ライフサイエンスコーパス: diazirine

1 targets with an efficiency comparable to the diazirine.

2 e, 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine.

3 with highly reactive and non-chemoselective diazirines.

4 thane (DCE) by photolysis of the appropriate diazirines.

5 3-(Trifluoromethyl)-3-(m-[(125)I]iodophenyl)diazirine ([(125)I]TID) and [(3)H]tetracaine, an aromati

6 3-(trifluoromethyl)-3-(m-[(125)I]iodophenyl)diazirine ([(125)I]TID) and the phosphatidylcholine anal

7 3-Trifluoromethyl-3-(m-[(125)I]iodophenyl)diazirine ([(125)I]TID) has been shown to be a potent no

8 be 3-trifluoromethyl-3-(m-[(125)I]iodophenyl)diazirine ([(125)I]TID) to compare the state-dependent p

9 el 3-trifluoromethyl-3-(m-[(125)I]iodophenyl)diazirine ([(125)I]TID) was used to identify the amino a

10 3-(trifluoromethyl)-3-(m-[(125)I]iodophenyl)diazirine ([(125)I]TID) were performed.

11 e 3-(trifluoromethyl)-3-(m- [125I]iodophenyl)diazirine ([125I]-TID).

12 c probe 3-(trifluoromethyl)-3-(m-iodophenyl) diazirine ([125I]TID) and exposed to agonist for either

13 und 3-trifluoromethyl-3-(m-[125I]iodophenyl) diazirine ([125I]TID) has revealed important structural

14 th 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine ([125I]TID) in the presence of phospholipid ve

15 with 3-trifluoromethyl-3-(m-[125I]iodophenyl)diazirine ([125I]TID) to determine functionality.

16 ic reagent 3-trifluoro-3-(m-[125I]iodophenyl)diazirine ([125I]TID) which partitions into membranes an

17 th 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine ([125I]TID), a lipophilic probe, specific for

18 be 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine ([125I]TID).

19 corresponding cyclic alpha,alpha"-dicarbonyl diazirine 2 (phi(350) = 0.024).

20 Diazirine 2 and the lithium salt of the corresponding co

21 i(254) = 0.31), while at longer wavelengths, diazirine 2 becomes an important byproduct (Phi(350) = 0

22 reaction, while at 355 nm, the formation of diazirine 2 becomes the predominant process (Phi(350) =

23 UV photolysis of diazirine 2 is accompanied by two competing processes: l

24 The UV irradiation of diazirine 2 leads to the loss of nitrogen and the Wolff

25 Mild heating of diazirine 2 produces quantitative yields of diazo Meldru

26 Benzocyclobutadienyl diazirine (2) was synthesized and reacted with hydroxide

27 although resulting in a common intermediate diazirine 3, which undergoes subsequent photoconversion

28 The photoactive diazirine 4, a potent SIRT2 inhibitor, was subjected to

29 compound however, a halogenated three-carbon diazirine 4, is a potent anesthetic, is apparently nonto

30 m the reaction of 3-chloro-3-(p-nitrophenoxy)diazirine (5) with tetrabutylammonium fluoride (TBAF) un

31 rated photochemically from the corresponding diazirines (6).

32 (Av) nitrogenase with two diazene analogues: diazirine, a photolabile diazene containing the azo (-N=

33 was photolabeled with three photo-activable diazirine alcohol analogs, 3-azioctanol, 7-azioctanol, a

34 Valence isomerization of 3H-diazirines also afforded diazo compounds.

35 minimalist linkers containing both an alkyl diazirine and a cyclopropene.

36 to impart structural diversity and introduce diazirine and alkyne functionalities for target capture

37 in kinases, as well as trifluoromethylphenyl diazirine and alkyne moieties that allow covalent modifi

38 Compared with diazirine and benzophenone, two commonly used photoaffin

39 with extrusion of N2, leading to photostable diazirine and thiocarbodiimide derivatives.

