ライフサイエンスコーパス: diacylglycerol

1 c stimulation with the physiological agonist diacylglycerol.

2 ate, phosphatidate, and reduces the product, diacylglycerol.

3 effectors in signaling pathways regulated by diacylglycerol.

4 glycerol kinase, resulting in an increase in diacylglycerol.

5 messengers inositol 1,4,5-trisphosphate and diacylglycerol.

6 ospholipase-C, apparently not acting through diacylglycerol.

7 2, an enzyme that catalyzes the synthesis of diacylglycerol.

8 monoglucosyl diacylglycerol and glucuronosyl diacylglycerol.

9 lation of phosphatidic acid (PA) to generate diacylglycerol.

10 t DGAT2 can utilize monoacylglycerol-derived diacylglycerol.

11 polyglycerol-phosphate linked to di-glucosyl-diacylglycerol.

12 reticulum by fusion of CDP-ethanolamine and diacylglycerol.

13 messengers inositol 1,4,5-trisphosphate and diacylglycerol.

14 Among the parameters considered, the total diacylglycerols/1,3-diacylglycerols ratio could be used

15 Although enriched in diacylglycerol, 10:0 was not detected in phosphatidylcho

16 triguingly, two metabolites, oxalic acid and diacylglycerol 36:3, were robustly and quantitatively re

17 g microwave heating is isomerisation between diacylglycerols, a change that could give a potential lo

18 dipose tissue lipolysis promotes myocellular diacylglycerol accumulation.

19 Euonymus alatus diacylglycerol acetyltransferase (EaDAcT) catalyzes the

20 multimer channels with TRPC6 and function as diacylglycerol-activated cation channels coordinately, t

21 umans have elucidated a key role for hepatic diacylglycerol activation of protein kinase Cepsilon in

22 terning is evident as annexin A1, dysferlin, diacylglycerol, active Rho, and active Cdc42 are recruit

23 Kinetically improved diacylglycerol acyltransferase (DGAT) variants were crea

24 Acyl CoA:1,2-diacylglycerol acyltransferase (DGAT)-2 is an integral m

25 A pool, making these PUFAs available for the diacylglycerol acyltransferase (DGAT)-catalyzed reaction

26 g chemical and genetic approaches to disrupt diacylglycerol acyltransferase (DGAT)-dependent LD bioge

27 lation of sn-1,2-diacylglycerol catalyzed by diacylglycerol acyltransferase (DGAT, EC 2.3.1.20).

28 nes of a lead optimization effort to develop diacylglycerol acyltransferase (DGAT1) inhibitors.

29 PHOSPHOLIPID:DIACYLGLYCEROL ACYLTRANSFERASE (PDAT) is an enzyme that

30 ROL ACYLTRANSFERASE1 (DGAT1) or PHOSPHOLIPID:DIACYLGLYCEROL ACYLTRANSFERASE (PDAT) on seed lipid comp

31 accumulation, and co-expression of FUS3 and diacylglycerol acyltransferase 1 (DGAT1) further increas

32 ery and optimization of a series of acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors base

33 Diacylglycerol acyltransferase 1 (DGAT1) is an integral

34 The ER-resident diacylglycerol acyltransferase 1 (DGAT1) selectively cha

35 Expression of castor phospholipid:diacylglycerol acyltransferase 1A in this line increased

36 ology of imidazopyridine-based inhibitors of diacylglycerol acyltransferase 2 (DGAT2) is described.

37 y and noncompetitively inhibiting hepatocyte diacylglycerol acyltransferase 2.

