ライフサイエンスコーパス: diastereomeric

1 rotonation/trapping experiments on a pair of diastereomeric 1,4-benzodiazepine-2,5-diones provide evi

2 The reaction of HNE with DNA produces four diastereomeric 1,N(2)-gamma-hydroxypropano adducts of de

3 Grignards resulted in a separable mixture of diastereomeric 2,3-dihydro-4-pyridones.

4 These adducts were directly converted to the diastereomeric 2,4,5-trisubstituted piperidines syn-5m,

5 ve configurations for the complete set of 16 diastereomeric 2-(2-ethyl-1,3-dioxolan-2-yl)-7-hydroxy-3

6 to assign the relative configurations of 13 diastereomeric 2-(2-ethyl-1,3-dioxolan-2-yl)-7-hydroxy-3

7 Electrophilic quench of the resolved diastereomeric 2-lithiopyrrolidine-chiral ligand complex

8 The regiodivergent ring contraction of diastereomeric 2-silyl-5,6-dihydro-6-aryl-(2H)-pyrans vi

9 ,4-dimethyl-5-ketohexanoic acid (3a) and the diastereomeric (2S,4S)-3b.

10 In the case of diastereomeric (3RS,4RS)- and (3RS,4SR)-N-Boc-3-amino-2-

11 elease of carboxylic acids with formation of diastereomeric 5-hydroxyoxazolidin-4-ones 2a,c in the ca

12 yzed and the pH-independent reactions of two diastereomeric 6-methoxy-trans-1,2,3,4,4a,10a-hexahydrop

13 l basis for this difference, the HNE-derived diastereomeric (6S,8R,11S) and (6R,8S,11R) cyclic hemiac

14 Diastereomeric 8,5'-cyclopurine 2'-deoxynucleosides, con

15 lic [5.3.1] and [4.3.1] ring systems in high diastereomeric (97-99% de) and enantiomeric purity.

16 obtained via a stereodivergent resolution to diastereomeric acetals.

17 ,1-dichlorocyclopentane yielded a mixture of diastereomeric activation products.

18 in enantiomerically pure form via the highly diastereomeric addition of metal phosphonates to masked

19 de to advanced aldehyde 51 afforded a single diastereomeric adduct 53 which is tentatively assigned t

20 Diastereomeric adduct pairs were separated and character

21 Diastereomeric adducts comprising an enantiomerically pu

22 ormed in the photoaddition, namely, the four diastereomeric adducts to the C1-C2 and C5-C6 bonds of t

23 ework that lead to energetically more stable diastereomeric adducts.

24 rivatives, namely, the spirocyclic ketone 6, diastereomeric alcohols 7 and isomeric diols 8.

25 mizations of the duplexes containing the two diastereomeric aldehydes predicted that the (6S,8R,11S)

26 tals, the conformations of the corresponding diastereomeric aldehydes were predicted, using molecular

27 lectivity is set during the formation of the diastereomeric alkoxyphosphonium salts (DAPS), such that

28 The ratio of diastereomeric allenes varies depending on the substitut

29 dative addition step to form the more stable diastereomeric allyl complex leads to the high enantiose

30 attack to the rates of epimerization of the diastereomeric allyliridium complexes containing a weakl

31 ization of the less thermodynamically stable diastereomeric allyliridium complexes to the thermodynam

32 ulation was evaluated and enhanced utilizing diastereomeric allylsilanes anti-5 and syn-5 to establis

33 ysis' relies on the fact that the protons in diastereomeric alpha-methoxy-alpha-trifluoromethylphenyl

34 Analyses of the meteorite diastereomeric amino acids alloisoleucine and isoleucine

35 mposition and abundances, in particular some diastereomeric amino acids may gauge its extent by the c

36 ctive formation of only one of four possible diastereomeric aminopalladation products of the chiral P

37 Comparison between such diastereomeric analogues thus implies that the T state r

38 esis, which delivered 1872 compounds in high diastereomeric and chemical purity.

39 stereogenic centers in good yields with high diastereomeric and enantiomeric ratios.

