ライフサイエンスコーパス: development

1 e was believed to regulate cell function and development.

2 gene known to have a crucial role in kidney development.

3 vity, a fundamental event for all subsequent development.

4 during a defined window of postnatal tissue development.

5 ogenesis requires mechanical activity during development.

6 y female sex hormones accelerate lung cancer development.

7 d Sox19 appear to play major roles in neural development.

8 e at a restricted time window during retinal development.

9 major monocrops as drivers of prosperity and development.

10 ch receptor involved in normal and malignant development.

11 n primary cells, an initial barrier to tumor development.

12 e lincRNAs might be involved during parasite development.

13 rucial role in positive selection and T cell development.

14 king this scaffold a good candidate for drug development.

15 edial, dorsolateral) identifiable throughout development.

16 vo mutations occurred during early germ cell development.

17 f the body axis is a key aspect of body plan development.

18 n and cell commitment during preimplantation development.

19 lapping function that is essential for early development.

20 sts to coordinating cellular propagation and development.

21 elective microenvironments permissive for DC development.

22 mesenchymal interactions required for normal development.

23 is increased irrespective of the risk of PBC development.

24 e the sequence of cell fate decisions during development.

25 xr region to test for their ability to block development.

26 tress pathways and accelerated limbic system development.

27 ls new regulatory candidate genes of phellem development.

28 ids play a so far unrecognized role in organ development.

29 to eutheria, suggesting a role in placental development.

30 role for NKG2D in the regulation of B1a cell development.

31 ener in early life may be able to prevent AD development.

32 R) expressing neuronal population throughout development.

33 sses can therefore have a profound impact on development.

34 provide a strong constraint on further model development.

35 ubpopulation might be crucial for CF therapy development.

36 lls at six different time points during seed development.

37 dosiRNAs present during primordial germ cell development.

38 critical role in HBV-related hepatocarcinoma development.

39 profile in wound-healing markers during ONJ development.

40 which are automatic, but do not fade through development.

41 infant stool samples in relation to allergy development.

42 phases are a current area of focus in alloy development.

43 complete epithelial loss at later stages of development.

44 een chronic inflammation and atherosclerosis development.

45 ors that will facilitate further therapeutic development.

46 dying RNA in mammalian cells and therapeutic development.

47 zation, axon patterning and other aspects of development.

48 le in early life influences child health and development.

49 rce and deeper insight into normal pulmonary development.

50 g the two guidelines and highlighting recent developments.

51 With the recent technological developments a vast amount of high-throughput data has b

52 u acquisition and is essential for embryonic development, a homologous protein, Ctr2, has been propos

53 PP TC development across juvenile, transition, and adult leave

54 utions of TGFbeta family signaling to normal development, adult homeostasis and disease, and also rev

55 nt decline in oocyte cleavage and blastocyst development after in-vitro fertilization.

56 e with two physiological challenges (ovarian development after queen loss and immune activation after

57 nto a two thirds set (Nd = 10 083) for model development and a one third set (Nv = 5042) for validati

58 e discuss the contribution of lncRNAs in the development and activation of immune cells and their rol

59 Successful development and application of precision oncology approa

60 Nevertheless, the development and commercialization of point-of-care combi

61 that both regulate normal cell fates during development and contribute to the epigenetic plasticity

62 Its malformation during development and degeneration in adulthood impairs motor

63 Their spectacular development and diversity are attracting worldwide inter

64 RADE (Grading of Recommendations Assessment, Development and Evaluation) method.

65 eart formation is initiated during embryonic development and for applying stem cell biology to regene

66 cal techniques were used to study ovule/seed development and germination of Austrobaileya.

67 Further development and growth is proposed to rely on layer-rest

68 During animal development and homeostasis, the structure of tissues, i

69 eneity in cell function emerges during early development and how structural patterning goes hand-in-h

70 DLG4 is thus apparently involved in brain development and impacts inter-individual susceptibility

71 ession in lymphatic vessels at all stages of development and in adult zebrafish.

72 althy cerebellar tissue throughout postnatal development and in primary cerebellar medulloblastoma ti

73 omplexes are essential for normal motoneuron development and indicate that mRNA handling is a critica

74 is characterized by severely impaired T-cell development and is fatal without treatment.