38 r triacylglycerols than controls but similar diacylglycerol acyltransferase activity, triacylglycerol

39 attributed to decreased expression of sn-1,2 diacylglycerol acyltransferase and mitochondrial acyl-Co

40 The activity of Dga1p, a diacylglycerol acyltransferase, and TG accumulation were

41 es in acyl-CoA synthetase long 1 (ACSL1) and diacylglycerol acyltransferase-2 (DGAT2), and (b) decrea

42 c activity, increased expression of acyl CoA:diacylglycerol acyltransferase-2 in the liver, and eleva

43 of glycolysis and fatty acid synthesis) and DIACYLGLYCEROL ACYLTRANSFERASE1 (a triacylglycerol biosy

44 ted by introducing a mutation in Arabidopsis diacylglycerol acyltransferase1 (AtDGAT1) in a line expr

45 d or decreased expression of ACYL-COENZYME A:DIACYLGLYCEROL ACYLTRANSFERASE1 (DGAT1) or PHOSPHOLIPID:

46 We previously reported that PHOSPHOLIPID:DIACYLGLYCEROL ACYLTRANSFERASE1 (PDAT1) is crucial for d

47 Since seedlings deficient in PHOSPHOLIPID:DIACYLGLYCEROL ACYLTRANSFERASE1 (PDAT1) were unable to a

48 e WRINKLED1 transcription factor, along with DIACYLGLYCEROL ACYLTRANSFERASE1 and the OLEOSIN1 oil bod

49 hosphatidic acid acyltransferases (LPAT) and diacylglycerol acyltransferases (DGAT) that are required

50 Diacylglycerol acyltransferases (DGATs) catalyze a rate-

51 onoacylglycerol acyltransferases (MGATs) and diacylglycerol acyltransferases (DGATs) catalyze the two

52 In the presence of a combination of diacylglycerol acyltransferases 1 and 2 (DGAT1 and DGAT2

53 , in vitro, and in vivo activities of type-2 diacylglycerol acyltransferases in Nannochloropsis ocean

54 the endoplasmic reticulum, and that certain diacylglycerol acyltransferases may be the candidate enz

55 d PKC, differences in Ca(2+) sensitivity and diacylglycerol affinity were excluded as mediators of th

56 Ala-PG and a novel alanylated lipid, Alanyl-diacylglycerol (Ala-DAG).

57 sic effect was seen after treatment with the diacylglycerol analog 1-oleoyl-2-acetyl-sn-glycerol (OAG

58 Unlike pyrrophenone, the diacylglycerol analog 1-oleoyl-2-acetyl-sn-glycerol and

59 The diacylglycerol analogue 1-oleoyl-2-acetyl-sn-glycerol (O

60 4,5-bisphosphate into the second messengers diacylglycerol and 1,4,5-inositol trisphosphate.

61 macrophages showed a decreased production of diacylglycerol and activation of MAPKs and AP-1.

62 sed, triglyceride content was decreased, and diacylglycerol and ceramide content were unaltered in ga

63 f the nonsolubilized components in saturated diacylglycerol and ceramide.

64 talyzes triacylglycerol (TG) synthesis using diacylglycerol and fatty acyl CoA as substrates.

65 ating leads to a significant increase in the diacylglycerol and free fatty acid contents as well as i

66 ences between the minor components including diacylglycerol and free fatty acids in the heated sample

67 phosphate deficiency, including digalactosyl diacylglycerol and glucosylgalactosyl diacylglycerol syn

68 utants of Agrobacterium lacking monoglucosyl diacylglycerol and glucuronosyl diacylglycerol or all gl

69 netic resonance spectroscopy as monoglucosyl diacylglycerol and glucuronosyl diacylglycerol.

70 n of phospholipase C and to the formation of diacylglycerol and inositol 1,4,5-trisphosphate, leading

71 domain represents the recognition module for diacylglycerol and phorbol esters in protein kinase C, R

72 r regulator that controls the switch between diacylglycerol and phosphatidic acid signaling pathways.

