ライフサイエンスコーパス: diazo

1 lopropanation reactions in the presence of 2-diazo-1,1,1-trifluoroethane (CF3CHN2) as the carbene don

2 The macrocyclic 18-diazo-1,4,7,10,13,16-hexaoxacyclononadeca-17,19-dione (3

3 es in the same molecule was examined using 3-diazo-1-(ethyl 2-diazomalonyl)indolin-2-one under rhodiu

4 asive photoactivation of a calcium chelator (Diazo-2) was used to specifically disrupt the transient

5 10,13,16-hexaoxacyclononadeca-17,19-dione (3-diazo-2,4-dioxo-19-crown-6, 1) readily forms complexes w

6 1-Diazo-2,4-pentadiyne (6a), along with both monodeuterio

7 Esterification of GFP with 2-diazo-2-(p-methylphenyl)-N,N-dimethylacetamide was effic

8 escribed starting from decanal and diethyl 3-diazo-2-oxopropylphosphonate.

9 ) relaxed more slowly on flash photolysis of diazo-2.

10 1-Diazo-3,3-dimethyl-5-phenylhex-5-en-2-one (2) reacts wit

11 such a transformation by using a range of 2-diazo-3,6-diketoesters with bicyclo[2.2.1]alkenes and st

12 (disubstituted)acenaphthenones (11a-d) and 2-diazo-3,8-dimethoxyacenaphthenone (12) are reported.

13 ith the rhodium carbene derived from ethyl 2-diazo-3-[1-(2-nitrobenzenesulfonyl)indol-3-yl]-3-oxoprop

14 sing methyl 3-(tert-butyldimethylsilyloxy)-2-diazo-3-butenoate (1) as a bifunctional reagent.

15 usly been found with a series of 2-alkynyl-2-diazo-3-oxobutanoates.

16 Irradiation of 2-diazo-3-oxochlorins (200 W, lambda > or = 345 nm, 10 deg

17 sis of metalated (Cu and Ni) and free base 2-diazo-3-oxochlorins within a frozen matrix (lambda = 457

18 ion/Cope rearrangement, between methyl (E)-2-diazo-3-pentenoate and 1-methyl-1,2-dihydronaphthalenes.

19 Photolysis (lambda > 472 nm) of 2-diazo-3-pentyne (11) affords triplet 1,3-dimethylpropyny

20 Ethyl 2-diazo-4,4,4-trifluoro-3-oxobutanoate is a highly versati

21 aracterized by photoaffinity labeling with 3-diazo-4-keto-11-cis-retinal and by high resolution mass

22 varied thermal and photolytic reactions of 2-diazo-5,6-(disubstituted)acenaphthenones (11a-d) and 2-d

23 ree-component process in which t-butyl (E)-2-diazo-5-arylpent-4-enoates are treated with Rh2(S-NTTL)4

24 ous acid yielded the primary explosive bis(4-diazo-5-nitro-3-oxopyrazolyl)methane (8), which showed s

25 The lead prodrug, isopropyl 6-diazo-5-oxo-2-(((phenyl(pivaloyloxy)methoxy)carbonyl)ami

26 ntly, we show that glutaminase inhibitors, 6-Diazo-5-oxo-L-norleucine (DON) or CB-839, hypersensitize

27 Here we show that the glutamine analog 6-diazo-5-oxo-L-norleucine (DON) rescues mice from CM when

28 e investigated by chemical modulation with 6-diazo-5-oxo-L-norleucine (DON) to decrease or O-(2-aceta

29 The glutamine antagonist 6-diazo-5-oxo-l-norleucine (DON, 1) has shown robust antic

30 The glutamine antagonist 6-diazo-5-oxo-l-norleucine (DON, 14) attenuates glutamate

31 reover, experiments with the GGT inhibitor 6-diazo-5-oxo-l-norleucine and purified recombinant GGT pr

32 wever, targeting glutamine metabolism with 6-diazo-5-oxo-l-norleucine uniformly sensitized MM cell li

33 e anti-tumor effect of a glutamine analog (6-diazo-5-oxo-L-norleucine) as an adjuvant treatment to se

34 he effect of the glutamine antagonist DON (6-diazo-5-oxo-l-norleucine) on the outcome of NSV infectio

35 inhibition was reversed by glutamine or by 6-diazo-5-oxo-l-norleucine, a non-metabolizable glutamine

36 by the K9 DON peptide (with the Q isostere 6-diazo-5-oxo-norleucine) and iodoacetamide were further e

37 S-NTTL)4-catalyzed reaction of t-butyl (Z)-2-diazo-5-phenylpent-4-enoate gives the Buchner cyclizatio

38 with rhodium carbenoids derived from alkynyl diazo acetates.

