ライフサイエンスコーパス: diazene

1 ansposition of the in situ generated allylic diazene.

2 duction pathway at the level of reduction of diazene.

3 a-unsaturated aldehydes and various aromatic diazenes.

4 described HNO-donor sodium 1-(isopropylamino)diazene-1-ium-1,2-diolate (IPA/NO), and compare HNO prod

5 -formyl-4-((2E)-1-methylbut-2-en-1-yl)phenyl)diazene-1-oxide (13).

6 E)-2-chloro-1-(chloroimino)-2,2-dinitroethyl}diazene) (10), N1, N2-dichloro-1, 2-diazenedicarboximida

7 m ion center with loss of N(2) to generate a diazene 25 that subsequently decomposes into 21 with los

8 Arylazide and diazene activation by highly reduced uranium(IV) complex

9 ate in which FeMo-co binds the components of diazene (an N-N moiety, perhaps N2 and two [e(-)/H(+)] o

10 obacter vinelandii (Av) nitrogenase with two diazene analogues: diazirine, a photolabile diazene cont

11 y structures of 1-benzoyl-2-(perfluorophenyl)diazene and 1-(perfluorophenyl)-3-phenyl-1,4-dihydrobenz

12 o examine the energetics of the reactions of diazene and isodiazene with H(2) and the properties of t

13 he normal N2-reduction pathway, and that the diazene- and hydrazine-trapped turnover states represent

14 of signal intensity observed for hydrazine-, diazene-, and methyldiazene-trapped states.

15 talyst loadings to preclude oxidation to the diazene ArN=NAr.

16 The UV absorption of this diazene at 382 nm indicates that the compound is the tra

17 ve cyanide, isocyanide, alkyne, N 2, alkene, diazene, azide, CO 2, carbodiimide, and Bronsted acid co

18 of the H2 releasing reaction indicates that diazene binding occurs prior to H2 elimination, and the

19 -membered ring, and trans-dimethyldiazene, a diazene containing an unstrained trans-disubstituted N=N

20 diazene analogues: diazirine, a photolabile diazene containing the azo (-N=N-) group in a strained,

21 ligands, cyanide, imidazole, and the phenyl(diazene)-derived radical inhibit superoxide generation.

22 NDOR establish that this state consists of a diazene-derived [-NHx] moiety bound to FeMo-cofactor.

23 ereas treatment of RPA with oxidizing agent, diazene dicarboxylic acid bis[N,N-dimethylamide] (diamid

24 uadrigemine C, and (-)-psycholeine through a diazene-directed assembly of cyclotryptamine fragments i

25 Our synthesis features the expedient diazene-directed assembly of two advanced fragments to s

26 Through in situ generation of diazene during nitrogenase turnover, we show that diazen

27 union of complex amines in the form of mixed diazenes followed by photoexpulsion of dinitrogen in a s

28 lysed formal [2+2+1] reaction of alkynes and diazenes for the oxidative synthesis of penta- and trisu

29 anilines are particularly resistant towards diazene formation and participate in the amination of st

30 A transformation from cis- to trans-diazene has been found.

31 tate (denoted E4(2N2H)) with a moiety at the diazene (HN horizontal lineNH) reduction level bound to

32 reby is activated to promptly generate bound diazene (HN=NH).

33 e intermediates at the level of reduction of diazene (HN=NH, also called diimide) and hydrazine (H2N-

34 in controlled retro-ene reaction of an allyl diazene, i.e., an allylic diazene rearrangement.

35 ted diazenes, pyrolysis of alkyl-substituted diazenes in the presence of molecular oxygen generates a

36 hydrazine group into a highly reactive acyl diazene intermediate which reacts with an alpha-amino ac

37 dinitrogen from transiently formed monoalkyl diazene intermediates accessed by sequential Mitsunobu d

38 nt synthesis of highly complex bis- and tris-diazene intermediates.

39 varying the length of the tether within the diazenes investigated.

40 ne during nitrogenase turnover, we show that diazene is a substrate for the wild-type nitrogenase and

41 -N moiety, perhaps N2 and two [e(-)/H(+)] or diazene itself).

