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1 deling at 6 months included decreases in end-diastolic (161 +/- 36 ml to 122 +/- 30 ml; p < 0.001) an
2 95% confidence interval [CI], 2.64-6.51) and diastolic (2.25 mm Hg; 95% CI, 0.83-3.67) blood pressure
4 arts revealed that all LV parameters (LV end-diastolic and -systolic dimensions, ejection fraction, a
10 ted at an advanced age, reverses age-related diastolic and microvascular dysfunction; these data sugg
13 9%, 2.5%, and 3.1% of variation in systolic, diastolic, and pulse pressure, respectively, in GERA non
15 sure control (<140 mm Hg systolic, <90 mm Hg diastolic), angiotensin-converting enzyme inhibitor or a
16 (peak ); and diastolic uncoupling (systolic -diastolic at same volume) during early diastole (UNCOUP_
17 tolic (SRs), early diastolic (SRe), and late diastolic atrial contraction phases (SRa) were analyzed
18 ovel index AI rd , a combination of AI r and diastolic augmentation index (AI d ) with a weight alpha
19 tenth percentile and absent or reversed end-diastolic blood flow in the umbilical artery on Doppler
20 ned as systolic blood pressure >/=140 mm Hg, diastolic blood pressure >/=90 mm Hg, or initiation of a
21 e medications while maintaining systolic and diastolic blood pressure <140 mm Hg and 90 mm Hg, respec
22 CI, -1.77 to -0.75]; 22 trials [n = 57953]), diastolic blood pressure (-0.49 mm Hg [95% CI, -0.82 to
23 the definition of hypertension, systolic and diastolic blood pressure (BP) thresholds for initiation
24 s were similar for each 10 mmHg increment in diastolic blood pressure (DBP) (p < 0.001) or each 15 mm
25 al in both systolic blood pressure (SBP) and diastolic blood pressure (DBP) between the magnesium-sup
26 (GL) with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in healthy individuals.A
28 g or greater and less than 180 mm Hg, office diastolic blood pressure (DBP) of 90 mm Hg or greater, a
32 e age of 7 y, systolic blood pressure (SBP), diastolic blood pressure (DBP), and the prevalence of ch
36 .34; 95% CI: 1.05, 1.70), and new-onset high diastolic blood pressure (OR: 1.25; 95% CI: 0.99, 1.58)
39 ; 15 trials, 1190 participants), and diurnal diastolic blood pressure (WMD, -1.3 points [95% CI, -2.2
40 otoxin, resiniferatoxin, selectively lowered diastolic blood pressure both at daytime and night-time
41 with acute respiratory infection and reduced diastolic blood pressure but not with other health measu
44 d mean baseline office and 24-h systolic and diastolic blood pressure levels were 154 (14)/90 (11) mm
45 individuals provided 1,342,814 systolic and diastolic blood pressure measurements for a genome-wide
46 lic blood pressure of at least 140 mm Hg, or diastolic blood pressure of at least 90 mm Hg, or self-r
47 blood pressure 160 vs 110 mm Hg) but not for diastolic blood pressure or lipid measures with VTE.
48 average rate of change in both systolic and diastolic blood pressure was greater among African-Ameri
51 Retirement was accompanied by a reduction in diastolic blood pressure, a slowdown in the increase of
53 ensity lipoprotein cholesterol, systolic and diastolic blood pressure, and fasting glucose were measu
54 in biological (body-mass index, systolic and diastolic blood pressure, and handgrip strength), behavi
55 icant increases were detected in systolic or diastolic blood pressure, and no heterogeneity was obser
56 , triglycerides, fat mass (FM), systolic and diastolic blood pressure, fasting insulin and glucose, a
57 ht cardiometabolic traits (BMI, systolic and diastolic blood pressure, LDL cholesterol, HDL cholester
58 ociated with self-reported IHD, systolic and diastolic blood pressure, low-density lipoprotein- and t
59 d several cis-eGenes (ALDH2 for systolic and diastolic blood pressure, MCM6 and DARS for total choles
60 mbers of patients treated per center, higher diastolic blood pressure, off-hour admission, and absenc
62 n the average rate of change in systolic and diastolic blood pressure, respectively, whereas family S
63 tation (nitric oxide, rho = -0.66, P = 0.06; diastolic blood pressure, rho = 0.68, P = 0.04) and infl
64 ngestive heart failure, warfarin, age, race, diastolic blood pressure, stroke), and observed that all
65 status, postmenopausal hormone therapy use, diastolic blood pressure, total cholesterol, high-densit
66 ween retirement and systolic blood pressure, diastolic blood pressure, waist circumference, body mass
69 o HDL cholesterol (TC:HDL), and systolic and diastolic blood pressures (SBP and DBP, respectively)].
