ライフサイエンスコーパス: diastereoisomer

1 stereoisomer) and (+/-)-isosolenopsin A (cis diastereoisomer).

2 rovide allenyl alcohol product 3 as a single diastereoisomer.

3 ct with four stereogenic centers as a single diastereoisomer.

4 stereoselective manner, leading to a single diastereoisomer.

5 irreversible conversion to a single, stable diastereoisomer.

6 ratio larger than 95:5 in favor of the anti-diastereoisomer.

7 aminophosphonate being obtained as the major diastereoisomer.

8 aside from deuteration, which gives the cis-diastereoisomer.

9 ucture of the berkelic acid core as a single diastereoisomer.

10 ubstituted octahydro[2]pyrindene as a single diastereoisomer.

11 r protection, and were isolated as phosphate diastereoisomers.

12 a different cytostatic activity for the two diastereoisomers.

13 center and therefore can occur as 2 distinct diastereoisomers.

14 reby validating the fluorous-tag encoding of diastereoisomers.

15 ctroscopic data suggest that 7 exists as two diastereoisomers.

16 ghly enantioenriched cyclopropanes as single diastereoisomers.

17 a 1:1 mixture of activated phosphonate ester diastereoisomers.

18 he NAMs, SAMs, and type I PAMs are cis-trans-diastereoisomers.

19 SH-related products including positional and diastereoisomers.

20 n, results in an equilibrium mixture of four diastereoisomers.

21 s some chiral separations of enantiomers and diastereoisomers.

22 reliability of stereochemistry assignment of diastereoisomers.

23 hile 1,2,2-trisubstituted systems afford syn-diastereoisomers.

24 n diastereoisomers, two of the four possible diastereoisomers.

25 in the presence of DCC and DMAP provided two diastereoisomers, 18 and 19, which were separated by fla

26 nt here the first synthesis of the 6S and 6R diastereoisomers 2 and 3, which represent analogues of (

27 of the major metabolites of 2 is its P1-(R)-diastereoisomer, 3 (VRT-394), containing an inversion at

28 d pyrrolidin-2-ones 5 are isolated as single diastereoisomers (40 examples, 33-84% yield).

29 chloride, the most effective receptor is the diastereoisomer 4ii with the two P horizontal lineO grou

30 totoxin (1) delivered, in addition to 4, its diastereoisomers 85-epi-QRSTU and 86-epi-QRSTU ring syst

31 zep ane as the major product and as a single diastereoisomer after chromatography.

32 tional isomers were also resolved to several diastereoisomers, although their stereostructures could

33 ssigned on the basis of COSY spectra of both diastereoisomers and confirmed by HMQC spectra.

34 -bisphosphate but not by their nonbiological diastereoisomers and depends on PH domain mediated bindi

35 tal and molecular structures of 134 pairs of diastereoisomers and of 279 racemic-homochiral pairs wer

36 Many of which could be isolated as single diastereoisomers and without significant erosion of ee,

37 hetic route toward (+/-)-solenopsin A (trans diastereoisomer) and (+/-)-isosolenopsin A (cis diastere

38 he interaction is markedly different between diastereoisomers, and multiple preferred conformations e

39 tected iodoalanine that yielded a mixture of diastereoisomers, and one utilized a trityl-protected io

40 elf is found to have the ability to identify diastereoisomers, and simultaneous use of these chiropti

41 te, carpanone and a so far unknown carpanone diastereoisomer are formed in a 9:1 ratio.

42 s in the VT CD spectra indicate that the two diastereoisomers are interconverting slowly in solution

43 Only two of the four possible diastereoisomers are observed, with diastereomeric ratio

44 For chiral amines, inherently chiral diastereoisomers are observed.

45 These compounds exist as libraries of diastereoisomers as a result of their multiple stereoele

46 ces for the protons corresponding to the two diastereoisomers at a range of coalescence temperatures

47 could be perfectly assembled, with a single diastereoisomer being obtained.

48 f nonactin and all-(-)-nonactin; the natural diastereoisomer bound K(+) 880-fold better than all-(-)-

49 l synthesis of (+)-giganin and its unnatural diastereoisomer (+)-C10-epi-giganin has been completed i

50 ation around the alpha carbon and mixture of diastereoisomers (chloroephedrine and chloropseudoephedr

51 eactions to the synthesis of four propionate diastereoisomers combining an aldol reaction, followed b

52 tion influenced DNA cleavage, metallopeptide diastereoisomers containing L- and D-Arg (or Lys) within

53 The high bioavailability of both diastereoisomers contrasts with previous findings for th

54 electivity (about 120:1) with respect to its diastereoisomer, CP-97,587 (5), which differs structural

55 Here we show that a diastereoisomer, D-GlcNalpha1-6-L-myo-inositol-1-P-sn-1,

56 The final lactones were obtained as single diastereoisomers, demonstrating that the mixture of the

57 conformational enantiomers or conformational diastereoisomers depending on the local symmetry of the

58 he interconversion of the two conformational diastereoisomers derived from each configurationally ena

59 e is known about the pharmacokinetics of the diastereoisomers, despite current interest in developing

60 The diastereoisomers differ in the relative spatial orientat

61 relative to each other, and thus, individual diastereoisomers display different backbone carbon chain

62 livered approximate 1:1 mixtures of syn/anti diastereoisomers due to tiny differences (<0.5 kcal/mol)

63 UHPLC can separate the diastereoisomers (epicoprostanol, coprostanol, and chole

64 nges the rates and mechanisms by which these diastereoisomers equilibrate.