73 1 activates PLC, which increases submembrane diacylglycerol and thereby activates PKC, resulting in m

74 increased reesterification of acyl-CoAs into diacylglycerol and triacylglycerol, with subsequent acti

75 Three diacylglycerols and 7 triacylglycerols were associated w

76 holipids with monoglucosyl- and glucuronosyl-diacylglycerols and by synthesizing new ornithine lipids

77 L), which catalyzes the hydrolysis of TGs to diacylglycerols and free fatty acids.

78 aled a reduced concentration of a variety of diacylglycerols and phospholipids containing mostly poly

79 /=1 diet compared with the others, including diacylglycerols and triacylglycerols, branched-chain ami

80 hatidylglycerol, phosphatidylserine, and CDP-diacylglycerol) and inhibited by zwitterionic (phosphati

81 ilayer structures (phosphatidylethanolamine, diacylglycerol, and ergosterol) are essential.

82 atidylcholine formation from CDP-choline and diacylglycerol, and full activity required divalent mang

83 cted curvature-inducing lipids (cardiolipin, diacylglycerol, and lyso-phosphatidylcholine) can modula

84 ipid signaling molecules 1-monoacylglycerol, diacylglycerol, and malonyl-CoA; the predominance of KAT

85 ing of completely saturated triacylglycerol, diacylglycerol, and monoacylglycerol with palmitate and

86 polar head group of the plant sulfolipid SQ-diacylglycerol, and SQ comprises a major proportion of t

87 esterified fatty acids; and increased IMCLs, diacylglycerols, and ceramides.

88 of apoC-II, apoC-III, triacylglycerols, and diacylglycerols, and increased apoA-I, apoA-II, and apoM

89 distinct specificities toward acyl CoAs and diacylglycerols, and may work in concert spatially and t

90 ate to form lysophosphatidic acid, mono- and diacylglycerols, and other glycerolipids, some implicate

91 sferases, transmembrane enzymes that use CDP-diacylglycerol as donor substrate for this reaction, and

92 ephosphorylation of phosphatidate to produce diacylglycerol at the endoplasmic reticulum membrane, pl

93 oline polar head group, respectively, to the diacylglycerol backbone.

94 ad groups are predominantly borne by a C38:4 diacylglycerol backbone.

95 fects the partitioning of palmitate-enriched diacylglycerol between the phosphatidylcholine and triac

96 lphostin C, a PKC inhibitor that targets the diacylglycerol-binding site of the kinase.

97 ular lipid accumulation (triacylglycerol and diacylglycerol but not ceramide), and severe glucose int

98 s of triacylglycerol (i.e. the production of diacylglycerol by dephosphorylation of phosphatidate).

99 th phosphatidylcholine to short-chain SM and diacylglycerol by SM synthase, led to the segregation of

100 on of the protein kinase C-activating lipid, diacylglycerol, cAMP/Epac signaling blocks the bottlenec

101 y the acyl-CoA-dependent acylation of sn-1,2-diacylglycerol catalyzed by diacylglycerol acyltransfera

102 Cytidine diphosphate diacylglycerol (CDP-DAG) is a central lipid intermediate

103 Mogat1 ASO treatment did not reduce hepatic diacylglycerol, cholesterol, or free fatty acid content;

104 E0021 (herein designated cpt) encoding a 1,2-diacylglycerol choline phosphotransferase homologous to

105 e cytidylyltransferase activities with a 1,2-diacylglycerol choline phosphotransferase that is common

106 ostasis observed in E-Syts KO cells, delayed diacylglycerol clearance from the PM and impaired Ca(2+)

107 in hepatic triglyceride (44%, P < 0.05) and diacylglycerol content (60%, P < 0.01) but a 30% increas

108 sistance was associated with increased C18:1-diacylglycerol content and protein kinase Cepsilon trans

109 istance could be attributed to reductions in diacylglycerol content and reduced PKC-epsilon and PKC-t

110 on and reduction of hepatic triglyceride and diacylglycerol content in livers of diet-induced obese a

111 ized lipase from Rhizomucormiehei, a maximum diacylglycerol content of 23% was obtained, after optimi

112 amyocellular triglyceride, sphingolipid, and diacylglycerol content were measured in vastus lateralis

113 s not associated with differences in hepatic diacylglycerol content, activated protein kinase C- (PKC

114 and decreased ectopic lipid (triacylglycerol/diacylglycerol) content in liver and muscle.

