ライフサイエンスコーパス: developmental

1 ther the primary role of this pathway may be developmental.

2 ising, as defective gene silencing underlies developmental abnormalities and disease.

3 in vivo This work describes early postnatal developmental abnormalities in visual and olfactory sens

4 nd devastating ophthalmologic and neurologic developmental abnormalities.

5 h as transverse hemimelia (TH), a congenital developmental abnormality characterized by absence of a

6 t in organizing neural circuits required for developmental acquisition of meaningful complex behavior

7 important role for Ube3A/E6AP in ASD-related developmental alteration in dendritic arborization and s

8 auxin-dependent and here we investigate the developmental and environmental regulation of root and s

9 e to which environmental modifications shape developmental and fitness outcomes, how their influences

10 ch DA cluster, our analysis promotes further developmental and functional analyses of this important

11 ogenesis and osteogenesis are one continuous developmental and lineage-defined biological process, in

12 The first two talks discuss novel developmental and neuronal subtype-specific contribution

13 A preponderance of evidence supports developmental and pathophysiological roles for the MET r

14 d hormones mediate critical lineage-specific developmental and physiologic responses.

15 The developmental and physiological complexity of the audito

16 cell to show metabolic, transport, genetic, developmental and signaling pathways.

17 rstanding the interplay among dispositional, developmental, and contextual factors in shaping behavio

18 life cycle, as well as in various cellular, developmental, and disease processes.

19 the correct daily phasing of the behavioral, developmental, and molecular events needed for the prope

20 ar biology, involving fields such as cancer, developmental, and stem cell biology.

21 P1 in the OL lineage and is recapitulated in developmental assays performed on OL progenitor cells pu

22 The dates of the data developmental assessments were February 23, 2012, to Apr

23 In the peripheral nervous system (PNS), developmental axon pruning relies on receptor-mediated e

24 charophycean alga from which they inherited developmental, biochemical, and cell biological attribut

25 Developmental biology (including embryology) is proposed

26 uable forum to explore the interface between developmental biology and metabolism.

27 sive use of zebrafish as a model organism in developmental biology and regeneration research, genetic

28 of possibilities for scientific discovery in developmental biology as well as in translational resear

29 A long-standing question in evolutionary developmental biology is how new traits evolve.

30 A landmark of developmental biology is the production of reproducible

31 set of paradigms, examples, and techniques, developmental biology remains vigorous, pluripotent, and

32 g of repeated structures is a major theme in developmental biology, and the inter-relationship betwee

33 omyocytes provide a promising tool for human developmental biology, regenerative therapies, disease m

34 rmation of new organs is a major question in developmental biology.

35 pe organogenesis is an important question in developmental biology.

36 ple contexts of interest to neuroscience and developmental biology.

37 and systems biology each has its ancestry in developmental biology.

38 tages was unaffected, with no overt signs of developmental blocks.

39 in early life stages, as PAH toxicity causes developmental cardiac abnormalities and impaired cardiov

40 New work reported in Developmental Cell from Diaz-Diaz and colleagues (2017)

41 In this issue of Developmental Cell, Bulusu et al. (2017) and Oginuma et

42 In this issue of Developmental Cell, Dickinson et al. (2017) and Rodrigue

43 Reporting in this issue of Developmental Cell, Pae et al. (2017) show that GCL bloc

44 In this issue of Developmental Cell, Roh-Johnson et al. (2017) reveal tha

45 anisms and can coordinate their responses to developmental challenges and environmental aggressions.

46 showing a dissociation in the origins of and developmental change seen in these two sets of processes

47 at a fixed CO2 level and show that ignoring developmental changes impacts conclusions on trees' W i

48 The model implies that developmental changes in sleep homeostasis and circadian

49 nstructions using tree rings often disregard developmental changes in W i as trees age.

50 n of greatly increased rates of dispersal by developmental changes when populations experience string

51 Critically, such developmental changes within PSCs were significantly ass

52 e culture, taking into account experimental, developmental, comparative, and archaeological evidence.

53 ays in which this framework can motivate new developmental, comparative, and cross-cultural research

54 In agreement with a potential developmental compensation for loss of torsinA in rodent

55 r data suggest an unanticipated mechanism of developmental compensation whereby cerebellin-1 and neur

56 2 null-allele mouse strain that circumvented developmental compensations found in constitutive Drd2(-

57 Developmental conditions can strongly influence adult ph

58 Our results suggest that that variation in developmental conditions experienced by adult group memb

59 tructures in the older age group may reflect developmental consolidation of the language system.

60 recalibrated to partly compensate for these developmental constraints (adaptive growth plasticity).

