ライフサイエンスコーパス: diapause

1 oward sugar feeding and lipid sequestration (diapause).

2 e in response to starvation (L1 arrest or L1 diapause).

3 e between reproductive development and dauer diapause.

4 gulate the response to starvation-induced L1 diapause.

5 l pests, DH prompts the termination of pupal diapause.

6 al of nematodes during starvation-induced L1 diapause.

7 DH antagonist that blocks the termination of diapause.

8 rvae that are environmentally programmed for diapause.

9 on of the timing of entry into and exit from diapause.

10 hat are much more active than DH in breaking diapause.

11 to enter diapause and how long to remain in diapause.

12 about the molecular modifications underlying diapause.

13 egulate longevity, stress response and dauer diapause.

14 icles were arrested in a stage comparable to diapause.

15 vely expressed ancestral life history trait: diapause.

16 rmone signaling, which is a prerequisite for diapause.

17 hromosomes and remain arrested throughout L1 diapause.

18 y, is not required for germline arrest in L1 diapause.

19 to take a blood meal upon the termination of diapause.

20 arrest, implying that CeTOR regulates dauer diapause.

21 of type-Ia(1) cells can impede induction of diapause.

22 t on the duration of the overwintering pupal diapause.

23 rvae on the photoperiodic induction of pupal diapause.

24 an important role in the induction of pupal diapause.

25 l instar but are highly upregulated in early diapause.

26 and are then downregulated throughout pupal diapause.

27 late diapause, or intermittently throughout diapause.

28 of many genes that were downregulated during diapause.

29 ted throughout the fly's overwintering pupal diapause.

30 fourfold, even in adults that mature without diapause.

31 he deficient strain is unable to enter dauer diapause.

32 sipalpis, show expression patterns unique to diapause.

33 in the intestinal epithelial cells at larval diapause.

34 ter a state of dormancy similar to embryonic diapause.

35 n important role in the modulation of larval diapause.

36 it remains unknown how ILPs modulate larval diapause.

37 here were nine identical pathways related to diapause.

38 cells lacking Mga are lost during embryonic diapause.

39 hysiological processes both before and after diapause.

40 ntriguing maternal effects that regulate egg diapause.

41 ASI neuron pair, to promote entry into dauer diapause.

42 ct species to prepare for winter by inducing diapause.

43 sa191), causes constitutive entry into dauer diapause.

44 Late in diapause (2-3 months at 18 degrees C), the genes encodin

45 Diapause, a dominant feature in the life history of many

46 logical element that is necessary to trigger diapause, a gyne trait.

47 se environments, animals arrest at the dauer diapause, a long-lived stress resistant stage.

48 onse to protect embryos in utero by inducing diapause, a natural form of suspended animation.

49 The exception to this rule is embryonic diapause, a reversible state of suspended development tr

50 n synthesis inhibition, but in the course of diapause, a state of dormancy and increased stress toler

51 es for vector persistence include dry-season diapause (aestivation) and long-distance migration (LDM)

52 cumnatal life history strategies, voltinism, diapause, aestivation, oviposition site, clutch size, an

53 vated by FOXO are highly up-regulated during diapause and are thus strong candidates for implementati

54 ot included in our experiments (e.g., during diapause and gonad maturation), and for contaminant tran

55 his information to regulate whether to enter diapause and how long to remain in diapause.

56 and embryonic development, as well as dauer diapause and life span, and that DAF-16 transduces these

57 story traits, including entry into the dauer diapause and longevity.

58 or Rb critically promotes survival during L1 diapause and most likely does so by regulating the expre

59 performed to examine the differences between diapause and non-diapause eggs at both transcriptional a

60 These clones were then screened against diapause and nondiapause pupal poly(A)+ Northern blots.

61 d clones, 8 clones expressed equally in both diapause and nondiapause, and 75 clones without detectab

62 mpose large fitness costs on insects showing diapause and other life cycle responses, threatening pop

63 les in cryoprotection and storing energy for diapause and post-diapause stages.

64 hronic acid (DA) promote bypass of the dauer diapause and proper gonadal migration during larval deve

65 when the animal makes the commitment between diapause and reproductive development.

66 a crucial role in the decision between dauer diapause and reproductive growth.

