ライフサイエンスコーパス: dialkyl

1 The structure of this first 1,16-dialkyl-1,16-dihydro[60]fullerene was assigned from (13)

2 effect on ring closure was studied using 2,2-dialkyl-1,3-propanediamines.

3 and the calculations suggest that perfluoro dialkyl 10-X-2 ate-complexes should be experimentally ob

4 The reaction leads to 5,5'-dialkyl-2,2'-bifuran 4 as a byproduct.

5 isopropylphenylamide in the presence of 4,4'-dialkyl-2,2'-bipyridyl (R(2)bpy; R = Me, (t)Bu) or triph

6 Syntheses are reported of new 4,4'-dialkyl-2,2'-bithiazole oligomers that have alkenoxy sid

7 emiconductors based on the conventional 3,3'-dialkyl-2,2'-bithiophene, the resulting SBT systems are

8 mines, yields from the carbonylation of N,N'-dialkyl-2,2-dimethyl-1,3-propanediamines were lower than

9 d for the synthesis of 1-alkyl and (+/-)-1,2-dialkyl-2,3-dihydro-1,8-naphthyridin-4(1H)-ones.

10 e dynamic kinetic resolutions of racemic 3,5-dialkyl-2-cyclopenten-1-ones.

11 3,5-dihydro-3,5-dialkyl-3,5-diaryl-4H-pyrazol-4-ones stimulate interest

12 inediones (8a-f) and 2,2'-ethylidene-bis[4,4-dialkyl-3,5-isoxazolidinedione]s (9a-f).

13 tituted malonyl chlorides gave 2-alkenyl-4,4-dialkyl-3,5-isoxazolidinediones (8a-f) and 2,2'-ethylide

14 2-Alkyl- and 2,4-dialkyl-3-iodo-1-oxocyclohexan-2,4-carbolactones undergo

15 2-Alkyl- and 2,4-dialkyl-3-iodo-1-oxocyclohexan-2,4-carbolactones undergo

16 e 23 which may serve to access 4-alkyl-, 3,4-dialkyl-, 3,4-disubstituted and 3,3, 4-trisubstituted 2-

17 A series of N,N'-dialkyl-4,13-diaza-18-crown-6 lariat ethers possessing t

18 ) ring to form inclusion complexes with 1,1'-dialkyl-4,4'-bipyridinium radical cationic (BIPY(*+)) gu

19 A series of N-alkyl- and N,N-dialkyl-4-[alpha-[(2S,5R)-4-allyl-2,5-dimethyl-1-piperaz

20 (II)-catalyzed oxidative C-C coupling of 2,2-dialkyl-4-phenyl-2H-imidazole 1-oxides with indoles was

21 We have continued to explore the 3,3-dialkyl-5-aryloxindole series of progesterone receptor (

22 tors possessing a (2E,4E,6Z)-3-methyl-7-(3,5-dialkyl-6-alkoxyphenyl)-octa-2,4,6-trienoic acid scaffol

23 3,5-Diacyl-2,4-dialkyl-6-phenylpyridine derivatives have been found to

24 nge were observed for certain 3,5-diacyl-2,4-dialkyl-6-phenylpyridine derivatives in displacement of

25 ly enantioselective catalysts for alpha,beta-dialkyl (95-99% ee) and nearly all of alpha-alkyl-beta-a

26 sphoryl azides), and N,N-dialkyloxyformamide dialkyl acetal via electrophilic addition of immonium io

27 -determining acid hydrolysis of benzaldehyde dialkyl acetals to hemiacetal intermediates that breakdo

28 inhydrin, malononitrile, primary amines, and dialkyl acetylenedicarboxylates under mild conditions in

29 Whereas alkyl phenyl and dialkyl acetylenes undergo cycloadditions to afford mixt

30 Dialkyl-, alkyl-aryl-, and diaryl-allenes are accessible

31 The rates of reaction with a dialkyl alkyne at the two sites of a pyridine substrate

32 lectivity-determining in the reaction with a dialkyl alkyne, but C-H activation can be selectivity-de

33 Substrates covered comprise alpha,beta-dialkyl, alpha-alkyl-beta-aryl, and alpha,beta-diarylvin

34 nantioselective synthesis of the alpha,alpha-dialkyl-alpha-amino acid (1S,3R)-ACPD has been achieved

35 preparation of the corresponding heteroaryl dialkyl amides via a strategy of sequential base-mediate

36 amination of unactivated alkenes with simple dialkyl amines remains an unsolved problem in organic sy

37 amination of internal alkynes with secondary dialkyl amines, a process with little precedent.

