ライフサイエンスコーパス: diastereoselective

1 groups four carbon atoms away can be highly diastereoselective.

2 insertions, with only the latter step being diastereoselective.

3 and is functional-group-tolerant and highly diastereoselective.

4 we describe the development of a regio- and diastereoselective 1,4-aminothiolation of 1,3-dienes wit

5 demonstrated via Lewis acid catalyzed highly diastereoselective (3 + 2) cycloaddition reactions of th

6 A diastereoselective (3 + 2) dearomative annulation of 3-s

7 on from the dirhodium-bound enol-carbene and diastereoselective [3 + 2]-cycloaddition by uncatalyzed

8 rephedrine as a ligand to promote the highly diastereoselective (32:1) propargylation.

9 bon-carbon bond constructions include highly diastereoselective acetylide additions to the N-methylim

10 ent years, our group has reported the highly diastereoselective acid-catalyzed N,O-acetalization/intr

11 ite the northern and southern hemispheres, a diastereoselective, acid-mediated delta-hydroxy enone cy

12 e discussed considering mechanisms involving diastereoselective addition of alkynylcopper complex for

13 A quinidine-catalyzed diastereoselective addition of alpha-angelica lactone to

14 The diastereoselective addition of an allylic indium interme

15 rs of this class of alkaloids exploiting the diastereoselective addition of an axially chiral lithiat

16 res a powerful photochemical opening step, a diastereoselective addition of an ethyl cuprate and an u

17 Using the diastereoselective addition of an organocerate as a key

18 ted 3-hydroxyoxindole by DBU-mediated highly diastereoselective addition of aryl acetonitrile to N-pr

19 The diastereoselective addition of organozinc species to 1,2

20 vanced enone intermediate and the chemo- and diastereoselective addition of trimethylaluminum to a ke

21 anocopper intermediates and their subsequent diastereoselective addition to ketones, allowing for the

22 l adducts subsequently undergo base-promoted diastereoselective aldol cascade reactions resulting in

23 issamine has been developed that relies on a diastereoselective aldol reaction between a suitably pro

24 e to construct the C5-C11 polyol fragment, a diastereoselective aldol reaction to control the stereog

25 The protocol entails a highly diastereoselective aldol/Brook rearrangement/cyclization

26 enic fragments were coupled using a 1,5-anti diastereoselective aldolization followed by a 1,3-anti r

27 nvolves two C-C bond-forming steps, a highly diastereoselective alkene hydration, and asymmetric keto

28 he key stereodifferentiating step involves a diastereoselective alkylation of an alpha-monosubstitute

29 locks for asymmetric transformations such as diastereoselective alkylation of the alpha-position.

30 ituted gamma-sultam alpha-carbanions undergo diastereoselective alkylation reactions with alkyl halid

31 5a-i supports previous conclusions that the diastereoselective alkylation step proceeds via an alpha

32 ey steps of this sequence include a matched, diastereoselective alkylation with an iodomethylphenyl s

33 rt-butyl (E)-hexa-2-en-4-ynoates followed by diastereoselective alkyne reduction.

34 ghly enantioselective (most >/= 98:2 er) and diastereoselective (all >/= 15:1 dr) N-heterocyclic carb

35 zation, a 1,3-syn aldolization, enantio- and diastereoselective allylations, a hemiacetalization/oxa-

36 endently in sequential Mukaiyama-Michael and diastereoselective alpha,alpha'-diketone coupling.

37 The strategy is based on the diastereoselective amination of enantioenriched trans-ga

38 Reported herein are diastereoselective and enantioselective allylic substitu

39 was realized by the development of a highly diastereoselective and enantioselective C-C bond-forming

40 catalysts to achieve highly site-selective, diastereoselective and enantioselective C-H functionaliz

41 Both diastereoselective and enantioselective catalytic method

42 in a highly chemoselective, regioselective, diastereoselective and enantioselective fashion.

43 e starting oxindoles allowed a site-specific diastereoselective and enantioselective transformation.

44 Reported herein are the first diastereoselective and Lewis acid-mediated radical react

45 e identified high-yielding protocol is mild, diastereoselective, and catalytic.

46 cade electrocyclizations is also potentially diastereoselective, and di- and trisubstituted tetraenes

47 The first highly enantioselective, diastereoselective, and regioselective [2,3]-rearrangeme

48 The reaction is convergent, completely diastereoselective, and shows a broad scope with regard

49 loying a divergent approach that relies on a diastereoselective anionic oxy-Cope rearrangement to set

50 prepared from citronellol using a divergent diastereoselective approach.