40 course of this study, a strong self-induced diastereomeric anisochronism (SIDA) phenomenon was obser

41 s result is in contrast to the reaction of a diastereomeric benzo[a]pyrene 7,8-diol 9,10-epoxide (DE-

42 ctive anti-PAH monoclonal antibody with four diastereomeric benzo[a]pyrene tetrols (BPTs) is studied

43 The brominative cyclization of diastereomeric beta-silyloxy tryptophan derivatives proc

44 goes photocyclization to generate separable, diastereomeric bicyclic-aziridines, which are then indep

45 ing to the stereocontrolled synthesis of six diastereomeric bis-tetrahydrofuran structures correspond

46 3-phenyldiboronic acid to afford mixtures of diastereomeric boronate esters whose homochiral/heteroch

47 1, an antiulcer drug, were synthesized from diastereomeric building blocks (-)-5a and (+)-5b.

48 Synthesis and characterization of two diastereomeric C-shaped molecules containing cofacial th

49 resented suggesting that the origin of these diastereomeric C3'(S) and C3'(R) derivatives of 1-thymin

50 ugate base of adenine or thymine to give two diastereomeric C3'(S) and C3'(R) derivatives of 1-thymin

51 distinct for xenon encapsulated in different diastereomeric cage molecules.

52 s); temperature-dependent equilibria between diastereomeric cages are also quantified.

53 An 11-step synthesis is described of two diastereomeric candidates for a bis(acetylenic) enol eth

54 ctive total synthesis of the two most likely diastereomeric candidates for the structure of 5 solidif

55 To access both diastereomeric catalysts and to determine if the reactio

56 An unusual diastereomeric CB[6] with a Mobius geometry (13) is prop

57 those obtained in dichloromethane using the diastereomeric chiral cationic dirhodium(II,III) carboxa

58 A new series of customizable diastereomeric cis- and trans-monocyclic enol-phosphonat

59 The diastereomeric complex will favor either P or M helicity

60 Following its resolution by diastereomeric complexation, 5,5',6,6'-tetrahydroxy-3,3,

61 In this study, the formation of diastereomeric complexes by coadsorbed methyl 3,3,3-trif

62 le step and combines practical resolution of diastereomeric complexes due to signal sharpness and eff

63 ielding unique coordinates for the generated diastereomeric complexes is assessed.

64 e of the chemical shifts (Deltadelta) in the diastereomeric complexes is comparable with other, well-

65 Isolation and X-ray characterization of both diastereomeric complexes, as well as an examination of t

66 amine controls the assembly of the resulting diastereomeric complexes, even if this chirality is rela

67 of a thermodynamic preference for one of the diastereomeric complexes.

68 e paired guanine towards BPDE and modify the diastereomeric composition of N(2)-BPDE-dG adducts.

69 pling reaction, resulting in highly emissive diastereomeric compounds that were studied by UV-vis, fl

70 id, particularly hydroquinine, with complete diastereomeric control and up to 87% enantiomeric contro

71 g natural variants and novel enantiomeric or diastereomeric counterparts.

72 alkali labile lesion can exist in up to four diastereomeric cyclic forms, in addition to the acyclic

73 Both exist primarily as diastereomeric cyclic hemiacetals when placed into duple

74 he conformational flexibility of a series of diastereomeric cyclic urea HIV-1 protease inhibitors has

75 We isolated two of the six possible diastereomeric deep cavitand receptors resulting from th

76 We have polymerized rac-LA using the diastereomeric densely substituted amino acids (2S,3R,4S

77 o separation of enantiomers via formation of diastereomeric derivatives with three stereogenic center

78 Such complexes are diastereomeric, differing in structure and free energy f

79 the C11-C13 atoms of the target, to provide diastereomeric diketones in 60% or 48% yield (for coupli

80 use oxiranyllithium has a chiral center, two diastereomeric dimers were formed, the RR and the RS, al

81 re prepared by chromatographic separation of diastereomeric dipeptide derivatives formed from N-Boc-L

82 The combination of chiral-NEA driven diastereomeric docking with a tautomeric preference enha

83 ) switching for selection of components of a diastereomeric (E,Z) and enantiomeric (R,S) oxime into a

