ライフサイエンスコーパス: diamino

1 2,2'-Diamino-1,1'-bianthryl (15) has been resolved into enant

2 The chiral scaffold for the catalyst is 2,2'-diamino-1,1'-binaphthalene (BINAM), and a bis-conjugate

3 regio- and atroposelective synthesis of 2,2'-diamino-1,1'-binaphthalenes (BINAMs).

4 Condensation of fac-Re(5,6-diamino-1,10-phenanthroline)(CO)3Cl to o-quinone edge de

5 cis- and trans-2,6-diamino-1,2,3,5,6,7-hexahydro-s-indacene-2,6-dicarboxyli

6 novel carbon-supported copper complex of 3,5-diamino-1,2,4-triazole (Cu-tri/C) is investigated as a c

7 the formation of the cocrystal of 5 with 3,5-diamino-1,2,4-triazole, which was found to be remarkably

8 thesis of 1,4-disubstituted 3-amino- and 3,5-diamino-1,2,4-triazoles based on quaternization of readi

9 optimize the pharmacological profile of [1,2-diamino-1,2-bis(4-fluorophenyl)ethane]dichloridoplatinum

10 A method for the synthesis of chiral 1,2-diamino-1,2-dideoxy-myo-inositol-based bis-pyridyl ligan

11 2,4-Diamino-1,3,5-triazinyl (DAT) groups are known to form N

12 , we have synthesized compounds in which 2,4-diamino-1,3,5-triazinyl groups are attached to derivativ

13 For 2,3-diamino-1,4-benzoquinone, adiabatic E(T1) and E(S1) ener

14 = azophenine = N,N',N",N'''-tetraphenyl-2,5-diamino-1,4-diiminobenzoquinone) affords the complex [(T

15 eed via the initial formation of dimeric 2,5-diamino-1,4-dioxane species, which were hydrolyzed in si

16 We report a new naphthalene bis(4,8-diamino-1,5-dicarboxyl)amide (NBA) building block for po

17 idines 6 and 17 were prepared by heating 2,7-diamino-1,8-naphthyridine (13) with butylisocyanate and

18 oplatinum(II) complexes, we synthesized [1,2-diamino-1-(4-fluorophenyl)alkanol]dichloridoplatinum(II)

19 [threo-1,2-Diamino-1-(4-fluorophenyl)propan]dichloridoplatinum(II)

20 fluoroacetic acid generates the unstable 2,3-diamino-1-(phenylsulfonyl)indole (3), which can be trapp

21 2-Hydroxy-4,6-diamino-[1,3,5]triazines are described which are a novel

22 ernization of 1-substituted 3-amino- and 3,5-diamino-1H-1,2,4-triazoles by many alkyl halides proceed

23 e global nucleophilicity of 3-amino- and 3,5-diamino-1H-1,2,4-triazoles was predicted to be higher th

24 New derivatives of 1,1-diamino-2, 2-dinitroethene (FOX-7) are reported.

25 nhibited by appropriate MAPK inhibitors 1, 4-diamino-2, 3-dicyano-1, 4-bis (2-aminophenylthio) butadi

26 '-methoxyphenyl)-oxanaphthalen-4-one and 1,4-diamino-2, 3-dicyano-1,4-bis(2-aminophenylthio)butadiene

27 reatment of cells with the MKK inhibitor 1,4-diamino-2, 3-dicyano-1,4-bis[2-aminophenylthio]butadiene

28 [omega-[4-(4-cyanophenyl)phenoxy]hexyl] 4,4'-diamino-2,2'-biphenyldicarboxylate (nCBBP, n = 6), abbre

29 characterization of two new halogenated 1,1-diamino-2,2-dinitroethene (FOX-7) compounds and three ha

30 ion were controllably synthesized by using 1-diamino-2,2-dinitroethene as a precursor.