38 ophilic amines such as N-alkyl anilines, N,N-dialkyl amines, and primary aliphatic amines using this

39 Substitutions by the alpha, alpha-dialkyl amino acid in place of D-Ala2 or Phe3, or both,

40 large asymmetry in isovaline and other alpha-dialkyl amino acids found in altered CI and CM meteorite

41 llylic carbonates and a variety of protected dialkyl aminomalonates is reported.

42 l cyclophanes containing aromatic groups and dialkyl ammonium ions were created as model systems of t

43 The C(7)-mono- and dialkyl analogues exhibited more than an order of magnit

44 thetic approaches to C(7)-monoalkyl and C(7)-dialkyl analogues using a sequence involving (1) AgNO3-m

45 In contrast to reactions of dialkyl and alkyl/silyl peroxides, the displacements of

46 nder the optimized reaction conditions, both dialkyl and alkylaryl alkyne substrates were found to un

47 Cobalt dialkyl and bis(carboxylate) complexes bearing alpha-dii

48 tabolized and excreted in the urine as their dialkyl and diaryl compounds which function as biomarker

49 -disubstituted 1,2-dioxines along with a 1,3-dialkyl and steroidal example, with yields ranging from

50 of aryl iodides and aryl bromides by diaryl, dialkyl, and diheteroaryl diselenides in water and PEG-6

51 A series of 3,3-dialkyl- and 3-alkyl-3-benzyl-substituted 2-pyrrolidinon

52 attractive alternative to electron releasing dialkyl- and diarylamino groups, the most commonly used

53 lectron-acceptor head groups and hydrophobic dialkyl-aniline electron donors have high molecular hype

54 organolithium/(-)-sparteine pair versus N,N-dialkyl aryl O-carbamate starting materials, temperature

55 tho-protected or functionalized tertiary N,N-dialkyl aryl O-carbamates 5-7 (Scheme 2 ) and meta-prote

56 drolysis of a series of five triaryl and two dialkyl aryl phosphate triesters, previously studied exp

57 difference in reactivity between triaryl and dialkyl aryl phosphate triesters.

58 The new dialkyl(aryl) lithium zincates [(THF)(2)Li(C(6)H(4)-OMe)

59 Dialkyl, aryl alkyl, and diaryl ketones reacted as well

60 Aldehydes and ketones of different types (dialkyl, aryl-alkyl, diaryl) are hydrogenated quantitati

61 The reaction conditions are tolerable for dialkyl-, aryl(hetaryl) alkyl-, and cycloalkyl ketones.

62 fer substantial stability to both diaryl and dialkyl ate-complexes, and the calculations suggest that

63 electrophilic amination of pent-4-ynal with dialkyl azodicarboxylate promoted by l-proline and funct

64 equent reaction with hydrogen-bond activated dialkyl azodicarboxylates delivers alpha-aminocarbonyl c

65 n this novel proline-catalyzed reaction with dialkyl azodicarboxylates to give alpha-amino aldehydes

66 or 9-BBN-OTf) to give the corresponding B,B-dialkyl-B-(1-acyldipyrromethane)boron(III) complex.

67 binding of nitrobenzoxadiazole (NBD)-labeled dialkyl-based ligands (phosphatidylcholine, sphingomyeli

68 condary amines to produce N-monoalkyl or N,N-dialkyl benzaldehyde hydrazones in 44-87% yield.

69 We report the synthesis of syn-alpha,beta-dialkyl beta-amino acid derivatives suitably protected f

70 syn-alpha,beta-Dialkyl beta-amino acids are interesting building blocks

71 These amino acids, as well as syn-alpha,beta-dialkyl beta-amino acids that contain diverse hydrophobi

72 The described route to 3,4-dialkyl-beta-lactones is based on a two-step process inv

73 of monoligated L.Pd(II)(Ar)X complexes (L = dialkyl biaryl phosphine) have been prepared and studied

74 ical asymmetric route to pseudosymmetric 3,4-dialkyl-cis-beta-lactones.

75 Herein, we report the first isolated Ni(III)-dialkyl complex and show that this species is involved i

76 Planar, low-spin cobalt(II) dialkyl complexes bearing bidentate phosphine ligands, (

77 A series of stable dialkyl complexes of Pd, (alpha-diimine)PdR2 (alpha-diim

78 ryl ate-complexes are more stable than their dialkyl counterparts.