51 A diversity-oriented access to diastereoselective arylidene 2,5-diketopiperazines is el

52 One ligand exhibits a highly diastereoselective assembly into homochiral (either Delt

53 boron, and imines allows regio-, chemo-, and diastereoselective assembly of branched alpha,beta-subst

54 (R)-alpha-methylbenzylamine, giving a highly diastereoselective asymmetric Mannich-type addition with

55 The diastereoselective asymmetric synthesis of vicinal all-c

56 A diastereoselective auxiliary-mediated vinylation/[1,2]-B

57 title compounds have been developed using a diastereoselective aziridination reaction of 4-O-substit

58 The highly diastereoselective base-promoted intramolecular cyclizat

59 n of tricyclic hexahydroxanthene-dione and a diastereoselective bis-hydroxylation.

60 nsformations enabling the approach include a diastereoselective borylative enyne cyclization and a la

61 Key transformations include a highly diastereoselective bromoallylation of a sensitive alpha,

62 An enantioselective and highly diastereoselective bromoetherification and desymmetrizat

63 via regioselective epoxide-ring opening and diastereoselective bromoetherification.

64 riety of indole analogues and thiophenol for diastereoselective C-C, C-N, and C-S bond-forming reacti

65 lylations and functionalizations, as well as diastereoselective C-H silylations of a chiral, natural-

66 A method for the diastereoselective carboboration of 1,2-disubstituted st

67 A highly diastereoselective carbon-carbon bond-forming reaction i

68 ination with XeF(2) mediates the consecutive diastereoselective cation-olefin cyclization/fluorinatio

69 Lewis acid-controlled, diastereoselective cationic oxycyclizations enabled asym

70 scussed, including the evolution of a highly diastereoselective, chiral auxiliary controlled version

71 es several key steps, including a regio- and diastereoselective chlorinative oxabicycle ring-opening

72 intermediates under mild regio-, chemo- and diastereoselective conditions that are fully orthogonal

73 +)-preussin B have been developed, using the diastereoselective conjugate addition of lithium (S)-N-b

74 ino-alpha,beta-unsaturated ester, and doubly diastereoselective conjugate addition of the antipodes o

75 ne alkaloids (T1-T8) were achieved using the diastereoselective conjugate additions of lithium amide

76 Diastereoselective conjugate additions to alpha,beta-uns

77 ophilic partners for the direct enantio- and diastereoselective construction of beta-fluoroamine moti

78 ophilic partners for the direct enantio- and diastereoselective construction of quaternary carbon ste

79 e newly designed chiral ligand exhibits high diastereoselective control during cluster formation, lea

80 ioselectivities (up to 95% ee), and complete diastereoselective control in a single-pot operation.

81 ns with a chemoselective, site-selective and diastereoselective copper-boron addition to a monosubsti

82 med in a single vessel, involving regio- and diastereoselective copper-catalyzed carbomagnesiation of

83 A highly enantio- and diastereoselective copper-catalyzed three-component coup

84 postrearrangement transformations: A highly diastereoselective Corey-Bakshi-Shibata reduction of a b

85 ve organocatalytic oxidation of an aldehyde, diastereoselective Cu(OTf)2-catalyzed Michael reaction/t

86 This is because diastereoselective Cu-H elimination may be avoided and/o

87 ttractively functionalized cyclopropanol and diastereoselective cyclization of the resulting aminoall

88 irectly from thymidine, via butenylation and diastereoselective cyclization promoted by N,N-dimethyl-

89 An unexpected diastereoselective cyclization reaction was observed, le

90 cyclization catalyzed by PS-BEMP, and (ii) a diastereoselective cyclization, which formally constitut

91 and (+)-frondosin A are reported based on a diastereoselective cycloaddition between tetrabromocyclo

92 An unprecedented gold-catalyzed diastereoselective cycloisomerization of 1,6-diynes bear

93 ion reactions has allowed for the catalytic, diastereoselective cycloisomerization of biogenic alkene

94 We first establish highly diastereoselective cycloisomerizations using an achiral

95 C-H insertion and catalyse the enantio- and diastereoselective cyclopropanation of unactivated olefi

96 The diastereoselective cyclopropanation of various alkenes w

97 Novozyme-435-mediated diastereoselective deacylation of one of the two diaster

98 The reaction is highly diastereoselective depending on the homoallylic amine us

99 microsolvation-controlled choices of highly diastereoselective derivatizations of 1.