84 s were screened in one step to determine the diastereomeric/enantiomeric composition of the final pro

85 difference of the hydrogenolysis between two diastereomeric epoxide intermediates shed some light on

86 imerizable pyryliums and the kinetics of the diastereomeric equilibration of these and one other exam

87 s (the set of Delta delta(SR) values) in the diastereomeric esters (or amides), the absolute configur

88 2b was achieved by crystallization of their diastereomeric esters or by kinetic resolution of the ra

89 tituted homoallylic amines, prepared in >98% diastereomeric excess (de) and 68-90% ee via allylborati

90 honium salts (DAPS), such that their initial diastereomeric excess (de) limits the final enantiomeric

91 ases and, most notably, with very high (>98% diastereomeric excess (de)) stereoselectivity at both ne

92 which were isolated in 80-84% yield and high diastereomeric excess (dr > 97/3) after purification via

93 cellent yields and, in some cases, excellent diastereomeric excess (up to >95%) at 100 degrees C in 8

94 DERA with enantiomeric excess at >99.9% and diastereomeric excess at 96.6%.

95 wist is achieved using chiral amino ligands (diastereomeric excess up to 77%, the highest reported to

96 ase, which lacks a cavity, shows much higher diastereomeric excess with the encaged proazaphosphatran

97 More recently, ee and its cousin de (diastereomeric excess) have been used (inappropriately)

98 erene in an efficient manner and with a good diastereomeric excess.

99 uction of substituted N-heterocycles in high diastereomeric excesses via stereocontrolled enolate for

100 d crystal, these enantiomeric domains become diastereomeric, exhibiting unexpected and markedly diffe

101 ddition of deoxyguanosine to HNE yields four diastereomeric exocyclic 1,N(2)-dG adducts.

102 -configured [Fe(bisDHBS)](2-) from a pool of diastereomeric Fe(III)-bisDHBS species that includes com

103 These studies indicate, inter alia, that one diastereomeric form of the complexes cis-[Pt(NH3)2(Am)(R

104 The major diastereomeric form of the product is determined by the

105 examined in detail and shown to exist in 10 diastereomeric forms as a result of in-/out-isomerism.

106 re simulated, evidencing the presence of two diastereomeric forms of 4a, and single diastereomers of

107 r, and the rapid interconversion between two diastereomeric forms results in the unusual heme electro

108 These Zr-allyls, which exist in two diastereomeric forms, have been characterized by physica

109 simple epimers, which when combined produce diastereomeric glycoconjugates indistinguishable by mass

110 dipole/dipole interactions destabilizing the diastereomeric ground states and facilitated out-of-plan

111 function of sulfur dioxide to give a pair of diastereomeric heterocyclic six-membered ring products d

112 These isomerized to diastereomeric hydroxymethylphosphonamidates (phosphate-

113 resubmission experiments establish that the diastereomeric iCB[6] and iCB[7] are kinetic products th

114 The diastereomeric identities were established by X-ray crys

115 in which a rapid tautomeric equilibration of diastereomeric iminium cations is combined with a diaste

116 es in which dynamic kinetic equilibration of diastereomeric iminium ions precedes a stereochemistry-d

117 rom hydrogen isocyanide to imine to generate diastereomeric iminium/cyanide ion pairs that are bound

118 scopic analysis of the resultant mixtures of diastereomeric iminoboronate esters.

119 atives (of unknown chirality) to produce two diastereomeric iminoboronates that differ in their fluor

120 Here we present evidence for strong diastereomeric interaction effects at the mesoscale, man

121 se of the near-infrared technique to measure diastereomeric interactions between an added carbohydrat

122 use of the fluorescence technique to measure diastereomeric interactions between both enantiomeric fo

123 The results show that diastereomeric interactions between NEA and MP occur pre

124 al IL to solubilize an analyte and to induce diastereomeric interactions for the determination of ena

125 iral RTIL to solubilize a drug and to induce diastereomeric interactions for the determination of ena

126 Diastereomeric interactions in 2D crystals formed at sol

127 usion complex formation to produce effective diastereomeric interactions.