40 alities include aryl azides, diazocarbonyls, diazirines, and benzophenones.

41 Diazirines are an attractive class of potential molecula

42 Diazirines are intrinsically smaller than benzophenones

43 ative demonstrates the potential of (15) N2 -diazirines as molecular imaging tags for biomedical appl

44 The diazirine-based footprinting probe is effectively seques

45 A diazirine-based nucleoside analogue (DBN) efficiently fo

46 higher photo-cross-linking efficiency than a diazirine-based photo-cross-linker, AbK, when placed at

47 rt an improved synthesis of photo-leucine, a diazirine-based photoreactive analogue of leucine, and d

48 The first known 3H-diazirines bearing a carbonyl group and a halogen atom o

49 ker, 3-trifluoromethyl-3-(m[125I]iodophenyl) diazirine benzoic acid ester, was incorporated into inne

50 As recently reported, (15) N2 -diazirine can be hyperpolarized by the SABRE-SHEATH meth

51 C-N bonds, a positive charge at the para and diazirine carbon atoms, and a negative charge at the nit

52 minary studies on the use of a photoreactive diazirine-containing amino acid to cross-link peptide mo

53 e application of this strategy to a (15) N2 -diazirine-containing choline derivative demonstrates the

54 aturable specific binding was found with the diazirine-containing ligand.

55 This multifuctional diazirine-containing peptide was a substrate for Ste14p,

56 A tailored WOBE437-derived diazirine-containing photoaffinity probe (RX-055) irreve

57 ying upon photo-cross-linking with synthetic diazirine-containing RNA probes and quantitative proteom

58 MP), perfluorinated aryl azide (FAB-dUMP) or diazirine (DB-dUMP) coupled to 5-aminoallyl deoxyuridine

59 Here, using a photolyzable diazirine derivative of a novel stimulator compound, IWP

60 We synthesized a transportable diazirine derivative of D-glucose,3-deoxy-3,3-azi-D-gluc

61 inding sites on ligand-gated ion channels, a diazirine derivative of the potent intravenous anestheti

62 The Km value of diazirine does not depend on the ratio of nitrogenase Fe

63 eaction of the minimal photochemical reagent diazirine (DZN) with polypeptides.

64 aracterize the interactions of a second aryl diazirine etomidate derivative, TFD-etomidate (ethyl-1-(

65 olute rates of carbene/alkene additions, the diazirine exchange reaction and derived carbenes, carben

66 er, x-alk-16, which contains an alkyne and a diazirine, for metabolic labeling of S-palmitoylated pro

67 uctures containing, or entirely composed of, diazirine-functionalized peptides.

68 cs, n-octan-1-ol geometric isomers bearing a diazirine group on either the third or seventh carbon (3

69 al photoactivatable cross-linker, sulfo-SDA (diazirine), has yielded high-density data that facilitat

70 Although aryl(trifluoromethyl)diazirines have achieved great popularity in photoaffini

71 f 3-trifluoromethyl-3-(m-[(125)I]iodophenyl) diazirine in a mutually exclusive manner.

72 Using cholesterol analogues with a diazirine in either the 7 position of the steroid ring (

73 it has about 20-fold higher solubility than diazirine in water at 30 degrees C. trans-Dimethyldiazen

74 to the wide range of substituted aryl(CF(3))diazirines in photoaffinity applications.

75 estions concerning the photoisomerization of diazirine into diazo compound and the denitrogenation in

76 omethylphenyl)pyrazolo]]-3-(trifluoromethy l)diazirine is a fipronil-based (i.e. fiprole), high-affin

77 Diazirine is reduced by nitrogenase under specific condi

78 reagent 3-trifluoro-3-(m-[(125)I]iodophenyl)diazirine, isolated, and cleaved with AspN and/or GluC,

79 es produced 10 to 25% cross-linking, whereas diazirine modified residues produced 5 to 8% cross-linki

80 culturing these cells with a cell-permeable, diazirine-modified form of GlcNAc-1-phosphate.