115 otility, and transcription) are placed under diacylglycerol control by the distinctive substrate spec

116 with lipin1, another enzyme that synthesizes diacylglycerol, could be detected.

117 In muscle, diacylglycerol (DAG) and intramyocellular triacylglycero

118 ation, which generates the second messengers diacylglycerol (DAG) and IP3 and ultimately results in m

119 In this study, we determined the effect of diacylglycerol (DAG) and monoacylglycerol (MAG) on the o

120 ipidomic analysis shows a marked increase of diacylglycerol (DAG) and phosphatidic acid, the precurso

121 Diacylglycerol (DAG) and Protein-kinase C (PKC) signalin

122 l stimulation increases the concentration of diacylglycerol (DAG) and the activity of DAG kinases (DG

123 LD that have implicated increases in hepatic diacylglycerol (DAG) content leading to activation of no

124 a transient increase in total and cytosolic diacylglycerol (DAG) content that was temporally associa

125 ulation of hepatic triacylglycerol (TAG) and diacylglycerol (DAG) content was significantly attenuate

126 teatosis as well as increased hepatocellular diacylglycerol (DAG) content, a well-documented trigger

127 both liver and muscle triglyceride (TAG) and diacylglycerol (DAG) content, which was associated with

128 responds to hypertrophic stimuli to generate diacylglycerol (DAG) from PI4P in the Golgi apparatus, i

129 tes, RasGRP1 is recruited to the membrane by diacylglycerol (DAG) in a phospholipase C-gamma (PLCgamm

130 to all other TRPC channels, the PLC product diacylglycerol (DAG) is not sufficient for channel activ

131 In the yeast Saccharomyces cerevisiae, Dgk1 diacylglycerol (DAG) kinase catalyzes the CTP-dependent

132 rtmannin's effects not being due to reducing diacylglycerol (DAG) or IP3 availability, i.e. PIP2 modu

133 ed by the membrane-embedded second messenger diacylglycerol (DAG) through its interactions with the C

134 acylation of both monoacylglycerol (MAG) and diacylglycerol (DAG) to generate DAG and TAG, respective

135 We found that DGKeta can phosphorylate diacylglycerol (DAG) with different acyl side chains (8:

136 reted by WT hepatocytes contained 69% PL, 9% diacylglycerol (DAG), and 23% triacylglycerol (TAG) with

137 diolipin and phosphatidylglycerol to produce diacylglycerol (DAG), dihydroxyacetone, and orthophospha

138 Diacylglycerol (DAG), levels of which are tightly regula

139 Controversial evidence has suggested diacylglycerol (DAG), polyunsaturated fatty acids (PUFAs

140 As TAG is produced from diacylglycerol (DAG), successful engineering strategies

141 Diacylglycerol (DAG), which is also increased in muscle

142 sphate pathway of triacylglycerol synthesis: diacylglycerol (DAG), which may cause insulin resistance

143 Ca(2+)- and diacylglycerol (DAG)-activated protein kinase C (cPKC) p

144 orms is associated with their Ca(2+)- and/or diacylglycerol (DAG)-dependent translocation to the plas

145 Diacylglycerol (DAG)-induced activation of phosphatidyli

146 One of these lipids-diacylglycerol (DAG)-rapidly accumulates in a broad doma

147 n of the intramyocellular lipid-intermediate diacylglycerol (DAG).

148 oduction of inositol 1,4,5-trisphosphate and diacylglycerol (DAG).