79 ratio (kappa/mu) > 200) compared to the N,N-dialkyl [D-Pro10]Dyn A-(1-11) analogues, although one di

80 We have identified amphiphilic 3',6-dialkyl derivatives of the small aminoglycoside neamine

81 es, we report here on the discovery of three dialkyl derivatives of the small aminoglycoside neamine

82 For the N,N-dialkyl derivatives the identity of the N-terminal alkyl

83 pear to dominate the equilibria for the N,N'-dialkyl derivatives.

84 fication reaction in the presence of various dialkyl dicarbonates or chloroformates.

85 e-catalyzed copolymerization of lactone with dialkyl diester and amino diol, and their hydrophobicity

86 t with surface silicon radicals included the dialkyl/diphenyl disulfides, diphenyl diselenide, and 1-

87 r oligoenes of 1,6-heptadiynes (derived from dialkyl dipropargylmalonates) with a single basic struct

88 ide in water and another diaryl/diheteroaryl/dialkyl diselenide in PEG-600 in the second step produce

89 romoiodobenzene with one diaryl/diheteroaryl/dialkyl diselenide in water and another diaryl/diheteroa

90 rticles (NPs) is identified as essential for dialkyl diselenide/disulfide to react with the Au(III) c

91 bled monolayers (SAMs)--a SAM formed from an dialkyl disulfide with a covalently linked tetracyanoqui

92 le of such bonding in a nontethered, acyclic dialkyl disulfide; (1)H-(1)H EXSY NMR data in solution s

93 erates thiols and amides from thioesters and dialkyl disulfides; a trigger that controls autocatalyti

94 tert-butyllithium was allowed to react with dialkyl ditellurides to provide ortho-(alkyltelluro)phen

95 h 5 equiv of tert-butyllithium to react with dialkyl ditellurides.

96 eties enhances catalytic efficency, with gem-dialkyl effect accelerations of 4.5 and 9.1, respectivel

97 ization of the reactivity of the ring-opened dialkyl epoxide.

98 eptide coupling of 7a-c with L-glutamic acid dialkyl ester followed by mild ester hydrolysis gave tar

99 substituted (4-aminobenzoyl)-L-glutamic acid dialkyl ester or N-(5-amino-2-thenoyl)-L-glutamate diest

100 ment in both efficiency and potency over the dialkyl ester prodrug strategy in which the inhibitor is

101 n-BuLi in diamine/dialkyl ether mixtures forms ensembles of hetero- and ho

102 g an attractive C-C bond-forming approach to dialkyl ether synthesis.

103 Homologous dialkyl ether/poly(hydrogen fluoride) (R(2)O/[HF](n,), R

104 DFT-based theoretical calculations of stable dialkyl ether/poly(hydrogen fluoride) complexes are repo

105 ide (LiHMDS; TMS(2)NLi) solvated by hindered dialkyl ethers (ROR') are described.

106 ,3-(SiMe3)2)(eta5-C9H5-1,3-(SiMe3)2)Zr, with dialkyl ethers such as diethyl ether, CH3OR (R=Et, nBu,

107 Comparisons of hindered dialkyl ethers with their isostructural dialkylamines re

108 ple process offers straightforward access to dialkyl ethers, many of which would be difficult to prep

109 ophene units are held coplanar by a bridging dialkyl germanium.

110 embranes are composed primarily of diacyl or dialkyl glycerol phospholipids, the first cell membranes

111 to identify complete series of core glycerol dialkyl glycerol tetraethers (GDGTs with 0 to 8 alicycli

112 of the abundance and composition of glycerol dialkyl glycerol tetraethers (GDGTs).

113 l chain lengths (C4, C6, C8) and also an N,N-dialkyl group (C6-C6) were synthesized via reactions bet

114 ich contain either glycine methyl ester or a dialkyl group displayed the lowest efficiency for tPA.

115 However, the larger 1,3-dialkyl groups (isobutyl and butyl) resulted in a decrea

116 sponding dipropyl analogues, the smaller 1,3-dialkyl groups (methyl and ethyl) increased the A(2B) Ad

117 s that it decreases in the order: alpha,beta-dialkyl > alpha-alkyl-beta-aryl > alpha,beta-diaryl.

118 binding equivalents) in comparison to simple dialkyl HPOs such as Deferiprone (CP20) which cause up t

119 ulted in the identification of unsymmetrical dialkyl-hydroxynaphthalenoyl-benzothiadiazines 2 and 3.

120 These dialkyl imidazoles are substantially less expensive to p

121 ucture-activity studies of a large number of dialkyl imidazoles as inhibitors of Trypanosoma cruzi la

122 =N-O*) = 90 degrees, for sterically hindered dialkyl iminoxyl radicals.