39 cyclization/cycloaddition sequence of alpha-diazo amides 64 and 68 were studied.

40 Arrays of catalysed reactions of alpha-diazo amides, whose outcome was critically dependent on

41 on the nitrogen atom of the tethered alkenyl diazo amido indolo ester seemingly provides better orbit

42 he Rh(II)-catalyzed reactions of 2-alkynyl 2-diazo amido-substituted esters.

43 ch case, or (b) via addition of PhCCl to the diazo analogues of noradamantyl- and adamantyldiazirine.

44 The chemoselectivity of diazo and alkynyl groups enables dual labeling of cells

45 nnane, offering an advantage over the use of diazo and azide functional groups as nitrogen sources fo

46 nformation of 1 has a Z,Z arrangement of the diazo and carbonyl groups.

47 anism for metalloradical based conversion of diazo and CO to ketene and N2 is proposed on the basis o

48 Diazo band integration reveals that photoisomerization f

49 Diazo-based precursors of photolabile groups have been u

50 In this work we find that these diazo-based reagents in fact react very poorly with back

51 ion of the pendant allyl group into an alpha-diazo beta-keto ester set the stage for Rh-mediated cycl

52 nation of a symmetrical indane-derived alpha-diazo beta-keto ester.

53 marked contrast to the cyclizations of alpha-diazo beta-ketoesters, which consistently deliver cyclop

54 However, attempts to use alpha-diazo-beta-ethylcaprolactone in intermolecular cycloprop

55 in agreement with the poor ability of alpha-diazo-beta-ethylcaprolactone to participate in intermole

56 pha,beta-unsaturated aldehydes affords alpha-diazo-beta-hydroxy-esters in high enantioselectivities.

57 eto sulfoxides to form stable isolable alpha-diazo-beta-keto sulfoxides has been achieved for the fir

58 ium tetraacetate catalyzed reaction of alpha-diazo-beta-keto-carboxylates and -phosphonates with aren

59 on of the aldehyde group into a second alpha-diazo-beta-ketoester gave a substrate for an intramolecu

60 cluded regiospecific cyclization of an alpha-diazo-beta-ketoester to build the cyclopentane ring, fol

61 iently accessed from the corresponding alpha-diazo-beta-ketoester, and a catalyst loading as low as 1

62 henylacetaldehyde is converted into an alpha-diazo-beta-ketoester, dirhodium(II)-catalyzed reaction o

63 C-O cleavage leading to delta-hydroxy-alpha-diazo-beta-ketoesters and beta-ketophosphonates.

64 thers derived from methyl ketones with alpha-diazo-beta-ketoesters or alpha-diazoketones to afford 2-

65 ion-[2,3] sigmatropic rearrangement of alpha-diazo-beta-ketoesters possessing gamma-cyclic unsaturate

66 alpha-Diazo-beta-ketonitriles also undergo highly efficient in

67 These studies reveal that alpha-diazo-beta-ketonitriles exhibit unique reactivity in the

68 olecular cyclopropanation reactions of alpha-diazo-beta-ketonitriles is reported.

69 Alpha-diazo-beta-ketosulfones behave similarly and give 5-sulf

70 he singlet carbene p orbital in 5 (or of the diazo carbon in an excited state of 1) to the stronger a

71 alpha-diazo carbonyl compounds in which the diazo carbon was disubstituted, N-Boc imines react with

72 recombination through cation addition to the diazo carbon.

73 nactivated imines were not reactive to alpha-diazo carbonyl compounds in which the diazo carbon was d

74 alyzed carbenoid insertion reaction of alpha-diazo carbonyl compounds into Si-H and S-H bonds was dev

75 azirine-2-carbaldehydes, primary amines, and diazo carbonyl compounds under Rh(II) catalysis.

76 , formed in Rh2(OAc)4-catalyzed reactions of diazo carbonyl compounds with 2H-azirines, dramatically

77 ng versatile strategy of replacing hazardous diazo carbonyl compounds with benign and readily availab

78 dium(II)-catalyzed domino reactions of alpha-diazo carbonyl compounds, intramolecular [4 + 2]-cycload

79 es has been achieved successfully with alpha-diazo carbonyl compounds.

80 venient to prepare by adding lithiated alpha-diazo carbonyls to alpha-oxy ketones.