149 Presynaptic activation of the diacylglycerol (DAG)/protein kinase C (PKC) pathway is a

150 ority of these lipid species belonged to the diacylglycerol (DAG, 17 species) and triacylglycerol (TA

151 muscle accumulation of triglycerides, toxic diacylglycerols (DAG) and ceramides or suppress muscle P

152 The aim of this work was to produce diacylglycerols (DAG) and monoacylglycerols (MAG) with a

153 preparation of a nutritionally enriched 1,3-diacylglycerol(DAG)-rich oil from a blend of refined sun

154 Diacylglycerols (DAGs) are important intermediates of li

155 into oligogalactolipids, acylated MGDGs, and diacylglycerols (DAGs), the direct precursor of TAGs, wa

156 Unlike diacetyl tartaric esters of mono- and diacylglycerols (DATEM, used as control), lipase use did

157 both endoplasmic reticulum store release and diacylglycerol-dependent microtubule organizing center r

158 kinase C activation as a result of increased diacylglycerol (DG) production in diabetic hyperglycaemi

159 oxidized phosphatidylcholine (PC/Ox-PC), and diacylglycerol (DG) species within implantation sites of

160 isplayed DGAT activity with 10:0-CoA and the diacylglycerol didecanoyl, that was approximately 4-fold

161 drolase (PAP) required for the generation of diacylglycerol during glycerolipid synthesis, and exhibi

162 Conical lipids, phosphatidylethanolamine and diacylglycerol, enhanced transporter activity up to 3-fo

163 However, the diacylglycerol enrichment was not accomplished in the sa

164 a final reaction mixture comprised mainly of diacylglycerol ethers (10.6%), monoacylglycerol ethers (

165 ive intrinsic curvature lipids (cardiolipin, diacylglycerol) facilitating fusion.

166 thaliana lipin homologs provide most of the diacylglycerol for TAG synthesis and that loss of their

167 yeast Saccharomyces cerevisiae that produces diacylglycerol for triacylglycerol synthesis and concurr

168 catalyzes the conversion of phosphatidate to diacylglycerol for triacylglycerol synthesis and simulta

169 affect the time course of alpha1B-AR-induced diacylglycerol formation, excluding a contribution of PK

170 ated into four fractions: polar lipids (PL), diacylglycerols, free fatty acids and triacylglycerols (

171 idate (PA) phosphatase Pah1, which generates diacylglycerol from PA, targets a nuclear membrane subdo

172 is activated by an intracellular gradient of diacylglycerol generated by PLCgamma.

173 r the conversion of phosphatidic acid to CDP-diacylglycerol in phospholipid biosynthesis.

174 y, phosphatidic acid (PtdOH), generated from diacylglycerol in the PM, has to reach the ER for PtdIns

175 study deals with the enzymatic synthesis of diacylglycerols in rapeseed oil by the esterification of

176 omal region, and is required for calcium and diacylglycerol-induced exocytosis.

177 entity at position 252 and complexation with diacylglycerol influence the geometry of C1Bdelta-micell

178 PI(4,5)P2, phosphatidylinositol 4-phosphate, diacylglycerol, inositol 1,4,5-trisphosphate, and Ca(2+)

179 Diacylglycerol kinase (DGK) activity was important for t

180 Diacylglycerol kinase (DGK) converts DG into phosphatidi

181 pathways generate PA: phospholipase D (PLD), diacylglycerol kinase (DGK), and lysophosphatidic acid a

182 (PA) generated by phospholipase D (PLD) and diacylglycerol kinase (DGK).

