1 ester reduction, excellent levels of chemo-,
diastereo-, and enantiocontrol can be realized in the re
2 on of cyclobutanones, with excellent regio-,
diastereo-, and enantiocontrol, under mild conditions (2
3 The addition occurs with high regio-,
diastereo-, and enantiocontrol.
4 acid (R,R-1) was developed with high regio-,
diastereo-, and enantiocontrol.
5 n good yields, with rigorous chemo-, regio-,
diastereo-, and enantiocontrol.
6 eaction partner and with outstanding regio-,
diastereo-, and enantiocontrol.
7 to excellent yields and as a single regio-,
diastereo-, and enantiomer is described.
8 A regio-,
diastereo-, and enantioselective [4+3] cycloaddition bet
9 d aldol addition reaction in 1973, the site,
diastereo-, and enantioselective aldol reaction has been
10 The first regio-,
diastereo-, and enantioselective allylic alkylation of a
11 A highly regio-,
diastereo-, and enantioselective allylic alkylation reac
12 Regio-,
diastereo-, and enantioselective coupling reactions betw
13 An organocatalytic and highly regio-,
diastereo-, and enantioselective intermolecular haloethe
14 e report a new method for the highly regio-,
diastereo-, and enantioselective palladium-catalyzed all
15 re thus turned into highly efficient gamma-,
diastereo-, and enantioselective transformations that ex
16 ing quaternary, in excellent chemo-, regio-,
diastereo-, and enantioselectivities in high chemical yi
17 tuted hydroquinolines with excellent regio-,
diastereo-, and enantioselectivities.
18 diaminated in good yields with high regio-,
diastereo-, and enantioselectivities.
19 acids in high yields with excellent regio-,
diastereo-, and enantioselectivities.
20 rresponding aldol products with high regio-,
diastereo-, and enantioselectivities.
21 chlorolactonization suffers from low chemo-,
diastereo-, and enantioselectivities.
22 azines in high yields with excellent regio-,
diastereo-, and enantioselectivities.
23 yields (86-98%) and with outstanding regio-,
diastereo-, and enantioselectivity (88-99% ee).
24 reaction can proceed with very high regio-,
diastereo-, and enantioselectivity and represents a surr
25 substituted cyclic dienones with high site-,
diastereo-, and enantioselectivity has been achieved.
26 The high levels of regio-, anti
diastereo-, and enantioselectivity observed in these rea
27 osyl aldimines and ketimines in high regio-,
diastereo-, and enantioselectivity.
28 icyclo[4.3.1]decadienes in excellent regio-,
diastereo-, and enantioselectivity.
29 ed dihydro-1,2-oxazines in excellent regio-,
diastereo-, and enantioselectivity.
30 ted beta-amino ynones with excellent chemo-,
diastereo-, and enantioselectivity.
31 5a-5o with excellent control of regio-, anti-
diastereo-, and enantioselectivity.
32 c alcohols with excellent control of regio-,
diastereo-, and enantioselectivity.
33 The development of the first enantio-,
diastereo-, and regioselective iridium-catalyzed allylic
34 in high yields and with excellent enantio-,
diastereo-, and regioselectivity through catalytic asymm
35 l possible stereoisomers with high enantio-,
diastereo-, and regioselectivity.
36 nale for the origins of the observed regio-,
diastereo-, and stereoselectivity and of the unusual rea
37 ters, giving anti-dihydropyranones with high
diastereo- and enantiocontrol (up to 98:2 dr, up to 99%
38 g carbo- and heterocyclic products with high
diastereo- and enantiocontrol (up to 99:1 dr, up to 99%
39 In the benzaldehyde series, optimal product
diastereo- and enantiocontrol is observed using 2-nitrob
40 The [3,3]-rearrangement occurs with high
diastereo- and enantiocontrol, forming beta-imino amides
41 angement in good overall yield and with good
diastereo- and enantiocontrol.
42 four contiguous stereocenters with complete
diastereo- and enantiomeric control by a formal [2 + 2]-
43 the addition products were obtained in high
diastereo- and enantiomeric purity.
44 eated in a single-pot operation in excellent
diastereo- and enantiomeric ratios.
45 verted, in situ, to the catalytically active
diastereo- and enantiomerically pure N-heterocyclic carb
46 The preparation of
diastereo- and enantiopure 1,2-amino alcohols is also re
47 o orthogonal mechanisms and are converted to
diastereo- and enantiopure amines bearing adjacent stere
48 Herein, four new fluorinated
diastereo- and enantiopure isatin sulfonamide-based pote
49 ranched and functionalized aldehydes of high
diastereo- and enantiopurity.
50 l-containing side chains with high levels of
diastereo- and enantioselection.
