ライフサイエンスコーパス: diastereomer

1 99:1 er after recrystallization of the major diastereomer).

2 syn diastereomer and ca. 2 ppm for the anti diastereomer.

3 rate constant for decomposition of the minor diastereomer.

4 ng four contiguous stereocenters as a single diastereomer.

5 upported the preferential formation of the M diastereomer.

6 configurationally lowest energy (2S,4R,4aR) diastereomer.

7 neralized anomeric effect to afford a single diastereomer.

8 yl fragment and a C6F5-unit as a single anti-diastereomer.

9 od for stereochemical assignment of a single diastereomer.

10 parative scale synthesis of a single product diastereomer.

11 ty and affords the previously unreported syn diastereomer.

12 ytic reaction is formed from the more stable diastereomer.

13 the cyclocoupling product afforded a single diastereomer.

14 in vitro and in vivo, forming a less potent diastereomer.

15 rs of petrocortyne A and the racemate of its diastereomer.

16 t was found to be the cis- and not the trans-diastereomer.

17 ing the deprotected piperidine as single cis diastereomer.

18 ne-3-carboxylates in high yields as a single diastereomer.

19 ly to the final product obtained as a single diastereomer.

20 lectivity, forming the E-alkene as the major diastereomer.

21 a[b]furan derivatives are obtained as single diastereomers.

22 nment of the gas-phase MW data to individual diastereomers.

23 rongly preferred compared to the next stable diastereomers.

24 e corresponding (2S)-2-methyl-3-ketoacyl-ACP diastereomers.

25 differences for C60 binding within the cage diastereomers.

26 vide a better basis for discriminating these diastereomers.

27 converted into either enantiomer as well as diastereomers.

28 rresponding secondary sulfonamides as single diastereomers.

29 sting of monohydroxy species and presumptive diastereomers.

30 tophanes gives rise to the two anti- and syn-diastereomers.

31 are evaluated from the syn and anti reactant diastereomers.

32 cules such as rotamers from nonequilibrating diastereomers.

33 and experimental values of NMR parameters of diastereomers.

34 oup migration to give the products as single diastereomers.

35 st in a kinetically controlled separation of diastereomers.

36 tallization of mixtures of the corresponding diastereomers.

37 o describe the preparation of single peptide diastereomers.

38 adiation generated the two expected cyclized diastereomers.

39 with differences of 3-10x between phostonate diastereomers.

40 st cases, to oxazolines and amides as single diastereomers.

41 ngement delivered the ketone as a mixture of diastereomers.

42 ns support the isomerization to generate two diastereomers.

43 cage to a greater degree than the other two diastereomers.

44 and highly sensitive identification of these diastereomers.

45 ison to stereoisomers such as enantiomers or diastereomers.

46 existing in solution as pairs of two racemic diastereomers.

47 high yields (up to 96%) as a mixture of two diastereomers.

48 -ketols to form [4+2] cycloadducts as single diastereomers.

49 that exists as a pair of pseudo-enantiomeric diastereomers.

50 als corresponding to pairs of conformational diastereomers.

51 reactions to form trialkylboranes as single diastereomers.

52 stereoisomerization of the beta- and gamma- diastereomers.

53 s (HYSs), one of which produces a mixture of diastereomers.

54 f one of three hexabromocyclododecane (HBCD) diastereomers.

55 diffusion in a related set of cyclic peptide diastereomers.

56 nding hydrodimer as a mixture of meso and dl diastereomers.

57 sistent formation of predictable cyclobutane diastereomers.

58 ptane and tetrahydrofuran products as single diastereomers.

59 good diastereoselectivity favoring the trans-diastereomer (11 examples with dr >/= 82:18, dr up to 92

60 on method achieve 65% yield of desired (R,S)-diastereomer 12.

61 tion of the keto function of 23, the correct diastereomer, 12-syn, was converted to lingzhiol (1) via

62 Log D adjustments yielded single diastereomers 14 (TK-666) and 46, showing a broad antiba

63 anes 16 as an approximate 1:1 mixture of two diastereomers (16A and 16B).

64 uently intermolecularly transformed into its diastereomer 2C.

