ライフサイエンスコーパス: diaminopimelic acid

1 lycan-derived muropeptides that contain meso-diaminopimelic acid.

2 rectly convert tetrahydrodipicolinate to L,L-diaminopimelic acid.

3 mosome to impose an obligate requirement for diaminopimelic acid.

4 r the bacterial synthesis of lysine and meso-diaminopimelic acid.

5 , and 42% had peptide side chains containing diaminopimelic acid, 29% of which was involved in cross-

6 es are probably involved in the synthesis of diaminopimelic acid (a component of peptidoglycan), main

7 tinal bacteria bearing gamma-d-glutamyl-meso-diaminopimelic acid, a ligand for the intracellular pept

8 ctrometry) analysis of the unique amino acid diaminopimelic acid (after derivatization with isopropyl

9 Diaminopimelic acid, also formed by this enzymatic pathw

10 The dapE operon enzymes synthesize both meso-diaminopimelic acid and lysine and, therefore, represent

11 NOD1 and NOD2 ligands (gamma-d-glutamyl-meso-diaminopimelic acid and muramyl dipeptide, respectively)

12 e bacterial components gamma-d-glutamyl-meso-diaminopimelic acid and muramyl dipeptide, respectively.

13 Mutants also retain more diaminopimelic acid and N-acetylmuramic acid during germ

14 ts N-succinyl-L,L-diaminopimelic acid to L,L-diaminopimelic acid and succinate.

15 amidation at the alpha-(l)-carboxyl of meso-diaminopimelic acid and the presence of muropeptides cro

16 ctodomains together and the critical role of diaminopimelic acid as the specificity determinant for P

17 sulting in defective cell wall synthesis and diaminopimelic acid auxotrophy.

18 aA, i.e., hydrolysis of the gamma-D-glutamyl-diaminopimelic acid bond in the murein tripeptide L-alan

19 Hydrolysis of N-succinyl-L,L-diaminopimelic acid by the dapE-encoded desuccinylase is

20 NOD1 recognizes diaminopimelic acid-containing dipeptide or tripeptide m

21 Nod1, a cytosolic protein that senses meso-diaminopimelic acid-containing ligands derived from pept

22 Diaminopimelic acid-containing peptidoglycan, produced b

23 ved LPXTG motif and the amino group of the m-diaminopimelic acid crossbridge within the listerial pep

24 , UDP-N-acetylmuramyl-L-Ala-gamma-D-Glu-meso-diaminopimelic acid-D-Ala-D-Ala (UDP-MurNAc-pentapeptide

25 y N-acetylmuramyl-L-alanine-D-glutamate-meso-diaminopimelic acid-D-alanyl-D-alanine, whereas those is

26 usly used to synthesize amino-differentiated diaminopimelic acid (DAP) and biologically active analog

27 asd, resulting in obligate requirements for diaminopimelic acid (DAP) and d-alanine for growth.

28 n to occur by way of a pathway that utilizes diaminopimelic acid (DAP) as a central intermediate, the

29 We generated a diaminopimelic acid (DAP) auxotroph (AA400) of L. pneumo

30 A variant of the diaminopimelic acid (DAP) pathway uses diaminopimelate a

31 tion by amidation of cell wall peptidoglycan diaminopimelic acid (DAP) residues.

32 lysine biosynthetic pathway converting meso-diaminopimelic acid (DAP) to l-lysine.

33 It was found that a diaminopimelic acid (DAP)-containing muramyl tetrapeptid

34 itive (lysine-containing) and Gram-negative (diaminopimelic acid (DAP)-containing) bacteria to demons

35 Thirteen mono-N-acyl derivatives of 2,6-diaminopimelic acid (DAP)-new potential inhibitors of th

36 Mutants of a diaminopimelic acid (Dap)-requiring strain of Escherichi

37 bacterial infections through recognition of diaminopimelic acid (DAP)-type peptidoglycan and activat

38 and secreted/cytosolic PGRP-LE, which relay diaminopimelic acid (DAP)-type peptidoglycan sensing to

39 of the muramyl peptides was replaced by meso-diaminopimelic acid (DAP).

