ライフサイエンスコーパス: diacylglycerol lipase

1 ntial activities of phosphoinositidase C and diacylglycerol lipase.

2 mediated by the enzymes phospholipase C and diacylglycerol lipase.

3 , which is co-localized presynaptically with diacylglycerol lipase.

4 he sequential activities of phospholipase C, diacylglycerol lipase, 5-lipo-oxygenease, and leukotrien

5 sustained rise in intracellular calcium, and diacylglycerol lipase activity.

6 sn-1-Diacylglycerol lipase alpha (DAGL-alpha) is the main enz

7 s the role of the main 2-AG producing enzyme diacylglycerol lipase alpha (DAGL-alpha).

8 Both diacylglycerol lipase alpha (DAGLalpha) and DAGLbeta can

9 Diacylglycerol lipase alpha (DAGLalpha) is responsible f

10 nced expression of a biosynthesizing enzyme (diacylglycerol lipase alpha (DAGLalpha)) of 2-AG in tast

11 cy by deleting its primary synthetic enzyme, diacylglycerol lipase alpha (DGLalpha), from dopamine D1

12 rade signal 2-arachidonoylglycerol (2-AG) by diacylglycerol lipase alpha (DGLalpha).

13 ybridization, we measured CB1R, GAD(67), and diacylglycerol lipase alpha (the synthesizing enzyme for

14 lethanolamine phospholipase D [NAPE-PLD] and diacylglycerol lipase alpha [DAGLalpha]) in the spinal c

15 pocampal protein concentrations for the sn-1-diacylglycerol lipase alpha and beta isoforms, synthesiz

16 Expression of diacylglycerol lipase alpha mRNA, which is not altered i

17 c glutamate receptor 5a (mGluR5a), Homer 2b, diacylglycerol lipase alpha, and CB(1)R.

18 d proteins involved in eCB signaling such as diacylglycerol lipase alpha, N-acyl-phosphatidylethanola

19 d by inhibiting the 2-AG-synthesizing enzyme diacylglycerol lipase alpha.

20 f endocannabinoid (eCB) biosynthetic enzymes diacylglycerol lipase-alpha (DAGLalpha) and -beta (DAGLb

21 1a))-positive GABAergic interneurons express diacylglycerol lipase-alpha (DGL-alpha), a synthesizing

22 nteraction between the 2-AG synthetic enzyme diacylglycerol lipase-alpha (DGLalpha) and calcium/calmo

23 2-arachidonoyl-sn-glycerol-producing enzyme, diacylglycerol lipase-alpha (endocannabinoid signalosome

24 Here we show the localization of diacylglycerol lipase-alpha and -beta (DGLalpha/beta), i

25 of 2-AG is calcium-dependent and mediated by diacylglycerol lipase and COX-2.

26 can be inferred in part through measures of diacylglycerol lipase and monoglyceride lipase, which sy

27 heimer's (Braak stage VI), with ectopic sn-1-diacylglycerol lipase beta expression found in microglia

28 embers of this large enzyme class, including diacylglycerol lipase-beta (DAGLbeta), a principal biosy

29 s), type 1 cannabinoid receptors (CB1Rs) and diacylglycerol lipase (DAGL) in the VTA.

30 f inhibitors of the 2-AG-synthesizing enzyme diacylglycerol lipase (DAGL) or the 2-AG-degrading enzym

31 tidylethanolaminephospholipase D (NAPE-PLD), diacylglycerol lipase (DAGL), or phospholipase C (PLC),

32 Diacylglycerol lipase (DAGL)-alpha and -beta are enzymes

33 to selectively inhibit 2-AG biosynthesis by diacylglycerol lipase (DAGL).

34 the enzyme responsible for 2-AG generation, diacylglycerol lipase (DAGL).

35 ), an inhibitor of the 2-AG synthesis enzyme diacylglycerol lipase (DAGL).

36 Diacylglycerol lipases (DAGLalpha and DAGLbeta) convert

37 t as selective and CNS-active inhibitors for diacylglycerol lipases (DAGLs), enzymes responsible for

38 a mechanism dependent upon both postsynaptic diacylglycerol lipase (DGL) activity, which releases 2-A

39 aptic response was blocked by inhibitors for diacylglycerol lipase (DGL), which biosynthesizes 2-AG,

40 cerol, suggesting that SMc01003 also acts as diacylglycerol lipase (DglA) in its native background.

41 d 2-arachidonylglycerol 1) is synthesized by diacylglycerol lipase in pyramidal neurons; 2) travels r

42 xygenases), LOXs (lipooxygenases), and DGLs (diacylglycerol lipases), indicating the involvement of a

43 ited by antibodies to the FGF receptor and a diacylglycerol lipase inhibitor (RHC80267) that blocks t

44 mediated by 2-AG since it was blocked by the diacylglycerol lipase inhibitor DO34.

45 in iron-overloaded NRVMs was reduced by the diacylglycerol lipase inhibitor RHC80267 but was largely

46 e phospholipase C inhibitor U-73122, and the diacylglycerol lipase inhibitor tetrahydrolipstatin (THL

47 of either the CB1R antagonist, AM251, or the diacylglycerol lipase inhibitor, DO34.

48 bition of the major 2-AG synthesizing enzyme diacylglycerol lipase or blockade of CB1 receptors aboli

49 main containing 4 protein, cyclooxygenase 2, diacylglycerol lipase paralogs (DAGLalpha, DAGLbeta), fa

50 ction via the phosphatidate phosphohydrolase/diacylglycerol lipase pathway.

51 Inhibitors of diacylglycerol lipase (RHC 80267), cyclooxygenase (indom

52 phatidate phosphohydrolase (propranolol) and diacylglycerol lipase (RHC-80267), attenuated ET-1-induc

53 An inhibitor of diacylglycerol lipase, RHC-80267, inhibited AVP-evoked S

54 : cytosolic phospholipase A(2) (cPLA(2)) and diacylglycerol lipase; the former cascade is responsible

55 the postsynaptic membrane-associated lipase, diacylglycerol lipase type-alpha (DGL-alpha), in mGlu re

56 B(1)R (SR141716 and AM251) and inhibition of diacylglycerol lipase using tetrahydrolipstatin also aug

57 rs, we demonstrated that phospholipase D and diacylglycerol lipase were required for providing AA for