65 pharmacological characterization of the pure diastereomers (2R,7R)- and (2S,7S)-2 and a series of hom

66 cological profile, whereas the C4beta-methyl diastereomer (3) possessed dual mGlu2/3 receptor agonist

67 4; CCH(3)F, 13/14; CClF 15/16), a single CXF-diastereomer (3, 13, 16) is observed in the active site

68 labeling than an equal concentration of its diastereomer [(3)H](3beta,5beta)-6-AziP.

69 ynthesis of the novel unnatural parthenolide diastereomer (+/-)-4,5-dia-parthenolide was accomplished

70 further reaction of the malonate-containing diastereomer 5 with a second C60 molecule has afforded d

71 with stereochemical assignment as the threo diastereomer (5'S,6'S)-GlyU.

72 Isocyanide 5 and synthetic diastereomers 5a and 5c showed activity against Plasmodi

73 ave the corresponding dipeptides as a single diastereomer (6 examples).

74 Diastereomer 6a thermally decomposed twice as fast as 6b

75 ers, which provided access to the individual diastereomers 7a-1, 7a-2, 7b-1, and 7b-2 by preparative

76 on of a mixture of beta-aminophosphine oxide diastereomers accessed by ring-opening of an amino alcoh

77 The calculated ratio of the two diastereomers agrees with experimental observations, and

78 Locked nucleic acid (LNA) and its diastereomer alpha-L-LNA are two interesting examples th

79 roton chemical shifts: ca. 7 ppm for the syn diastereomer and ca. 2 ppm for the anti diastereomer.

80 ls were proposed to predict the preferential diastereomer and its twist, and computational studies pr

81 FR901464, spliceostatin A, six corresponding diastereomers and an evaluation of their splicing activi

82 was achieved, both by classical methods via diastereomers and by HPLC on a chiral phase.

83 was established by synthesizing the possible diastereomers and comparison of the data with those repo

84 to (7Z,7'E), (7E,7'E), and (7E,7'Z) morinol diastereomers and the (7Z,8'E) and (7E,8'E) conjugated a

85 or TBBP-A, HBCDs (the alpha, beta, and gamma diastereomers), and HBCD degradation products: pentabrom

86 yl amine leading preferentially to the trans diastereomer, and free homoallylamine affording the depr

87 ctone products was determined to be the anti-diastereomer, and its formation was rationalized by a po

88 hemistry of the title compound, an unnatural diastereomer, and of a decalin building block was studie

89 , CMC values for the (R,R), (S,S), and (S,R) diastereomers are approximately an order of magnitude hi

90 central and axial chirality, the two planar diastereomers are in slow equilibrium.

91 imentally demonstrate that the trans and cis diastereomers are interconvertible under reaction condit

92 he absolute configurations of the individual diastereomers as determined from the X-ray crystallograp

93 Generally, the reactions afford the endo-diastereomers as the major products, except for the reac

94 ad reduced and transaminated to the opposite diastereomer at C(4), 2S,4S,7R-H(4)Tyr.

95 strictosidinic acid isomers are (R) and (S) diastereomers at their glucosylated C21 positions.

96 T-wave drift-times for the protonated diastereomers betamethasone and dexamethasone are reprod

97 ce was observed in the reactivity of the two diastereomers between them and with respect to the diast

98 stereodivergent products with anti- and syn-diastereomers both in good diastereoselectivities and en

99 le to "split the difference" between the two diastereomers by preparation of their corresponding unsa

100 The resulting (S,S)-complex diastereomer can be easily purified by chromatography.

101 The diastereomer configurations are considered resolved, if

102 l (QM) calculations for the determination of diastereomer configurations is demonstrated using four d

103 e report the synthesis of cyclic hexapeptide diastereomers containing gamma-amino acids (e.g., statin

104 Both the (5'S,4'R) and the (5'R,4'R) diastereomers could be prepared selectively in good yiel

105 The protein diastereomer [D-Ala(B8)]proinsulin produced higher foldi

106 r the M isomer as compared to that for the P diastereomer (DeltaDeltaG = 3.48 kcal/mol).

107 Moreover, only a single pure diastereomer, derived from attack of the aza-anion on th

108 with previously reported results for an ShK diastereomer designated d-allo-ShK, for which significan

109 d after an efficient separation by selective diastereomer destruction.

