ライフサイエンスコーパス: developmentally

1 ession of TEs and found them to be regulated developmentally.

2 f I2-containing SAP102 isoforms is regulated developmentally.

3 ependent components of these traits, because developmentally acclimated flies respond positively to s

4 Motoneurons developmentally acquire appropriate cellular architectur

5 model in which the sequential actions of two developmentally activated enhancers are linked to a corr

6 ased the toxicity to C. elegans of the least developmentally active compounds to the level of the mos

7 ly active compounds to the level of the most developmentally active.

8 er Eye Splicer, to facilitate exploration of developmentally altered splicing events and to improve u

9 s its transport capacity to nutritional cues developmentally, although relatively little is known abo

10 dolescents to ensure service development are developmentally and culturally appropriate.

11 ells into an anatomically distinct SVZ, both developmentally and evolutionarily, may be shared across

12 g that both receptor expression profiles are developmentally and functionally linked.

13 er, these proteins may all be regulated both developmentally and functionally, restricting their util

14 ophrenia to identify increased expression of developmentally and genetically regulated isoforms in th

15 last cell type harbors a large collection of developmentally and phenotypically heterogeneous subtype

16 etons of limbs and fins differ structurally, developmentally, and histologically.

17 upon the broader machinery that orchestrates developmentally appropriate chromatin status.

18 reliability of a fundamentally objective and developmentally appropriate delirium assessment tool for

19 The control group received a developmentally appropriate home safety intervention als

20 We used developmentally appropriate standard questionnaires, int

21 t intervention packages should be applied at developmentally appropriate times during the life course

22 Hereditary forms of Wilms arise from developmentally arrested clones of renal progenitor cell

23 Similarly, in developmentally arrested GATA1-deficient murine megakary

24 or extreme sexual size dimorphism (SSD), are developmentally arrested larvae that produce sperm from

25 Developmentally, bistability was observed soon after Pur

26 cle, in both adult muscle homeostasis and in developmentally compensated contexts.

27 differentiation of the female gamete into a developmentally competent oocyte relies on the protected

28 closely resembling those of blastocysts from developmentally competent oocytes.

29 CTD code that may augment gene regulation in developmentally complex organisms.

30 yers in multiple autoimmune diseases and are developmentally contingent on reciprocal functionality b

31 classified to identify metabolites that were developmentally controlled and/or responded to the treat

32 we detected distinct folding patterns at the developmentally controlled beta-globin locus.

33 ivity during the final cell cycle prior to a developmentally controlled cell cycle exit leads to extr

34 icate that the transcriptional signatures of developmentally controlled cell death are largely distin

35 ate their effects on Z-ring stability during developmentally controlled cell division via a network o

36 thway, as a central regulator for generating developmentally controlled ependymal cells along the ven

37 ncRNA engages with proteins in a modular and developmentally controlled manner to coordinate chromati

38 NMD is regulated in a tissue-specific and developmentally controlled manner, raising the possibili

39 ble ratio of mutant to wild-type tissue in a developmentally controlled manner.

40 These results indicate a developmentally controlled mechanism for sgammac express

41 In summary, developmentally controlled mitophagy promotes a metaboli

42 These results corroborate complex developmentally controlled ompA expression in C. trachom

43 ides functional evidence that the 3'RR has a developmentally controlled potential to constitutively a

44 l role in differentiating tissues to promote developmentally controlled quiescence through the regula

45 Central to this mechanism is the developmentally controlled transcription of an alternate

46 plasticity markers, many recognized as being developmentally controlled, and multi-year-long postnata

47 available microarray data, which revealed a developmentally coordinated expression of carbohydrate t

48 is important to know what factors drive this developmentally critical behavioral output.

49 ory connectivity in a network that governs a developmentally critical behavioral sequence in Drosophi

50 bivalency resolution and activation of most developmentally critical homeobox (Hox) a-d genes.

51 ction, we deleted the entire pxr gene from a developmentally defective strain that fails to remove Px

52 of studies have now started to connect these developmentally defined populations with their roles in

53 vation of adult-born neurons, revealing that developmentally defined sets of neurons may differential

54 ypically developing children; and 22 matched developmentally delayed children.