67 response (UPR) in promoting entry into dauer diapause and suggest that, in addition to cell-autonomou

68 an Hsp70 cognate, Hsc70, is uninfluenced by diapause, and Hsp90 is actually down-regulated during di

69 uggesting a general link between metabolism, diapause, and longevity.

70 Insects accumulate reserves prior to diapause, and metabolic depression during diapause promo

71 on patterns: Some are upregulated throughout diapause, and others are expressed only in early diapaus

72 o Culex pipiens into its overwintering adult diapause, and these two critical signaling pathways appe

73 Fall migrants are in reproductive diapause, and they use a time-compensated sun compass to

74 Scys-A transcripts are present in both diapause- and non-diapause-destined third instar wanderi

75 lations but differs between reproductive and diapausing animals.

76 ion of starvation-induced adult reproductive diapause (ARD) in Caenorhabditis elegans.

77 ogical processes and initiation mechanism of diapause are not well understood.

78 climate change, plastic responses involving diapause are often critical for population persistence,

79 and factors affecting population growth and diapause are reviewed.

80 defective phenotype and are epistatic to the diapause arrest and life span extension phenotypes of da

81 portant rice pest in Asia enters facultative diapause as larvae.

82 e also discuss other possible candidates for diapause-associated nutrient regulation including adipok

83 g at the surface and the rest of the year in diapause at depth.

84 including an option for dauer formation and diapause at larval stage L3 in adverse environments.

85 l state corresponding to the epiblast of the diapaused blastocyst and indicate that mTOR regulates de

86 ion, maintain a gene expression signature of diapaused blastocysts and remain pluripotent.

87 We show that both naturally diapaused blastocysts in vivo and paused blastocysts ex

88 Indeed, c-Myc is depleted in diapaused blastocysts, and the differential expression s

89 ecision to enter diapause or the duration of diapause, but it had a profound effect on the pupa's abi

90 not required for the animals' entry into L1 diapause, but plays a critical role in long-term surviva

91 ly grown, third-instar larvae programmed for diapause by a photoperiodic (short-day) signal were assa

92 atures, female Cx. pipiense prepares for the diapause by actively feeding on carbohydrates to increas

93 role of asm-3 in regulation of lifespan and diapause by modulating IIS pathway.

94 y period, the northern boundaries of modeled diapausing C. glacialis expanded poleward and the annual

95 n the tobacco hornworm, Manduca sexta, pupal diapause can be induced by exposure of fifth-instar larv

96 squito Culex pipiens to enter a reproductive diapause characterized by an arrest in ovarian developme

97 nals, the ascarosides, control developmental diapause (dauer), olfactory learning, and social behavio

98 GE-1 protein controls lifespan and the dauer diapause decision.

99 one of two developmental fates (adulthood or diapause) depending on environmental conditions.

100 eed with reproductive development or undergo diapause depends on food abundance, population density,

101 Diapause-destined adult females and nondiapausing counte

102 trypsin-like protease) are down-regulated in diapause-destined females, and that concurrently, a gene

103 cripts are present in both diapause- and non-diapause-destined third instar wandering larvae, and are

104 pupal diapause, dynamically regulated across diapause development, and differentially regulated after

105 ccession of eco-physiological phases termed "diapause development." The phasing is varied in the lite

106 ofile, we could readily distinguish distinct diapause developmental phases associated with induction/

107 y) signal were assayed as they traversed the diapause developmental program.

108 ctually down-regulated during diapause, thus diapause differs from common stress responses that elici

109 identified 4 diapause-up-regulated clones, 7 diapause-down-regulated clones, 8 clones expressed equal

110 In contrast, it regulates diapause during development.

111 e seasons in a hormonally regulated state of diapause during which their activity ceases, development

112 thways differentially regulated during pupal diapause, dynamically regulated across diapause developm

113 In contrast, cysts formed during the diapause egg-resting stages of many metazoans share feat

114 e populations, and from residual, historical diapausing egg banks.

115 ine the differences between diapause and non-diapause eggs at both transcriptional and translational

116 addition, it reveals cellular metabolism in diapause eggs is more active than in non-diapause eggs,

117 in diapause eggs is more active than in non-diapause eggs, and up-regulated enzymes may play roles i

118 In post-diapausing eggs, 100% of viral mRNAs had sequence 1 at t

119 hetically active (embryonating) and dormant (diapausing) eggs.