183 udy, we demonstrate that genetic deletion of diacylglycerol kinase (DGK)zeta, a negative regulator of

184 (beta2AR), the peptide transporter (PepTSt), diacylglycerol kinase (DgkA), the alginate transporter (

185 so applied to the integral membrane protein, diacylglycerol kinase A where the structures determined

186 Here we show that depletion of diacylglycerol kinase alpha (DGKalpha), a kinase devoid

187 In particular, forced expression of diacylglycerol kinase beta abrogated DAG accumulation at

188 of DAG kinases or expression of an inactive diacylglycerol kinase beta mutant increased the proporti

189 Diacylglycerol kinase catalyses the ATP-dependent conver

190 complement defect, some have either impaired diacylglycerol kinase epsilon (DGKepsilon) activity, cob

191 genome-wide association studies have linked diacylglycerol kinase eta (DGKeta) to bipolar disorder (

192 ells with induced expression of DGK1-encoded diacylglycerol kinase indicated that alteration in phosp

193 s work, we showed that a functional level of diacylglycerol kinase is regulated by the Reb1p transcri

194 While a number of diacylglycerol kinase isoforms have been implicated in c

195 P is mostly associated with one unique mRNA: diacylglycerol kinase kappa (Dgkkappa), a master regulat

196 , the liver can synthesize PAs by activating diacylglycerol kinase or phospholipase D, both of which

197 es arachidonic acid via phospholipase D2 and diacylglycerol kinase rather than phospholipase A2.

198 -reactive T cells deficient in the regulator diacylglycerol kinase zeta (DGKzeta) with or without PD-

199 genetic ablation of a negative regulator of diacylglycerol kinase zeta increased the suppressive abi

200 peroxide was suppressed by the loss of Dgk1 diacylglycerol kinase, indicating that the underpinning

201 In this pathway, RHO-1 inhibits diacylglycerol kinase, resulting in an increase in diacy

202 Loss of the DGK1-encoded diacylglycerol kinase, which converts diacylglycerol to

203 transcriptional activity of HIF-1alpha in a diacylglycerol kinase-dependent manner.

204 cases; however, mutations in the non-C gene diacylglycerol kinase-epsilon have been described recent

205 DGKE, encoding diacylglycerol kinase-epsilon, has not been implicated i

206 Overexpression of diacylglycerol kinase-theta inhibited insulin signaling

207 by overexpression of phospholipase D1/D2 or diacylglycerol kinase-theta was always accompanied by di

208 G), levels of which are tightly regulated by diacylglycerol kinases (DGKs), is a lipid mediator linke

209 lecule, three bryostatin analogues bearing a diacylglycerol lactone-based C-ring, which possessed the

210 that had been stimulated with PKC activator diacylglycerol lactone.

211 The most selective of the diacylglycerol lactones showed only a 10-fold reduction

212 ein kinase C zeta and iota, we have prepared diacylglycerol lactones substituted with hydrophilic gro

213 obtained through appropriate substitution of diacylglycerol lactones.

214 ated that alteration in phosphatidate and/or diacylglycerol levels might be the signal that triggers

215 s), type 1 cannabinoid receptors (CB1Rs) and diacylglycerol lipase (DAGL) in the VTA.

216 f inhibitors of the 2-AG-synthesizing enzyme diacylglycerol lipase (DAGL) or the 2-AG-degrading enzym

217 tidylethanolaminephospholipase D (NAPE-PLD), diacylglycerol lipase (DAGL), or phospholipase C (PLC),

218 Diacylglycerol lipase (DAGL)-alpha and -beta are enzymes

219 to selectively inhibit 2-AG biosynthesis by diacylglycerol lipase (DAGL).

220 cerol, suggesting that SMc01003 also acts as diacylglycerol lipase (DglA) in its native background.

221 sn-1-Diacylglycerol lipase alpha (DAGL-alpha) is the main enz

222 s the role of the main 2-AG producing enzyme diacylglycerol lipase alpha (DAGL-alpha).

223 Diacylglycerol lipase alpha (DAGLalpha) is responsible f

224 nced expression of a biosynthesizing enzyme (diacylglycerol lipase alpha (DAGLalpha)) of 2-AG in tast

225 cy by deleting its primary synthetic enzyme, diacylglycerol lipase alpha (DGLalpha), from dopamine D1

226 d proteins involved in eCB signaling such as diacylglycerol lipase alpha, N-acyl-phosphatidylethanola

227 d by inhibiting the 2-AG-synthesizing enzyme diacylglycerol lipase alpha.