100 Catalytic tandem diastereoselective desymmetrization of cyclohexadienone-

101 ara oxidative phenolic coupling and a highly diastereoselective "desymmetrization" of the resulting c

102 t time to probe the configuration and highly diastereoselective deuteration of a chiral organosamariu

103 The steps involve Mg-mediated diastereoselective dibromocyclopropanation of alkylidene

104 e cross-metathesis, and a chemoselective and diastereoselective dichlorination of a complex diene.

105 f allahabadolactone A is described employing diastereoselective Diels-Alder and selenocyclization rea

106 idation with (-)-camphorsulfonyloxaziridine, diastereoselective dihydroxylation of a 2,3-syn-gamma,de

107 A novel, base-catalyzed and highly diastereoselective direct Michael addition-isomerization

108 al C-H functionalization reactions, namely a diastereoselective dirhodium carbene insertion followed

109 termediate 7-oxo-5-enones underwent a highly diastereoselective (dr >/=96:4) acid-catalyzed aza-Micha

110 proach takes advantage of a highly efficient diastereoselective electrophilic fluorination reaction (

111 Key steps include a highly diastereoselective enamine/enal cycloaddition and the se

112 , and this represents the first example of a diastereoselective enolate hydrogen borrowing alkylation

113 Key steps include a highly diastereoselective enzymatic desymmetrization, substrate

114 Diastereoselective epoxidation and regioselective ring-o

115 ed epoxidation reagent was developed for the diastereoselective epoxidation of one class of stericall

116 by variable-temperature NMR experiments and diastereoselective epoxidation reactions.

117 This epoxide results from the diastereoselective epoxidation, performed at a multigram

118 Furthermore, highly diastereoselective examples are presented, allowing acce

119 synthesis was conducted in an asymmetric and diastereoselective fashion with respect to the imbedded

120 bsequent deborylative alkylation occurs in a diastereoselective fashion, both for intermolecular and

121 rough the use of simple reagents in a highly diastereoselective fashion.

122 rifluoromethylated alkylboron compounds in a diastereoselective fashion.

123 ound was shown to be an enantioselective and diastereoselective fluorescent sensor for chiral diamine

124 imal use of protecting groups and the highly diastereoselective formation of a hindered, quaternary s

125 ta-lactams were deployed as synthons for the diastereoselective formation of chiral 2-(2,2,2-trifluor

126 preferences as well as the mechanism for the diastereoselective formation of specific azabicycloalkan

127 um-(P,olefin) complex-catalyzed enantio- and diastereoselective formation of substituted spiroketals

128 Our synthesis of caribenol A features the diastereoselective formation of the seven-membered ring

129 As a demonstration of product utility, diastereoselective Friedel-Crafts reactions were perform

130 We report the first example of a highly diastereoselective Garratt-Braverman cyclization leading

131 ric aldol reaction using a titanium enolate, diastereoselective Grignard addition to a tert-butanesul

132 ring junction was desired, an intermolecular diastereoselective Grignard reaction followed by ring-cl

133 This chiral auxiliary was used for highly diastereoselective (>98% de) electrophilic fluorination

134 A rapid anti-diastereoselective halocyclization of these salts provid

135 c kinetic resolution (DKR) with enantio- and diastereoselective hydogenation on beta-keto-gamma-lacta

136 y prepared from tert-butyl sorbate using our diastereoselective hydroamination or aminohydroxylation

137 nd to the substrate, has been applied to the diastereoselective hydroformylation of homoallylic alcoh

138 azarov cyclization sequence, and a high-risk diastereoselective hydrogenation of a fully substituted

139 Subsequent diastereoselective hydrogenation provides an additional

140 g trans isomer and a coupling, followed by a diastereoselective hydrogenation using Wilkinson's catal

141 In this sequence, fully diastereoselective hydrogeneration of the endocyclic car

142 ct synoxazolidinone A was achieved through a diastereoselective imine acylation/cyclization cascade.