128 tion of the more reactive pi-allyl palladium diastereomeric intermediate as the enantiodiscriminating

129 ith the relative stability and reactivity of diastereomeric intermediates downstream in the catalytic

130 The diastereomeric intermediates were separated by chiral co

131 0 steps and a preparative HPLC separation of diastereomeric intermediates.

132 onstrating geometric differences between the diastereomeric intermolecular complexes.

133 The latter forms diastereomeric interstrand N(2)-dG:N(2)-dG cross-links i

134 The symmetric pathways give diastereomeric isomers.

135 closely paralleled that of the corresponding diastereomeric ketones (IC(50) = 1.0-46 nM).

136 Three pairs of cis versus trans diastereomeric lactones were used to assess the ability

137 Studies of the reactions of diastereomeric ligands containing (R) or (S) binaphthola

138 nitrogen, show that the complexes of the two diastereomeric ligands undergo cyclometalation at much d

139 Unique perylene diastereomeric linear and cyclic dimers were synthesized

140 rate flexibility, enabling the production of diastereomeric macrolactones.

141 tion of a racemic cyclitol derivative as its diastereomeric mandelate esters are the key steps in the

142 ibofuranose offered synthetic entry into the diastereomeric manifold, 2'-C-alpha-difluoromethyl-arabi

143 A similar reaction with 6 results in diastereomeric [Me(2)C(Cp)(Flu)]ZrMe(+) FAl(2-C(6)F(5)C(

144 With diastereomeric metal complexes that undergo rapid interc

145 reomers between them and with respect to the diastereomeric mixture (3S,4S) + (3S,4R).

146 The single diastereomer 51 of diastereomeric mixture 14 was crystallized, and an X-ray

147 g, the reaction proceeds with formation of a diastereomeric mixture [compounds 6 and 7 in 70:30 ratio

148 r in 32% yield and with dr = 98:2 from a 1:1 diastereomeric mixture after crystallization.

149 reaction, and (3) ring-opening reaction of a diastereomeric mixture of a diaminolactone to synthesize

150 asymmetric allylic alkylation reaction of a diastereomeric mixture of allylic carbonates that is ena

151 Base-mediated cyclocondensation of a diastereomeric mixture of aminophosphonates II leads exc

152 We demonstrate that the N-amidification of a diastereomeric mixture of CF3-PsiPro using Fmoc-protecte

153 The diastereomeric mixture of d/l-2,7-diaminooctanedioyl-bis

154 hat combines chiral liquid chromatography, a diastereomeric mixture of isotopically labeled internal

155 ene [generated from (CF3)2Hg and NaI] gave a diastereomeric mixture of the 3',4'-difluoromethylene co

156 eCp(CO)(3), 1, the olefin was converted to a diastereomeric mixture of the C(8)-dimer tricyclohexadec

157 +) ([Ru] = Cp(PPh3)2Ru) in CHCl3 generates a diastereomeric mixture of the substituted tetrahydropyra

158 mbers written within parentheses represent a diastereomeric mixture or racemate; compound numbers wit

159 The dimeric peptide 1 (BVD-74D, as a diastereomeric mixture) is a potent and selective neurop

160 Y and CrISY, the cyclization step produces a diastereomeric mixture.

161 en within brackets represent a racemate or a diastereomeric mixture; compound numbers without bracket

162 9a-e, 11a-d; LLL-tripeptides 18a-c, 20; and diastereomeric mixtures (9b+9b'), (9c+9c'), (11b+11b') a

163 erization was found to be pH dependent, with diastereomeric mixtures formed on condensation.

164 of nitroepoxides to chiral amines to afford diastereomeric mixtures of aminoimines and subsequent st

165 or ethyl iodide and potassium carbonate gave diastereomeric mixtures of N-alkyl derivatives, and the

166 bene (generated from PhHgCF(3) and NaI) gave diastereomeric mixtures of the 2,2-difluorospirocyclopro

167 Diastereomeric mixtures of thymidine glycol and the corr

168 nd numbers written within brackets represent diastereomeric mixtures or racemates; compound numbers w

169 tudies indicated that all adducts existed as diastereomeric mixtures.