228 d 2-arachidonylglycerol 1) is synthesized by diacylglycerol lipase in pyramidal neurons; 2) travels r

229 mediated by 2-AG since it was blocked by the diacylglycerol lipase inhibitor DO34.

230 of either the CB1R antagonist, AM251, or the diacylglycerol lipase inhibitor, DO34.

231 bition of the major 2-AG synthesizing enzyme diacylglycerol lipase or blockade of CB1 receptors aboli

232 rs, we demonstrated that phospholipase D and diacylglycerol lipase were required for providing AA for

233 f endocannabinoid (eCB) biosynthetic enzymes diacylglycerol lipase-alpha (DAGLalpha) and -beta (DAGLb

234 , which is co-localized presynaptically with diacylglycerol lipase.

235 Diacylglycerol lipases (DAGLalpha and DAGLbeta) convert

236 t as selective and CNS-active inhibitors for diacylglycerol lipases (DAGLs), enzymes responsible for

237 potential, ADP, Ca(2+), 1-monoacylglycerol, diacylglycerol, malonyl-CoA, and HMG-CoA.

238 NAFLD to hepatic insulin resistance involves diacylglycerol-mediated (DAG-mediated) activation of pro

239 Conversely, enhancement of diacylglycerol-mediated signaling downstream of PLCgamma

240 ol kinase (DGK)zeta, a negative regulator of diacylglycerol-mediated signaling, has the desired effec

241 rapid conversion of plastidic monogalactosyl diacylglycerols (MGDGs) into oligogalactolipids, acylate

242 Activation of protein kinase C (PKC) by the diacylglycerol mimic phorbol-myristic acid resulted in s

243 Tandem mass spectrometry revealed a diacylglycerol modification at the cysteine residue in p

244 Evidence of differential trafficking of diacylglycerol moieties from the ER to chloroplast was u

245 ose a V-shaped cavity that can accommodate a diacylglycerol molecule.

246 14 closely associated with fat content, the Diacylglycerol O-Acyltransferase 1 (DGAT1) gene turned o

247 xpression of placental FA synthase (FAS) and diacylglycerol O-acyltransferase 1 (DGAT1) was negativel

248 readily form LD largely via the enzyme DGAT (diacylglycerol O-acyltransferase 1) and degrade LD via A

249 The GC dinucleotide allele of diacylglycerol O-acyltransferase 1:g.10433-10434AA >GC w

250 monoglucosyl diacylglycerol and glucuronosyl diacylglycerol or all glycolipids are not impaired in gr

251 Exogenously added diacylglycerol or phorbol 12-myristate 13-acetate, known

252 dylcholine and phosphatidylinositol (but not diacylglycerol or sphingomyelin) are significantly eleva

253 e there changes in skeletal muscle ceramide, diacylglycerol, or amino acid metabolite levels.

254 sm in Gnb5(-/-) MIN6 cells showed that cAMP, diacylglycerol, or Ca(2+) levels were not significantly

255 egg sphingomyelin (SM) and either ceramide, diacylglycerol, or cholesterol.

256 s of Ca(2+) entry and ionic currents through diacylglycerol- or receptor-activated recombinant TRPC6

257 or through activation of the phospholipase-C-diacylglycerol pathway share characteristic properties w

258 synthesis of major phospholipids via the CDP-diacylglycerol pathway.

259 at C.sativa seeds have very high activity of diacylglycerol-phosphatidylcholine interconversion.

260 dephosphorylation of phosphatidate to yield diacylglycerol, plays a crucial role in the synthesis of

261 messengers inositol 1,4,5-trisphosphate and diacylglycerol, PLC, unlike the other phospholipase C fa

262 sphoglycerol (POPG) and 1-palmitoyl-2-oleoyl diacylglycerol (PODAG) stimulate the IMD pathway of tick

263 ugh TRPC3/C6/C7 can be directly activated by diacylglycerols produced by PLC breakdown of phosphatidy

264 tivation; 2) reactive oxygen species-induced diacylglycerol production by phospholipase Cgamma, leadi

265 sitol 4,5-bisphosphate (PIP2) depletion, and diacylglycerol production.