110 y of T-wave IM spectrometry to differentiate diastereomers differing in Omega(N(2)) value by only 1 A

111 eratrylglycerone) epimers, whereas the other diastereomer (differing in configuration at the beta-pos

112 ating metabolic interconversion of test HBCD diastereomers during biotransformation in trout.

113 arkably, isomers d can be converted to their diastereomers e quantitatively by heating, and e can be

114 a rare enantiodivergent reaction giving two diastereomers each in >98% ee.

115 in adducts 2-5, formation of mixtures of two diastereomers (each with their corresponding pair of ena

116 donor followed by separation of the derived diastereomers enables further advancement to either (+)-

117 trating that the mixture of the anti and syn diastereomers epimerized to the syn hydroxy ester during

118 dynamics simulations to investigate how two diastereomers (epimers) of dihydrofuroaporphine bind to

119 ntimicrobial peptide (AMP) Esc(1-21) and its diastereomer Esc(1-21)-1c were found to possess potent i

120 All diastereomers exhibit a minimum surface tension of about

121 cis and trans diastereomers exhibit different reactivities, but conver

122 Diastereomers exhibited differences in their collision c

123 in their nonionic states, whereas the (R,S) diastereomer exhibits a CMC about five times larger.

124 itable acquisition and data processing, each diastereomer exhibits characteristic chemical shifts of

125 Total metabolism of HBCD diastereomers followed the rank order ss > gamma > alpha

126 Different ECCD spectra found for diastereomers formed in the self-assembled tris(pyridine

127 of these spirooxindoles, which affords four diastereomers from a single compound.

128 nzofuran derivatives were obtained as single diastereomers from cyclic or acyclic enol ethers and sty

129 e relative configuration of a small-molecule diastereomer generated in a solution-phase organic synth

130 We assume that one of the diastereomers has very strong optical activity, which ov

131 the starting compound, (+)-antrocin and its diastereomer have been synthesized.

132 At pH 4.0 (nonionic), all diastereomers have a critical micelle concentration (CMC

133 re often observed as equilibrium mixtures of diastereomers having two different point symmetries (D2d

134 rs of unifloral honeys such as abscisic acid diastereomers, homogentisic acid, methyl syringate and k

135 f trifluoromethyl ketone 22 gave the desired diastereomer in 32% yield and with dr = 98:2 from a 1:1

136 ion was developed which provided the desired diastereomer in 4:1 diastereoselectivity and 75% yield w

137 t alpha-HBCD would be the most dominant HBCD diastereomer in biological tissues because it was metabo

138 nce, providing selective access to the trans diastereomer in good yield.

139 e same isomer with lesser amounts of its 10R diastereomer in human epidermis.

140 The selectivity for the syn diastereomer in the electrophilic activation manifolds i

141 The selectivity for the anti diastereomer in the nucleophilic manifold is explained b

142 The diaziridines are formed as a single diastereomer in up to 96% ee, containing two orthogonal

143 e continuous stereogenic centers as a single diastereomer in up to 99% ee.

144 fford diverse indolizidine systems as single diastereomers in good overall yields.

145 ee) were obtained simultaneously for the two diastereomers in good yields.

146 dged stereocenter produces readily separable diastereomers in high yield (>92%) and with excellent op

147 a re-equilibration among the different cage diastereomers in order to maximize the binding affinity

148 ith the reported ECD assignments for the dSp diastereomers in the nucleoside context, in which the fi

149 formational preferences of the (D)P and (L)P diastereomers in the protonated peptide [YAPAA+H](+), wh

150 bsolute configuration assignments of the dSp diastereomers in which the first eluting from a Hypercar

151 lo[2.2.1]heptanes 18a/18b gave trans and cis diastereomers, in which the chirality of the C4 center i

152 ion induced slow rearrangement of the stable diastereomer into byproducts that were identified.

153 The major diastereomer is derived from addition of the furan to th

154 rted providing a hypothesis for why a single diastereomer is observed when the chiral benzylic methyl

155 al chemistry, we show that the lowest energy diastereomer is the desired cis-pyran found in neopeltol

156 tions indicate that differentiation of these diastereomers is a result of the stabilization of differ

157 and dynamics characterization of each of the diastereomers is achieved based on the joint analysis of

158 MR analysis, especially when the presence of diastereomers is also possible.

159 asurable mobility difference between the two diastereomers is mainly due to short-range van der Waals

160 Of the two diastereomers isolated of each of the trioxanes, more po

161 Two phosphorescent dinuclear iridium(III) diastereomers (LambdaDelta/DeltaLambda) and (LambdaLambd

162 re considerably more active than their axial diastereomers, lending strong support to crystallographi

163 riggered by metabolites M2, M13, and its two diastereomers M13-1 and M13-2.