81 Cyclic gamma-oxy-beta-hydroxy-alpha-diazo carbonyls undergo Lewis acid induced ring fragment

82 e fluorinated reagent with alpha-nitro-alpha-diazo carbonyls was established.

83 n-acceptor-substituted aryl azides and alpha-diazo carboxylic esters are used as substrates for visib

84 first report on using aryl azides and alpha-diazo carboxylic esters as substrates for asymmetric cat

85 dical process with the aryl azides and alpha-diazo carboxylic esters serving as precursors for nitrog

86 oughs in the synthetically valuable field of diazo chemistry.

87 by varying the aldehyde, 1,3-dicarbonyl, and diazo component individually.

88 ohydrins and anion-stabilizing groups in the diazo-component are tolerated, affording novel functiona

89 e Wolff rearrangement and isomerization into diazo compound 1.

90 at 2080 cm(-1) ascribed to the corresponding diazo compound 13D.

91 state leads to the formation of the isomeric diazo compound and singlet carbene.

92 ing the photoisomerization of diazirine into diazo compound and the denitrogenation into carbenes.

93 270 nm excitation, both singlet carbene and diazo compound are formed in a much more rapid process f

94 alyst, aldehyde, and amine, and instead, the diazo compound could be added directly.

95 g and irreversible and that insertion of the diazo compound favors electron-deficient substrates.

96 thane (BDE) produces an excited state of the diazo compound in acetonitrile, cyclohexane, and methano

97 nsition-metal-catalyzed decomposition of the diazo compound in the presence of the imine presumably g

98 Sodium ion coordination with the reactant diazo compound inhibits oxonium ylide formation in coppe

99 stepwise process involving activation of the diazo compound leading to formation of a Co(III)-carbene

100 from [1,2,3]triazolo[1,5-a]pyridine 1T, the diazo compound lying ca. 5 kcal/mol above the triazole.

101 f distortion energies with substituents in a diazo compound or dipolarophile can enhance reactivity a

102 ever, the difficulty in forming the unstable diazo compound partner in a mild fashion has hitherto li

103 ced photochemically from their corresponding diazo compound precursors and studied spectroscopically

104 action occurs when both the catalyst and the diazo compound were immobilized, but the slow rate precl

105 ived from rhodium(II) tetracarboxylate and a diazo compound) and a chiral spirophosphoric acid ((R)-S

106 ent proceeds via intermediate formation of a diazo compound, and can be catalyzed by acids via the pr

107 a catalyst-complexed carbonyl ylide from the diazo compound, followed by intermolecular cycloaddition

108 pyrrole-2-carboxylate into the corresponding diazo compound, followed by intramolecular azo coupling

109 e to react for 20 min before addition of the diazo compound.

110 which is assigned to an excited state of the diazo compound.

111 nd carboxylic acid avoids the buildup of the diazo compound.

112 xcited state, generated by UV irradiation of diazo compound: isomerization to alpha-ketodiazirine pro

113 ed directed C-H bond functionalizations with diazo-compound substrates.

114 to as lambda(5)-phosphorus-containing alpha-diazo compounds (PCDCs), represent a vast class of extre

115 Catalysed X-H insertion reactions into diazo compounds (where X is any heteroatom) are a powerf

116 Direct 254 nm photolysis of diazo compounds 1-3 in methanol results in the formation

117 Photolysis of diazo compounds 6a-c (lambda > 444 nm; Ar or N2, 10 K) g

118 can guide the design and application of both diazo compounds and azides in "orthogonal" contexts, esp

119 vatives are generally reliable precursors to diazo compounds and carbenes, although cyclization of th

120 The fact that diazo compounds and other carbene precursors are known m

121 tric coupling of flow-generated unstabilized diazo compounds and propargylated amine derivatives, usi

122 reaction between flow-generated unstabilized diazo compounds and terminal alkynes provides di- and tr

123 d catalyzed reactions and transformations of diazo compounds are also discussed.

124 thane, alpha-diazo esters, and disubstituted diazo compounds are covered, commenting on the complex r

125 Diazo compounds are in widespread use in synthetic organ

126 coupling of aldehydes, 1,3-dicarbonyls, and diazo compounds as well as tosyl hydrazones.