31 The compound U0126 (1,4-diamino-2,3-dicyano-1, 4-bis[2-aminophenylthio]butadiene

32 try demonstrated that pro-treatment with 1,4-diamino-2,3-dicyano-1,4-bis butadiene (U0126) could sign

33 as inhibited by the ERK kinase inhibitor 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio) butadiene

34 2'-amino-3'-methoxyflavone (PD98059) or 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)-butadiene

35 romoter activity was repressed by U0126 [1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene]

36 hoxy-3,4-difluoro-benzamide], and U0126 [1,4-diamino-2,3-dicyano-1,4-bis(2-aminophynylthio)butadiene]

37 llular signal-regulated kinase inhibitor 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophynyltio)butadiene (

38 th pertussis toxin, MAPK activation with 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophynyltio)butadiene (

39 lated kinase (ERK)-dependent [blocked by 1,4-diamino-2,3-dicyano-1,4-bis(methylthio) butadiene (U0126

40 This down-regulation was attenuated by 1,4-diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126)

41 Two other MEK inhibitors, 1,4-diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126)

42 On the other hand, inhibition by 1,4-diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126)

43 2'-amino-3'-methoxyflavone (PD98059) or 1,4-diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126)

44 ted protein kinase kinase/ERK inhibitor [1,4-diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126)

45 e MAP kinase kinase 1/2 inhibitor U0126 [1,4-diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto) butad

46 tivated protein kinase-kinase) inhibitor 1,4-diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto) butad

47 ls with the MAPK kinase (MEK) inhibitors 1,4-diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto) butad

48 bolished by the MEK/ERK inhibitor U0126 [1,4-diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadi

49 tenuated by the MEK/ERK inhibitor U0126 [1,4-diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadi

50 tivated protein) kinase inhibitor U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-amino-phenylthio]butadiene

51 f the MAP kinase kinase inhibitor U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-amino-phenylthio]butadiene

52 ed kinase (ERK) 1/2 activation by UO126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio] butadiene

53 PD98059 or another MEK inhibitor, 1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene

54 AP kinase kinase (MEK) inhibitor, U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene)

55 egulated kinase kinase inhibitor, U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene)

56 synthesize lipid A molecules containing 2,3-diamino-2,3-dideoxy-d-glucopyranose (GlcN3N) units in pl

57 d GnnB, involved in the formation of the 2,3-diamino-2,3-dideoxy-d-glucopyranose moiety.

58 sence a beta-1',6-linked disaccharide of 2,3-diamino-2,3-dideoxy-d-glucopyranose units.

59 ine residues are replaced with the sugar 2,3-diamino-2,3-dideoxy-d-glucopyranose.

60 nterobacterial lipid A was replaced by a 2,3-diamino-2,3-dideoxy-d-glucopyranosyl-(GlcpN3N) disacchar

61 ing abundance of LA d-glucosamine versus 2,3-diamino-2,3-dideoxy-d-glucose, and phosphorylation statu

62 of the products have been converted into 2,3-diamino-2,3-dideoxyglycosides and methyl N-acetyl-D-livi

63 A 1,4-diamino-2,3-disila-1,3-butadiene derivative of compositi

64 (1), 1,4-diamino-2-chloro-2-butene (2), 1,6-diamino-2,4-hexadiyne (3), and 2-chloro-5-phthalimidopen

65 yielded an orthogonal arrangement of the 2,6-diamino-2,6-dideoxy-D-glucose and D-xylose rings, as opp

66 tment of T. vaginalis T016 with >/=20 mM 1,4-diamino-2-butanone (DAB) to inhibit ODC resulted in grow

67 bacterial transformant was inhibited by 1, 4-diamino-2-butanone (DAB), a known inhibitor of eukaryoti

68 Reactions of 1,4-diamino-2-butyne with selected amine oxidases were also

69 n the formation of diversely substituted 1,4-diamino-2-butynes,is described.

70 nd aryl group at the 1,4-position of the 1,4-diamino-2-butynes.

71 , 4-(2-naphthyloxy)-2-butyn-1-amine (1), 1,4-diamino-2-chloro-2-butene (2), 1,6-diamino-2,4-hexadiyne

72 unit could self-assemble dendrimers, the 2,8-diamino-2-N-ethylpyrimido-(4,5-b)(1,8)naphthyridine-3H-4

73 days by visualizing RPE ingrowth with 4',6'-diamino-2-phenylindole (DAPI) filters.

74 t counting of propidium iodide (PI) or 4',6'-diamino-2-phenylindole (DAPI)-stained cells.

75 Our results from 4, 6-diamino-2-phenylindole (DAPI)-stained spreads showed tha

76 eloped based on multiphoton imaging of 4',6'-diamino-2-phenylindole (DAPI)-stained tissue to quantify

77 Cell nuclei were stained with 4',6'-diamino-2-phenylindole (DAPI).

78 ng with a membrane impermeable dye and 4',6'-diamino-2-phenylindole (DAPI).