55 ypically developing children; and 22 matched developmentally delayed children.

56 located in the 3'UTR of FMR1 enriched among developmentally delayed males with normal repeat lengths

57 ly MZT, undergo cell-cycle pause, and remain developmentally delayed throughout larval life.

58 ected individuals had short stature and were developmentally delayed.

59 gs establish a regulatory system controlling developmentally deposited suberin, which likely differs

60 ans suggesting that the modern human face is developmentally derived.

61 le shell, the carapace and the plastron, are developmentally different entities.

62 Here we have engineered and developmentally differentiated NKX2-1GFP reporter plurip

63 t CD172a(+) and CD172a(-) pre-cDCs represent developmentally discrete populations that differentially

64 artificially reconstitute this programme in developmentally distant fibroblasts, converting them int

65 tors Scl, Lmo2, Runx1 and Bmi1 can convert a developmentally distant lineage (fibroblasts) into 'indu

66 NK cells and ILC1s are developmentally distinct but share so many features that

67 tes are the most ancient social insects, and developmentally distinct from highly-studied, hymenopter

68 dent SMG tissue-resident NK (trNK) cells are developmentally distinct from liver trNK cells.

69 ells in the ventral pallium; it is therefore developmentally distinct from the Nr4a2-postive dorsal e

70 ic" cancer gene that plays opposing roles in developmentally distinct hematopoietic malignancies.

71 In cells in which two developmentally distinct LCR-regulated globin genes are

72 d modality-specific, but the significance of developmentally distinct neuronal populations remains un

73 ) is regulated by the neighboring hindgut, a developmentally distinct organ.

74 eral miscanthus genotypes harvested at three developmentally distinct time points.

75 bout how the flower is partitioned into four developmentally distinct whorls.

76 Type 1 innate lymphocytes comprise two developmentally divergent lineages, type 1 helper innate

77 Neuronal precursor cell-expressed developmentally down-regulated 4 (Nedd4) was the first u

78 tin ligase neuronal precursor cell-expressed developmentally down-regulated 4-1 (NEDD4-1).

79 hat removes neural precursor cell-expressed, developmentally down-regulated 8 (NEDD8) moieties from c

80 otein NEDD8 (NEural precursor cell expressed Developmentally Down-regulated 8) (neddylation) and deac

81 n or Nedd8 (Neural precursor cell expressed, developmentally down-regulated 8) to p53.

82 we show that neural precursor cell expressed developmentally down-regulated protein 4 (NEDD4), an E3

83 ase Nedd4-2 (neural precursor cell expressed developmentally down-regulated protein 4) and endocytosi

84 PDGF BB) and neural precursor-cell-expressed developmentally down-regulated protein 9 (NEDD9)-govern

85 tein NEDD8 (NEURAL PRECURSOR CELL EXPRESSED, DEVELOPMENTALLY DOWN-REGULATED8) belongs to the family o

86 fied NEDD4 (neural precursor cell expressed, developmentally downregulated 4) as a novel interaction

87 discovered neural precursor cell expressed, developmentally downregulated 4-Like (NEDD4L) as a previ

88 ) or NEDD8 (neural precursor cell expressed, developmentally downregulated 8).

89 miR-184 in the heart and cardiac myocyte was developmentally downregulated and was low in mature myoc

90 We show here that it is a developmentally downregulated but dynamic component of K

91 and Nedd4l (neural precursor cell expressed developmentally downregulated gene 4-like; chromosome 18

92 gates Nedd8 (neural precursor cell expressed developmentally downregulated) to specific targets, is a

93 Cluster analysis revealed hundreds of developmentally-dynamic introns that exhibit increased I

94 contrast to the individual single knockouts, developmentally early conditional double knockout of bot

95 Strikingly, developmentally early conditional knockout of cerebellin

96 lly redundant candidate genes, we identified developmentally early expression of another synaptic neu

97 d the spontaneous reacquisition of a latent, developmentally encoded epigenetic landscape.