61 rcuits activated by twitching limbs, and the developmental context in which activation occurs, could

62 This research provides novel evidence of developmental continuity in the neural code underlying n

63 Our findings provide further evidence of a developmental contribution to the risk of later allergic

64 Genetic dissection of this developmental coordination showed that Epr3 is integrate

65 evere scoliosis in most individuals and rare developmental coxa vara distinguish individuals with FN1

66 both prenatal maternal factors and postnatal developmental cues.

67 ecular principles regulating the fascinating developmental cycle of this species.

68 anio rerio) genetic, genomic, phenotypic and developmental data.

69 s naivete and prevents premature deleterious developmental decisions.

70 f selective BCR-ABL inhibitors in humans and developmental defects in Abl1 knockout mice, suggest tha

71 Phf8 deficient mice neither display obvious developmental defects nor signs of cognitive impairment.

72 endent splicing programs between phyla, most developmental defects observed in vertebrate mutants are

73 ng biallelic truncating variants in GLI1 and developmental defects overlapping with Ellis-van Creveld

74 ctivation of Crkl in the mouse model induced developmental defects similar to those observed in patie

75 lterations of cilia function lead to various developmental defects, including supernumerary or missin

76 ish revealed compromised ciliary beating and developmental defects.

77 w birth weight, fetal growth retardation and developmental defects.

78 Developmental deformities for larval exposures included

79 s early in development causes dose-dependent developmental delay and lethality in Caenorhabditis eleg

80 Moderate and late preterm children exhibited developmental delay compared with their term-born peers,

81 d show that some individuals can have severe developmental delay without dystonia at least until mid-

82 acterized by a dyskinetic movement disorder, developmental delay, and autism.

83 factors for autism spectrum disorder (ASD), developmental delay, and infantile seizures.

84 herited UBE3A allele and is characterized by developmental delay, intellectual disability, ataxia, se

85 ssense variants presented with severe global developmental delay, syndactyly of 2(nd) and 3(rd) toes,

86 rocephaly, spastic quadriparesis, and global developmental delay.

87 IGNIFICANCE STATEMENT Prematurity results in developmental delays and neurobehavioral disorders, whic

88 show cognitive and behavioral dysfunctions, developmental delays in childhood and risk of developing

89 is the most common known inherited cause of developmental disability.

90 transcriptional regulation of various human developmental, disease, or immunity pathways.

91 e maternal chromosome is associated with the developmental disorder Beckwith Wiedemann Syndrome (BWS)

92 Autism spectrum disorder (ASD) is a developmental disorder defined by behavioral features th

93 le X Syndrome (FX) is generally considered a developmental disorder, arising from a mutation that dis

94 Since schizophrenia is a developmental disorder, we examined the effects that per

95 development of novel modulators of HH-driven developmental disorders and diseases.

96 components of the Ras/MAPK pathway result in developmental disorders called RASopathies, affecting ab

97 osphate-5-phosphatase that is mutated in the developmental disorders Joubert and MORM syndromes, is e

98 ities and cerebral folate deficiency-related developmental disorders.

99 ers (PBDEs), but few have examined diagnosed developmental disorders.

100 , and KMT5B haploinsufficiency with dominant developmental disorders.

101 and the importance of this process in human developmental disorders.

102 ity could be utilized for early diagnosis of developmental disorders.

103 e frequently encountered in individuals with developmental disorders.

104 sfunction such as that seen in ASD and other developmental disorders.

105 f the cerebral cortex (MCCs) are devastating developmental disorders.

106 grating macrophages (hemocytes) during their developmental dispersal, which is critical for embryogen

107 als that establish and maintain the distinct developmental domains required for formation of hinged j

108 nts are a sensitive subpopulation for PFAA's developmental effects and receive higher exposures than

109 ire explicit accounting for species-specific developmental effects before CO2 and climate effects are

110 promoters: housekeeping enhancers (hkCP) and developmental enhancers (dCP).

111 ir resolution, resolving causal mutations in developmental enhancers, validated transcription-factor-

112 iminate environmental modifications from the developmental environment of Onthophagus dung beetles.

113 important biological mechanism through which developmental environments shape inflammatory phenotypes

114 Planar cell polarity (PCP) signaling orients developmental events in vertebrates and invertebrates, i

115 zing organoids excel at recapitulating early developmental events, bioengineered constructs reproduci

116 Nuclear movement is critical for developmental events, cell polarity, and migration and i

117 trauterine period is a critical time wherein developmental exposure can influence risk for chronic di

118 Preventing developmental exposure to PBDEs could help prevent loss

119 a cohort of 258 undiagnosed UK patients with developmental eye disorders, including anophthalmia, mic

120 ontal cortex and ending in the modulation of developmental factors in the amygdala and hypothalamus,

121 ethanol exposure (PE) is among many adverse developmental factors known to increase drug addiction r

122 chological/health belief, communication, and developmental factors to fertility preservation outcomes

123 often generates two daughters with different developmental fates.