79 alized to the acidocalcisomes by using 4',6'-diamino-2-phenylindole staining and identified by using

80 o localized to the volutin granules by 4',6'-diamino-2-phenylindole staining.

81 labeled with markers for nuclei (DAPI; 4',6'-diamino-2-phenylindole), endothelial cells (isolectin IB

82 nsduced cells as demonstrated by DAPI (4', 6-diamino-2-phenylindole), TUNEL (terminal deoxynucleotidy

83 ssic monomeric DNA binders Hoechst 33258, 4'-diamino-2-phenylindole, pentamidine, berenil, spermine,

84 Diamino-2-quinoxalinols are reacted with salicylaldehyde

85 2,4-Diamino-[2'-methoxy-5'-(3-carboxyphenyl)ethynylbenzyl]py

86 tantially weaker against Pc and Tg DHFR, 2,4-diamino-[2'-methoxy-5'-(4-carboxyphenyl)ethynylbenzyl]py

87 e (4), was obtained by the nitration of 5,5'-diamino-3,3'-azo-1,2,4-oxadiazole using 100 % nitric aci

88 N(6)-(2-Deoxy-D-erythro-pentofuranosyl)-2,6-diamino-3,4-dihydro-4-oxo-5-N-methylf ormamidopyrimidine

89 s and related higher sugars derived from 5,7-diamino-3,5,7,9-tetradeoxynon-2-ulosonic acids.

90 The pseudaminic acids are a family of 5,7-diamino-3,5,7,9-tetradeoxynonulosonic acids that are fun

91 synthetic route to three derivatives of 3,5-diamino-3,5-dideoxy-d-ribofuranose.

92 exclusively regioselective synthesis of 2,7-diamino-3,6-dibromo- and 2,3-diamino-6,7-dibromo-NDIs fo

93 e and chloroform without an additive the 2,7-diamino-3,6-dibromo-NDI isomer was formed regioselective

94 N'-bis-(6-chloro-2-methoxy-acridin-9-yl)-1,8-diamino-3,6-dioxaoctane, and (1-[[4-(6-chloro-2-methoxy-

95 The third possible regioisomer 2,6-diamino-3,7-dibromo product was formed, if at all, in an

96 propan]dichloridoplatinum(II) and [threo-2,3-diamino-3-(4-fluorophenyl)propan-1-ol]dichloridoplatinum

97 ontains the alpha-amino acid bioisostere 3,4-diamino-3-cyclobutene-1,2-dione and an additional ring f

98 egio- and stereoselective synthesis of a 1,2-diamino-3-hydroxycyclohexane.

99 2-(2-Diamino-3-methoxyphenyl-4H-1-benzopyran-4-one (PD98059)

100 on with the MAP kinase kinase inhibitor 2-(2-diamino-3-methoxyphenyl-4H-1-benzopyran-4-one (PD98059)

101 on of the appropriate 1-nitroalkene with 2,6-diamino-3H-pyrimidin-4-one or 2,4,6-triaminopyrimidine,

102 Condensation of 1,2-diamino-4,5-bis(n-alkoxy)arenes with an oligopyridyl-typ

103 ompared with both published HPAE-PAD and 1,2-diamino-4,5-methylenedioxybenzene (DMB) derivatization f

104 hy (RP-UHPLC) analysis of acid-released, 1,2-diamino-4,5-methylenedioxybenzene (DMB) labeled sialic a

105 ses, including Western blotting and mild 1,2-diamino-4,5-methylenedioxybenzene-HPLC, that revealed th

106 Condensation of 5,6-diamino-4,7-phenanthroline with glyoxal provides 1,4,5,1

107 O uptake in the presence of a hexamine, 1,21-diamino-4,9,13, 18-tetraazahenicosane (H2N(CH2)(3)NH(CH2

108 in a high-throughput screening campaign, 3,6-diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-

109 A major DNA oxidation product, 2,2-diamino-4-[(2-deoxy-beta-D-erythro-pentofuranosyl)amino]

110 ing and CDK inhibition was reproduced by 2,6-diamino-4-cyclohexylmethyloxy-5-nitrosopyrimidine (NU602

111 eoxy-alpha,beta-d-erythropentofuranosyl)-2,6-diamino-4-hydroxy -5-formamidopyrimidine) is a modified

112 oxy-alpha,beta-d-erythro-pentofuranosyl)-2,6-diamino-4-hydroxy-5-f ormamidopyrimidine (Fapy.dGTP) and

113 Another common lesion, 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapydG), shares

114 hydantoin (Sp), guanidinohydantoin (Gh), 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG) and 4,6-

115 The oxidatively induced DNA lesions 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG) and 4,6-

116 genic 8-oxo-7,8-dihydroguanine (8-oxoG), 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG), 4,6-dia

117 to 8-oxo-7,8-dihydroguanine (8-oxoG) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG).