164 marine Streptomyces sp. CNQ-617 produces two diastereomers, marineosins A and B.

165 Although six diastereomers may be formed by this approach, only one o

166 The solvolysis of two diastereomers may give the same two products, but in dif

167 field (1)H NMR spectroscopy in which the two diastereomers (meso and +/- pair) are distinguishable.

168 e show that the (19)F NMR spectra of 1 (~1:1 diastereomer mixture prepared by coupling of UMP-morphol

169 s was a mixture of enantiomers with no other diastereomers observed.

170 Further, the 4R diastereomer of 1 was fully efficacious and approximatel

171 xchange of 3 produces 81-82% of the 2R*, 3R* diastereomer of 2-deuterio 3 (the anti product).

172 ity, providing selective synthesis of either diastereomer of di- and trisubstituted cyclopropanes.

173 rom Penicillium aethiopicum makes the 2'-epi diastereomer of FQA, differing only in the stereochemist

174 occurred and was tentatively identified as a diastereomer of I3',II8-binaringenin.

175 in oxidative protein repair each targeting a diastereomer of methionine sulfoxide, their deletion res

176 rvation suggests that formation of the major diastereomer of Michael product B does not occur via an

177 LDA induces equilibration to form the minor diastereomer of Michael product B.

178 e method provides selective access to either diastereomer of optically enriched five-, six-, and seve

179 vements in side-chain attachment and a novel diastereomer of salino A.

180 attern of the starting amide leads to either diastereomer of the alpha-methyl-alpha-ethyl-beta-hydrox

181 The reaction provides a single diastereomer of the corresponding adducts in good to hig

182 cal conformation needed to generate a single diastereomer of the cyclopentenone product obtained expe

183 r formation, leading exclusively to a single diastereomer of the desired host.

184 The C8-diastereomer of the fully elaborated tetracyclic core of

185 A diastereomer of the natural product was also synthesized

186 lds are observed for the formation of either diastereomer of the product from a single alkene isomer.

187 The more polar diastereomer of the trioxanes 26a, 26b, and 26d, were th

188 , two-step synthesis of a 1:1 mixture of the diastereomers of 3-bromo-2-methyl-1-propyl camphorsulfon

189 f two diastereomeric forms of 4a, and single diastereomers of 4b and 6.

190 riethylsilyl derivatives of the four racemic diastereomers of 6-(2-ethyl-1,3-dioxolan-2-yl)-5-hydroxy

191 The individual diastereomers of 7 (7a/b) were obtained by HPLC separati

192 ly induced bulky DNA lesions including (5'S) diastereomers of 8,5'-cyclo-2'-deoxyguanosine (cyclo-dG)

193 er configurations is demonstrated using four diastereomers of a trisubstituted epoxide.

194 All four diastereomers of a typical saturated oligoisoprenoid, 4,

195 Conformationally locked cis diastereomers of bis(sulfide)-anchor-equipped 1,2-disila

196 translesion synthesis (TLS) across the (5'S) diastereomers of cdA and cdG.

197 tures of the oxidative cleavage reactions of diastereomers of dimeric lignin model compounds, which a

198 With both diastereomers of each substrate available, the KIEs can

199 The first total syntheses of two possible diastereomers of gliomasolide E, a 14-membered macrolide

200 enabled the synthesis of two of the possible diastereomers of JBIR-22 and allowed the assignment of i

201 pha-L-LNA: i.e., one of the most interesting diastereomers of LNA.

202 natural oligosaccharides (i.e., various d-/l-diastereomers of oligosaccharides as well as deoxysugars

203 mical relationship via the synthesis of four diastereomers of palmyrolide A aldehyde, a known degrada

204 structure analysis of natural and unnatural diastereomers of polyhalogenated stereohexads.