120 Analysis of embryonic stem cells and diapaused embryos reveals near-complete conservation of

121 Diapausing embryos in utero require san-1 to survive, in

122 ential expression signatures of dKO ESCs and diapaused epiblasts are remarkably similar.

123 dependently confirmed this ability to impact diapause expression through genetic complementation mapp

124 ts are functionally distinct with respect to diapause expression, and the polymorphism also shows geo

125 We show that two signatures of diapause (extended maturation time and enhanced synthesi

126 tant exits L1 arrest and IIS-dependent dauer diapause faster than control worms, but is not involved

127 As the females then enter diapause, fatty acid synthase is only sporadically expre

128 We propose the definition of "metabolic diapause" for the changes induced by Foxo1 to protect be

129 C. elegans diapause, gonadal outgrowth, and life span are regulated

130 The study of hormonal regulation of mosquito diapause has focused primarily on adult diapause, with l

131 e genetic basis for environmental control of diapause has wider implications for evolutionary respons

132 Environmental and hormonal regulators of diapause have been reasonably well defined, but our unde

133 diapause in moths is the 24-aa neuropeptide, diapause hormone (DH).

134 atory peptide 2b (CAPA); CAPAr, 2) pyrokinin/diapause hormone (PK1/DH); PKr-A, -B, 3) pyrokinin/phero

135 risk-spreading, particularly in facultative diapause, I have been unable to find any definitive test

136 rates of C. glacialis individuals attaining diapause in a circumpolar transition zone increased subs

137 cell infection and during embryogenesis and diapause in A. triseriatus eggs.

138 erlying evolutionary genetic architecture of diapause in any organism.

139 Here we demonstrate embryonic diapause in C. elegans, and show that this diapause prot

140 G protein signaling pathways control meiotic diapause in C. elegans, highlighting contrasts and paral

141 mate finding, aggregation, and developmental diapause in Caenorhabditis elegans, but it is unknown wh

142 regulator of longevity, metabolism and dauer diapause in Caenorhabditis elegans.

143 ified by the diverse developmental stages of diapause in closely related species.

144 ole of the circadian clock in the control of diapause in Drosophila and other insects.

145 We examine the genetic control of diapause in insects and show how the failure to recogniz

146 Low temperature induces diapause in locusts.

147 hway influences longevity, reproduction, and diapause in many organisms.

148 One of the hormones that regulates diapause in moths is the 24-aa neuropeptide, diapause ho

149 of the timeless gene affect the incidence of diapause in response to changes in light and temperature

150 p-regulation of Hsps appears to be common to diapause in species representing diverse insect orders i

151 ARD differs from the C. elegans dauer diapause in that it enables sexually mature adults to de

152 omics tools to identify molecules linked to diapause in the locust.

153 ic variation in the photoperiodic control of diapause in the pitcher-plant mosquito Wyeomyia smithii

154 one, an endocrine trigger known to terminate diapause in this species.

155 ey characteristic of overwintering dormancy (diapause) in the mosquito Culex pipiens is the switch in

156 ad to the induction of developmental arrest (diapause) in their progeny, allowing winter survival of

157 osely mirrors the known latitudinal cline in diapause incidence.

158 Up-regulated genes related to diapause included glutathiones-S-transferase et al., and

159 thin and among populations; the incidence of diapause increases with more temperate climates and has

160 Diapausing insects pass through a stereotypic succession

161 nerations, depending on weather, facultative diapause interrupts host feeding and oogenesis, and flie

162 Diapause is a complex and dynamic process.

163 Diapause is a complex phenotype, and FOXO emerges as a p

164 Nutrient utilization during diapause is a dynamic process, and insects appear capabl

165 us propose that up-regulation of Hsps during diapause is a major factor contributing to cold-hardines

166 Diapause is a physiological reproductive strategy widely

167 Diapause is a widespread adaptation to seasonality acros

168 The termination of diapause is accompanied by a rapid decline in expression

169 dictates the O(2) tension at which embryonic diapause is engaged.