51 nthesis has been accomplished using a highly
diastereo- and enantioselective [4 + 2] annulation for t
52 ghly effective in promoting the first direct
diastereo- and enantioselective addition of alkylazaaren
53 The first highly
diastereo- and enantioselective additions of a halogen a
54 Highly
diastereo- and enantioselective additions of substituted
55 An efficient
diastereo- and enantioselective Ag-catalyzed method for
56 We report a highly
diastereo- and enantioselective allylation of azlactones
57 We report highly
diastereo- and enantioselective allylations of substitut
58 ric Mannich-type reactions led to the highly
diastereo- and enantioselective and concise synthesis of
59 is was explored in the development of highly
diastereo- and enantioselective Au(I)-catalyzed cycloadd
60 as nucleophiles to engage in chemo-, regio-,
diastereo- and enantioselective C-C bond-forming reactio
61 Thus, anti-
diastereo- and enantioselective carbonyl crotylation fro
62 A highly chemo-,
diastereo- and enantioselective catalytic method that ef
63 ing ethyl- and phenyl-substituents engage in
diastereo- and enantioselective coupling, as illustrated
64 A
diastereo- and enantioselective CuH-catalyzed method for
65 of cytochrome P450(BM3) that catalyze highly
diastereo- and enantioselective cyclopropanation of styr
66 A novel Cu-catalyzed
diastereo- and enantioselective desymmetrization of cycl
67 heir reactivity is unveiled through a highly
diastereo- and enantioselective Diels-Alder/lactonizatio
68 catalysts was explored in the development of
diastereo- and enantioselective direct aldol reactions o
69 A highly
diastereo- and enantioselective exo-Diels-Alder reaction
70 We describe a palladium-catalyzed
diastereo- and enantioselective formal [3 + 2]-cycloaddi
71 The first catalytic
diastereo- and enantioselective hydroformylation of cycl
72 tabilized cyclic ketone enolates can undergo
diastereo- and enantioselective Ir-catalyzed allylic sub
73 A highly
diastereo- and enantioselective Mannich-type reaction of
74 to the reaction mixture leads to the highly
diastereo- and enantioselective one-pot synthesis of dia
75 tion reagents is described, including highly
diastereo- and enantioselective preparation of numerous
76 A concise
diastereo- and enantioselective route that furnishes the
77 appa agonists restricted to the periphery, a
diastereo- and enantioselective synthesis of (4aR,5S,8aS
78 The first highly
diastereo- and enantioselective synthesis of armeniaspir
79 chiral silane Lewis acid leads to the highly
diastereo- and enantioselective synthesis of beta-chloro
80 ) aldol lactonization (NCAL) process for the
diastereo- and enantioselective synthesis of N-heterocyc
81 MeOH conditions, resulted in an exceedingly
diastereo- and enantioselective synthesis of talo-gamma-
82 constitutes an efficient approach for highly
diastereo- and enantioselective synthesis of tetrahydrof
83 Here, we report a catalytic,
diastereo- and enantioselective three-component strategy
84 A convergent
diastereo- and enantioselective total synthesis of antic
85 Finally,
diastereo- and enantioselective versions of the title re
86 We report a highly regio-,
diastereo- and enantioselective vicinal dihalogenation o
87 and afforded anti-Mannich products with high
diastereo- and enantioselectivities (anti/syn up to 99:1
88 ided the bicyclic derivatives with excellent
diastereo- and enantioselectivities (up to >20:1 dr and
89 The observed
diastereo- and enantioselectivities are determined by bo
90 2 are obtained in high yields with excellent
diastereo- and enantioselectivities from stereochemicall
91 mechanical calculations reveal the origin of
diastereo- and enantioselectivities of aldol reactions b
92 Accomplishing high
diastereo- and enantioselectivities simultaneously is a
93 In most cases, both excellent
diastereo- and enantioselectivities were achieved.
94 With doubly substituted enol lactones, high
diastereo- and enantioselectivities were obtained, thus
95 ive trisubstituted aziridines with excellent
diastereo- and enantioselectivities.
96 products in high yield and with exceptional
diastereo- and enantioselectivities.
97 nd provided the Michael adducts in excellent
diastereo- and enantioselectivities.
98 obutanol substrates proceeded with excellent
diastereo- and enantioselectivities.
99 ffords aldol products with good to excellent
diastereo- and enantioselectivities.
100 btained in good to high yields and excellent
diastereo- and enantioselectivities.
101 gs in high yields and with good to excellent
diastereo- and enantioselectivities.
102 acemic spirocyclic ketones with high yields,
diastereo- and enantioselectivities.
103 quaternary stereocenters in high yields and
diastereo- and enantioselectivities.
104 opanes in high yields (61-99%) and excellent
diastereo- and enantioselectivity (97-99.9% de and ee).