124 expression differences influence respective developmental fitness.

125 , and cis-regulatory logic contribute to the developmental function of network circuits.

126 are enriched near sets of genes with common developmental functions and significant overlap across l

127 s two-tiered mechanism globally orchestrates developmental gene expression, including extremely wides

128 evolutionary changes that have restructured developmental gene regulatory networks (GRNs).

129 ajor Trl cofactor that functions to moderate developmental gene transcription.

130 PRC1-Br140 bind developmental genes in fly embryos, with analogous co-oc

131 es, obscures a recurring theme emerging from developmental genetic studies in grass models, that is t

132 Yet the developmental-genetic mechanisms underlying sex-specific

133 The regulatory information encompassed in developmental GRNs thus goes far beyond the control of i

134 is prenatally perturbed and that a critical developmental insult is key to the afferent pathology.

135 ecent discoveries of tissue-resident NK cell developmental intermediates, non-NK innate lymphoid cell

136 Adopting a developmental lens, we review recent evidence that sheds

137 s of IYO knockdown at the transcriptomic and developmental levels.

138 t visual feedback is well-established in the developmental literature.

139 isolated cleft palate (CP) are common human developmental malformations with a complex etiology that

140 t a function of these genes during the early developmental manifestation of heterosis under fluctuati

141 that NCoR1 plays a major role in repressing developmental maturation of the intestines.

142 However, its developmental mechanisms remain largely unknown.

143 -threatening cardiac complications; however, developmental mechanisms underpinning coronary artery fo

144 Here, we investigated shared developmental mechanisms.

145 This is the first time morphological and developmental modules are described for the paired fins

146 We show that developmental mutations in the zebrafish paralogous gene

147 differentiation and myelination, both during developmental myelination as well as during myelin regen

148 and this may result in an increased risk for developmental neuropathies.

149 egments recapitulates dimensional aspects of developmental neuropsychiatric disorders in mice.

150 ecture of how these two organs covary during developmental ontogeny, we conducted a mapping experimen

151 on markers (Ki-67, BrdU), pallial/subpallial developmental origin (Tbr1, Sp8), and neuronal/glial ant

152 issue localization and morphology, but their developmental origin and mode of homeostatic maintenance

153 (GU) system are fundamentally linked by the developmental origin of multiple GU tissues, including t

154 y of skull modules are associated with their developmental origin, with regions derived from the ante

155 Here we show that developmental origins influence fine-scale synapse forma

156 linical drug studies and for elucidating the developmental origins of pediatric neoplasms.

157 However, much less is known about the developmental origins of pigment cells produced in adult

158 accounts for approximately 20% of the gap in developmental outcomes between children from low- and hi

159 of photomorphogenesis action, but the organ developmental outcomes differ: while TOR-dependent energ

160 the mutation rates, mutational processes and developmental outcomes of cell dynamics that operate dur

161 iencing the death of a sibling on children's developmental outcomes.

162 mental trajectories and are at risk for poor developmental outcomes.

163 ancy that could lead to adverse pregnancy or developmental outcomes; however, these results should be

164 ate, enabling the interplay during different developmental paths, where each phage genome may make an

165 Understanding the developmental pathway of these antibodies has provided i

166 various genes involved in such cellular and developmental pathways as regulation of transcription, b

167 T cells were also associated with genes from developmental pathways that had alphaKG-sensitive expres

168 To examine the developmental pathways that lead to first-episode adoles

169 tor differences by histologic phenotypes and developmental pathways.

170 adation of multiple regulators of endogenous developmental pathways.

171 omic studies to parse gene function in human developmental pathways.

172 ar disease by repressing the reactivation of developmental pathways.

173 as and in the species, and all have a unique developmental pattern.

174 gnal regulated kinase (Erk) signaling, a key developmental patterning cue.

175 nt cognitive ability and FCA identified four developmental patterns leading to diverse psychiatric di

176 t evidence supporting an association between developmental PBDE exposure and reduced IQ.

177 Adolescence is a developmental period marked by heightened attunement to

178 GNIFICANCE STATEMENT Adolescence is a unique developmental period of heightened awareness about other

179 -3 FAs depends on the cognitive function and developmental period studied.