205 The synthesis of both trans- and cis-diastereomers of pyrrolidinine-thioxotetrahydropyrimidin

206 est separation of DAP derivatives, including diastereomers of some of them, was achieved by MEKC in a

207 per(II) bis(oxazoline) catalyst deliver both diastereomers of the Henry adduct with high enantiomeric

208 Different diastereomers of the intermediates as well as different

209 satile synthetic methodology from which four diastereomers of the most common monorhamnolipid, alpha-

210 synthesis of a library that contains all 16 diastereomers of the natural products macrosphelides A a

211 luorous mixture synthesis provided all eight diastereomers of the phytophthora hormone alpha1 with th

212 Between the two diastereomers of the PS RNA chiral center, the R(p) isom

213 Both diastereomers of these compounds are isolated in moderat

214 describe herein the synthesis of all C13/14 diastereomers of this spiro molecule through controlled

215 ly reported the inability to distinguish the diastereomers of uridine 5'-beta,gamma-fluoromethylenetr

216 prephenate to a tetrahydrotyrosine (H(4)Tyr) diastereomer on the way to the anticapsin warhead of the

217 , it is likely that the 2S,4S-H(4)Tyr is the diastereomer "on pathway".

218 either as a result of providing an incorrect diastereomer or due to lack of synthetic efficiency.

219 The observation that psymberin diastereomers or dihydroisocoumarin-truncated analogs lo

220 uprate reagents give either the trans or cis diastereomers or mixtures.

221 Anti-adducts were obtained as single diastereomers or with excellent diastereoselectivities w

222 e traces of paramagnetic ions, at pH ~10 the diastereomer pairs 12a,b exhibit discrete P(alpha) and P

223 Diastereomer pairs entered cells equally well, and there

224 city by pol beta on the mixed beta,gamma-CHX diastereomer pairs using nuclear magnetic resonance and

225 A model "diastereomer" pathway for camptothecin biosynthesis in C

226 lenging compounds, namely amino alcohols and diastereomers possessing more than one stereocenter.

227 in the central beta-amino acid, whereas SRS diastereomers preferred an extended delta-turn (C9) conf

228 trans-1,2-disubstituted indane as the single diastereomer product.

229 Cyclization of enriched mixtures of diastereomers provided similar yields of acetyl tetrahyd

230 pid epimerization of meso-lactide (LA) or LA diastereomers quantitatively into rac-LA.

231 The two phosphorothioate diastereomers (R(p) or S(p)) were separated, and nitroxi

232 etric isomers (fac/mer), and configurational diastereomers (R/S) arising from carbon stereocenters.

233 MPA (2) phenyl ester (5 and 6, respectively) diastereomers ((R(p))-5, (R(p))-6, (S(p))-6) was determi

234 zed the first individual beta,gamma-CHX-dGTP diastereomers [(R)- or (S)-CHX, where X is F or Cl] and

235 c) were determined at 195 K by measuring the diastereomer ratio of deuteration product d1-3b as a fun

236 nts were conducted: (1) determination of the diastereomer ratio of dSp products upon one-electron oxi

237 addition to the target molecule, a series of diastereomers reflective of many other isolates.

238 This suggests that R5a linked to mixed diastereomers reports on the composite behaviors of R(p)

239 -6a and (1M,5M)-9a to their (M,P)- and (P,M)-diastereomer, respectively, the possible transition stat

240 em with four examples of beta,gamma-CXY dNTP diastereomers: (S)- and (R)-beta,gamma-CHCl-dGTP (12a-1/

241 ldehydes to give the title allenes as single diastereomers (see scheme; Ts=4-toluenesulfonyl).

242 The chiral substituent allows diastereomer separation and departs during a subsequent

243 gram scale synthesis was developed utilizing diastereomer separation at a later stage in the synthesi

244 ximum levels of total hexabromocyclododecane diastereomers ( summation operatorHBCDs) in these specie

245 All diastereomers tested showed significant antiviral activi

246 According to the calculations, the single diastereomers that are formed during the self-assembly p

247 isimide compounds, including a mixture of 21 diastereomers that cannot be deracemized at the molecula

248 idation step results in the formation of two diastereomers that exhibit markedly different levels of

249 H(4+) 4 Cl(-) ) as a mixture of Lambda/Delta diastereomers that separate on chiral-phase Sephadex col

250 resulted in the identification of a pair of diastereomers that showed 50-fold enzyme and cell based

251 n producing a greater amount of the 2R*, 3S* diastereomer (the syn product).