98 However, the impact of developmentally encountered alloantigens in shaping the

99 Developmentally, environmental manipulation of OL progen

100 CC to ethylene), and ethylene evolution were developmentally, environmentally, and tissue-specificall

101 We show that fetal lambs that are developmentally equivalent to the extreme premature huma

102 Torsins are developmentally essential AAA+ proteins, and mutation of

103 bipolar disorder that implicate deficits in developmentally established stress-response pathways.

104 ouse calyx of Held synapse, and discovered a developmentally exacerbating phenotype of reduced sponta

105 nscriptional profiles in CD8(+) T cells from developmentally exposed mice reflect changes in pathways

106 ultures and in vivo We found that ZSCAN21 is developmentally expressed in neurons in different rat br

107 These changes involved both developmentally fixed and plastic changes in gene expres

108 Our findings reveal how RAG activity is developmentally focused and implicate mechanisms by whic

109 gnition of MHC class I proteins is important developmentally for the acquisition of full NK cell effe

110 cal component of executive function, expands developmentally from childhood through adulthood.

111 vy-chain variable region exons are assembled developmentally from V, D, J gene segments.

112 Developmentally, GATA-binding protein-2 (GATA-2) was exp

113 ial context to exert a dominant influence on developmentally hard-wired hypothalamus-mediated male te

114 feed-forward regulatory mechanisms with both developmentally hardwired and olfactory receptor activit

115 Developmentally, high neo-natal adiposity and preferenti

116 tem cell (hPSC) derived tissues often remain developmentally immature in vitro, and become more adult

117 e in vitro, the resultant cells often appear developmentally immature or incompletely specified, limi

118 ore probable and feasible via reversion to a developmentally immature state.

119 repertoire that facilitates morphogenesis of developmentally immature young.

120 on lipopolysaccharide stimulation were more developmentally impaired as assessed by the Mullen Scale

121 ter phytohemagglutinin stimulation were more developmentally impaired as measured by the Mullen Scale

122 e and childhood) phenotypes likely represent developmentally impaired myelination, whereas the adult-

123 commitment, in particular the activation of developmentally important enhancers.

124 tal defects, but little is known about which developmentally important genes are regulated by IBM1 an

125 global 5hmC loss we identified a handful of developmentally important genes that maintained their 5h

126 ts should build a foundation for identifying developmentally important genes, especially those regula

127 portant role in regulating the expression of developmentally important genes, including many transcri

128 bility to regulate transcription of a set of developmentally important genes.

129 ption factors and regulate the expression of developmentally important genes.

130 ase has been reported as a stimulator of the developmentally important Hedgehog (Hh) pathway, but cel

131 ly distinct, stable across cell division and developmentally important in directing the Ig repertoire

132 r there is compensation for the provision of developmentally important nutrients that other species g

133 Finally, we proposed developmentally important proteins as either directly or

134 TF binding specificity and reveals that many developmentally important proteins display preference fo

135 standing of the neural underpinnings of this developmentally important social behavior, as well as th

136 we tested the hypothesis that overexpressing developmentally important transcription factors in adult

137 th functionally specialized subsets that are developmentally imprinted and modulated by local tissue

138 neurodevelopmental disorder characterised by developmentally inappropriate levels of inattention and

139 Developmentally incompetent haploid embryos (parthenogen

140 hat the expression level of Nogo-A in the OB developmentally increased during axonal collateral forma

141 DGKzeta deficiency is NK cell-intrinsic and developmentally independent.

142 e; however, in non-salt conditions, they are developmentally indistinguishable from wild-type plants.

143 ites; however, we find the first examples of developmentally induced circular RNAs processed by the m

144 bound in their 3' UTRs by both CELF1 and the developmentally induced MBNL1 protein, a threefold great

145 ly, confirming several features predicted by developmentally informed models of feather evolution [4-

146 ain of vertebral sympathetic ganglia, arises developmentally is incompletely understood.