105 inhibitor) in high yield and with excellent
diastereo- and enantioselectivity (98-99.9% de; 96-99.9%
106 iency (up to 46,800 turnovers) and excellent
diastereo- and enantioselectivity (98-99.9%) was develop
107 ketone to form a range of diamides with high
diastereo- and enantioselectivity (up to >95:5 dr and >9
108 -alpha-amino acid derivatives with excellent
diastereo- and enantioselectivity (up to >95:5 dr; up to
109 fins to produce cyclopropanes with excellent
diastereo- and enantioselectivity and in high yield.
110 Rates, yields, turnover,
diastereo- and enantioselectivity are comparable with co
111 idual stereoisomers and showed a significant
diastereo- and enantioselectivity in HIV-1 inhibition, t
112 are exploited to enforce high levels of anti-
diastereo- and enantioselectivity in the formation of an
113 etrasubstituted carbon stereocenters in high
diastereo- and enantioselectivity in the presence of sta
114 The step leading to
diastereo- and enantioselectivity is an asymmetric Picte
115 ding BINOL-derived systems, and the opposite
diastereo- and enantioselectivity is observed.
116 Notably, the observed
diastereo- and enantioselectivity is the opposite of tha
117 The
diastereo- and enantioselectivity obtained experimentall
118 The
diastereo- and enantioselectivity obtained experimentall
119 r can be formed in good yield with excellent
diastereo- and enantioselectivity simply by switching th
120 n high yields with effective control of both
diastereo- and enantioselectivity.
121 aziridine-2-carboxylic esters with very high
diastereo- and enantioselectivity.
122 uous stereocenters in high yields, with good
diastereo- and enantioselectivity.
123 etric byproducts and with high levels of syn-
diastereo- and enantioselectivity.
124 rature, resulting in enhanced levels of anti-
diastereo- and enantioselectivity.
125 opane products in high yields with both high
diastereo- and enantioselectivity.
126 s in high chemical yield with high levels of
diastereo- and enantioselectivity.
127 erate to good yields and with high levels of
diastereo- and enantioselectivity.
128 r bonds in a single operation with excellent
diastereo- and enantioselectivity.
129 prepared in good yields, with high levels of
diastereo- and enantioselectivity.
130 variety of aromatic aldehydes with excellent
diastereo- and enantioselectivity.
131 ha-hydroxy ester in good yield and excellent
diastereo- and enantioselectivity.
132 alcohols with high levels of chemo-, regio-,
diastereo- and enantioselectivity.
133 rnary stereocenter with excellent control of
diastereo- and enantioselectivity.
134 4a-4l with roughly equivalent levels of anti-
diastereo- and enantioselectivity.
135 s syn-alpha-amino acid derivatives with high
diastereo- and enantioselectivity.
136 ond formation 4a-4l with good levels of anti-
diastereo- and enantioselectivity.
137 ing either the syn- or anti-adduct with high
diastereo- and enantioselectivity.
138 high yields with good to excellent levels of
diastereo- and enantioselectivity.
139 yl glycolate derivatives with high levels of
diastereo- and enantioselectivity.
140 alcohol derivatives with excellent levels of
diastereo- and enantioselectivity.
141 chiral [3.1.0]-bicyclic aziridines with high
diastereo- and enantioselectivity.
142 tionalized products with catalyst-controlled
diastereo- and enantioselectivity.
143 l-carbon quaternary centers with exceptional
diastereo- and enantioselectivity.
144 ceeds in nearly quantitative yield with high
diastereo- and enantioselectivity.
145 onalized 2-iminothiazolidines with excellent
diastereo- and enantiospecificity (de, ee up to >99%).
146 rnary stereocenter, generally with excellent
diastereo- and high enantioselectivity.
147 This article presents complete
diastereo- and highly enantioselective synthesis of nitr
148 lanes proceed in good yields giving a single
diastereo- and regioisomer of the branched allylic aceta
149 Key transformations include a
diastereo- and regioselective Pd-mediated intramolecular
150 ons, the cycloaddition reactions were highly
diastereo- and regioselective to yield, in most of the c
151 The first highly efficient,
diastereo- and regioselective transition metal-catalyzed
152 earth abundant Zn as catalyst and is highly
diastereo- and regioselective.
153 20 g L(-1) olefin substrate with no loss in
diastereo- and/or enantioselectivity.
154 These allylboranes undergo highly
diastereo- (> or = 90: 10) and enantioselective (typical
155 N,N-diprotected 1,2-diamines with no loss in
diastereo- or enantioselectivity.
156 ds (Mannich products) in excellent enantio-,
diastereo-, regio-, and chemoselectivities.
157 72-95% yields after purification) as well as
diastereo- (
up to >98:2 dr) and enantioselectivity (up t
158 reocenter with high enantio- (ca. 93% e.e.),
diastereo- (
up to 25:1 d.r.), and regioselectivity (>50: