ライフサイエンスコーパス: developmental gene

1 t encoded by EARLY FLOWERING 3 (ELF3), a key developmental gene.

2 ly visualized transcription of an endogenous developmental gene.

3 cross animals, many of which are enriched in developmental genes.

4 dhesion proteins, and in the upregulation of developmental genes.

5 ates a redeployment of mesenchyme-associated developmental genes.

6 ponse and late expression of several "early" developmental genes.

7 enhancers, which regulate expression of key developmental genes.

8 signals modulate RNAi silencing to regulate developmental genes.

9 transferase that regulates the expression of developmental genes.

10 ty of this important regulator of M. xanthus developmental genes.

11 rn, regulates the expression of a variety of developmental genes.

12 elopment by directly regulating a set of key developmental genes.

13 Ring1b subunit of PRC1 and TBP co-enrich at developmental genes.

14 the maintenance of transcriptionally poised developmental genes.

15 gnaling, and (d) inappropriate expression of developmental genes.

16 portant but redundant or partially redundant developmental genes.

17 ion and thereby regulates cell type-specific developmental genes.

18 at" that finely calibrates PRC2 functions at developmental genes.

19 h H3K27me3 and H3K4me2), a characteristic of developmental genes.

20 to provide specificity to activation of key developmental genes.

21 eptor, a transcription factor that regulates developmental genes.

22 ign and successfully applied them to several developmental genes.

23 ember of the T-box gene family of mesodermal developmental genes.

24 patterns due to epigenetic modifications of developmental genes.

25 egulation, unlike FruA, which regulates many developmental genes.

26 itment and transcriptional regulation of key developmental genes.

27 was little overlap with putative heterocyst developmental genes.

28 inent roles in the coordinated expression of developmental genes.

29 transcriptional repressors that control many developmental genes.

30 wild-type cells by inducing a subset of late developmental genes.

31 evelopment and causing altered expression of developmental genes.

32 results from aberrant expression of cardiac developmental genes.

33 to sequential reprogramming of metabolic and developmental genes.

34 27me3), particularly at CGIs associated with developmental genes.

35 the DPY30-COMPASS histone modifiers onto key developmental genes.

36 cle regeneration, and derepression of muscle developmental genes.

37 d PRC2 are well known for silencing specific developmental genes.

38 s for tissue growth and directly targeted by developmental genes.

39 PRC2 and poised RNAPII at Erk2-PRC2-targeted developmental genes.

40 s in their content of neurogenic, immune and developmental genes.

41 ently are located megabases away from target developmental genes.

42 AT signaling, NF-kappaB signaling and B cell developmental genes.

43 erentially regulating "housekeeping" versus "developmental" genes.

44 These fetal biomarkers included 27 developmental genes, 5 sensory perception genes, and 22

45 , we uncover novel relatedness of particular developmental genes across different organs and tissues

46 Although FGFR3 is a crucial developmental gene, acting as a negative regulator of bo

47 vivo to simultaneously orchestrate distinct developmental gene activation and repression programmes.

48 omains are considered to poise expression of developmental genes, allowing timely activation while ma

49 cleosomes regulates the origins that mediate developmental gene amplification during Drosophila oogen

50 Here, we use developmental gene amplification in Drosophila ovarian f

51 ng the activation of origins responsible for developmental gene amplification in Drosophila.

52 sis, both via epigenetic regulation of a key developmental gene and by promoting genome stability in

53 ers decreases gene expression in a subset of developmental genes and alters ESC differentiation, wher

54 anchors regulate some of the most important developmental genes and are less likely to be expressed

55 ily conserved sequences, are associated with developmental genes and are marked with active enhancer

56 K27me3, and PHF19/PCL3 at a subset of poised developmental genes and demonstrated that PHF19/PCL3 Tud

57 of these events, through RNA interference of developmental genes and ectopic hormonal treatments.

58 ecific transcriptional "memory" of embryonic developmental genes and exhibited differential promoter

59 associated with birth weight were linked to developmental genes and have methylation levels which ar

60 tem cells (mESCs) causes the derepression of developmental genes and induction of early differentiati

61 the dHP1c complex, localizes at promoters of developmental genes and is required for transcription.

62 scle proteins and upregulation of oncogenes, developmental genes and lungfish LSGs.

63 ound the transcriptional start site (TSS) of developmental genes and mediates the recruitment of the

64 it practical to systematically decipher the developmental genes and pathways encoded in the genome o

65 lls by altering the expression timing of key developmental genes and pluripotent genes.