147 Our findings expand the notion of a developmentally layered immune system.

148 Disruption of miRNA homeostasis is developmentally lethal, indicating that fetal tissue dev

149 orth a social plasticity model that includes developmentally limited enhanced social attunement (ie,

150 s patterns are consistent with management of developmentally limited impulsive and aggressive behavio

151 esenchymal-like spermatogonia also displayed developmentally linked DNA demethylation at meiotic gene

152 o active enhancer elements where it promotes developmentally-linked gene silencing and directly marks

153 Developmentally, males are exposed to high levels of tes

154 Because developmentally matured B cells undergo biologically pro

155 ek eye contact, and they prefer to fixate on developmentally meaningful objects, such as the human fa

156 Clec11a-deficient mice appeared developmentally normal and had normal hematopoiesis but

157 H3K27me3 at the Hox clusters, these mice are developmentally normal.

158 They differ from developmentally normative or stress-induced transient an

159 e we show that Hox11 paralogous genes, which developmentally pattern the zeugopod (radius/ulna and ti

160 This developmentally patterned and epigenetically maintained

161 in non-neural cells in embryos, we show that developmentally patterned K(+) flux is required for corr

162 Most morphological traits are developmentally plastic, irreversible, and generally con

163 before injury, which is normally observed in developmentally poised enhancers.

164 1-deficient cells induce lineage-appropriate developmentally poised genes poorly while lineage-inappr

165 xr to prevent fruiting body development by a developmentally proficient wild-type strain under high-n

166 ccessibility across autosomes was pervasive, developmentally programmed and composed of several patte

167 have shown that metabolism and autophagy are developmentally programmed and essential for neutrophil

168 work establishes the molecular mechanism of developmentally programmed crinophagy in Drosophila and

169 re we show that TEX19.1, which is induced by developmentally programmed DNA hypomethylation, can dire

170 Developmentally programmed genome rearrangement accompan

171 Indicative of developmentally programmed MetS, adult F2, formerly IUGR

172 enetics in multigenerational transmission of developmentally programmed obesity and associated cardio

173 ract to influence neural circuits underlying developmentally programmed social interactions such as m

174 ntiation, gammadelta T cells instead can be 'developmentally programmed' in the thymus to generate di

175 These differences could be attributable to developmentally-programmed local branching for larger ve

176 ulated indices for functional pairs that are developmentally regulated (GluA2:GluN1; GluN2A:GluN2B),

177 This developmentally regulated acetylation event critically g

178 22-1133) demonstrate severe dysregulation of developmentally regulated alternative splicing and polya

179 expression, were uncovered, suggesting that developmentally regulated alternative splicing occurs in

180 YBS3 homolog, MYBH, plays a critical role in developmentally regulated and dark-induced leaf senescen

181 Tau splicing is developmentally regulated and dysregulated in disease.

182 man mPFC-amygdala functional connectivity is developmentally regulated and figures prominently in num

183 We show that MAP7 expression is developmentally regulated and perturbation of this expre

184 ins have linked their functional capacity to developmentally regulated biosynthetic pathways.

185 Both are developmentally regulated by the inflammatory prostaglan

186 UTR (untranslated region) and is involved in developmentally regulated carotenoid formation, such as

187 Our findings highlight developmentally regulated changes in mitotic behaviour t

188 These findings suggest that developmentally regulated changes in nucleosome location

189 nd dynamic pairing among these CBEs mediates developmentally regulated chromatin loops.

190 (mPFC) and amygdala plays important roles in developmentally regulated cognitive and emotional proces

191 -409-5p located within the embryonically and developmentally regulated DLK1-DIO3 (delta-like 1 homolo

192 , we have identified DNA hypermethylation of developmentally regulated enhancers as a new type of epi

193 ding on recent studies supporting a role for developmentally regulated epigenetic variation in the mo

194 Although their developmentally regulated expression has been shown, the

195 is sensitivity is partially mitigated by the developmentally regulated expression of HsfA2 and severa

196 and modifies KAR gating in DRG neurons in a developmentally regulated fashion in mice.

197 ic knockout of NRF2 demonstrates its role in developmentally regulated gamma-globin gene expression a

198 on allowed for mechanistic classification of developmentally regulated genes by TLR/IL-1R (TIR) signa

199 sed "facultative heterochromatin," including developmentally regulated genes in plants and animals.