170 yclic nature of ScP0 regulation during pupal diapause is linked to the JH-mediated metabolic cycles c

171 quiescence of germline development during L1 diapause is not a passive consequence of nutrient depriv

172 The results suggest that insect diapause is not merely a shutdown of gene expression but

173 Diapause is the classic adaptation to seasonality in art

174 The dormant state known as diapause is widely exploited by insects to circumvent wi

175 y of INS-35 and INS-7, which suppress larval diapause, is changed in the intestinal epithelial cells

176 iapause: photoperiodism, hormonal events and diapause itself.

177 e environmental conditions induce a state of diapause known as dauer by inhibiting the conserved DAF-

178 ause, and others are expressed only in early diapause, late diapause, or intermittently throughout di

179 e, indicating that hypoxia-induced embryonic diapause may be mechanistically related to suspended ani

180 s evidence for risk-spreading in facultative diapause, migration polyphenism, spatial distribution of

181 drates on glycogen and lipid biosynthesis in diapausing mosquitoes was investigated in vivo using 13C

182 e and glucose are metabolized differently in diapausing mosquitoes.

183 Molecular mechanisms involved in diapause nutrient regulation remain poorly known, but in

184 This process of diapause occurs naturally in lactating females or can be

185 "L1 arrest" (also known as "L1 diapause") occurs without morphological modification but

186 Delayed implantation (embryonic diapause) occurs when the embryo at the blastocyst stage

187 After diapause of a double-infected line, sublines were produc

188 enger that is positively correlated with the diapause of C. suppressalis.

189 ity of this response to that observed in the diapause of Drosophila melanogaster and in dauer formati

190 S. crassipalpis with the adult reproductive diapause of Drosophila melanogaster and the larval dauer

191 rchived expression data to compare the pupal diapause of S. crassipalpis with the adult reproductive

192 The adult diapause of the linden bug, Pyrrhocoris apterus, involve

193 Elevated water temperature prolonged summer diapause of the mayfly and shifted its life cycle to the

194 To understand the molecular basis of diapause, 'omics' analyses were performed to examine the

195 ing RNAi did not alter the decision to enter diapause or the duration of diapause, but it had a profo

196 ttle current information available on larval diapause or the intriguing maternal effects that regulat

197 s are expressed only in early diapause, late diapause, or intermittently throughout diapause.

198 Though many genes are shut down during diapause, others are specifically expressed at this time

199 After an autumnally initiated diapause, overwintered flies emerge in spring and reprod

200 inent role in developmental recovery from L1 diapause partly through repressing the expression of cer

201 rves must be sequestered to both survive the diapause period and enable postdiapause development that

202 egulation of the Hsps begins at the onset of diapause, persists throughout the overwintering period,

203 he physiological relevance of the concept of diapause phasing.

204 o (cpo) as a major genetic locus determining diapause phenotype in D. melanogaster and independently

205 h linkage association that variation for the diapause phenotype is caused by a single Lys/Ile substit

206 of the downstream gene FOXO, leading to the diapause phenotype.

207 rse physiological pathways that generate the diapause phenotype.

208 the complex suite of genes that subserve the diapause phenotype.

209 ng functionally related genes - that lead to diapause: photoperiodism, hormonal events and diapause i

210 n-type cryptochrome 2 gene that promotes the diapause program.

211 ent the early steps linked to termination of diapause programming.

212 to diapause, and metabolic depression during diapause promotes reserve conservation.

213 c diapause in C. elegans, and show that this diapause protects embryos from otherwise lethal hypoxia.

214 Several cDNAs isolated from brains of diapausing pupae of the flesh fly, Sarcophaga crassipalp

215 , and control-operated larvae developed into diapausing pupae.

216 To isolate such cDNAs a diapause pupal brain cDNA library was screened by using

217 tion causes young larvae to enter a state of diapause rather than progressing to adulthood.

218 was injected into mosquitoes programmed for diapause (reared under short day lengths) fat storage wa

219 l signaling pathways considered critical for diapause regulation.

220 t gut, the decision between reproduction and diapause relies on an interaction between JH signaling a

221 understanding of the molecular regulation of diapause remains in its infancy.

222 an nuclear receptor, DAF-12, regulates dauer diapause, reproductive development, fat metabolism, and

223 t state by the inhibition of MYC, resembling diapause, requires the presence of the RB family protein

224 How the diapause response can be molded evolutionarily is critic

225 ogically, largely disrupts the photoperiodic diapause response of the wasps.