252 In the pathway that generates the favored diastereomer, the oxygen lone pairs from the substituent

253 For both the F and Cl diastereomers, the R isomer is favored over the S isomer

254 nding was that only one of the two resulting diastereomers, the SP methylphosphonate, was compatible

255 proposed structure for amphidinolide B2 and diastereomers thereof display potent antitumor activitie

256 The presence of multiple diastereomers throughout the pathway is consistent with

257 t inverse agonist (TMP778), and its inactive diastereomer (TMP776).

258 ontain clues that the preference of the (D)P diastereomer to support a trans-amide bond and the procl

259 ncoded (labelled) mixture of natural-product diastereomers to be prepared-enabled us rapidly to pinpo

260 Binding of the two (13)C-labelled glycosyl diastereomers to NKA were studied by solid-state NMR (SS

261 tification of possible conformations in each diastereomer using relaxed grid search analysis and MD s

262 clear magnetic resonance and on the separate diastereomers using transient kinetics.

263 anti-1",2"-syn adduct, one of eight possible diastereomers, via a diastereoselective (dr > 20) prefer

264 Stereopreference for the (R)-CHF-dGTP diastereomer was abolished for k(pol) but not K(d) with

265 The unique symmetry of each diastereomer was confirmed by NMR spectroscopy.

266 nuclidinone buffer, only 44% of the 2R*, 3R* diastereomer was formed.

267 In addition, the diastereomer was more efficient in reducing the systemic

268 A preference for formation of the trans diastereomer was observed in these reactions.

269 terphenylenediamine was used, the T-symmetry diastereomer was observed to predominate.

270 The stability of each diastereomer was studied in aqueous phosphate buffer and

271 The minor diastereomer was thermally less stable than the major on

272 Each diastereomer was well absorbed (73-83%), and distributed

273 The configuration of the diaza[6]helicene diastereomers was demonstrated by time-dependent density

274 Each of the three diastereomers was isolated, and by following the equilib

275 Concise syntheses of the four candidate diastereomers were achieved using a common strategy base

276 The spectroscopic properties of the C-shaped diastereomers were compared to a model compound containi

277 HBCD diastereomers were detected in all samples with alpha-HB

278 Three Marbon diastereomers were detected in the water and sediment sa

279 The equilibria between diastereomers were influenced through variation in ligan

280 mation of the Prato monoaduct, two different diastereomers were isolated by HPLC (4, 5) whose absolut

281 values for the drug-like calibrants and two diastereomers were measured using a drift-tube instrumen

282 Guided by bioinformatics, four diastereomers were synthesized, and the relative and abs

283 The individual diastereomers were tested against HIV-1 and HIV-2 infect

284 Six key diastereomers were then synthesized to probe the importa

285 ffering metal-complexed forms adopted by the diastereomers when cationized by an alkali metal cation,

286 onal synthetic methods generate a mixture of diastereomers when the bridging carbon substitution is n

287 iamine generated predominantly the S(4) cage diastereomer, whereas 2',5'-dimethylterphenylenediamine

288 rmodynamically more stable than the C-shaped diastereomers which we attribute to the conformational p

289 hat this transition state leads to the major diastereomer, which is consistent with the structure of

290 synthesized and was shown to exist as three diastereomers, which interconvert via a reversible cycli

291 The two diastereomers, which show a high structural variability,

292 lysis of the P-N bond then afforded "portal" diastereomers, which were readily coupled to morpholine-

293 Acylation of compound 23 gave 24 as a single diastereomer with the desired stereochemistry but in low

294 ucts, we identified a pair of 8,15-dihydroxy diastereomers with all-trans-conjugated trienes that inc

295 nc acetate to give a mixture of two C-shaped diastereomers with cofacial bromine-substituted quinoxal

296 ists mainly as a mixture of cyclic hemiketal diastereomers, with an open-chain tautomer as a minor co

297 parent diaminoterphenyl, all three possible diastereomers, with T, S(4), and C(3) point symmetries,

298 3)C NMR chemical shifts for all 32 potential diastereomers, with the predicted structure being in acc

299 A single conformational isomer of the (L)P diastereomer, [YA(L)PAA+H](+), is found and assigned to

300 conversion of the enantiomeric mixture into diastereomers yielded well-resolved peaks for D and L am