75 nd that this G-actin pool functions in spine development and its modification during synaptic plastic

76 IIgamma:c-Myc axis critically influences the development and maintenance of TCL and represents a pote

77 5 viral antigen (iDCpp65) exhibited a faster development and maturation of T cells.

78 alloproteinases (MMPs) are central to cancer development and metastasis.

79 ferior to OPD in terms of pancreatic fistula development and other major postoperative outcomes.

80 ype lectin receptor CD69 controls tTreg cell development and peripheral Treg cell homeostasis through

81 egulation of endosome dynamics during fungal development and plant infection.

82 , liraglutide resulted in lower rates of the development and progression of diabetic kidney disease t

83 in is intimately connected with human cancer development and proliferation.

84 hat fails to remove Pxr-mediated blockage of development and reintroduced variably truncated fragment

85 he activation of EPDCs during cardiovascular development and repair.

86 poptotic BCL-2 proteins contributes to tumor development and resistance to therapy by suppressing BAX

87 iously recognized aspects of post-natal lung development and revealed several insights, including in

88 dies have reported an association between IA development and single nucleotide polymorphisms (SNPs),

89 rategy for biosensors facilitates both rapid development and small-scale manufacturing.

90 ors have a recognized role in mammary ductal development and stem cell maintenance, but the ligands i

91 ssential role for n1-src in amphibian neural development and suggest that alternative splicing of C-S

92 p16 inactivation and Kras activation in PDAC development and suggest that NOX4 is a potential therape

93 ablish that PXR signaling contributes to ALD development and suggest that PXR antagonists may provide

94 We now report the development and technical validation of a rabbit monoclo

95 k shows the role of SOCS1 in murine melanoma development and the potential of SOCS1-silenced tumor ce

96 Tumor development and therapeutic resistance are linked with t

97 eading to pulp necrosis, arrested tooth-root development and tooth loss.

98 Their development and wide-spread investigation has, however,

99 the Grading of Recommendations, Assessment, Development, and Evaluation approach and summarized the

100 a wide range of applications in therapeutic development, and fundamental understanding of cellular b

101 ues of MIP deposition as thin films, surface development, and introduction of additional properties a

102 crowding, nucleic acid based pharmaceutical development, and nucleic acid based biosensor device des

103 state theory (VTST), its recent theoretical development, and some modern applications.

104 highlighting impediments to progress, recent developments, and promising future directions.

105 oral changes in growth and physiology during development are critical for their spawning success.

106 These patterns of atypical development are difficult to explain with existing model

107 unique behavioral profiles and potential for development as cocaine use disorder therapeutics.

108 inin regulates diverse aspects of growth and development as well as responses to biotic and abiotic f

109 We view these developments as essential components of an emerging 'res

110 eight, body weight, Tanner stage of pubertal development, axial length, and spherical equivalent refr

111 tronics are a burgeoning area in electronics development, but are often stymied by the large minimum

112 ORC1 signaling is dispensable for alpha cell development, but essential for alpha cell maturation dur

113 have seen much progress in theory and method development, but existing applications make simplifying

114 atal age, PIEZO2 may contribute to hair cell development, but it does not underlie the normal MT curr

115 monstrate a causal role for microglia in the development, but not maintenance, of morphine tolerance

116 within and across organs throughout disease development by integrating in vivo analysis of gene expr

117 ty of protein structures released since SCOP development concluded in 2009, using a combination of ma

118 2014 National Institutes of Health Consensus Development Conference on Criteria for Clinical Trials i

119 foundation from which to make informed drug development decisions.

120 hereas loss of a single suppressor of female development drives male-to-hermaphrodite conversion.

121 CaMKII-null mutants remain viable throughout development, enabling morphological and electrophysiolog

122 am of 29 members with expertise in guideline development, evidence analysis, and family-centered care

123 tal role in brain, where it affects neuronal development, function, and disease.

124 , based on a selection of the 17 Sustainable Development Goals that apply to health.

125 cal Diversity and United Nations Sustainable Development Goals, but success to date has been very lim

126 24, represents an attractive target for drug development; however, the molecular determinants that go

127 oma) in 23.6%, and malformations of cortical development in 19.8% (focal cortical dysplasia was the m

128 FY has more obvious roles in floral and leaf development in C. hirsuta than in A. thaliana.

129 rty in male and female rats or mammary gland development in female rats.

130 s in a manner reminiscent of spoken language development in humans.