226 n the insulin signaling pathway, mediate the diapause response.

227 critical for population persistence, but key diapause responses under dry and hot conditions remain p

228 ine signaling, and metabolism that accompany diapause, several of which appear to be common features

229 nked, QTL that overlap with QTL for stage of diapause (SOD), and a QTL that interacts epistatically w

230 as well as developmental arrest at the dauer diapause stage in Caenorhabditis elegans.

231 epletion, its young larvae enter a migratory diapause stage, called the dauer.

232 r arrest development at the long-lived dauer diapause stage.

233 st and an increase in longevity at the dauer diapause stage.

234 eriod from the first feeding stage N3 to the diapausing stage C4).

235 that involves sexual selection, or a sexual diapausing stage that allows survival through harsh peri

236 ion and storing energy for diapause and post-diapause stages.

237 the nematode Caenorhabditis elegans enters a diapause state, termed dauer, which is accompanied by re

238 the dauer stage, a developmentally arrested diapause state.

239 assess whether invertebrates with different diapause strategies have converged toward similar transc

240 The upregulation of Scys-B in early diapause suggests a possible role for this proteinase in

241 hism results in the variable expression of a diapause syndrome that is associated with the seasonal p

242 strong candidates for implementation of the diapause syndrome.

243 The phase of diapause termination is associated with enhanced transcr

244 After diapause termination, C. suppressalis remained in quiesc

245 s dauer state is a hibernation-like state of diapause that displays a dramatic reduction in spontaneo

246 sophila melanogaster exhibits a reproductive diapause that is variable within and among populations;

247 -16/FOXO to induce development into dauer, a diapause that withstands harsh conditions.

248 a, Coleoptera, and Hymenoptera as well as in diapauses that occur in different developmental stages (

249 rthermore, it is shown that prolonged larval diapause (the overwintering stage of the wasp) of a doub

250 ogressed in the dormant overwintering stage (diapause), the predominant scavenged sequence became 5'

251 Diapause, the dormancy common to overwintering insects,

252 As the eggs emerged from diapause, the LAC mRNA 5' termini were more variable; 33

253 n important role in the regulation of larval diapause, the long-lived growth arrest state called daue

254 lopment and promoting long-term survival (L1 diapause), thereby providing an excellent model for the

255 and Hsp90 is actually down-regulated during diapause, thus diapause differs from common stress respo

256 The photoperiod-dependent switch from diapause to reproduction is systemically transmitted thr

257 Inversions on chromosomes 1-3 affecting diapause traits adapting flies to differences in host fr

258 therefore have evidence that genes affecting diapause traits involved in host race formation reside w

259 on with inversion polymorphism affecting key diapause traits, forming adaptive clines.

260 (L1s) halt development in "L1 arrest" or "L1 diapause" until ample food is encountered and triggers s

261 chlings arrest in a dormant state termed "L1 diapause" until food is supplied.

262 The diapause up-regulated Hsps include two members of the Hs

263 The diapause-up-regulated and down-regulated clones were fur

264 The secondary screen identified 4 diapause-up-regulated clones, 7 diapause-down-regulated

265 nied by a rapid decline in expression of the diapause-upregulated genes and, conversely, an elevation

266 Classes of diapause-upregulated genes can be distinguished based on

267 Sometime later (perhaps +/-1 million years), diapause variation in the latitudinal clines appears to

268 expression of downstream genes that mark the diapause vs. reproductive states of the gut.

269 ratio of female to male in the initiation of diapause was 0.22.

270 Our results demonstrated in Yangzhou, China, diapause was initiated between September 4 and 12, 2010.

271 elopment, and differentially regulated after diapause was pharmacologically terminated in the flesh f

272 genes based on their functional relevance to diapause, we identified five gene categories of potentia

273 describe also prevents the entry into pupal diapause when administered to larvae that are environmen

274 lic resources is critical for insects during diapause when food sources are limited or unavailable.

275 During diapause, when ATP concentrations are low, heat shock pr

276 east 100 mammalian species exhibit embryonic diapause, where fertilized embryos arrest development in

277 verns glycogen and lipid biosynthesis during diapause, which is fundamental for the insect survival d

278 A comparison of insect diapause with other forms of dormancy in plants and anim

279 uito diapause has focused primarily on adult diapause, with little current information available on l