42 These observations suggest that diazene joins the normal N2-reduction pathway, and that

43 neN horizontal lineNR(2)] with a neutral 1,1-diazene ligand.

44 nsfer complex with ferric cytochrome a3; the diazene may serve to bridge the heme iron of this cytoch

45 nitrogenase under turnover conditions using diazene, methyldiazene (HN = N-CH(3)), or hydrazine as s

46 (Mes)PDI(Me)) (2-Cp*), only 1-Cp* can cleave diazene N horizontal lineN double bonds to form the same

47 termediates, including hydrazine (N(2)H(4)), diazene (N(2)H(2)), nitride (N(3-)) and imide (NH(2-)),

48 f lithium hydroxide forms lithium methanebis(diazene-N-oxide-N'-hydroxylate) and lithium pivalate.

49 of the previously observed sodium methanebis(diazene-N-oxide-N'-hydroxylate) and sodium acetate.

50 d sodium ethoxide to yield sodium methanebis(diazene-N-oxide-N'-hydroxylate) and sodium acetate.

51 ally hydrated forms of potassium methanetris(diazene-N-oxide-N'-hydroxylate) are characterized by sin

52 sults in the formation of lithium methanebis(diazene-N-oxide-N'-hydroxylate) exclusively.

53 s reaction of the silver salt of methanetris(diazene-N-oxide-N'-hydroxylate) with ammonium iodide, th

54 for the different conformers of methanetris(diazene-N-oxide-N'-hydroxylate)(3-) trianion, a new type

55 ion of six nitric oxides, sodium methanetris(diazene-N-oxide-N'-hydroxylate), forms as the main produ

56 potassium 3,3-dimethylbutan-2-one-1,1,1-tris(diazene-N-oxide-N'-hydroxylate), respectively.

57 Diazene (N2H2), a proposed 2e-/2H+ intermediate on the r

58 pha-70(Ala)/alpha-195(Gln) MoFe protein with diazene or hydrazine as substrate correspond to a common

59 A wide variety of previously unknown diazene precursors was synthesized and cyclized.

60 ppears that this band is actually due to the diazene produced as a result of the oxidation of the hyd

61 aryltrifluoromethyl enones or N-aryl-N-aroyl diazenes, providing useful synthetic building blocks in

62 Unlike the reaction of aryl-substituted diazenes, pyrolysis of alkyl-substituted diazenes in the

63 Diazene reacts rapidly with cytochrome c oxidase to redu

64 action of an allyl diazene, i.e., an allylic diazene rearrangement.

65 Diazene reduction, like N2 reduction, is inhibited by H2

66 ted by Ala during steady-state turnover with diazene resulted in conversion of the S = 3/2 resting st

67 nd N(3)Ad at ambient temperature to give the diazenes RN=NR (6a, R = Mes; 6b, R = Ad) in good yield.

68 otryptamine monomers, respectively, used for diazene synthesis.

69 inates sulfinic acid, yielding a propargylic diazene that performs an alkyne walk to afford the allen

70 Starting from dienals and readily available diazenes, the strategy involving the hemiaminal formatio

71 mido via the disproportionation of an eta(2)-diazene-Ti(II) complex.

72 vity of the hydrogenation of artemisinate by diazene to form dihydroartemisinate (diastereoselective

73 A similar diazene to iron charge-transfer band is found following

74 ponent reactions couple alkenes, alkynes and diazenes to form either alpha,beta-unsaturated imines or

75 Ensuing high-yielding diazene-to-aldehyde tranformations and subsequent deriva

76 new methodology for synthesis of aryl-alkyl diazenes using electronically attenuated hydrazine-nucle

77 The synthesis of these complex diazenes was made possible through a new methodology for

78 etone trityl hydrazone with tBuOCl to give a diazene which readily collapses to the alpha-chlorocarbi

79 ly eliminate methanesulfinic acid, affording diazenes which extrude nitrogen affording the desired de

80 sfer band is found following the reaction of diazene with ferric horseradish peroxidase and with hemi