131 In this article, we report rapid lymphoma development in Id2/Id3 double-knockout mice that is caus

132 Calcipotriol suppressed skin cancer development in mice in a TSLP-dependent manner.

133 esis in culture and for brown adipose tissue development in mice.

134 n integrative study of Zea mays (maize) seed development in order to identify key genes in a complex

135 e necessary for the initiation of gametocyte development in the subsequent cell cycle.

136 a highlight novel aspects of SHF, OFT and HM development in zebrafish that will inform mechanistic in

137 -wide association studies (GWASs) and recent developments in islet (epi)genome and transcriptome prof

138 We exemplify current developments in structure-guided target identification a

139 Here, we present new developments in the Reactome visualization system that f

140 consider the implications for rational drug development, in particular regionally selective dopamine

141 Land-cover change from energy development, including solar energy, presents trade-offs

142 AF-12, which is required for normal nematode development, including the all-important infectious stag

143 Rice morphological development is conservative to carbon acquisition.

144 Using light-sheet microscopy, early neural development is here followed in vivo in real time at hig

145 Understanding of their development is of high interest for plant science resear

146 though dispensable for homeostatic Th17 cell development, JunB is required for induction and maintena

147 ins being postulated as essential for normal development, little is known about the specific function

148 ral products, including contributions to SAR development, mode of action studies, and eventually medi

149 of investigations of mural cells in vascular development, neurovascular coupling and neuropathology.

150 In this study, we report the development of a high sensitivity assay for the detectio

151 econd phase is the guiding principle for the development of a host of high strength structural alloys

152 f malaria vaccine candidates have slowed the development of a Plasmodium falciparum multiantigen vacc

153 This approach was informed by the development of a pseudo first-order rate constant model,

154 RATIONALE: The development of a refractory period for Ca(2+) spark init

155 In this study, we report the development of a second-generation BET protein degrader,

156 Herein, we report the development of a set of R-based scripts that allow for p

157 n efficacious malaria vaccine continues, the development of a whole-organism vaccine is now receiving

158 breakthroughs and remaining obstacles to the development of active and passive HIV-1 vaccines.

159 y we found that EZH2 was required for proper development of adaptive, but not innate, lymphoid cells.

160 ve reduced inflammatory responses during the development of allergic airway disease (AAD).

161 of neurons reveals potential avenues for the development of alternate antiviral drugs.

162 Herein, we report the development of an aptamer-initiated fluorescence complem

163 These findings lay the foundation for the development of antimicrobials that target this novel, es

164 logy and important risk factors both for the development of ARDS and for important patient-centered o

165 nowires, have had major contributions in the development of artificial muscles.

166 The primary end point was the development of asthma until age 12 years.

167 The nuclease ARTEMIS is essential for the development of B and T lymphocytes.

168 Lastly, outlook and the future development of biosensors for the control of antibiotic

169 ic vessel density did not impact the time to development of BOS or RAS in lung transplantation (low v

170 approaches, and the data support the further development of both vaccine viruses to optimally prepare

171 over to resection (5% vs 11%; P< 0.0001) and development of carcinoma (1% vs 3%; P= 0.008).

172 In prostate cancer, the development of castration resistance is pivotal in progr

173 cell death by excitotoxicity, hindering the development of cell-based assays for NMDAR drug discover

174 atment, supporting a role for SLC16A5 in the development of cisplatin-induced ototoxic effects.

175 s are increasingly antibiotic resistant, and development of clinically effective antibiotics is laggi

176 cardiovascular events and predisposes to the development of clinically important mitral valve regurgi

177 d risk for colon cancer, but its role in the development of colorectal cancer has yet to be fully exa

178 toward a conserved hypoxia program, with the development of compartment-specific programs later in th

179 thus represents a significant advance in the development of complex macromolecule synthesis, where a

180 r vaccines or therapy, as well as more rapid development of countermeasures against potential biothre

181 The study of hepatitis B virus and development of curative antivirals are hampered by a sca

182 over, our work also provides a rationale for development of CXCR2 antagonists to inhibit or prevent m

183 With the rapid development of deep sequencing techniques in the recent

184 dies, generation of oncolytic virus vectors, development of delivery platforms of genes for vaccines

185 terial that has been extensively used in the development of devices for the medical proposes due to p

186 iotic therapy is a major risk factor for the development of diarrhea and colitis with varying severit

187 ncRNAs play important roles in directing the development of diverse immune cells and controlling the

188 on disrupts normal cellular architecture and development of E. muelleri.