40 Here, we find that N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) facilitates fun

41 ing sites in the dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) from Haemophilu

42 N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) is a key enzyme

43 nhibitors of the dapE-encoded N-succinyl-l,l-diaminopimelic acid desuccinylase (DapE; EC 3.5.1.18)-we

44 The dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase functions in a late st

45 In E. coli, dapE encodes N-succinyl-L-diaminopimelic acid desuccinylase, which catalyzes the h

46 , whereas PGN of Bacillus subtilis with meso-diaminopimelic acid directly tethered with d-alanine is

47 -N-acetylmuramyl-l-alanyl-d-isoglutamyl-meso-diaminopimelic acid (GM-triDAP), human monocyte-derived

48 imulatory molecules is gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP), but the identity of the ma

49 its agonist, bacterial gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP), in term trophoblast cultur

50 imal component of bacterial cell walls, meso-diaminopimelic acid (iE-DAP).

51 tiates inflammation in response to bacterial diaminopimelic acid (iE-DAP).

52 y NOD1 is a dipeptide, gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP).

53 Biosynthesis of lysine and meso-diaminopimelic acid in bacteria provides essential compo

54 es forming a subsite to accommodate meso-2,6-diaminopimelic acid in both the DD-carboxypeptidase and

55 de or tripeptide side chains, and 11% of the diaminopimelic acid in these side chains was involved in

56 plasmid inhibits the incorporation of [(3)H]diaminopimelic acid into cell wall and leads to a profil

57 N-acetylmuramyl-Ala-gamma-Glu-A2pmAla (A2pm, diaminopimelic acid), is released by Bordetella pertussi

58 l L,L diaminopimelic acid (L,L-NSDAP) to L,L-diaminopimelic acid (L,L-DAP) and succinate.

59 llohydrolase which hydrolyses N-succinyl L,L diaminopimelic acid (L,L-NSDAP) to L,L-diaminopimelic ac

60 E was shown to only hydrolyze L,L-N-succinyl-diaminopimelic acid (L,L-SDAP) and was inactive toward D

61 sis of N-succinyl-L-diaminopimelic acid to L-diaminopimelic acid (L-DAP) and succinate.

62 , the enzyme immediately preceding it in the diaminopimelic acid/lysine biosynthetic pathway.

63 The synthesis of meso-diaminopimelic acid (m-DAP) in bacteria is essential for

64 inylase pathway for the biosynthesis of meso-diaminopimelic acid (meso-DAP) and L-lysine.

65 ining protein-1 (Nod1, which recognizes meso-diaminopimelic acid (mesoDAP)-containing peptidoglycan f

66 etal-dependent, with a Km for N-succinyl-L,L-diaminopimelic acid of 1.3 mM and a turnover number of 2

67 et interact with the third position meso-2,6-diaminopimelic acid residue of the peptidoglycan stem pe

68 ation is the free carboxyl group of the meso-diaminopimelic acid residue.

69 sidues and direct cross-linkage between meso-diaminopimelic acid residues.

70 synthesis of orthogonally protected meso-2,6-diaminopimelic acid, starting from easily accessible chi

71 nzyme discriminates between L-lysine and D,L-diaminopimelic acid, the predominant amino acid that rep

72 p of the pathway and converts N-succinyl-L,L-diaminopimelic acid to L,L-diaminopimelic acid and succi

73 ich catalyzes the hydrolysis of N-succinyl-L-diaminopimelic acid to L-diaminopimelic acid (L-DAP) and

74 l dipeptide (MDP) and l-Ala-gamma-D-Glu-meso-diaminopimelic acid (Tri-DAP) into cells.

75 Drosophila, the Imd pathway is activated by diaminopimelic acid-type peptidoglycan and triggers the

76 rosophila immune response, bacterial derived diaminopimelic acid-type peptidoglycan binds the recepto

77 y mediate discrimination between lysine- and diaminopimelic acid-type PGNs.

78 he bacterial dipeptide gamma-d-glutamyl-meso-diaminopimelic acid was intact in MyD88 deficient mice b

79 etitive inhibitors of the substrate, but d,d-diaminopimelic acid was not.

80 in tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelic acid, was demonstrated in the cell extrac

81 ptane-2,2'-dicarboxylic acid, an analogue of diaminopimelic acid, was prepared in racemic form and th

82 Both L,L- and D,L-diaminopimelic acid were competitive inhibitors of the s

83 threonine and the side-chain amino group of diaminopimelic acid within the cell wall peptidoglycan o

84 mide-linked to the side chain amino group of diaminopimelic acid within the peptidoglycan peptide ste

85 mide linked to the side chain amino group of diaminopimelic acid within the wall peptides of B. anthr