66 Expression of mucins and developmental genes and proliferation were assessed by i

67 regulating distinct chromatin states at key developmental genes and propose a novel mechanism by whi

68 h cryptic introns to form heterochromatin at developmental genes and retrotransposons, Ctr1 functions

69 trajectories of transposable elements (TEs), developmental genes and sex chromosomes onto the snake p

70 erable effort is being invested in isolating developmental genes and studying their expression patter

71 models, the identification of specific renal developmental genes and the application of novel sequenc

72 The rapid evolution of essential developmental genes and their protein products is both i

73 ands of human-specific genome alterations in developmental genes and their regulatory regions.

74 This up-regulation affects many developmental genes and transcription factors, including

75 We have applied this method to mouse developmental genes, and have evaluated the predicted CR

76 Dysregulation of the developmental gene anterior gradient protein 2 (AGR2) ha

77 In contrast, we observed that developmental genes are acutely up-regulated after cycli

78 which transcriptional enhancers controlling developmental genes are contained within nearby bystande

79 Developmental genes are essential in the formation and f

80 Well-known developmental genes are often reused in surprising tissu

81 CD was originally identified as an essential developmental gene associated with mRNA and Golgi-endopl

82 very and validation of Aldh1a2, an essential developmental gene associated with various important car

83 2A (H2A(ub)) and is associated with silenced developmental genes at facultative heterochromatin.

84 analyzed the gene expression patterns of 96 developmental genes at single-cell resolution.

85 hylation with a lower expression of specific developmental genes at stage 5 raises the possibility th

86 to alterations in expression of the critical developmental gene bldN, and other key downstream genes

87 Morphology evolves often through changes in developmental genes, but the causal mutations, and their

88 ditis elegans complexes that repress pivotal developmental genes, but the mammalian complex has been

89 ulatory gains near transcription factors and developmental genes, but this trend was replaced by inno

90 Oct1 and Sox2 synergistically regulate developmental genes by binding to adjacent sites within

91 Repression of the developmental genes by mTOR is necessary for the mainten

92 ntal stage and that hypomorphic mutations in developmental genes can elicit profound adult behavioral

93 gy and identity, including regulation of all developmental genes, cell differentiation, stem and soma

94 hibit significantly increased enrichment for developmental genes compared with differentially methyla

95 of pluripotency genes and underexpression of developmental genes during differentiation in the absenc

96 ion, as a component of the bivalent mark, at developmental genes during the ESC fate transitions.

97 Bivalency of developmental genes during the G1 phase of the pluripote

98 ore open-chromatin conformation at key heart developmental genes, enabling their promoters and enhanc

99 expression characteristic of their proximal developmental gene, even in the absence of sequence cons

100 A recent study compares developmental gene expression among very distantly relat

101 These results indicate a dysregulation of developmental gene expression and an uncoupling of trans

102 trates removal of H3K27me3, thus controlling developmental gene expression and cell differentiation.

103 was substantially slowed with delayed early developmental gene expression and that chemotaxis toward

104 ole as a transcription regulator controlling developmental gene expression are unknown.

105 ies data sets to determine the regulation of developmental gene expression by cell cycle, lineage, mo

106 ecerebellar nucleus in the mouse that shares developmental gene expression characteristics with mossy

107 tor machine (SVM) model, trained using brain developmental gene expression data, for the classificati

108 rnative sigma factors governs the program of developmental gene expression during sporulation in Baci

109 s work with epigenetic processes to regulate developmental gene expression during tissue cyst formati

110 xts, a direct link between B-type lamins and developmental gene expression in an in vivo system is cu

111 Live imaging of developmental gene expression in Drosophila embryos open

112 ins play an important role in the control of developmental gene expression in higher organisms.

113 abling sigma(F), promotes the switch to late developmental gene expression in the forespore.

114 of SpoIIIE plays a key role in reprogramming developmental gene expression in the forespore.

115 The altered pattern of developmental gene expression in the mutant implied that

116 Thus, precise spatiotemporal control of developmental gene expression is achieved by complex mul

117 For instance, developmental gene expression is extremely similar in a

118 o distinct degradation rates, I propose that developmental gene expression is shaped by a complex 'mR

119 le that they play in functionally regulating developmental gene expression pathways or whether they a

120 for T-box proteins in establishing specific developmental gene expression pathways.

121 that a variety of human cancers recapitulate developmental gene expression patterns (that is activate

122 In particular, for the analysis of developmental gene expression patterns, it is biological

123 cis-Regulatory modules that control developmental gene expression process the regulatory inp

124 d chromatin looping can override a stringent developmental gene expression program and suggest a nove

125 er chromatin-modifying activities to control developmental gene expression programs remain unclear.