189 d neuropil could provide a framework for the development of E/I balance at the cellular level.

190 The baseline characteristics, development of early dermatologic reactions, and cause o

191 These data support development of eCB-based treatment approaches for mood a

192 RATIONALE: The development of evidence-based treatment guidelines for p

193 Further development of EVs isolation protocols urgently needs a

194 s study aims to identify the role of IRF6 in development of exocrine glands, specifically the major s

195 The development of exogenous molecules to control stem cell

196 Previously, we demonstrated that development of fatty liver depends on adipocyte GH signa

197 icle provides a concise review on the latest development of folate-mediated nanomedicines and nanopro

198 in, which has important implications for the development of future PALM tags.

199 to increased cell cycle progression and the development of genomic instability with aneuploidy.

200 or the first time, as the redox probe in the development of HCV core antigen electrochemical immunose

201 t advances in genetic and biochemical tools, development of high-resolution microscopy, and identific

202 be improved by accommodating the protracted development of human neural cells.

203 predictive of poor outcomes than the rate of development of hyponatremia or the absolute decrease in

204 ement of ACTH and TSH and a relatively rapid development of hypopituitarism.

205 riggered extensive research interest for the development of III-V/graphene functional hybrid heterost

206 resent a significant step forward toward the development of implantable drug-delivery systems.

207 metabolomics is a powerful tool to help with development of improved infant formulas.

208 d negative antigenic interaction, to support development of improved influenza vaccines and vaccinati

209 ave spurred efforts toward the discovery and development of improved or novel new compounds, includin

210 roenvironmental factors of importance to the development of improved regenerative medicine for patien

211 Despite development of improved treatments, these conditions are

212 Little is known about the functional development of individual neurons in vivo.

213 onment has been shown to protect against the development of inflammatory diseases, such as allergy, a

214 Our findings reveal how UTX regulates the development of iNKT cells through multiple epigenetic me

215 inished tubular iron deposition, blocked the development of interstitial fibrosis, and prevented immu

216 and, if consumed regularly, can lead to the development of kidney stones.

217 through porous materials is critical for the development of lateral flow assays and analytical device

218 on of CaV 3.1 channels completely suppressed development of long-term potentiation (LTP) in the CA1-s

219 It is hoped that the steady advances in the development of LRAs now being paired with emerging immun

220 Gammaherpesviruses are associated with the development of lymphomas and lymphoproliferative disease

221 The development of machine learning and network structure st

222 interdisciplinary character that impacts the development of many functional materials and systems.

223 t origin of organohalogens could have primed development of metabolic machineries for their degradati

224 echanical behaviour of skin due to the rapid development of microneedle devices for drug delivery app

225 interventions in regulatory networks, to the development of mitigation policies for infectious diseas

226 ex mechanisms of the disease and lead to the development of more effective individualized treatment.

227 h of girls and women is an investment in the development of nations and their futures.

228 With the development of new high-throughput DNA sequencing techno

229 cture-reactivity relationship may aid in the development of new highly efficient photoreactions.

230 e directions that are centralized around the development of new oxide compositions capable of featuri

231 (bsAbs) are of significant importance to the development of novel antibody-based therapies, and heavy

232 s B virus cure should occur in parallel with development of novel antiviral and immune modulatory the

233 ns of these synthetic approaches and how the development of novel Ub-based reagents is greatly assist

234 vation of IL-36gamma may be important in the development of numerous IL-36gamma-driven pathologies, i

235 chanisms by which chronic stress promote the development of pancreatic ductal adenocarcinoma (PDAC) a

236 methodology provides a blueprint toward the development of photoredox catalysis as a generic platfor

237 d their high-computational needs require the development of pipelines orchestrating the entire workfl

238 on-enzymatic PAD has great potential for the development of point-of-care testing (POCT) devices that

239 ive donor rim fungal culture results and the development of postkeratoplasty fungal infection using c

240 brane and CaM binding to Akt may help in the development of potential targets to control the pathophy

241 MMP-14 inhibitor as a starting point for the development of protein-based anticancer therapeutics.

242 DNA methylation profiles in relation to the development of PTSD symptoms in two prospective military

243 The development of rapidly tuning quantum cascade lasers has

244 atial variation in deadwood is vital for the development of regional and global carbon budgets.