143 The reaction is diastereoselective, in favor of the 1S epimer, when larg

144 around the cyclopentane ring, namely highly diastereoselective installation of carbo- and heterocycl

145 ormed in an iterative fashion allowing for a diastereoselective installation of two aryl groups along

146 we report a zirconium-catalyzed enantio- and diastereoselective inter/intramolecular double carboalum

147 An iron-catalyzed diastereoselective intermolecular olefin amino-oxygenati

148 An advanced protocol for the diastereoselective intramolecular aziridination reaction

149 Chloroacetic acid promotes an efficient and diastereoselective intramolecular cascade reaction of el

150 n with N-allyl-N-(p-tosyl)amine and a highly diastereoselective intramolecular Diels-Alder reaction o

151 The key step in this approach is a diastereoselective intramolecular enamine/Michael cascad

152 A diastereoselective intramolecular iodoamination-cyclizat

153 ine C have been accomplished through a novel diastereoselective, intramolecular amide Michael additio

154 Highlights of the approach include a highly diastereoselective, intramolecular Diels-Alder reaction

155 n the first study of a ZnI2-catalyzed highly diastereoselective inverse electron demand hetero-Diels-

156 We present highly regio- and diastereoselective inverse electron demand oxa-Diels-Ald

157 of C20 in steroidal derivatives by a highly diastereoselective Ir-catalyzed isomerization of primary

158 ange of allylic alcohols participates in the diastereoselective isomerization under the optimized rea

159 ve hydroacylation cycle followed by a slower diastereoselective ketone reduction cycle.

160 employs two key strategic cyclizations: 1) a diastereoselective light-mediated cyclization of an O-ar

161 a-amino acids in chiral, nonracemic form via diastereoselective malonate alkylation followed by C- to

162 onstruct cyclobutanes in a highly regio- and diastereoselective manner in solution under visible ligh

163 ries of highly substituted pyrrolidines in a diastereoselective manner is reported.

164 -6-oxa-2-azabicyclo[3.2.1]octane in a highly diastereoselective manner through an unexpected intramol

165 e of a catalytic amount of ZnBr2 in a highly diastereoselective manner with excellent yield.

166 struct indoline units in a highly regio- and diastereoselective manner with yields ranging from 63 to

167 o proceed in high yields and in a regio- and diastereoselective manner, giving interlocked 3,4-disubs

168 ntrol, the reaction proceeded in a much less diastereoselective manner.

169 t pyrrolidine units in a highly enantio- and diastereoselective manner.

170 on affords the bicyclic products in a highly diastereoselective manner.

171 ntial Diels-Alder/aldol approach in a highly diastereoselective manner.

172 Low temperature NMR studies revealed that a diastereoselective Mannich reaction between a phenyl oxa

173 uction with Schwartz's reagent followed by a diastereoselective Mannich/Michael tandem reaction of th

174 of selectivity was achieved by using a novel diastereoselective Matteson homologation.

175 putational investigations unveiled a complex diastereoselective mechanism.

176 A diastereoselective mercury(II)-promoted intramolecular c

177 Highly diastereoselective metalloamination/cyclization reaction

178 A general, efficient, and highly diastereoselective method for the synthesis of structura

179 chelation and dipole minimization models for diastereoselective methyl ketone aldol reactions, the di

180 r(II) complex-catalyzed enantioselective and diastereoselective Michael reactions of cyclic ketoester

181 In situ silylation and enolization induces diastereoselective migration of the N'-aryl group to the

182 All the reactions are found to be fully diastereoselective, mild, and high yielding.

183 A robust, scalable, and highly diastereoselective montmorillonite K10-promoted allylati

184 The synthesis highlights the use of a highly diastereoselective Mukaiyama-type [3 + 2]-annulation of

185 Diastereoselective multicomponent reactions of enantioen

186 ture of the dianion (SP,RC)-10 formed in the diastereoselective N,Cortho dilithiation of the phosphin

187 Key features of the synthesis include diastereoselective Nazarov and ring-closing metathesis r

188 assembled with trans geometry using a highly diastereoselective Nishiyama cyclopropanation, and the o

189 ore structure, an unusual intramolecular and diastereoselective Nozaki-Hiyama-Kishi reaction involvin

190 etal complexes to effect chemo-, regio-, and diastereoselective NT.

191 It involved, as the key step, a diastereoselective nucleophilic addition of the Ruppert-

192 Key steps are a totally diastereoselective nucleophilic addition to the cyclic n

193 rs' chiral hydrazone derivatives followed by diastereoselective nucleophilic addition to the hydrazon

194 m ion intermediates that then undergo highly diastereoselective nucleophilic additions.