118 SB in the repair of formamidopyrimidines 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) and 4,

119 NA lesions 5-hydroxycytosine (5-OH-Cyt), 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) and 4,

120 mino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) from D

121 wed that 8-hydroxyguanine (8-OH-Gua) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) were e

122 Excision of purine lesions 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua), 4,6-d

123 nly other one acted on by S3 protein was 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua).

124 fied in DNA, only purine-derived lesions 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-

125 NEIL1 possess common substrates, namely, 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-

126 glycol, and two purine-derived lesions, 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-

127 c DNA lesions (7,8-dihydro-8-oxoguanine; 2,6-diamino-4-hydroxy-5-formamidopyrimidine; 4,6-diamino-5-f

128 oxy-alpha,beta-D-erythro-pentafuranosyl)-2,6-diamino-4-hydroxy-5-formyl amidopyrimidine (Fapy-dG), is

129 The Ntg1 and Ntg2 proteins also release 2, 6-diamino-4-hydroxy-5-N-methylformamido-pyrimidine from da

130 DNA substrates containing dihydrouracil, 2,6-diamino-4-hydroxy-5N-methylformamidopyrimidine (FaPy-7-M

131 Cyclocondensation of 2,4-diamino-4-oxopyrimidine with the alpha-bromoketones, cou

132 Silica gel was modified with 2,6-diamino-4-phenil-1,3,5-triazine and characterized by FTI

133 ine radicals at G1 to form alkali-labile 2,5-diamino-4H-imidazolone lesions (Iz1Py).

134 ydroxy-5-formamidopyrimidine (FapyG) and 4,6-diamino- 5-formamidopyrimidine (FapyA), but not 8-oxo-7,

135 The synthesis of seven 2,4-diamino-5,6,7,8-tetrahydro-7-substituted pyrido[4',3':4,

136 ypyrimidine to afford regiospecifically 2, 4-diamino-5,6,7,8-tetrahydropyrido[4',3':4,5]furo[2, 3-d]p

137 omplex of NADPH, the potent antifolate [2, 4-diamino-5- inverted question mark3-[3-(2-acetyloxyethyl)

138 ritrexim (PTX), 10 previously unreported 2,4-diamino-5-(2'-methoxy-5'-substituted)benzylpyrimidines (

139 ombine the enzyme-binding selectivity of 2,4-diamino-5-(3',4',5'-trimethoxybenzyl)pyrimidine (trimeth

140 The new analogues were all obtained from 2,4-diamino-5-(5'-iodo-2'-methoxybenzyl)pyrimidine via a Son

141 the Ma enzyme and was the most selective 2,4-diamino-5-(5'-substituted benzyl)pyrimidine inhibitor of

142 horamidites 23 and 25 were prepared from 2,4-diamino-5-(beta-d-ribofuranosyl)-1,3-pyrimidine (22) and

143 enol, followed by a Wittig reaction with 2,4-diamino-5-(chloromethyl)furo[2,3-d]pyrimidine (6), catal

144 were synthesized by a Wittig reaction of 2,4-diamino-5-(chloromethyl)furo[2,3-d]pyrimidine with ethyl

145 Two analogues, 2,4-diamino-5-[(2'-naphthylthio)methyl]furo[2, 3-d]pyrimidin

146 io)methyl]furo[2, 3-d]pyrimidine (5) and 2,4-diamino-5-[(2'-phenylanilino)methyl]furo[2,3-d]pyrimidin

147 the substrate and NADPH as the cofactor, 2,4-diamino-5-[(2-methoxy-4-carboxybutyloxy)benzyl]pyrimidin

148 Three previously unreported (R,S)-2,4-diamino-5-[(3,4,5-trimethoxyphenyl) alkyl]-6,7-dihydro-5

149 exim, PTX), seven previously undescribed 2,4-diamino-5-[2'-methoxy-5'-(substituted benzyl)]pyrimidine