245 f IT data has been hindered by the piecemeal development of relevant statistical models.

246 f efficient entry inhibitors to minimize the development of resistance by viral mutations.

247 inhibitors than sporadic BCCs, with minimal development of resistance.

248 Further development of rovalpituzumab tesirine in DLL3-expressin

249 Neonatal BCG had no effect on the development of RW before 13 months of age.

250 electrically driven entirely soft robots.The development of self-contained electrically driven soft a

251 atients with palliative needs has led to the development of several service-level interventions inten

252 Development of severe IgE-mediated hypovolemia and shock

253 s and provide a structural basis for further development of Sirt6 activators as tools and therapeutic

254 rally occurring compounds and efforts toward development of small molecules and biologics that could

255 These polymorphisms may be critical for the development of specialized plant feedstocks for bioenerg

256 Development of standardized assays for novel biomarkers

257 To fully dissect this data requires the development of stochastic models that can both deconvolv

258 The development of sustainable solid waste management (SWM)

259 lade model of integrin activation, where the development of tensile force yields physiological integr

260 s provide a foundation for investigating the development of the central complex, and tools for charac

261 somatic and neural elements following early development of the central nervous system.

262 its acoustic capabilities should inspire the development of the first combined audio-visual nanotechn

263 s host defences to facilitate the growth and development of the important rice pathogen Magnaporthe o

264 ased microvessel barrier function and to the development of the vascular disorder Cerebral Cavernous

265 fluence brain processes is essential for the development of therapies to prevent or treat postoperati

266 Further development of this approach could lead to fast and auto

267 r high-concentration materials, prior to the development of this method, all LA-ICP-MS analyses of gl

268 Together, these results support the further development of this multifunctional vaccine approach for

269 To facilitate development of topical therapeutics, we need an efficien

270 ands for the discovery of new biomarkers and development of treatment solutions to benefit patients w

271 vator of NRF2 and HSF1, protects against the development of UV irradiation-mediated cutaneous squamou

272 Herein, we address the recent developments of electrochemical DNA methylation detectio

273 ge were all significant predictors of new MA development (P = 0.04, 0.01, 0.04, 0.004, 0.01, respecti

274 lications for regulation of pluripotency and development.Polycomb repressive complexes modify histone

275 characteristics on accuracy of periodontitis development prediction.

276 oteins are indispensable to the survival and development process of living organisms.

277 Based on prior flavivirus vaccine development programs, knowledge of flavivirus particle s

278 oncentrated at stereocilia tips as hair cell development progressed, similar to the CAPZB-interacting

279 es of PCBP, ferritin, and NCOA4 in erythroid development remain unclear.

280 gy, but how renal tubules regulate capillary development remains unclear.

281 tical modeling of intraerythrocytic parasite development revealed an unexpected and substantial slowi

282 utational modelling of the heart tube during development reveals the interplay between tissue asymmet

283 Neuropsychological development scores at 4-5 y of age were estimated with t

284 es, may be a viable strategy for future drug development.SIGNIFICANCE STATEMENT Memantine and ketamin

285 Our development simplifies complicated assays and the transp

286 IR operates as a crucial modulator of hyphal development, since genetic ablation of the HIR complex s

287 ion in nascent merozoites to initiate sexual development through a hitherto unknown mechanism.

288 uggesting the possibility to program adipose development through dietary fatty acids before birth.

289 umour 1 (WT1), which plays multiple roles in development, tissue homeostasis and disease.

290 on occurs in disparate circumstances: during development to refine neuronal connections, after injury

291 paucity of novel acting antibacterials is in development to treat the rising threat of antimicrobial

292 54 wild-type parasites at multiple stages of development, we show that sexually committed, AP2-G(+) m

293 e existing framework for grass inflorescence development, which invokes homeotic shifts in multiple d

294 ssing PtabZIP1L showed precocious LRP and LR development, while PtabZIP1L suppression significantly d

295 ed enrollment and the other in late protocol development) will determine the clinical efficacy of fos

296 ed to a specific and profound defect in lung development with lung buds failing to undergo branching

297 of Rapamycin) pathway to balance growth and development with the available energy and nutrients.

298 e of this end point may expedite therapeutic development with the intent of bringing novel therapies

299 portance of neuronal progenitors in vascular development within the CNS is well recognized, how these

300 oding effector molecules that block parasite development within the vector, and then use the nuclease