70 , we found significantly higher systolic and diastolic blood pressures among those who entered or con
71 mentation significantly reduced systolic and diastolic blood pressures, cardiac fibrosis, and left ve
72 40 to 79 years of age, with clinic systolic/diastolic BP <140/90 mm Hg, who completed ambulatory BP
73 : -2.14, 0.06) and a 0.63-mm Hg decrement in diastolic BP (95% CI: -1.35, 0.09), controlling for sex,
74 tory hypertension (daytime systolic BP [SBP]/diastolic BP [DBP] >/=135/85 mm Hg, 24-hour SBP/DBP >/=1
75 ciated with BP (P<10(-320)) for systolic and diastolic BP and CVD events regardless of the underlying
76 utcomes were the differences in systolic and diastolic BP changes from baseline to the end of follow-
78 upper tail of the systolic (except boys) and diastolic BP distribution shifted downwards, whereas the
84 uction in sodium in drinking water, systolic/diastolic BP was lower on average by 0.95/0.57 mmHg, and
85 cross-sectional associations of systolic and diastolic BP with blood-derived genome-wide DNA methylat
86 2002 to 2005 and increased slightly to 2014, diastolic BP z-score decreased slightly from 1999 to 200
87 uggesting that older age, black race, higher diastolic BP, and higher lipids were associated with gre
88 ractions with age, baseline systolic BP, and diastolic BP, and the SAE model had 8 variables includin
89 e matched 1:2 by age, race, body mass index, diastolic BP, parity, and diabetes status, r-AKI remaine
92 versus noncarriers (Delta systolic BP/Delta diastolic BP: -12.3/-8.2 versus -6.8/-3.5 mm Hg, respect
102 tivity of systolic Ca(2+) to LCC density and diastolic Ca(2+) to SERCA density decreased by 16-fold a
103 The factors responsible for regulation of diastolic [Ca(2+) ]i , in particular the relative roles
114 ssue, resulting in a decrease in the rate of diastolic depolarization and, consequently, the heart ra
115 rmination of the threshold potential and the diastolic depolarization rate that is independent of the
117 HIIT and MCT (P=0.45); left ventricular end-diastolic diameter changes compared with RRE were -2.8 m
120 d smaller LV cavity, higher ratio of LVWT to diastolic diameter, and higher echocardiographic LV ejec
121 electrocardiography; decreased LV systolic, diastolic diameter, or septal E' velocity; higher ratio
122 septal E' velocity; higher ratio of LVWT to diastolic diameter; serum troponin level; and natriureti
123 en with preeclampsia had smaller mean LV end-diastolic diameters (5.2 versus 6.0 cm; P=0.001), greate
124 versus -9.06+/-3.89, P<0.001) and lower end-diastolic dimension z scores (4.12+/-2.61 versus 4.91+/-
126 239.9 vs. 576.7 +/- 472.9 events h(-1) ) and diastolic dysfunction (0.008 +/- 0.004 vs. 0.027 +/- 0.0
131 CV values (>/=0.40) were more likely to have diastolic dysfunction (P = .003) and increased left atri
134 ks of a high-salt diet, 31 of 38 rats showed diastolic dysfunction and preserved ejection fraction al
135 orubicin-injected fish developed ventricular diastolic dysfunction and worsening global cardiac funct
136 Increased left ventricular (LV) mass and diastolic dysfunction are associated with cardiovascular
140 rdial fibrosis in SCA mice, but the cause of diastolic dysfunction in humans with SCA is unknown.
143 Incorporation of longitudinal strain and diastolic dysfunction into the Stage B definition reclas
148 lar thickening at 4 weeks of age, as well as diastolic dysfunction that progressed with age, in Hyal2
149 ter, mean limb lead QRS voltage, and grade 3 diastolic dysfunction yielded excellent discriminatory c
150 ontributes to the development of age-related diastolic dysfunction, and (2) initiation of late-life e
152 normalities result in progressive and severe diastolic dysfunction, culminating in heart failure.
