18 A primary
deuterium kinetic isotope effect [(
D)(k(for) + k(rev)) a
19 x10(6) M(-1) s(-1) and (b) the small primary
deuterium kinetic isotope effects, (
D)V = 1.3 and (D)V/K
20 A solvent
deuterium kinetic isotope effect (
D2OVmax = 1.5) was mea
21 Kinetic studies and
deuterium kinetic isotope effects demonstrate that these
22 Deuterium kinetic isotope effect determinations for the
23 the solvent reorganization energies, and the
deuterium kinetic isotope effects determined from the ca
24 The corresponding
deuterium kinetic isotope effects (
e.g., KIE(OD)(H) = k(
25 ing that the observed value is the intrinsic
deuterium kinetic isotope effect for oxidation of this s
26 A normal
deuterium kinetic isotope effect for the overall reactio
27 o suggested by a substantial decrease in the
deuterium kinetic isotope effect for the reaction of Q w
28 The calculated hydrogen/
deuterium kinetic isotope effect for the standard rate c
29 The
deuterium kinetic isotope effects for epimerization of U
30 oduces the experimentally measured rates and
deuterium kinetic isotope effects for ET and PCET.
31 Reaction rate constants and
deuterium kinetic isotope effects for the reactions of B
32 Activation parameters and
deuterium kinetic isotope effects for the substrate reac
33 The substrate
deuterium kinetic isotope effects for the wild-type and
34 owever, experimental measurements of solvent
deuterium kinetic isotope effects for this enzyme do not
35 In addition, the
deuterium kinetic isotope effect from reactions of cyclo
36 Beta-secondary and solvent
deuterium kinetic isotope effects have been determined f
37 Beta-Secondary and solvent
deuterium kinetic isotope effects have been determined f
38 Primary and alpha-secondary
deuterium kinetic isotope effects have been measured for
39 The secondary
deuterium kinetic isotope effect in the reaction leading
40 ange of 5.5-9.3, and there is no significant
deuterium kinetic isotope effect in the reaction of UDP-
41 The
deuterium kinetic isotope effect increases to 3.2, consi
42 otope effect is increased, while the primary
deuterium kinetic isotope effect is decreased, indicatin
43 The observed
deuterium kinetic isotope effect is discussed briefly, a
44 For cyclohexane, the
deuterium kinetic isotope effect (
k(H)/k(D)) of 1.28 (5)
45 law, rate = k1[1] + k2[1][BzOH], and a small
deuterium kinetic isotope effect,
k(Pd-H)/k(Pd-D) = 1.3(
46 The observation of primary
deuterium kinetic isotope effects,
k(H2)/k(D2) = 3.1(3)
47 It is shown here that the
deuterium kinetic isotope effect (
KIE) for the reaction
48 ion of TpTSO(2)(-) and TpT exhibits a V(max)
deuterium kinetic isotope effect (
KIE) of 1.7 +/- 0.2, w
49 Temperature-dependent measurements of this
deuterium kinetic isotope effect (
KIE) show a large diff
50 Deuterium kinetic isotope effect (
KIE) values of 5.3, 3.
51 In this time period, the apparent
deuterium kinetic isotope effects (
KIE(app)) were observ
52 ion kinetics, with pH, substrate and solvent
deuterium kinetic isotope effects (
KIE) as mechanistic p
53 -androstene-3,17-dione ( 3), alpha-secondary
deuterium kinetic isotope effects (
KIE) at C-6 of the st
54 Deuterium kinetic isotope effects (
KIE) were measured, a
55 Deuterium kinetic isotope effects (
KIEs) are reported fo
56 measurement of [Formula: see text]-secondary
deuterium kinetic isotope effects (
KIEs) at all sites of
57 Deuterium kinetic isotope effects (
KIEs) of the H(*)(D(*
58 Extraction of intrinsic
deuterium kinetic isotope effects (
KIEs) using single tu
59 We show, by the criterion of solvent
deuterium kinetic isotope effect measurements and proton
60 The small primary
deuterium kinetic isotope effects observed using NADPH a
61 A solvent
deuterium kinetic isotope effect of 1 is measured for ho
62 Similarly, the large alpha-secondary
deuterium kinetic isotope effect of 1.15 +/- 0.02 observ
63 lyzed rate of dehydration of scytalone had a
deuterium kinetic isotope effect of 1.2 at pH 7.0 and 25
64 bined with simulation reveal a large primary
deuterium kinetic isotope effect of 3.3 on the covalent
65 The unusually high
deuterium kinetic isotope effect of 81 is due to the sma
66 A hydrogen/
deuterium kinetic isotope effect of nearly 2 implicates
67 Primary
deuterium kinetic isotope effects of 1.3 and 1.5 on V(fo
68 Solvent
deuterium kinetic isotope effects of 1.5 and 3.2 were ob
69 Large primary
deuterium kinetic isotope effects of 13.4 +/- 1.0 and 16
70 The pre-steady-state primary
deuterium kinetic isotope effect on enzyme reduction has
71 stic studies have revealed a large substrate
deuterium kinetic isotope effect on galactose oxidase tu
72 , exhibits an unusual and unexpected primary
deuterium kinetic isotope effect on its Arrhenius activa
73 by S124A-GalE proceeds with a pH-independent
deuterium kinetic isotope effect on k(cat) of 2.0 +/- 0.