195 The development of a diastereoselective nucleoside phosphorylation is describ

196 Reported herein is a new iron-catalyzed diastereoselective olefin diazidation reaction which occ

197 After diastereoselective olefinic oxidation of the resultant e

198 omopipecolic acids, have been prepared using diastereoselective olefinic oxidations of a range of ena

199 Our approach features a diastereoselective one-pot sequence for constructing the

200 The diastereoselective one-pot synthesis of hexahydrocyclope

201 Substituents on the tether lead to diastereoselective outcomes dictated by transannular int

202 we conduct carefully orchestrated site- and diastereoselective oxidations and other transformations.

203 the catalytic asymmetric halocyclization and diastereoselective oxyamination reactions of tryptamine

204 ran-2(5H)-one, followed by an intramolecular diastereoselective Passerini-type reaction.

205 The diastereoselective Pd(OAc)2-catalyzed, bidentate ligand-

206 A trans-diastereoselective Pd-catalyzed dearomative [3 + 2] cycl

207 arbon atoms are then installed by means of a diastereoselective Pd-catalyzed decarboxylative allylati

208 d position-specific allylic rearrangement in diastereoselective Pictet-Spengler cyclization were the

209 Key steps include a diastereoselective Pictet-Spengler reaction and an intra

210 an enantioselective ketone alkylation and a diastereoselective pinacol cyclization.

211 transformation of the sequence involves the diastereoselective preparation of the desired trifluorom

212 These regio- and diastereoselective processes enable convergent construct

213 tereoselectivity of the enantioselective and diastereoselective processes in aminodialkene cyclizatio

214 ucts all being accessed through these highly diastereoselective processes.

215 ion of intermediates, chirality transfer and diastereoselective product formation.

216 The catalytic diastereoselective protocol can be extended to aryl, alk

217 A highly chemo- and diastereoselective protocol toward amino-substituted don

218 Subsequent divergent regio- and diastereoselective protonation of the dihydropyridines u

219 nate by diazene to form dihydroartemisinate (diastereoselective ratio, dr, 97:3) necessary for effici

220 s new mode of reactivity was employed in the diastereoselective reaction of arylboron reagents with s

221 Low-yielding and moderately alpha- and diastereoselective reactions are thus turned into highly

222 nol has been accomplished using three highly diastereoselective reactions as pivotal steps: 1) an int

223 of the terminal chiral residues, and permits diastereoselective reactions such as alkene hydrogenatio

224 The synthesis relies on three highly diastereoselective reactions, including an intramolecula

225 e mainly been used as chiral auxiliaries for diastereoselective reactions.

226 Diastereoselective recognition between OPV3T and thymidi

227 In addition, diastereoselective reduction of 3-azabicyclo[3.1.0]hex-2

228 the Horner-Wadsworth-Emmons reaction and the diastereoselective reduction of alpha,beta-unsaturated k

229 involved chelation and substrate-controlled diastereoselective reduction of cyclohexenone and lacton

230 ficient than those commonly reported for the diastereoselective reduction of five- and six-membered c

231 Lactone synthesis facilitated the diastereoselective reduction of ketone, which help contr

232 alpha-Epimerization by oxidation and diastereoselective reduction then gave access to the cor

233 alpha-hydroxymethyl ketimines undergo highly diastereoselective reduction to syn- or anti-1,3-amino a

234 d regiospecific rearrangement and subsequent diastereoselective reduction.

235 genolytic N-debenzylation was accompanied by diastereoselective reductive cyclization in situ; reduct

236 N-Debenzylation and concomitant diastereoselective reductive cyclization, followed by re

237 amide to tert-butyl 4-phenylbut-2-enoate and diastereoselective reductive cyclizations of gamma-amino

238 The diastereoselective Reformatsky reactions employed in the

239 In addition, a diastereoselective reverse prenylation of tryptophan met

240 tion of conjugated enyne oxiranes provides a diastereoselective route to (E)-configured 7-hydroxy-2,3

241 Here, we describe a highly enantio- and diastereoselective route to complex indanes bearing all-

242 We report a concise, enantio- and diastereoselective route to novel nonsymmetrically subst

243 e ligands were designed and synthesized by a diastereoselective S(N)Ar substitution of the correspond

244 This ligand undergoes completely diastereoselective self-assembly into D2-symmeteric doub

245 ty of this approach to achieve high-fidelity diastereoselective self-assembly via chiral self-sorting

246 on is reported and a method for carrying out diastereoselective solid-supported Evans' syn-aldol reac

247 An efficient, mild, and highly diastereoselective strategy for the synthesis of trans-2

248 eaction products are shown to undergo highly diastereoselective substrate-controlled reduction to giv