150 xy-5-alkoxybenzyl]pyrimidines (3a-e) and 2,4-diamino-5-[2-methoxy-5-(omega-carboxyalkyloxy)benzyl]pyr

151 A series of previously undescribed 2,4-diamino-5-[2-methoxy-5-alkoxybenzyl]pyrimidines (3a-e) a

152 The final compound, 2,4-diamino-5-[3'-(4-carboxy-1-butynyl)-4'-bromo-5'-methoxyb

153 dole dihydrochloride), propidium iodide (3,8-diamino-5-[3-(diethylmethylammonio)propyl]-6-phenylphena

154 2,4-Diamino-5-[5'-(4-carboxy-1-butynyl)-2'-methoxybenzyl]pyr

155 2,4-Diamino-5-[5'-(5-carboxy-1-pentynyl)-2'-methoxybenzyl]py

156 2,4-Diamino-5-[5'-(5-carboxypentyl)-2'-methoxybenzyl]pyrimid

157 2,4-Diamino-5-[5'-(6-carboxy-1-hexynyl)-2'-methoxybenzyl]pyr

158 or the synthesis of 3, 4, and 11-27 were 2,4-diamino-5-alkylsubstituted-7H-pyrrolo[2,3-d]pyrimidines,

159 cation for the classical analogue N-[4-[(2,4-diamino-5-deaza-6,7,8,9-tetrahydropyrido[3,4-g]pteridin-

160 Seven novel 2,4-diamino-5-deaza-6,7,8,9-tetrahydropyrido[3,4-g]pteridine

161 esis to construct the tricyclic nucleus, 2,4-diamino-5-deaza-7H-6,7,8,9-tetrahydropyrido[3,4-g]pterid

162 ypotheses were developed for a series of 2,4-diamino-5-deazapteridine inhibitors of Mycobacterium avi

163 The cation of the salt ethidium bromide (3,8-diamino-5-ethyl-6-phenylphenanthridinium bromide) has be

164 ydroxy-5-formamidopyrimidine (FapyG) and 4,6-diamino-5-formamidopyrimidine (FapyA) are formed abundan

165 4-hydroxy-5-formamidopyrimidine (FapyG), 4,6-diamino-5-formamidopyrimidine (FapyA), and 8-oxo-7,8-dih

166 bits a strong preference for excision of 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-

167 oxy-5-formamidopyrimidine (FapyGua) and 4, 6-diamino-5-formamidopyrimidine (FapyAde) in cultured cell

168 hydroxy-5-formamidopyrimidine (FapyGua), 4,6-diamino-5-formamidopyrimidine (FapyAde), and 8-hydroxygu

169 roxy-5-formamidopyrimidine (FapyGua) and 4,6-diamino-5-formamidopyrimidine (FapyAde), which are subst

170 mino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidine from gamma-irradiated DNA.

171 studies show elevated 8-OHG, 8-OHA, and 5,6-diamino-5-formamidopyrimidine in both nuclear and mtDNA

172 mino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidine were significantly excised

173 diamino-4-hydroxy-5-formamidopyrimidine; 4,6-diamino-5-formamidopyrimidine) and strong plant growth i

174 These were 4, 6-diamino-5-formamidopyrimidine, 5,6-dihydroxyuracil, and

175 rmined for the following modified bases: 4,6-diamino-5-formamidopyrimidine, cis- and trans-thymine gl

176 derivatives and a purine-derived lesion, 4,6-diamino-5-formamidopyrimidine, from DNA containing multi

177 mino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidine.

178 The 2,4-diamino-5-ketopyrimidines 6 reported here represent a no

179 nanoparticles as thiolate ligands, using 3,8-diamino-5-mercaptododecyl-6-phenylphenanthridinium (ethi

180 hree DHFRs compared to the corresponding 2,4-diamino-5-methyl analogues previously reported; however,

181 Two novel classical antifolates N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-

182 (trimethoprim, TMP) with the potency of 2,4-diamino-5-methyl-6-(2',5'-dimethoxybenzyl)pyrido[2,3-d]p

183 2,4-diamino-5-methyl-6-(substituted-phenyl)thiopyrrolo[2,3-d

184 Thirteen 2,4-diamino-5-methyl-6-[(monosubstituted anilino)methyl]pyri

185 loro groups from the phenyl ring in the 2, 4-diamino-5-methyl-6-[(substituted anilino)methyl]pyrido[2