74 ) by Y149F-GalE proceeds with a pH-dependent
deuterium kinetic isotope effect on k(cat) of 2.2 +/- 0.
75 alogues with para substituents exhibit large
deuterium kinetic isotope effect on k(cat), on k(cat)/K(
76 the alpha-carbon of the thiolactone caused a
deuterium kinetic isotope effect on k2 of 3.2 +/- 0.2, c
77 The effect of introducing a primary
deuterium kinetic isotope effect on the hydrogen transfe
78 he potential for substantial benefits of the
deuterium kinetic isotope effect on the safety and dispo
79 mation and also that there is an observed C5-
deuterium kinetic isotope effect on this elimination ste
80 Deuterium kinetic isotope effects on k(cat), k(red), k(c
81 The
deuterium kinetic isotope effects on k(red) and k(cat) a
82 Deuterium kinetic isotope effects on steady state kineti
83 We then measured
deuterium kinetic isotope effects on the rate of cleavag
84 The solvent
deuterium kinetic isotope effects on V 1 and V1/K Ser de
85 Primary
deuterium kinetic isotope effects on V and V/K at pH 7.5
86 The primary
deuterium kinetic isotope effects on V and V/K for the f
87 The solvent
deuterium kinetic isotope effects on V and V/K in the di
88 The magnitude of the primary
deuterium kinetic isotope effects on V and V/K varied su
89 Steady-state primary
deuterium kinetic isotope effects on V have been determi
90 Solvent
deuterium kinetic isotope effects on V/K were uniformly
91 Solvent
deuterium kinetic isotope effects revealed an inverse va
92 Deuterium kinetic isotope effects revealed that reaction
93 ueous tetrahydrofuran have inverse secondary
deuterium kinetic isotope effects,
SDKIEs.
94 Initial velocity, product inhibition, and
deuterium kinetic isotope effect studies were consistent
95 The primary
deuterium kinetic isotope effect suggests that the conve
96 show apparent bimolecular rate constants and
deuterium kinetic isotope effects that increase in propo
97 overall antarafacial fashion; (c) secondary
deuterium kinetic isotope effects that suggest substanti
98 On the basis of the small values of
deuterium kinetic isotope effects,
the relatively high a
99 Key features of this route include the
deuterium kinetic isotope effect to block undesired indo
100 ural products feature the strategic use of a
deuterium kinetic isotope effect to improve the efficien
101 d value of 12.6 for the ratio of the primary
deuterium kinetic isotope effect to the secondary isotop
102 In this study, we used
deuterium kinetic isotope effects to probe the chemical
103 hSH exhibits biphasic decay kinetics with no
deuterium kinetic isotope effect upon PhSD substitution.
104 The steady-state primary
deuterium kinetic isotope effect using NADH coincide wit
105 The alpha-secondary
deuterium kinetic isotope effect using OAS-3,3-d2 is 1.1
106 Furthermore, the measurement of
deuterium kinetic isotope effects using [1(S)-(2)H]DHAP
107 The magnitude of these primary
deuterium kinetic isotope effects varied with metal ion
108 On the basis of data from solvent
deuterium kinetic isotope effects,
viscosity effects, an
109 A substrate
deuterium kinetic isotope effect was also measured on th
110 A
deuterium kinetic isotope effect was observed in the (3-
111 e reverse reaction direction, finite primary
deuterium kinetic isotope effects were observed for all
112 Significant and identical primary
deuterium kinetic isotope effects were observed for V (2
113 Significant primary
deuterium kinetic isotope effects were observed with [4S
114 Substrate
deuterium kinetic isotope effects with 1,2-[(2)H(4)]nitr
115 Solvent
deuterium kinetic isotope effects with 4,4-dithiopyridin