266 t not that of LPA2 or inhibition of LPA3, by diacylglycerol pyrophosphate.

267 ation of the phospholipase Cgamma (PLCgamma)-diacylglycerol-RasGRP1 pathway.

268 rs considered, the total diacylglycerols/1,3-diacylglycerols ratio could be used as freshness index o

269 riants in RASGRP2, which encodes calcium and diacylglycerol-regulated guanine exchange factor I (CalD

270 roduction of the second messengers InsP3 and diacylglycerol requires steady delivery of phosphatidyli

271 the fatty-acyl profile of phospholipids and diacylglycerol revealed that chronic stressed rats had h

272 elective preparation of sn-1 mono and sn-1,3 diacylglycerols rich in CLA, with a ratio of sn-1,3/sn-1

273 d for native TRPC6-like [Ca(2+)]i signals in diacylglycerol-stimulated rat pulmonary artery smooth mu

274 insensitive to desensitization by sustained diacylglycerol stimulation.

275 utant of S. meliloti transiently accumulates diacylglycerol, suggesting that SMc01003 also acts as di

276 reduced expression of the gene encoding CDP-diacylglycerol synthase 1 (Cds1), an enzyme that catalyz

277 rmore, this enzyme is the first glucuronosyl diacylglycerol synthase isolated.

278 study revealed the potential of an enzymatic diacylglycerol synthesis in edible oils as a suitable al

279 ctosyl diacylglycerol and glucosylgalactosyl diacylglycerol synthesized by a processive glycosyltrans

280 s conducted to investigate the enrichment of diacylglycerols, systematically.

281 ers form approximately 2-5 times faster from diacylglycerols than from monoacylglycerols.

282 phospholipids and galactolipids to generate diacylglycerol that can be phosphorylated to phosphatidi

283 binds to protein kinase C competitively with diacylglycerol, the endogenous protein kinase C regulato

284 Plasma levels of triacylglycerols and diacylglycerols, the lipoproteins that transport them, a

285 ium salmoninarum, with and without bound CDP-diacylglycerol to 3.6 and 2.5 A resolution, respectively

286 ignal sequence and catalyzes the addition of diacylglycerol to an invariant cysteine.

287 roup from acetyl-CoA to the sn-3 position of diacylglycerol to form 3-acetyl-1,2-diacyl-sn-glycerol (

288 Here we show that SMc01003 converts diacylglycerol to monoacylglycerol and a fatty acid, and

289 ncoded diacylglycerol kinase, which converts diacylglycerol to phosphatidate, partially suppressed th

290 se catalyses the ATP-dependent conversion of diacylglycerol to phosphatidic acid in the plasma membra

291 rol lipases (DAGLalpha and DAGLbeta) convert diacylglycerol to the endocannabinoid 2-arachidonoylglyc

292 ign for the signaling lipids sphingosine and diacylglycerol; uncaging of the probe for these two spec

293 enzyme responsible for the production of the diacylglycerol used for the synthesis of triacylglycerol

294 Binding activity for diacylglycerol was restored in parallel.

295 When diacylglycerol was used as the substrate, CrDGTT1 prefer

296 became stronger an increase of oxylipins and diacylglycerols was revealed.

297 ncorporation of sulfite into sulfoquinovosyl diacylglycerols were not sufficient to maintain low basa

298 inoleic acid containing triacylglycerols and diacylglycerols were significantly associated with AAA p

299 that mechanically activated AT1 R generates diacylglycerol, which in turn activates PKC which induce

300 e (MGAT) enzymes convert monoacylglycerol to diacylglycerol, which is the penultimate step in one pat