123 re used for the haloboration of terminal and dialkyl internal alkynes (see scheme).

124 chieved in the Cu(I)-catalyzed borylation of dialkyl internal alkynes with bis(pinacolato)diboron.

125 uilding block and a thermolytic precursor to dialkyl ketenes.

126 olecular asymmetric reductive amination of a dialkyl ketone with an aliphatic amine has been develope

127 ivities for a wide variety of aryl alkyl and dialkyl ketones (up to 99% ee).

128 to aryl alkenes to access chiral alpha-aryl dialkyl ketones is reported.

129 ability to use the enolates of unsymmetrical dialkyl ketones lacking alpha-branching for regio- and s

130 Second, dialkyl ketones undergo enantioselective coupling in goo

131 Condensation of aryl alkyl and dialkyl ketones with tert-butanesulfinamide followed by

132 nd regioselective synthesis of unsymmetrical dialkyl ketones.

133 l, providing complete conversion of aryl and dialkyl ketones.

134 two common stabilized carbanions-enolates of dialkyl malonates and alkyl cyanoesters-are reported.

135 tions of allylic geminal dicarboxylates with dialkyl malonates have been investigated.

136 ned as catalysts (10 mol %) for additions of dialkyl malonates to nitroalkenes.

137 ne 12 and cyclic sulfamidate 22 with lithium dialkyl methylphosphonate, affording 13 and 23, respecti

138 opropyl benzoates (TIB esters) and secondary dialkyl N,N-diisopropyl carbamates have been reported to

139 N,N-dialkyl-N-chloroamines are an effective source of electr

140 m-positive bacteria of new amphiphilic 3',4'-dialkyl neamine derivatives and of their smaller analogu

141 Thus, the processivity of dialkyl nitrosamine oxidation appears to be shared by a

142 ectrophilic cyclization of the resulting N,N-dialkyl-o-(1-alkynyl)anilines using I2 in CH2Cl2.

143 lds by coupling terminal acetylenes with N,N-dialkyl-o-iodoanilines in the presence of a Pd/Cu cataly

144 ies of reactions of sulfate diesters are for dialkyl or alkyl aryl diesters, which undergo reaction b

145 in 2011 for 6 chlorinated and nonchlorinated dialkyl or diaryl phosphates (DAPs), the expected major

146 chael additions have been revisited with 1,3-dialkyl- or 1,3-diarylimidazol(in)ium-2-carboxylates, th

147 Mixed lithium dialkyl- or alkyl(aryl)cuprate reagents containing one a

148 of 4-acetamido-3-iodopyridines and diaryl-, dialkyl-, or arylalkylalkynes is described along with a

149 ectrophilic cyclization of the resulting N,N-dialkyl-ortho-(1-alkynyl)anilines with arylsulfenyl chlo

150 um/copper-catalyzed crossing coupling of N,N-dialkyl-ortho-iodoanilines and terminal alkynes and subs

151 d also enables the use of nonstereogenic 3,3-dialkyl oxaziridines as terminal oxidants in the aminohy

152 erion that has led in this study to Ar = N,N-dialkyl-p-anilinyl, in which exceptionally low barriers

153 The intramolecular reaction of dialkyl peroxides with carbanions, generated via chemose

154 Dialkyl phosphate (DAP) metabolites in spot urine sample

155 Dialkyl phosphate (DAP) metabolites of OP pesticides, sp

156 a conformation favoring lactonization of the dialkyl phosphate alkylated intermediate.

157 All models included prenatal urinary dialkyl phosphate metabolite concentrations.

158 seven PEs metabolites, six PBs, BPA, and six dialkyl phosphate metabolites in five-hundred samples co

159 metabolites of OP pesticides [summed to six dialkyl phosphates (SigmaDAPs)] were measured in materna

160 ne methide derivatives capable of alkylating dialkyl phosphates.

161 s observed for monoaddition, and symmetrical dialkyl phosphinates do not form in significant amounts.

162 [b]thiophene linkers connecting the flanking dialkyl phosphine donors to the central carbene can be a

163 cyclic precatalyst supported by a new biaryl(dialkyl)phosphine ligand (VPhos) in combination with oct

164 involves cross-coupling of aryl halides and dialkyl phosphites (the Hirao reaction).