170 in neuraminidase inhibition over the parent diastereomeric mixtures.

171 After significant investigation, the diastereomeric molecule with the C11 and C13 configurati

172 the separable FAPY bases and nucleosides are diastereomeric N5 formyl derivatives involving axial asy

173 iary by H(2) (Pd/C) gave the four individual diastereomeric nucleotides 12, which were characterized

174 es, which complex Fe(II) to form a series of diastereomeric octahedral complexes that are CD-active i

175 ns, thereby validating the function of these diastereomeric oligonucleotides as prodrugs in vitro.

176 ifferent stereoinduction levels for designed diastereomeric organocatalysts.

177 -concept application in organocatalysis, the diastereomeric P-chiral beta-aminophosphine-based bifunc

178 manner, the enantiomeric ratio of the other diastereomeric pair decreases.

179 and L-threonine and to the preparation of a diastereomeric pair of N-Fmoc-protected dipeptidyl diazo

180 conformers of betaalphaL and betaalphaD form diastereomeric pairs (A/A', C/C', and G/G') that have ne

181 The diastereomeric pairs 11a/11b and 12a/12b were separated

182 e system undergoes isomerization, one of the diastereomeric pairs drifts spontaneously to a higher en

183 eoxyinosine, by the amino triol then yielded diastereomeric pairs of diol epoxide-adducted 2'-deoxyad

184 Diastereomeric pairs of methyl 2-oxoimidazolidine-4(S)-c

185 f the Xe shielding response in the Lr and Ll diastereomeric pairs permit the prediction of the relati

186 d the relative rates of reprotonation of the diastereomeric Pd-alkoxides.

187 ity functional theoretical investigations of diastereomeric phenanthriplatin analogs in order to prob

188 f the P-chiral center of the undesired (R,R)-diastereomeric phosphine oxide 19 through chlorination f

189 Individual diastereomeric phosphoramidites and mixtures of diastere

190 stereomeric phosphoramidites and mixtures of diastereomeric phosphoramidites were evaluated in the ir

191 ic products with complete consumption of the diastereomeric precorsors or their mixtures.

192 ubstrates without an ortho-methyl group, the diastereomeric precursors interconvert slowly at ambient

193 tution patterns control the connectivity and diastereomeric preference found in the products.

194 THF afforded exclusively (E)-1 as the other diastereomeric product and was mediated by a beneficial

195 affords a statistical 3:1 (anti,syn:syn,syn) diastereomeric product ratio.

196 limination is rate-determining for the major diastereomeric product, while the Cu(I) migration step i

197 computer simulation of the formation of the diastereomeric products as a function of time; for sever

198 1o in a site-selective manner to deliver the diastereomeric products of C-allylation syn-4m, -4n, -4o

199 itum generate either one or the other of two diastereomeric products with complete consumption of the

200 efficiency of the DKR (the ratio of the two diastereomeric products) is determined by the balance be

201 trans-2] is the major product among the four diastereomeric products, "allowed" and formally the resu

202 xample, (E)- and (Z)-3, cleanly give rise to diastereomeric products, and thus the rhodium-catalyzed

203 cyclization, which resulted in a mixture of diastereomeric products.

204 addition to afford a statistical mixture of diastereomeric products.

205 strates, as exemplified by alkylation of the diastereomeric pseudoephedrine alpha-methylbutyramides,

206 Detailed analysis showed that the diastereomeric purity of the target molecule was >91 %,

207 arget compounds in up to 95% yield with >95% diastereomeric purity.

208 nd accurate determination of N-sulfinylamine diastereomeric purity.

209 r inhibitors were tested at higher levels of diastereomeric purity.

210 on of nonracemic samples of [7]helquat 2 via diastereomeric (R,R)-dibenzoyltartrate salts is describe

211 th excellent levels of diastereoselectivity (diastereomeric ratio > 20:1).