126 with condensed chromatin and fine-tuning of developmental gene expression programs, is positively co

127 cells necessary for the proper execution of developmental gene expression programs.

128 ments required for specialized cell-type and developmental gene expression programs.

129 Developmental gene expression requires the successful co

130 Developmental gene expression results from the orchestra

131 mal pausing helps confer tissue-specific and developmental gene expression through a mechanism regula

132 Thus, integration of developmental gene expression with biological assessment

133 s two-tiered mechanism globally orchestrates developmental gene expression, including extremely wides

134 Although both are required for developmental gene expression, receptor occupancy promot

135 nally discovered as epigenetic regulators of developmental gene expression, the Polycomb (PcG) and tr

136 coronary blood vessel formation, and altered developmental gene expression.

137 ows users to perform online queries of mouse developmental gene expression.

138 (PITX2) homeodomain protein, which modulates developmental gene expression.

139 ubpallium have been proposed using conserved developmental gene expression.

140 tion patterns are strongly correlated with a developmental gene expression.

141 of repressed chromatin domains and regulate developmental gene expression.

142 Morphological characters are the result of developmental gene expression.

143 nome reprogramming, cell differentiation and developmental gene expression.

144 tional complexes that provide specificity of developmental gene expression.

145 ng chromatin features required for regulated developmental gene expression.

146 ed analysis of transcription factor (TF) and developmental-gene expression in the SCN from neurogenes

147 sease-related genes and the potential of one developmental gene for disease susceptibility in rice/Xo

148 op of a hierarchy of interactions by marking developmental genes for activation, beginning with the o

149 of pluripotency-associated genes, and primes developmental genes for differentiation.

150 Together BldO and BldD repress developmental genes from being expressed until the appro

151 tion in zebrafish can accelerate the pace of developmental gene function discovery.

152 ax pleiotropy and reveal both early and late developmental gene functions.

153 primary phototransduction protein) and some developmental genes had very early origins and were recr

154 ve expression pattern analysis of homologous developmental genes has been a successful approach to cl

155 ansmission and transcriptional activation of developmental genes, has potential as a bio-pesticide to

156 controlling the activation and silencing of developmental genes; however, the mechanistic details of

157 ions followed by transcriptional analysis of developmental genes identified four distinct candidate p

158 rs also had transcriptional dysregulation of developmental genes implicated in autism and schizophren

159 explain the sharp expression of a canonical developmental gene in response to a regulating transcrip

160 e required for the epigenetic maintenance of developmental genes in a silent state.

161 can be used to remove the wild-type copy of developmental genes in appropriate heterozygotes, result

162 Expression profiles of developmental genes in Dictyostelium were determined on

163 mb Repressive Complex 2 (PRC2) regulates key developmental genes in embryonic stem (ES) cells and dur

164 bivalent chromatin mark that typifies poised developmental genes in embryonic stem cells (ESCs).

165 indicate that PRC2 occupies a special set of developmental genes in ES cells that must be repressed t

166 We propose that bivalent domains silence developmental genes in ES cells while keeping them poise

167 PRC1-Br140 bind developmental genes in fly embryos, with analogous co-oc

168 ss functional tools available to study early developmental genes in insects, and provide examples in

169 translocations to cause excess expression of developmental genes in leukemia.

170 s can arise from inappropriate activation of developmental genes in mature tissues.

171 Developmental genes in metazoan genomes are surrounded b

172 f larger abrupt changes in the expression of developmental genes in morphological evolution.

173 (PRC1) and PRC2 maintain repression at many developmental genes in mouse embryonic stem cells and ar

174 activation in promoting the primed status of developmental genes in mouse ES cells and suggest that t

175 the dev operon, resembling the regulation of developmental genes in multicellular eukaryotes.

176 that modulates expression of many important developmental genes in Myxococcus xanthus.

177 , intrinsic differences in the expression of developmental genes in regional adipocytes provide a mec

178 heterochromatin needed for the silencing of developmental genes in the adult heart.

179 uggesting the specialized packaging of these developmental genes in the germline.

180 ize to the promoters of a specific subset of developmental genes in vivo, the SLED domain of Scml2 ma

181 y members in the regulation of several early developmental genes including homeobox transcription fac

182 signaling genes and contained cardiovascular developmental genes including TBX5.

183 refrontal cortex; neuropeptide signaling and developmental genes, including factor Bdnf, in the nucle

184 nd the expression of specific cell cycle and developmental genes, including growth-regulating factors

185 te nucleosomes to maintain repression of key developmental genes, including Hox genes whose temporal

186 ZMYND8 was found to be recruited to several developmental genes, including the all-trans-retinoic ac

187 ed as a model organism for investigating the developmental gene interactions.