186 mbination of potency and selectivity was 2,4-diamino-5-methyl-6-[2'-(5-carboxy-1-butynyl)-5'-methoxy]

187 tive amination of a common intermediate, 2,4-diamino-5-methylpyrido[2, 3-d]pyrimidine-6-carbonitrile

188 Z)-6-(2-[2,5-dimethoxyphenyl]ethen-1-yl)-2,4-diamino-5-methylpyrido[2,3-d ]pyrimidine (SRI-9662) were

189 t inhibitors 6-([5-quinolylamino]methyl)-2,4-diamino-5-methylpyrido[2,3-d]pyrimidine (SRI-9439) and (

190 Compounds 3 and 4 were obtained from 2,4-diamino-5-methylpyrrolo[2,3-d]pyrimidine 7 and 2-amino-4

191 Synthesis was achieved from 2,4-diamino-5-methypyrrolo[2,3-d]pyrimidine and substituted

192 AGF152 (6) and AGF163 (8), 2,4-diamino-5-substituted-furo[2,3-d]pyrimidine thiophene re

193 Racemic 2,2'-diamino-6,6'-dimethylbiphenyl is resolved using simulate

194 MF under similar reaction conditions the 2,3-diamino-6,7-dibromo isomer was observed as the major reg

195 ynthesis of 2,7-diamino-3,6-dibromo- and 2,3-diamino-6,7-dibromo-NDIs for the first time.

196 SAR exploration of the 2,4-diamino-6,7-dimethoxyquinazoline template led to the dis

197 Initial SAR exploration of the 2,4-diamino-6,7-dimethoxyquinazoline template represented by

198 lfonyl]pyrido[3, 2-d]pyrimidine (7), and 2,4-diamino-6-(2', 5'-dimethoxyanilino)pyrido[3,2-d]pyrimidi

199 hoprim (TMP), the heretofore undescribed 2,4-diamino-6-(2',5'-disubstituted benzyl)pyrido[2,3-d]pyrim

200 the most potent, to 90.4 x 10(-6) M for 2,4-diamino-6-(4'-methoxyanilino)pyrido[3,2-d]pyrimidine (12

201 A series of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines were

202 Nineteen previously undescribed 2,4-diamino-6-(arylmethyl)-5,6,7, 8-tetrahydroquinazolines (

203 from p-(N-methyl)aminobenzoic acid with 2,4-diamino-6-(bromomethyl)pteridine gave the target compoun

204 ylamine analogues were synthesized from 2, 4-diamino-6-(bromomethyl)pteridine in 50-75% yield by reac

205 ctive (the less active enantiomer, S-(-)-2,4-diamino-6-(fluromethyl)-5-(2,3,5-trichlorophenyl)-pyrimi

206 member of the lamotrigine family, R-(-)-2,4-diamino-6-(fluromethyl)-5-(2,3,5-trichlorophenyl)-pyrimi

207 pcDHFR ranged from 0.0023 x 10(-6) M for 2,4-diamino-6-(N-methyl-3',4'-dimethoxyanilino)pyrido[3, 2-d

208 phenyl)thio]pyrido[3,2-d]pyrimidine (4), 2,4-diamino-6-[(2'-methoxyphenyl)sulfonyl]pyrido[3, 2-d]pyri

209 trimetrexate (TMQ) or PTX, most notably 2, 4-diamino-6-[(3',4'- dimethoxyphenyl)thio]pyrido[3,2-d]pyr

210 Three simple 2, 4-diamino-6-alkyl-5,6,7,8-tetrahydroquinazoline model comp

211 tituted anilines with pivaloyl protected 2,4-diamino-6-bromo-pyrido[2,3-d]pyrimidine was successfully

212 4-6 was achieved by aryl displacement of 2,4-diamino-6-chloropyrido[3, 2-d]pyrimidine (27) with thiol

213 Toward this end, 2,4-diamino-6-hydroxypyrimidine (DAHP) has been used as the

214 Condensation of 2,4-diamino-6-hydroxypyrimidine 6 with 5a-d afforded the 6-s

215 bromomethylketones and condensation with 2,4-diamino-6-hydroxypyrimidine afforded the 6-substituted p