65 NP)]PF(6) as a mixture of noninterconverting diastereoisomers (ester group of 3b trans to P, 5b; or t

66 se of a cyclic procedure where the two minor diastereoisomers from a chiral Lewis acid-catalyzed reac

67 ation, an excess of any one of four possible diastereoisomers from the addition of a thiol and an alk

68 olases are highly discriminating between the diastereoisomers fructose bisphosphate and tagatose bisp

69 oxylated piperidines were isolated as single diastereoisomers (>99:1 dr) in good overall yield.

70 show that the 2-hydroxyterpenylic acid 2R,3R diastereoisomer has a time profile distinctly different

71 hemistry of the phosphorus center of the two diastereoisomers has been suggested.

72 All three carpanone diastereoisomers have been separated by HPLC, and their

73 s highly charge-polarized, wherein different diastereoisomers have distinctively different charge pol

74 ally obtained in high yields and as a single diastereoisomer having the (R*,R*) relative configuratio

75 tereoselectivities were in favor of a single diastereoisomer (I) in all but one case (2-CO(2)R).

76 molecules may then lead to the formation of diastereoisomers, if the enantiomeric interaction proces

77 nts in D2O point to the presence of a single diastereoisomer in solution with a very rigid structure.

78 plates gave (-)-ADMJ and (+)-ADANJ as single diastereoisomers in 16% and 24% overall yield, respectiv

79 possess three stereogenic centers, as single diastereoisomers in high enantioselectivity (83-99% ee)

80 or the biomimetic synthesis of flavonolignan diastereoisomers in milk thistle is proposed to proceed

81 ave been calculated for a set of 28 pairs of diastereoisomers in order to test the ability of NMR shi

82 s aimed at evaluating the potential of these diastereoisomers in the prevention and treatment of estr

83 centers in high optical purity and as single diastereoisomers is now reported.

84 renes, one cis-1 and two unprecedented cis-2 diastereoisomers, is reported.

85 tivity on the R(p) and none against the S(p) diastereoisomer, it bound these duplexes in the same coo

86 The faster eluting diastereoisomer, (-)-lk-9, was revealed to possess an (a

87 Both diastereoisomers not only showed the ability to synthesi

88 methyl acrylate a pathway leading to the two diastereoisomers obtained experimentally is predicted.

89 er of 1 and 2, as for example with the minor diastereoisomer of 1 log(k(d)'/s(-1)) = -4.84 + 0.37pi*

90 ed oligodeoxynucleotides containing a single diastereoisomer of 4-OHEN-dA (Pk-1, Pk-2, and Pk-3) were

91 1, Pk-2, Pk-3, and Pk-4) containing a single diastereoisomer of 4-OHEN-dC were prepared by a postsynt

92 Compound 11 (BI-97C1), the most potent diastereoisomer of compound 4, inhibits the binding of B

93 miscoding properties varied depending on the diastereoisomer of dG-N2-TAM adducts and the DNA pol use

94 seen in mice that were administered LY-D, a diastereoisomer of LY-411,575, which is a very weak gamm

95 ania major NMT were obtained, and the active diastereoisomer of one of the inhibitors was identified.

96 The enantiomers of the major diastereoisomer of oxa- and azabicyclo[3.2.0]heptane der

97 ed oligodeoxynucleotides containing a single diastereoisomer of trans or cis forms of dG-N2-TAM were

98 ese methods to distinguish up to 64 possible diastereoisomers of 117 different molecules, using NMR s

99 The diastereoisomers of 26-trans and 26-cis were synthesized

100 The diastereoisomers of 3 were separated via preferential cr

101 en the analysis of the cis- versus the trans-diastereoisomers of 3-methylcyclohexanol (1-cis versus 1

102 tate superstructures from two conformational diastereoisomers of a homochiral macrocycle is a rare, i

103 alysis, which can resolve the trans- and cis-diastereoisomers of alpha-(N(2)-deoxyguanosinyl)TAM (dG-

104 The route has also been used to prepare two diastereoisomers of anamarine in 14 steps.

105 ep, stereoselective synthesis of each of the diastereoisomers of C30 botryococcene.

106 The diastereoisomers of D-erythroC18-ceramide, D-threo-, and

107 With pol eta, all diastereoisomers of dG-N2-TAM promoted small amounts of

108 ive gramicidin A (gA), and in the SS- and RR-diastereoisomers of dioxolane-linked gA channels (SS and

109 ative gramicidin A (gA) and in the SS and RR diastereoisomers of dioxolane-linked gA channels in plan

110 In each case, and for both diastereoisomers of each probe-protein complex, the hydr

111 A series of diastereoisomers of endomorphin-1 (EM1, Tyr(1)-Pro(2)-Tr

112 y and amenable to scale-up leading to single diastereoisomers of N-Boc and N-Fmoc protected spiroisox

113 ir relative affinities for the (6S) and (6R) diastereoisomers of N5-methyltetrahydrofolate.