212 High diastereoselectivities (diastereomeric ratio > 98:2) and enantioselectivities (e

213 d yield, excellent purity (>95%), and a high diastereomeric ratio (>50:1).

214 arent nitroalkenes (60-87%), and with a high diastereomeric ratio (90:10 to mostly >95:5).

215 The diastereomeric ratio (dr) of the assembly was correlated

216 ence on both chemical yield and the level of diastereomeric ratio (dr) of the products.

217 e obtained in up to 83 per cent yield, >98:2 diastereomeric ratio (for allyl additions) and 99:1 enan

218 ituted allenes were achieved with up to 42:1 diastereomeric ratio and 94:6 enantiomeric ratio (up to

219 ld and in up to >98 % SN 2':SN 2 ratio, 96:4 diastereomeric ratio and 98:2 enantiomeric ratio.

220 rvations, and the factors that determine the diastereomeric ratio are discussed.

221 acid derivatives to afford the products in a diastereomeric ratio as good as 93:7, with the major iso

222 Products were formed consistently with a diastereomeric ratio larger than 95:5 in favor of the an

223 However, the relatively modest increase in diastereomeric ratio suggests that our substrate-Lewis a

224 inose in 11% overall yield and >99.5/0.5 dr (diastereomeric ratio).

225 or catalytic cross-coupling), 90:10 to >98:2 diastereomeric ratio, and 85:15-99:1 enantiomeric ratio.

226 tylboron compound, in up to 97% yield, 88:12 diastereomeric ratio, and 94:6 enantiomeric ratio.

227 tereoselectively in high yields (conversion, diastereomeric ratio, and enantiomeric excess).

228 The products are obtained in high yield, diastereomeric ratio, and enantiomeric excess.

229 propane aldol and a gamma-lactone in a >95:5 diastereomeric ratio.

230 89% and a approximately 7:1 [S,S(P):S,R(P)] diastereomeric ratio.

231 ed in up to 97 % yield, >98:2 Z/E, and >98:2 diastereomeric ratio.

232 Diastereomeric ratios >20:1 and up to 99% enantiomeric e

233 Typically, diastereomeric ratios (dr) ranged from 5 to 20:1 for the

234 All stereotetrads were obtained in high diastereomeric ratios and yields, and their relative ste

235 Diastereomeric ratios exceeding 1000 can be achieved wit

236 sulfinamide products in good yields and with diastereomeric ratios of up to 99:1.

237 possible diastereoisomers are observed, with diastereomeric ratios ranging from 3:2 to 40:1 when the

238 e of ZnCl2 gave N-acylhydrazine adducts with diastereomeric ratios ranging from 93:7 to 99:1.

239 ditions are neutral enough that the observed diastereomeric ratios reflect kinetic selectivities.

240 s have been obtained in very high yields and diastereomeric ratios up to >99:1.

241 hieved in enantiomeric ratios up to 99:1 and diastereomeric ratios up to 10:1.

242 bioactive compounds, in yields up to 88% and diastereomeric ratios up to 12:1.

243 s proceeded with at best modest selectivity (diastereomeric ratios up to 66:34 and 72:28, respectivel

244 uranone can be obtained in good yields, high diastereomeric ratios, and excellent enantiomeric excess

245 he reluctant anti adducts in high yields and diastereomeric ratios, which can be isolated and further

246 tituted benzopyrrolizidinones with excellent diastereomeric ratios.

247 c alcohols with high enantiomeric ratios and diastereomeric ratios.

248 ), enantioselectivities of 76-94%, and >20:1 diastereomeric ratios.

249 sulfones 8, 9, 14, and 16 in high yields and diastereomeric ratios.

250 - and anti-1,3-amino alcohols with very high diastereomeric ratios.

251 products from enol carbamate with excellent diastereomeric ratios.

252 in agreement with the observed experimental diastereomeric ratios.

253 ion-paired 1:1 complexes formed between the diastereomeric receptors and organic chloride salts were

254 ,7-dimethoxy-3,4-dihydroisoquinoline to form diastereomeric Reissert compounds 8-11 and 18-21, respec

255 Reactions of the anions of diastereomeric Reissert compounds, either as mixtures or

256 propagating step and a kinetically preferred diastereomeric relationship between a given chirality at

257 es gave rise to pairs of aminotetralins in a diastereomeric relationship.