180 in external inputs and experience during the developmental period.

181 in response to PREMS varied across offspring developmental periods as predicted.

182 While exposure to nicotine during developmental periods can significantly affect brain dev

183 ly in evolutionary biology and oncology, the developmental perspective is being reasserted as an impo

184 In plants, one of the most understated developmental phenomena is that of straightness - a root

185 ively, and antagonistically to establish the developmental phenotype.

186 Importantly, these data suggest that developmental plasticity and connectivity are impaired i

187 ipotent memory precursor (MP) cells maintain developmental plasticity and longevity to provide long-t

188 the role of this nutrient-sensing pathway in developmental plasticity and metabolic homeostasis.

189 metabolism with shoot-root coordination and developmental plasticity in shaping organ biomass and ar

190 stem cells (PSCs) sit atop the landscape of developmental potency and are characterized by their abi

191 twork that defines and restricts pluripotent developmental potential in cultured ESCs and iPSCs.

192 uff (erm) uniquely functions to restrict the developmental potential of intermediate neural progenito

193 and coordinate morphogenesis with changes in developmental potential.

194 t transiently silence their genome, an early developmental process that requires Nanos activity.

195 Seed maturation is an important developmental process to soybean seed quality and yield.

196 ll levels of network organization to control developmental process.

197 in order to identify key genes in a complex developmental process.

198 stem cells (hiPSCs) are invaluable to study developmental processes and disease mechanisms particula

199 Ethylene gas is essential for developmental processes and stress responses in plants.

200 biology, including the cell-fate decision in developmental processes as well as the genesis and progr

201 ), responsible for cuticle tanning and other developmental processes in insects.

202 ssors that mediate diverse physiological and developmental processes in plants [1, 2].

203 otL2/actin filaments plays a crucial role in developmental processes such as epithelial geometrical p

204 isms involving the reactivation of endocrine developmental processes that result in dramatic beta-lik

205 se individuals toward adiposity by affecting developmental processes, little is known about the chemi

206 tant to sustain TCR signals during these key developmental processes.

207 criptome during embryogenesis and subsequent developmental processes.

208 ain, are sufficient to mediate both of these developmental processes.

209 scuss how metabolism influences cellular and developmental processes.

210 ferent contrasts not only revealed a complex developmental profile for ON, OFF and ON-OFF responses,

211 ne, to control the establishment of a stable developmental program for the formation of flowers.

212 ctive pressure maintains the fitness of this developmental program, composed of hundreds of unique ge

213 which are required to execute the osteoclast developmental program.

214 for the establishment of the haematopoietic developmental program.

215 cell senescence is an intrinsic part of the developmental programme in amphibians.

216 the first time how early-life stress drives developmental programming and transgenerational effects

217 actation, protects offspring from WD-induced developmental programming of hepatic lipotoxicity and ma

218 NMDA receptor-signaling is prerequisite for developmental programs ultimately responsible for the ap

219 that specific, non-random components of the developmental programs underlying the Drosophila olfacto

220 gene expression, and their interactions with developmental programs, remain largely unknown.

221 relative to HR infants who showed more rapid developmental progress, as well as relative to all LR in

222 l conditions offers a system for delineating developmental progression from naive pluripotency.

223 h the coexistence of H3K4me3 and H3K27me3 at developmental promoters represents a poised transcriptio

224 Developmental prosopagnosia (DP) is characterised by sev

225 reens we identified PKL, a gene required for developmental regulation in plants, as a factor promotin

226 Among these, the conserved metabolic and developmental regulator ESRRA was highlighted for an esp

227 d by interlaced feed-forward loops that link developmental regulators with biosynthetic genes.

228 e characterized by a set of highly conserved developmental regulators.

229 related to embryo surrounding factor (ESF1) developmental regulators.

230 e the neuroendocrine stress axis coordinates developmental remodelling, immune function and energy al

231 vide a key link to those events that control developmental repression of UGT1A1 and hyperbilirubinemi

232 cells that lose epigenetic silencing during developmental reprogramming.

233 guages" - the view from sign linguistics and developmental research in cognition presented by Goldin-

234 A new role of EPiR in regulating the developmental responses of plants mediated by ethylene h

235 oculation with Rhizophagus irregularis, root developmental responses, fungal colonization and transcr

236 on therapy for glioblastoma was reviewed for developmental rigor by methodologists.

237 alyzed CB1R signaling in macrophages and its developmental role in T2D.

238 While the developmental sequence of plexiform layers in human reti

239 A developmental signature could be distinguished, characte

240 Developmental similarity of gene expression between pect

241 riation, regularity, noise or a pressure for developmental simplicity) enhance evolvability.