153 deformation indices with Doppler indices of diastolic dysfunction, functional capacity, biomarkers,
154 d ejection fraction and their correlation to diastolic dysfunction, functional class, pathophysiologi
155 uction, left ventricular hypercontractility, diastolic dysfunction, left-atrial enlargement and left
156 x and includes left ventricular systolic and diastolic dysfunction, pulmonary vascular disease, endot
157 ral chemoreflex pathway in HFpEF exacerbates diastolic dysfunction, worsens sympatho-vagal imbalance
169 nd E/e' ratios; 2) their roles in diagnosing diastolic dysfunction; 3) prognostic implications of abn
170 ar exercise training ameliorates age-related diastolic dysfunction; however, the underlying mechanism
172 Isovolumic relaxation time (IVRT), early diastolic filling (E/A), myocardial performance index (M
173 cardiac parameters, including reduced early diastolic filling rates as well as a higher prevalence o
174 r hypertension, E/A, a diagnostic measure of diastolic filling, decreases, and isovolumic relaxation
176 placentas displaying absent or reversed end-diastolic flow contained reduced myosin heavy chain, smo
178 ction fraction and longitudinal strain), and diastolic function (based on e', E/e', and left atrial v
179 ion = 49+/-10% versus 58+/-10%; P<0.001) and diastolic function (early relaxation velocity = 8.9+/-2.
180 tion = 52+/-11% versus 63+/-8%; P<0.001) and diastolic function (early relaxation velocity = 9.3+/-2.
181 ion (left ventricular ejection fraction), LV diastolic function (early relaxation velocity), and coro
182 in childhood was associated with LV mass and diastolic function after adjustment for conventional car
189 h age-associated changes in left ventricular diastolic function are well recognized, limited data exi
190 erminus impacts heart function by depressing diastolic function at baseline and limiting systolic res
191 either useful or challenging when evaluating diastolic function clinically; and 5) their usefulness i
194 imited data exist characterizing measures of diastolic function in older adults, including both refer
196 of GSK-3beta, reduced fibrosis, and restored diastolic function in the mice that had experienced an A
200 ic remodeling and impairment of systolic and diastolic function parameters, whereas an increase in FF
202 T1 measurements of blood and myocardium, and diastolic function was assessed by echocardiography.
204 ventricular (LV) morphology and systolic and diastolic function were evaluated with cardiac MRI and n
205 gen deposition and a decline in systolic and diastolic function were present only in WT mice, and not
206 s the relevant echocardiographic measures of diastolic function with blood-based biomarkers (such as
207 ic transmitral flow velocity (E/A) to assess diastolic function, and E to early diastolic mitral annu
215 hat Micu2(-/-) mice recapitulate features of diastolic heart disease and define previously unapprecia
216 ove Clinical Status and Exercise Capacity in Diastolic Heart Failure with Preserved Ejection Fraction
217 an earlier, more synchronized, and stronger diastolic LCR signal activating an earlier and larger in
221 we determined the continuous association of diastolic measures (tissue Doppler imaging [TDI] e', E/e
223 ere at intermediate risk (2.4%/y), and all 3 diastolic measures were abnormal in 5% who were at high
224 to assess diastolic function, and E to early diastolic mitral annular tissue velocity (E/e') to estim
225 uch as thickness (hypertrophy) and function (diastolic or systolic), which lack mechanistic specifici
229 ion, membrane potentials such as the maximum diastolic potential, and rates of change of the membrane
230 =0.02) and more likely to have higher RV end-diastolic pressure (HR, 1.07; 95% CI, 1.00-1.15; P=0.057
231 paradoxically decreased left ventricular end-diastolic pressure (LVEDP) and left ventricular end-dias
232 astolic volumes with little effect on LV end-diastolic pressure (LVEDP) or the end-diastolic P-V rela
233 evidenced by increased left ventricular end-diastolic pressure and left ventricular volume indexes.