200 g the silenced transcriptional state of many developmentally regulated genes.

201 nabled new statistical tests for identifying developmentally regulated genes.

202 rand breaks (DSBs) during repair, and direct developmentally regulated genome rearrangements in some

203 xpression signature shared between different developmentally regulated growth processes and responses

204 Here we report that the developmentally regulated H19 lncRNA binds to and inhibi

205 Here, we find that in the hypothalamus the developmentally regulated homeodomain-containing transcr

206 av1.2 channel also contains exon 33L that is developmentally regulated in heart.

207 SlymiR157 is expressed and developmentally regulated in normal tomato fruits and in

208 Histone H3 acetylation was developmentally regulated in primary visual cortex, with

209 OsbZIP48 protein levels are developmentally regulated in rice.

210 ognition of the precursor glycans, which are developmentally regulated in the neonate gut and abundan

211 The developmentally regulated intercalation of electrical ac

212 Comparing two developmentally regulated isoforms of CD45, the larger R

213 e II cells uniquely synthesize surfactant, a developmentally regulated lipoprotein that is essential

214 the capacity for de novo DNA methylation of developmentally regulated loci is preserved in different

215 This work establishes rDNA as developmentally regulated loci that receive direct input

216 acts as an architectural protein to connect developmentally regulated looping interactions; the loca

217 found that meso-zeaxanthin is produced in a developmentally regulated manner in chicken embryonic re

218 sly expressed 2,3-linked sialic acid and the developmentally regulated marker 2,8-linked polysialic a

219 to Smk1 activation through Ssp2 and define a developmentally regulated mechanism for activating MAPK

220 These observations suggest a dynamic and developmentally regulated model of PRC1 occupancy at con

221 Developmentally regulated mutagenesis indicates that TAZ

222 g these data, we identified two independent, developmentally regulated networks of interacting genes

223 Thus, developmentally regulated pro-miRNA processing is a key

224 Programmed DNA elimination is a developmentally regulated process leading to the reprodu

225 data further show that Rim4 aggregation is a developmentally regulated process.

226 Perforation formation occurs through developmentally regulated programmed cell death (PCD).

227 Data indicate that a developmentally regulated protein called RacA is involve

228 Recently, large developmentally regulated regions of the genome dynamica

229 the coagonist could be synapse specific and developmentally regulated remains elusive.

230 In Drosophila follicle cells, developmentally regulated rereplication is used to ampli

231 that H3K9me3 is important for silencing the developmentally regulated retrotransposon in Xenopus lae

232 e, we test the hypothesis that disruption of developmentally regulated RNA alternative processing pat

233 This developmentally regulated shift in the cullin neddylatio

234 To assess the effects of drought stress on developmentally regulated splicing in maize (Zea mays),

235 UG-BP and ETR-3-like factor proteins control developmentally regulated splicing of TNNT2, the gene th

236 However, developmentally regulated starch turnover within heterot

237 tions at disease-associated cis-elements and developmentally regulated super-enhancers reveals spatia

238 ong arm of Chromosome 4 underwent a dramatic developmentally regulated switch to late replication dur

239 Through developmentally regulated targeted mutagenesis, we demon

240 FAP2A-locus RNA), a novel lncRNA gene in the developmentally regulated TFAP2A locus.

241 target of the Psi/MED network in controlling developmentally regulated tissue growth is the transcrip

242 urons initially focused on the expression of developmentally regulated transcription factors and neur

243 progenitor cells, suggesting a model whereby developmentally regulated transcription factors protect

244 ng cancer metastasis model, we show that the developmentally regulated transcriptional repressor Capi

245 GluN3A expression is developmentally regulated, and changes in this normal pa

246 ed by microglia in immature mouse and human, developmentally regulated, and modulated by inflammation

247 This promoter may be developmentally regulated, because it was active in norm

248 only challenges the dogma that Cox-1 is only developmentally regulated, but also demonstrates a novel

249 BLC release is developmentally regulated, but the mechanism is largely

250 sts of 150 genes whose expression is tightly developmentally regulated, but which are collectively po

251 how that floor plate-derived neuropilin-2 is developmentally regulated, functioning as a molecular si

252 own that the number of ORDs in the retina is developmentally regulated, little is known about the mor

253 revealed that the expression of circRNAs is developmentally regulated, tissue and cell-type specific

254 iming of cell division is both invariant and developmentally regulated, yet how the cell cycle is con

255 vity domains are enriched for genes that are developmentally regulated.