242 ted integration of diverse cell fates across developmental space and time, yet understanding how comp

243 We studied the effect of dose, and the developmental stage at the beginning of Se-fortification

244 dels gave r>0.77 confirming that Se dose and developmental stage largely determine the behaviour of t

245 is system to study neonatal hematopoiesis, a developmental stage that has been difficult to analyze t

246 of NDCs change dramatically as a function of developmental stage.

247 c changes in chromatin accessibility between developmental stages and could thereby represent putativ

248 sponses to GA vary across cells and tissues, developmental stages and environmental conditions, the s

249 ene expression levels, including at specific developmental stages and in specific tissues.

250 ct of regulated deficit irrigation, cluster, developmental stages and two seasons (autumn 2015 and sp

251 es (up to 28.65mg/g dry matter) in the later developmental stages in both forms, mainly ester-bound i

252 o dissect/identify NPC subtypes and critical developmental stages of alternative lineage specificatio

253 Metabolite analysis of different developmental stages of leaf and fruit suggests tissue-s

254 2 and tsp-3 transcripts were detected in all developmental stages of O. viverrini.

255 riptomic and proteomic analyses of different developmental stages of the parasite; however, changes m

256 fferences associated with transition between developmental stages rather than specific adaptations to

257 mparative transcriptomics across mutants and developmental stages revealed clusters of co-regulated g

258 matic expression analyses across tissues and developmental stages validated two such isoforms, which

259 In most tissues and developmental stages we observe a relative contribution

260 o exhibit medial-lateral territories at both developmental stages with enrichment of glutamatergic (e

261 compartments A/B are highly similar at both developmental stages.

262 ation and survival of mDANs during embryonic developmental stages.

263 atlas covering a broad sample of organs and developmental stages.

264 expression in its major organs at different developmental stages.

265 form up to 9.85mg/g dry matter at the early developmental stages.

266 -80 contribute to brain development at early developmental stages.

267 ect analysis of potential roles during later developmental stages.

268 57 rice anther tissue microarrays across all developmental stages.

269 e of Streptomyces bacteria encompasses three developmental stages: vegetative hyphae, aerial hyphae a

270 gene regulation, as cells transition between developmental states.

271 abit-based behavior otherwise facilitated by developmental stress hormone exposure.

272 We show that similar developmental stress is necessary and sufficient to exte

273 he challenges involved and discuss how basic developmental studies have contributed to and are needed

274 s antecedents to schizophrenia in high-risk, developmental studies, might represent early manifestati

275 is essential for (1) detecting the source of developmental susceptibility, (2) identifying mechanisms

276 The uniqueness of this developmental system lies in not only the great diversit

277 sidues and has implications for use in other developmental systems.

278 but does not occupy differentially expressed developmental targets.

279 As has been the case for other unilinear, developmental theories of demographic/family change, the

280 s novel biomarkers and molecular targets for developmental therapeutics in aggressive PCa.

281 associates 5024 unnamed genes with distinct developmental time points.

282 ASD mouse models, especially during an early developmental time when experience-dependent plasticity

283 NAs act in the early embryo to function as a developmental timer that preserves naivete and prevents

284 Maternal folic acid (FA) protects against developmental toxicity from certain environmental chemic

285 fraction (WAF) of oil from the spill causes developmental toxicity through cardiac defects in pelagi

286 eason why preterm infants experience altered developmental trajectories and are at risk for poor deve

287 of biological diversity is regulated by both developmental trajectories and limits on available ecolo

288 Delays in early learning developmental trajectories in HR infants (validated in a

289 y, and also provide evidence that individual developmental trajectories of reaction time variability

290 Independent drivers of these aberrant developmental trajectories of respiratory microbiota mem

291 ging learning environments, and differential developmental trajectories.

292 The developmental trajectory of psychopathy seemingly begins

293 amming, FOXA1 upregulation, and a retrograde developmental transition in PDA metastasis.

294 hose expansion drives the final step of this developmental transition under optimal conditions.

295 nt transcriptional changes to ensure precise developmental transitions during cellular differentiatio

296 evidence that sheds light on the origin and developmental unfolding of the link between language and

297 Invertebrate microRNAs (miRNAs) can suppress developmental variability that is caused by environmenta

298 Finally, we identify a developmental window at postnatal Days 6 to 9 when Mulle

299 essential element deficiency during specific developmental windows increases ASD risk and severity, s

300 .SIGNIFICANCE STATEMENT Critical periods are developmental windows of opportunity that ensure the pro