81 e-modified UDP-GlcNAc (UDP-GlcNDAz), and the diazirine-modified GlcNAc analog (GlcNDAz) is transferre

82 We engineered mammalian cells to produce diazirine-modified O-GlcNAc by expressing a mutant form

83 this method, cells are engineered to produce diazirine-modified UDP-GlcNAc (UDP-GlcNDAz), and the dia

84 on of a new isoprenoid analogue containing a diazirine moiety that was prepared in six steps and inco

85 In addition to the diazirine moiety, fluorescein and biotin groups were als

86 y photoactivable groups based on either aryl diazirine or benzophenone chemistry, have been synthesiz

87 These compounds incorporate either a diazo, diazirine, or azido group to provide photolability in th

88 = 375 nm) of para-methoxy-3-phenyl-3-methyl diazirine (p-CH(3)OC(6)H(4)CN(2)CH(3)) produced a transi

89 l metabolic labeling method to introduce the diazirine photocross-linking functional group onto O-Glc

90 tocol describes metabolic incorporation of a diazirine photocrosslinker into sialic acids in cellular

91 al approach that enables introduction of the diazirine photocrosslinker onto the O-GlcNAc modificatio

92 g 3-trifluoromethyl-3-(m-[(125)I]iodophenyl) diazirine photoincorporation than the S(-)-enantiomers.

93 Mutations at alphaE262 that reduce diazirine photomodification decreased the irreversible i

94 model replication forks containing a phenyl diazirine placed at single locations, to determine the p

95 e benzophenone-derived diradical; this makes diazirines potentially more general photoaffinity-labeli

96 Diazirine potently and competitively inhibits acetylene

97 ss-linking experiments demonstrated that the diazirine probe photo-cross-linked to Ste14p with observ

98 formation of carbene 5 and isomerization to diazirine proceed from different electronically excited

99 s with diazirine reagents (especially with a diazirine reagent with a longer linker) and a moderate s

100 increased cross-linking in experiments with diazirine reagents (especially with a diazirine reagent

101 is compared with alternative schemes for the diazirine reduction.

102 Photo-crosslinking with diazirine revealed contacts of Pol III with DNA that are

103 e rapid process from the initially populated diazirine S(2) state (<4 ps), in competition with intern

104 ty of this approach by illustrating that the diazirine tag alone is sufficient for achieving excellen

105 3-(Trifluoromethyl)-3-(m-iodophenyl)diazirine (TID) is a hydrophobic inhibitor of nicotinic

106 e probe 3-(trifluoromethyl)-3-(m-iodophenyl) diazirine (TID) is a noncompetitive, resting-state inhib

107 r 3-[125I](trifluoromethyl)-3-(m-iodophenyl) diazirine (TID) to nicotinic acetylcholine receptor-rich

108 ane probe (3-trifluoromethyl-3-(m-iodophenyl)diazirine (TID)) were examined.

109 ic probe 3-(trifluoromethyl)-3-(m-iodophenyl)diazirine (TID).

110 gration reveals that photoisomerization from diazirine to diazo occurs within a few picoseconds of th

111 , 3'-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine, to label proteins in the outer membrane of el

112 The photostability of the photoproduced diazirine under the conditions used precluded its rearra

113 The photostability of the photoproduced diazirine under the conditions used precluded its rearra

114 For the first time, a 1H-diazirine was captured as intermediate in the photoisome

115 phenyl)-5-iodopyrazolo]]-3-( trifluoromethyl)diazirine, was prepared in 10 steps from pyrazole and 3,

116 3H-Diazirines were thermolyzed or photolyzed to generate th

117 (3-trifluoromethyl)-3-(m-[(125)I]iodophenyl)diazirine) which selectively labels proteins exposed to

118 4pi-electron three-membered-ring 3-methyl-1H-diazirine, which photorearranges to give methyl carbodii