256 e branching and peripheral substitutions are developmentally regulated.

257 ion, there has been success in reprogramming developmentally related cell types into beta cells.

258 Mast cells and basophils are developmentally related cells whose activation is a hall

259 nd in the accompanying poster, we review the developmentally related features of LPA signalling.

260 signaling pathways) by hyper-methylation of developmentally related genes, which further induced the

261 posed to act as an identity "switch" between developmentally related precursors in the spinal cord, r

262 eas, permitting genetic complementation in a developmentally relevant context.

263 ned conditions as they mature in response to developmentally relevant cues, and it provides a framewo

264 otent stem cells (hPSCs) through delivery of developmentally relevant cues, including NOTCH signaling

265 g the bridging of genotypes to phenotypes in developmentally relevant human cell lineages.

266 With the use of a developmentally relevant model, we correlated alveolar-c

267 cells in vitro, though its effects on other developmentally relevant stem cell populations, includin

268 e the transcription for highly expressed and developmentally required genes, lead to the formation of

269 first-trimester human embryos, identifying a developmentally restricted CD19(-)IL-7R(+) progenitor co

270 Thus, these developmentally restricted HSCs (drHSCs) define the orig

271 nactivation of either the ligand or receptor developmentally resulted in a profound hearing loss at y

272 reatments remain costly, time intensive, and developmentally sensitive for efficacy.

273 Developmentally sensitive pathophysiological models are

274 Findings provide evidence for a developmentally sensitive period whereby subcortical str

275 of higher protein intake, especially during developmentally sensitive periods, are poorly understood

276 To investigate whether NMN can impact developmentally-set metabolic deficits, we compared trea

277 polymorphisms that differ between active and developmentally silenced rRNA gene subtypes.

278 n in the newborn mouse in which the brain is developmentally similar to a second-trimester human fetu

279 not PLZF, for development and, therefore, is developmentally similar to the conventional NK cell subs

280 rom human patients confirmed the presence of developmentally similar, significant vascular depletion

281 e early retino-thalamo-cortical circuit uses developmentally specialized feedback amplification to en

282 in post-mitotic neuronal fate, and reveals a developmentally specific role for a broadly expressed in

283 represent discrete lineages, genetically and developmentally specified sets of cells derived from com

284 irritability and whether such influences are developmentally stable and/or dynamic.

285 ), we found that most fetal brain mQTLs were developmentally stable, although a subset was characteri

286 profile, indicating that this population is developmentally stable.

287 Distinct, developmentally-stable IR clusters are enriched in metal

288 specific neurons that remain in an immature, developmentally stalled state until pupation.

289 e and glutathione; (3) inhibition of several developmentally stereotypical energetic and metabolic tr

290 ic sustained and transient interactions with developmentally supportive stromal cells, and that the r

291 be differentiated in vitro by coculture with developmentally supportive stromal cells.

292 , required here for proper cellular invasion developmentally that is essential for specific aspects o

293 Developmentally, this organ arises as a result of a comp

294 Intrigued by the developmentally timed exchange of SIN3 isoforms, we exam

295 her show that much of the pathway regulating developmentally timed floral organ abscission is conserv

296 ike quiescent behavior under two conditions: developmentally timed quiescence (DTQ) occurs during lar

297 sm by which axons restrict their translatome developmentally to achieve proper targeting.

298 Here we identify a developmentally transient, corticothalamic amplification

299 st suggesting that centrosome disassembly is developmentally utilized to achieve the post-mitotic sta

300 indicated the reverse-polarity current seen developmentally was a manifestation of the same ion chan