216 Compound 2 was obtained from 2,4-diamino-6-hydroxypyrimidine and 1, 3-dichloroacetone.

217 O synthase because GPTCH-1 blockade with 2,4-diamino-6-hydroxypyrimidine during shear inhibited dimer

218 ndensation of 3-bromo-4-piperidone with 2, 4-diamino-6-hydroxypyrimidine to afford regiospecifically

219 mine, and an inhibitor of BH4 synthesis (2,4-diamino-6-hydroxypyrimidine) uncoupled eNOS, increasing

220 r of BH(4), because the GTPCH inhibitor, 2,4-diamino-6-hydroxypyrimidine, blocked cytokine-stimulated

221 ited by the GTP-cyclohydrolase inhibitor 2,4-diamino-6-hydroxypyrimidine.

222 Reduction of commercially available 2,4-diamino-6-nitroquinazoline 14 with Raney nickel afforded

223 yrimidinone 5'-phosphate (compound 3) to 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate (

224 e was shown to catalyze the formation of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (

225 ogues, SCO 1441 and 2687, convert GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (

226 produce the canonical product of GCH II, 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (

227 nucleotide-dependent reduction of either 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (

228 ation of a previously reported series of 2,4-diamino-6-substituted-pyrido[2,3-d]pyrimidines which had

229 ounds synthesized, (2S,8RS,11RS)-5-thia-2,11-diamino-8-methyldodecanedioic acid (11) was the most pot

230 Enantiomerically enriched syn-alpha,beta-diamino acid derivatives can be obtained in excellent yi

231 ategy provided highly substituted alpha,beta-diamino acid derivatives with excellent levels of stereo

232 luoromethyl esters, precursors of alpha,beta-diamino acid derivatives.

233 terminal NlpC/P60 domain (gamma-d-glutamyl-l-diamino acid endopeptidase) and is expected to play an i

234 od-coccus cycle, and contained lysine as the diamino acid in its cell wall.

235 with commercially available fluorophores and diamino acid starting materials.

236 on the photochemical synthesis of amino and diamino acid structures in simulated interstellar and ci

237 cursor to L-lysine is D,L-diaminopimelate, a diamino acid which is incorporated into the pentapeptide

238 Sugar diamino acids (SDAs), which differ from the widely used

239 otected delta,epsilon-unsaturated alpha,beta-diamino acids as templates for the preparation of 12 new

240 differentially protected erythro-alpha,beta-diamino acids from N-tosyloxy beta-lactams is reported.

241 ock approach for the synthesis of alpha,beta-diamino acids is described, which involves the diastereo

242 tes for the preparation of 12 new alpha,beta-diamino acids of biological relevance using simple techn

243 ptides prepared using commercially available diamino acids, which are Alloc-protected on the side-cha

244 Elaboration of these beta,gamma-diamino and alpha-hydroxy-beta,gamma-diamino esters gave

245 ly obtained at room temperature using amino, diamino, and triamino silica at recoveries of 93% (11 h)

246 ategy for the synthesis of chiral alpha,beta-diamino- and alpha-amino,beta-hydroxy ester derivatives

247 le carbamate synthon 6 with various terminal diamino- and dihydroxyalkanes.

248 pounds with fluoro-, cyano-, nitro-, amino-, diamino-, and nitroamino substituents are expected to em

249 reaction between substituted orthoesters and diamino benzene dithiol.

250 ups, we have investigated the effects of the diamino biguanide compound metformin and of hyperglycemi

251 xidant and gives rise to anti-configured 2,3-diamino carboxylates as bicyclic sulfamate derivatives.

252 A series of amino alcohol- and diamino-cis-decalins were synthesized and their conforma

253 he first example, to our knowledge, of a 2,4-diamino classical antifolate that has potent inhibitory

254 tant kinases (Arg to Ala mutations) by small diamino compounds, particularly imidazole; however, the

255 the MCMs with pH-insensitive pyrazine-based diamino cross-linkers, pH-responsive, photonic multicomp

256 kinetically by the subsequent addition of a diamino crosslinking agent, which underwent covalent cro

257 The cis diamino derivative showed a stronger hyperporphyrin effe

258 ng H-Trp-Arg-Nva-Arg-Tyr-NH(2) using various diamino-dicarboxylic acids containing either di-, tri-,