249 Many diastereoselective (substrate stereocontrol), and enanti

250 labeled cyclic enol ethers revealed a highly diastereoselective syn-selective protonation/nucleophile

251 Two concise and high-yielding diastereoselective syntheses of 4-aryl-3-methyl-4-piperi

252 Diastereoselective syntheses of dihydroconduramines (+/-

253 Here, we report the enantio- and diastereoselective synthesis and structure-activity rela

254 The first catalytic enantio- and diastereoselective synthesis of 1,2-hydroxyboronates is

255 We report herein the improved diastereoselective synthesis of 2,5-disubstituted pyrrol

256 A new strategy for the highly enantio- and diastereoselective synthesis of 3,4-dihydrocoumarin deri

257 The first catalytic enantio- and diastereoselective synthesis of 4-nitropyrazolidines is

258 A diastereoselective synthesis of 4-vinyl oxazolines syn-2

259 Diastereoselective synthesis of a polycyclic furan is de

260 ss to key intermediates for the enantio- and diastereoselective synthesis of a series of naturally oc

261 The identified protocol gives access to diastereoselective synthesis of alpha- and beta-araf, ri

262 A catalytic protocol for the diastereoselective synthesis of anti-1,2-hydroxyboronate

263 c formal [5+2] cycloaddition approach to the diastereoselective synthesis of azepino[1,2-a]indoles is

264 convenient route has been developed for the diastereoselective synthesis of beta-C-glycopyranosyl al

265 le we describe a catalytic procedure for the diastereoselective synthesis of beta-lactones bearing tw

266 A new highly diastereoselective synthesis of chiral alpha-substituted

267 The diastereoselective synthesis of cis and trans steroid-fu

268 A diastereoselective synthesis of cis-2,6-disubstituted te

269 An ecofriendly and diastereoselective synthesis of cis-3,5-disubstituted is

270 ternal alkynes can be used in the regio- and diastereoselective synthesis of complex trisubstituted a

271 The first catalytic enantio- and diastereoselective synthesis of diaziridines is presente

272 A highly diastereoselective synthesis of five-membered rings is a

273 Further, an enantio- and diastereoselective synthesis of homoallylic amines from

274 A short, diastereoselective synthesis of homocitric acid lactone

275 Extensive study of the diastereoselective synthesis of l-pyranosides utilizing

276 s the use of amino acid esters, allowing the diastereoselective synthesis of N,N-dicarboxymethylamine

277 A highly diastereoselective synthesis of N-acetyl dihydrotetrafib

278 t describes a catalyst-controlled regio- and diastereoselective synthesis of N-unprotected pyrrolidin

279 We report the diastereoselective synthesis of novel spiropiperidine te

280 tes in a new synthesis of anthraquinones and diastereoselective synthesis of tetrahydroanthraquinones

281 e current strategy could be utilized for the diastereoselective synthesis of tetrahydroquinoline deri

282 The method is also used for a highly diastereoselective synthesis of the N-Boc derivative of

283 A concise and highly diastereoselective synthesis of the polyfused tetracycli

284 The process described involves the first diastereoselective synthesis of this type of compound by

285 Similar yet different: A one-step regio- and diastereoselective synthesis of three new bis(pyrrolidin

286 A robust diastereoselective synthesis provided sufficient quantit

287 lohelix enantiomer Delta1a, available from a diastereoselective synthesis with no need for resolution

288 interest in developing strategies for their diastereoselective synthesis.

289 ffold led to a critical substrate controlled diastereoselective synthetic strategy whereby chiral inf

290 Key to the synthesis is a diastereoselective tethered aminohydroxylation of a homo

291 enals, followed by catalytic intramolecular diastereoselective Tishchenko reaction and lactonization

292 A catalyst-controlled enantio- and diastereoselective total synthesis of the two most likel

293 cade reactions that couple this enantio- and diastereoselective transformation to additional reversib

294 A diastereoselective two-step strategy for the synthesis o

295 tion represents one of the first examples of diastereoselective Ugi three-component reaction on a sev

296 in terms of yields and resulted in a highly diastereoselective unprecedented solvent/catalyst switch

297 Moreover, a diastereoselective variant of this method gives access t

298 deprotection operations, features the highly diastereoselective, vinylogous Mannich addition of a die

299 functionalized trans-gamma-lactams III in a diastereoselective way.

300 The reactions are highly diastereoselective with excellent yields.