258 that can be further exploited to improve the diastereomeric resolution when utilizing a drift gas wit

259 he following: (i) preparation of each of the diastereomeric S- and R-MTPA esters and (ii) comparative

260 The diastereomeric (S)-ester leads to the formation of dimer

261 A pair of diastereomeric salen cavitands and their uranyl complexe

262 fication via the dibenzoyl-(L)-tartaric acid diastereomeric salt 16 enriched the ee and de to 100%.

263 ective precipitation of a single form of the diastereomeric salt [TpW(NO)(PMe3)(DMBH)](DBTH).

264 Optical resolution was accomplished via diastereomeric salt formation or alternatively via chrom

265 Diastereomeric salts of racemic acids (RS)-1 and (RS)-2

266 ay diffraction analysis was performed on the diastereomeric salts of roof-shape amines and both isome

267 )-alpha-phenylethylamine was used, and their diastereomeric salts were investigated by (1)H and (19)F

268 n-induced dynamic resolution (CIDR) of their diastereomeric salts with chiral amines.

269 the spectra are ascribed to the formation of diastereomeric salts.

270 the quasiracemic mixture provided two quasi-diastereomeric samples, which were demixed and detagged

271 l decomposition of the DAPS shows consistent diastereomeric self-enrichment, indicating a higher rate

272 A resolution strategy based on diastereomeric separation by substitution of the dichlor

273 as substituted with a chiral amine, allowing diastereomeric separation, and the chiral forms were mon

274 lations that produce structures in divergent diastereomeric series possessing the critical vicinal al

275 The major, thermodynamically preferred diastereomeric (-)-sparteine-complexed lithated phosphin

276 d tumor-to-background ratio results for both diastereomeric species predict that both are effective f

277 ehydroguanidinohydantoin, oxaluric acid, and diastereomeric spiroiminodihydantoin lesions.

278 The diastereomeric spiroiminodihydantoin-2'-deoxyribonucleos

279 Interconversion of the diastereomeric starting esters of (S,R)-12a and (R,R)-12

280 The methods described were assayed on four diastereomeric stereodiads and on their parent epoxide.

281 and 16 enables access to all eight possible diastereomeric stereotetrads, seven of which are commonl

282 NMR shift calculation to distinguish between diastereomeric structures.

283 The permeability coefficients of diastereomeric sugars differed by as much as a factor of

284 permits the prediction of the Xe spectrum of diastereomeric systems in solutions containing Llr, Rlr,

285 d-glucose, resulted in the formation of two diastereomeric tetraols in each case.

286 eveloped an MD-based method for studying the diastereomeric transition state complexes and rationaliz

287 sulfur center in the ylide intermediate, two diastereomeric transition states (endo-TS1 and exo-TS1)

288 vities using computed Gibbs free energies of diastereomeric transition states are in fair agreement w

289 evailing steric interactions expected in the diastereomeric transition states for propagation during

290 of competing 1,3-diaxial interactions in the diastereomeric transition states for trapping on the alp

291 he reaction was subsequently attempted, with diastereomeric transition states identified for the turn

292 erefore the difference in energy between the diastereomeric transition states of the two enantiomers.

293 Two diastereomeric transition states with orthogonal and ske

294 te close structural similarities between the diastereomeric transition states, the relative energies

295 rily from differences in hydrogen bonding in diastereomeric transition states.

296 ergy difference between the rate-determining diastereomeric transition structures involved in the mos

297 derived from in situ decarboxylation of the diastereomeric tricyclic beta-lactone.

298 nerated multicomponent assembly that creates diastereomeric tris(pyridine) metal complexes incorporat

299 98 (as shown in Scheme 19 in the article) to diastereomeric vannusal B structure (+)-d-2 (as shown in

300 took us through the total synthesis of eight diastereomeric vannusal B structures [2, d-2, 3, d-3, 4,