188 Epigenetic modifications regulate developmental genes involved in stem cell identity and l

189 Further analyses on several developmental genes involved in the photoreceptor cell d

190 the epigenetically poised condition of these developmental genes is a fundamental property of the mam

191 Activation of developmental genes is coincident with PTIP protein bind

192 Precise spatial and temporal control of developmental genes is crucial during embryogenesis.

193 nd suggest that the transcription complex at developmental genes is different than the complexes form

194 e category of promoters, associated with key developmental genes, is frequently hypermethylated in ca

195 t one copy, 0.5 million bases from the neuro-developmental gene ISL1, is an enhancer that recapitulat

196 , visualized by changes in the expression of developmental genes like engrailed or cubitus interruptu

197 nteraction profiles and nuclear positions at developmental gene loci differ between human somatic cel

198 priately respond to differentiation signals, developmental gene loci should be structurally and spati

199 Moreover, we also demonstrate that developmental gene loci, which have bivalent histone mod

200 o the regulatory regions of pluripotency and developmental genes marked with H3K27me3 contributing to

201 ression, and that the regulation of neuronal developmental genes may be the most ancient and conserve

202 utations that cause the misexpression of key developmental genes may underlie a number of development

203 ures at poised genes, particularly those key developmental genes mediated by BAF250a.

204 t interfering RNAs participate in a range of developmental gene networks by base-pairing with their t

205 The sequential activation of distinct developmental gene networks governs the ultimate identit

206 their relationship is to core components of developmental gene networks, and what is the development

207 nes (Th, Gad1), as well as changes in neural developmental genes (Nurr, Ncam).

208 Recent reports have shown that developmental genes often possess multiple discrete enha

209 ution, the evolutionary rates of early-stage developmental genes, or on species diversification.

210 ifications/compositions genome-wide and find developmental genes packaged in large blocks of chromati

211 the adult heart results in reactivation of a developmental gene program in the epicardium, but the tr

212 brosis, show evidence of a recapitulation of developmental gene programs.

213 Methylation of developmental gene promoters during tumorigenesis may th

214 argely associated with a subset of essential developmental gene promoters, which are located within C

215 are associated with a particular set of key developmental gene promoters.

216 These findings support the concept of developmental gene re-activation in IPF, and FGF-10 defi

217 omb repressive complex 2 (PRC2) placement at developmental genes regulated by silencing in Arabidopsi

218 res bivalent epigenetic modifications of key developmental genes regulated by various transcription f

219 use of its value to enlighten the biology of developmental gene regulation and because fetal hemoglob

220 nts is therefore important for understanding developmental gene regulation and disease.

221 in locus are an important model of mammalian developmental gene regulation and do not contain CpG isl

222 can now test these sequences for effects on developmental gene regulation and downstream phenotypes

223 poson regulation, heterochromatin formation, developmental gene regulation and genome stability.

224 hat has been proposed to have a role in late developmental gene regulation in Chlamydia, but only a s

225 e that has been postulated to have a role in developmental gene regulation in Chlamydia.

226 represents a classical model system to study developmental gene regulation in mammalian cells.

227 mplexes PRC1 and PRC2 play a central role in developmental gene regulation in multicellular organisms

228 ucleosome positional changes associated with developmental gene regulation in WT.

229 ologists to address fundamental questions of developmental gene regulation on a genome-wide scale.

230 his work introduces a hierarchical model for developmental gene regulation, and reveals a major role

231 Epigenetic information plays a role in developmental gene regulation, response to the environme

232 a functional role for 3' CGI methylation in developmental gene regulation.

233 animal development, with widespread roles in developmental gene regulation.

234 riptional corepressors play complex roles in developmental gene regulation.

235 represents a clinically important example of developmental gene regulation.

236 ions, indicating a general role for MrpC2 in developmental gene regulation.

237 t drive widespread cell type, tissue type or developmental gene regulation.

238 to each other to study patterns of long-term developmental gene regulation.

239 t play central roles in numerous examples of developmental gene regulation.

240 e and provide support for a role for MBD2 in developmental gene regulation.

241 anner, providing a multitiered mechanism for developmental gene regulation.

242 -directed gene repositioning is critical for developmental gene regulation.

243 are linked to transcriptional repression and developmental gene regulation.