259 The solution structures of the dilithiated diamino diethers are also characterized by a variety of

260 Three dilithiated diamino diethers including (2S,2'S)-1,1'-(butane-1,4-diy

261 Four different chiral diamino diethers synthesized from N-isopropyl valinol or

262 Crystal structures of the dilithiated diamino diethers were determined by X-ray diffraction.

263 Coupling of 20a-d and 28 with the known diamino diol 22 delivered 9-13.

264 the diazotization reaction of dapsone (4,4'-diamino-diphenyl sulphone, DAP) and (naphthyl)ethylenedi

265 latter effect rests on stabilization of the diamino enol tautomer by Dipp substitution, and could be

266 denes readily form isolable, though reactive diamino enols with aldehydes and enals.

267 eto tautomers of imidazolidinylidene-derived diamino enols, and computational thermodynamic data for

268 a,gamma-diamino and alpha-hydroxy-beta,gamma-diamino esters gave the protected forms of the 3-deoxy-3

269 was saponified and coupled with alpha,gamma-diamino esters to afford the corresponding dipeptide der

270 o the corresponding alpha-hydroxy-beta,gamma-diamino esters.

271 ugmenting the accessible range of beta,gamma-diamino esters.

272 o- and diastereoisomerically pure beta,gamma-diamino esters.

273 The reaction of diaryl ketoalkynes with 1,2-diamino ethane leads to the full scission of the triple

274 urface structure has been documented for 1,2-diamino ethane radical cation and features two parallel

275 Nine classic diamino furo[2,3-d]pyrimidine antifolates with unsubstit

276 ationic polymer poly(cystamine bisacrylamide-diamino hexane) (p(CBA-DAH)) was modified with poly(ethy

277 o crude mixtures of porphyrazines containing diamino-hexapropyl-porphyrazine magnesium complexes.

278 DAHP (2,4-diamino hydroxyl pyrimidine), a specific inhibitor of GC

279 regioselectively, while without TBAF the 2,3-diamino isomer was formed exclusively.

280 , as in dichloromethane without TBAF the 2,7-diamino isomer was formed regioselectively, while withou

281 he corresponding difunctionalized alpha,beta-diamino methyl esters 15-18, 20.

282 rrolo[2, 3-d]pyrimidine ring binds in a "2,4-diamino mode" in which the pyrrole nitrogen mimics the 4

283 Legionaminic acid is a nine-carbon diamino monosaccharide that is found coating the surface

284 es 7-hydroxy methotrexate (7-OH MTX) and 2,4-diamino-N(10)-methylpteroic acid (DAMPA) in pure solutio

285 ound that the conventional beta-alanine-3,3'-diamino-N-methyldipropylamine (betaDa) linker strongly l

286 The combination of a bent diamino(nickel(II) porphyrin) with 2-formylpyridine and

287 taining the divalent metal chelator ethylene diamino-o-dihydroxyphenyl acetic acid, and the addition

288 ages were synthesized from substituted 4,4''-diamino-p-terphenyls, 2-formylpyridine, and iron(II).

289 lamine, n-propylamine, n-butylamine, and 1,5-diamino pentane as mimics for the side chain of lysine (

290 PS transformations of 1,6- and/or 1,7-diamino perylenes result in 2-fold annulated nitrogen-co

291 tic protocol for the formation of alpha,beta-diamino phenyl alanine derivatives.

292 robenzene sulfonic acid), the DNA stain 4',6-diamino-phenylindole, and confocal laser scanning micros

293 Epoxy groups were used to bind a layer of diamino-poly(ethylene glycol) (DAPEG) with terminal amin

294 The resulting diamino products belong to imidazolidine analogue and ca

295 pyrazine-bis(carboxamides) derived from 3,5-diamino-pyrazine-2,5-dicarboxylic acid bearing neutral a

296 ketone (8) followed by condensation with 2,6-diamino-pyrimidin-4-one (7) to afford the substituted fu

297 thyl-2',7'-difluorofluorescein diacetate and diamino-rhodamine-4M, respectively.

298 nes to give the corresponding monoamino- and diamino-substituted porphyrins in high yields under mild

299 lore the regioselectivity as three different diamino-substituted regioisomeric products can be formed

300 st members of a new family of spiro-bis-(1,9-diamino-substituted-phenalenyl)boron neutral radicals.

301 timization of orally active antimalarial 2,4-diamino-thienopyrimidines and with the help of metabolit