114 Site-selective DNA cleavage by diastereoisomers of Ni(II) x Gly-Gly-His-derived metallo

115 diastereoisomer, we generated two alternate diastereoisomers of nonactin, one prepared solely from (

116 te that the enantiomers of ibuprofen and the diastereoisomers of one of its main metabolites, the glu

117 to selectively control the formation of all diastereoisomers of reaction products possessing multipl

118 The syn and anti diastereoisomers of some 1,3,5-triarylisocyanurate deriv

119 tereoselective synthesis of all the possible diastereoisomers of the 2,6-diaryl-3,7-dioxabicyclo[3.3.

120 he key step in the syntheses of all possible diastereoisomers of the homalium alkaloids hoprominol an

121 nt here the first synthesis of the 5R and 5S diastereoisomers of the N-acyl derivatives of 5-hydroxy-

122 al nhatrangins led us to synthesize six more diastereoisomers of the proposed structure of nhatrangin

123 ate, for the first time, the presence of the diastereoisomers of these p-menthane lactones, as well a

124 ing a selective enzyme digestion, one of the diastereoisomers of this compound, (R(p))-E1-3-MTP, coul

125 Several diastereoisomers of unique dC and dA DNA adducts were de

126 the natural (C5'- S) and unnatural (C5'- R) diastereoisomers of uracil polyoxin C methyl ester have

127 containing two equilibrating conformational diastereoisomers, presumably present in unequal molar pr

128 lalanine, the derived deuterium-labeled beta-diastereoisomer product, derivatized as the N-acetyl met

129 PSI-7851 is a mixture of two diastereoisomers, PSI-7976 and PSI-7977, with PSI-7977 b

130 nd 17alpha-(2'R/S)-O-tetrahydropyranyl ether diastereoisomers revealed different combinations of axia

131 The nonsteroidal estrogen equol occurs as diastereoisomers, S-(-)equol and R-(+)equol, both of whi

132 These two conformational diastereoisomers self-organize-and self-sort-in the crys

133 g(H)) in native gramicidin A (gA) and in two diastereoisomers (SS and RR) of the dioxolane-linked gA

134 d are needed for the formation of a nonactin diastereoisomer that can act as an ionophore and has ant

135 corresponding piperidine radical as a single diastereoisomer that may either be trapped by tributylti

136 The stereodivergent synthesis includes diastereoisomers that cannot be selectively synthesized

137 o the formation of cyclopentenones as single diastereoisomers that incorporate two contiguous asymmet

138 In the case of racemic diastereoisomers, the two expected enantiomers (atropiso

139 total synthesis of (+)-varitriol and of two diastereoisomers thereof, which represent an unprecedent

140 cyclic iminium salts were obtained as single diastereoisomers through an atroposelective oxazolidine

141 wo peptides and enabled the identity of each diastereoisomer to be proposed.

142 ture or that required extensive synthesis of diastereoisomers to establish their stereochemistry.

143 formation of either the syn,anti or syn,syn diastereoisomers, two of the four possible diastereoisom

144 l, carpanone is accompanied by two carpanone diastereoisomers unknown so far in a 5:1:4 ratio.

145 We demonstrated that the iooo diastereoisomer was able to function as a multitopic rec

146 the natural product (+)-varitriol and of two diastereoisomers was acomplished.

147 achiral nonactin is the naturally generated diastereoisomer, we generated two alternate diastereoiso

148 Both non-natural diastereoisomers were 500-fold less active against gram

149 ture, and the biological activity of several diastereoisomers were accomplished by our group in 2007

150 or the inactivity and reduced potency of the diastereoisomers were investigated using NMR spectroscop

151 h applies to the case of assigning a pair of diastereoisomers when one has both experimental data set

152 nondesensitizing (type II) PAMs are cis-cis-diastereoisomers, whereas all of the NAMs, SAMs, and typ

153 complex [Ru(6a)(PNNP)](2+) (7a) as a single diastereoisomer, which contains the unsaturated beta-ket

154 n to reside in only one of the four possible diastereoisomers, which exhibited a perfect match with k

155 W 188 compound as a 2-hydroxyterpenylic acid diastereoisomer with 2R,3R configuration.

156 ction proceeds through formation of a single diastereoisomer with high stereoselectivity.

157 ontrolled elimination reaction of one of the diastereoisomers with DBU, followed by hydrogenation, ga

158 functionalized aziridine products as single diastereoisomers with retention of configuration at the

159 roduce stable heteroaromatic atropisomers or diastereoisomers, with one or two N-Csp2 stereogenic axe

160 step in the synthesis generated a couple of diastereoisomers, with only one able to act as a FGF tra