234 sure from randomization showed a benefit for diastolic pressure at month 12 (P = 0.039) but not at mo
237 section again blunted the increase in LV end-diastolic pressure secondary to volume expansion (+4+/-3
238 proach would mitigate the increase in LV end-diastolic pressure that develops during volume loading i
239 ericardiotomy blunted the increase in LV end-diastolic pressure with saline infusion, while enhancing
240 ction fraction [EF] and left ventricular end-diastolic pressure) was assessed at days 28 and 56.
241 velop increases in left ventricular (LV) end-diastolic pressures during exercise that contribute to d
244 sist devices (LVADs) has decoupling of their diastolic pulmonary artery pressure and pulmonary capill
246 QRS complex to calculate the QRS-gated DPD (diastolic pulmonary artery pressure-QRS-gated PAWP).
247 ents with Cpc-PH have severe PH, with higher diastolic pulmonary pressure gradient, transpulmonary pr
248 tic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants
249 ad higher indexed right ventricular (RV) end-diastolic (range 85-326 mL/m(2), mean 148 mL/m(2)) volum
252 ccounting for altered contractility, reduced diastolic relaxation, and increased energy consumption,
253 h greater LV concentricity, lower myocardial diastolic relaxation, reduced global longitudinal strain
256 the HAART-exposed group, LV mass and LV end-diastolic septal thickness were lower whereas LV contrac
258 s in RyR2 activity in response to increasing diastolic SR [Ca(2+)] are influenced by CSQ2 and are dis
259 nd strain rate (SR) at systolic (SRs), early diastolic (SRe), and late diastolic atrial contraction p
261 , ECV was strongly correlated with the early diastolic strain rate (r = -0.782, p < 0.001) and modera
263 displayed inotropic insufficiency, increased diastolic tension, and premature contractions; ranolazin
266 hermore, noise decreased from 0.105 (median, diastolic) to 0.042 (median, motion-corrected) (P = 0.02
267 phy guidelines recommend using early to late diastolic transmitral flow velocity (E/A) to assess dias
268 ole (Sslope); end-systolic peak (peak ); and diastolic uncoupling (systolic -diastolic at same volume
269 ral inflow velocity and mitral annular early diastolic velocity (E/e') ratio, had the highest left ve
270 reach statistical significance; however, the diastolic velocity-pressure gradient relation was consis
272 are cardiomyopathy characterized by impaired diastolic ventricular function resulting in a poor clini
273 ncing the saline-mediated increase in LV end-diastolic volume (+17+/-1 versus +10+/-2 mL; P=0.016).
274 significant decrease in left ventricular end-diastolic volume (-18 mL; P=0.009) and end-systolic volu
275 y associations with baseline and DeltaLV end diastolic volume (P<0.0001 for each) and not wall thickn
276 ic pressure (LVEDP) and left ventricular end-diastolic volume (preload) in CHF rats, which was not ob
277 ial lidocaine paradoxically decreased LV end-diastolic volume (preload) in CHF rats, which was not ob
278 ar events and a dilated LV (increased LV end-diastolic volume [EDV] indexed to body surface area) at
283 01), obesity (beta=1.3 mL/m(2), P<0.01), end-diastolic volume index (beta=0.4 mL/m(2), P<0.0001), Chi
284 a greater extent of LGE and a higher LV end-diastolic volume index than other groups, but levels of
285 tors (age, body mass index, diabetes, LV end-diastolic volume index, LGE, EF) (hazard ratio = 2.051 p
288 nd-systolic volumes (RVESVi) (indexed RV end-diastolic volume pPVR versus immediately after PVR versu
290 ions of RV mass and, to a lesser extent, end diastolic volume with PM10-2.5 mass among susceptible po
291 sed E-wave velocity and left ventricular end-diastolic volume, 2) exhibit a higher plasma volume, and
292 We quantified associations with RV mass, end-diastolic volume, and ejection fraction after control fo
294 provements in LV end-systolic volume, LV end-diastolic volume, left ventricular ejection fraction, le
296 : -4.3 [11.3] versus 7.4 [11.8], P=0.02; end-diastolic volume: -9.1 [14.9] versus 7.4 [15.8], P=0.02)
298 n in CHF rats increased cardiac systolic and diastolic volumes and further increased the elevated LVE
299 ate and midterm reductions in indexed RV end-diastolic volumes and RV end-systolic volumes (RVESVi) (
300 decreased left ventricular (LV) systolic and diastolic volumes with little effect on LV end-diastolic
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