244 Nuclear FGFR1 acts as a developmental gene regulator in cooperation with FGF-2,

245 pecific scUMCs are associated with essential developmental genes, regulators of cell differentiation,

246 In an A. thaliana developmental gene regulatory network, GRACE recovers ce

247 ore promoter functions in the dorsal-ventral developmental gene regulatory network.

248 Developmental gene regulatory networks (GRNs) are assemb

249 The modular components, or subcircuits, of developmental gene regulatory networks (GRNs) execute sp

250 Comparisons of orthologous developmental gene regulatory networks (GRNs) from diffe

251 lems in biology, from theoretical aspects of developmental gene regulatory networks (GRNs) to various

252 evolutionary changes that have restructured developmental gene regulatory networks (GRNs).

253 PNAS Special Feature are assembled papers on developmental gene regulatory networks governing the for

254 s occurred by alteration of the structure of developmental gene regulatory networks.

255 anism of BCL11A action and new clues for the developmental gene regulatory programs that function at

256 , by alterations in the structure of encoded developmental gene-regulatory networks (GRNs).

257 ns assemble a chromatin state that maintains developmental gene repression.

258 set of bivalent genes silent in mESCs, while developmental genes require MSL for expression during di

259 nstrate how hypomorphic mutation of an early developmental gene results in genomewide transcriptional

260 ects due to missense mutations in additional developmental genes seem to enhance the phenotypic varia

261 ic transposon-mediated mutation of the early developmental gene Semaphorin-5c (Sema-5c) results in ab

262 stone H3 (H3K27me3) is intimately related to developmental gene silencing through the so-called Polyc

263 , the Polycomb Group (PcG) proteins maintain developmental gene silencing using an array of chromatin

264 neuroepithelium expressing a combination of developmental genes: Six3, Six6, Fzd5, and transient Rx,

265 They express other developmental genes, such as Pdx-1 and Hes-1.

266 regulating behavior in the context of other developmental genes, such as retn.

267 possibility of sex-biased expression of key developmental genes, such as the segmentation genes cont

268 T-DMR-associated genes were enriched for developmental genes, suggesting that a specific set of a

269 First, DNA hypomethylation at embryonic developmental genes supports their epigenetic "poising"

270 hes1 is a key developmental gene that is overexpressed in certain canc

271 In addition, we identified a number of developmental genes that are differentially expressed be

272 ture is the poised chromatin state of master developmental genes that are transcriptionally repressed

273 ure, bilaterian animals share common sets of developmental genes that display conserved expression pa

274 These enhancers are linked to developmental genes that display coordinated transcripti

275 e discovered a group of CGIs associated with developmental genes that gain methylation after hESCs di

276 Notably, it is enriched among key developmental genes that have bivalent chromatin structu

277 lt-onset, age-associated events by silencing developmental genes that later have a deleterious influe

278 eatic CSCs display upregulation of important developmental genes that maintain self-renewal in normal

279 ts influencing putamen volume clustered near developmental genes that regulate apoptosis, axon guidan

280 There was also a subgroup of neurite/axonal developmental genes that were altered in response to UVR

281 jury to the adult kidney induces a number of developmental genes thought to regulate repair, includin

282 KDM2B repressed developmental genes through cobinding with Polycomb grou

283 Homeobox proteins are critical regulators of developmental gene transcription and cell specification.

284 ajor Trl cofactor that functions to moderate developmental gene transcription.

285 und homeodomain factor effectively activates developmental gene transcriptional programs.

286 system of flies and mammals, whereby various developmental genes undergo coordinate 3' UTR extension.

287 ts in the deployment and effects of a single developmental gene underlie morphological change.

288 K56Ac then relocates to developmental genes upon cellular differentiation.

289 hRPCs showed the expression of early retinal developmental genes: VIM (vimentin), KI67, NES (nestin),

290 as cultured, and expression of key beta-cell developmental genes was assessed by QRT-PCR.

291 Induction of early developmental genes was greatly reduced, and expression

292 hibited, expression of a number of conceptus developmental genes was not altered.

293 essed in early development and suppress late developmental genes), we hypothesized that the silencing

294 depot-specific differences in expression of developmental genes were observed in human subcutaneous

295 Streptomyces, repressing a large regulon of developmental genes when the bacteria are growing vegeta

296 ontaining H3K4me3 and H3K27me3 marks silence developmental genes, while keeping them poised for activ

297 The Polycomb module represses developmental genes, while the Myc module is associated

298 ubset represents a novel class of chlamydial developmental genes with features of both early and midc

299 g the regulatory landscape of RET, a crucial developmental gene within which we have recently identif

300 These developmental gene x environment interactions tune circa