165 action of a variety of terminal alkynes with dialkyl phosphites in the presence Cu2O (14 mol %) led t

166 The addition of potassium dialkyl phosphites to enantiopure O-protected alpha-hydr

167 by Mn(OAc)3 with diphenylphosphine oxide and dialkyl phosphites was described, and a new type of difu

168 cross-coupling reaction (Hirao coupling) of dialkyl phosphites with bromopyridinecarboxylates, follo

169 ane building blocks bearing mono or tripodal dialkyl phosphonate groups.

170 ia an attack of the terminal oxygen from the dialkyl phosphonate on the silicon atom in bromotrimethy

171 alysis allows the direct oxygen-arylation of dialkyl phosphonates with diaryliodonium salts.

172 adsorption strengths of a series of isomeric dialkyl phthalates were determined from their competitiv

173 he oxidative desymmetrization of achiral N,N-dialkyl piperidine-4-carboxylates to give products with

174 -111 were synthesized with NH2, N-alkyl, N,N-dialkyl, pyrrolidinyl, piperidinyl, and piperazinyl subs

175 , a two-component Povarov reaction forms 2,3-dialkyl quinolines under the same green conditions that

176 , CHCl3) is observed for n >/= 8, and in the dialkyl series, the melting-decomposition temperature of

177 pooled estimates of the association of total dialkyl (SigmaDAP), diethyl (SigmaDEP), and dimethylphos

178 metallole dianion and corresponding dichloro(dialkyl)silanes.

179 Protonation of these dialkyl species at low temperature results in loss of al

180 nyllithium reagents to the carbonyl group of dialkyl squarate-derived 1-alkynylbicyclo[3.2.0]hept-2-e

181 kylidene analogues are readily prepared from dialkyl squarates.

182 We found that the size of the 3,3-dialkyl substituent is important for controlling the fun

183 t of oxime carbamates having N-alkyl and N,N-dialkyl substituents were prepared via carbonyldiimidazo

184 e development of alpha-alkyl and alpha,alpha-dialkyl substituted amino acids for brain tumor imaging.

185 While oxide catalysts yielded the 2,3-dialkyl substituted products, cyclic secondary amines pr

186 he disrotatory outward ring opening of a cis-dialkyl substituted syn-chloro-gem-chlorofluorocycloprop

187 ly, and it is likely that for most beta,beta-dialkyl- substituted vinylic iodonium triflates enol tri

188 This finding indicates that dialkyl-substituted alkyne byproducts should be avoided

189 ional class of natural products--namely, 3,5-dialkyl-substituted alpha-pyrones.

190 Treatment of several N,N-dialkyl-substituted amido diazo-esters with Rh2(OAc)4 in

191 A dialkyl-substituted anthraquinone derivative was synthes

192 yclic enantiomerically enriched alpha,alpha'-dialkyl-substituted ketones, which are challenging motif

193 a number of polyfluorene copolymers and in a dialkyl-substituted poly(p-phenylenevinylene), all in th

194 1,8-Dialkyl substitution is used to direct the regiochemistr

195 mpressive stereoselectivity was obtained for dialkyl substitutions, which typically are challenging s

196 process employs the reagent combination of a dialkyl sulfide and triflic anhydride to effect anomeric

197 lowing order: thioanisole < ether-sulfides < dialkyl sulfides < dimethyl sulfide.

198 ion with 1-hydroxy glycosyl donors employing dialkyl sulfonium reagents is described.

199 ol-dependent (k(2)) pathways was slower from dialkyl Te(IV) species derived from 2 than from diaryl T

200 SH) for the introduction of PhSH to oxidized dialkyl tellurane 5 and oxidized diaryl tellurane 6 were

201 xidation of the Te atom of the electron-rich dialkyl telluride 2 was more rapid than oxidation of dia

202 The library consisted of dialkyl tertiary amine-containing commercially available

203 I-MS/MS) approach to the characterization of dialkyl tertiary amine-N-oxides is presented.

204 known to form through diagnostic losses from dialkyl tertiary amine-N-oxides.

205 The synthesis and characterization of p-dialkyl-tetraphenyl-carbo-benzenes (n = 2, 8, 14, 20) ar

206 have synthesized a series of cis- and trans-dialkyl THCs.

207 ables deprotonation of unactivated secondary dialkyl TIB esters, but not the carbamates.

208 n of a dinuclear tuck-in-tuck-over tuck-over dialkyl Tren-uranium(IV) complex and the first example o

209 In this work the reaction between dialkyl trimethylsilyl phosphites and alpha,beta,gamma,d

210 of the alkyl groups in the efficiency of TMP-dialkyl zincate bases.

211 tep deprotonation reaction of anisole by TMP-dialkyl zincates and show the relevance of the alkyl gro