127 Herein, we report that diazo compounds can be used to selectively alkylate the

128 Diazo compounds derived from (p-methylphenyl)glycine wer

129 Diazo compounds derived from aldehydes were reacted with

130 In addition, vinyl diazo compounds gave enynes selectively as single geomet

131 ehydroamino acids using aryl and unsaturated diazo compounds generated in situ from the corresponding

132 both a nucleophile and an electrophile onto diazo compounds give a fast access into important buildi

133 ortho-alkylation of phenoxy substrates with diazo compounds has been achieved for the first time usi

134 pling of readily available boronic acids and diazo compounds has emerged recently as a powerful metal

135 Metal-stabilized carbenes derived from diazo compounds have become broadly useful reactive inte

136 ates the efficient conversion of azides into diazo compounds in phosphate buffer at neutral pH and ro

137 azides to unleash the power of these classic diazo compounds in the context of both inter- and intram

138 lkenes, alkynes, and allenes with diacceptor diazo compounds is reported.

139 catalyst for the reaction of aldehydes with diazo compounds leading to alpha-alkylated derivatives.

140 that such reagents would provide over either diazo compounds or their in situ precursors.

141 Notably, chemoselective arylation of diazo compounds over other electrophiles were demonstrat

142 oyl benzhydroxamic acids with donor/acceptor diazo compounds provides isoindolones in high yield.

143 to a large variety of carboxylic acids using diazo compounds that are formed from the hydrazones of b

144 functionality to furnish alpha-cyclic-alpha-diazo compounds that are themselves subject to further t

145 In methanol, protonation of diazo compounds to give the corresponding 2-adamantyl ca

146 This review covers the addition of diazo compounds to ketones to afford homologated ketones

147 oesters that possess beta-hydrogens, as such diazo compounds typically give rise to alkenes via beta-

148 tion conditions, while dicarbonyl-containing diazo compounds undergo carbonyl migration to afford 1-a

149 e highly enantioselective oxyalkynylation of diazo compounds using ethynylbenziodoxol-(on)e reagents

150 for the generation of an unstable family of diazo compounds using flow UV photolysis and their first

151 Rh(III)-catalyzed cyclization of oximes and diazo compounds via aryl and vinylic C-H activation.

152 eactions of fluorine-containing ketones with diazo compounds via metalloporphyrin-catalyzed olefinati

153 The excited states of these diazo compounds were detected and found to decay with li

154 The diazo compounds were isolated in excellent yields (82-94

155 hrough rhodium catalyzed direct arylation of diazo compounds with arylboronic acids.

156 c acids, obtained by reacting flow-generated diazo compounds with boronic acids, and their applicatio

157 rans-aziridination of aldehydes, amines, and diazo compounds with BOROX catalysts is developed.

158 lving a copper-catalyzed oxy-alkynylation of diazo compounds with ethynylbenziodoxol(on)e (EBX) reage

159 The [3+2] cycloaddition of a variety of diazo compounds with o-(trimethylsilyl)aryl triflates in

160 rradiation (lambda > 497 nm) of the isomeric diazo compounds, 1-diazo-hexa-2,4-diyne (2) or 2-diazo-h

161 Dimerization of diazo compounds, a common side reaction in metal-mediate

162 Using keto-diazo compounds, a ruthenium catalyzed O-H insertion wit

163 from reaction of 2,3-diphenyl-2H-azirine and diazo compounds, do not produce indoles via 1,5-cyclizat

164 es a broad range of benzhydroxamic acids and diazo compounds, including substituted 2,2,2-trifluorodi

165 However, with other diazo compounds, primary thioamides also give enaminones

166 lticomponent cycloaddition reactions between diazo compounds, pyridines, and electrophilic alkenes to

167 Here, we show that diazo compounds, unlike azides, provide an opportunity t

168 details on handling non-carbonyl-stabilized diazo compounds.

169 osition of hazardous, not easily accessible, diazo compounds.

170 isomerization of 3H-diazirines also afforded diazo compounds.

171 ontrolled with fumaronitrile by trapping the diazo compounds.

172 of trisubstituted aziridines from imines and diazo compounds.

173 o acids in partially aqueous conditions) and diazo compounds.

174 the imine was found to be independent of the diazo compounds.

175 mploy excess substrates and slow addition of diazo compounds.

176 from simple precursors without isolation of diazo compounds.

177 for its broad scope in both EBX reagents and diazo compounds.

178 for nitrite levels using a combination of a diazo coupling method and high performance liquid chroma

179 Ph-N=N- group was efficiently introduced by diazo coupling of aryllithium with dry PhN(2)(+)BF(4)(-)

180 , and Cu(II) , as well as SiO2 , to promote diazo decomposition and subsequent cyclization/rearrange

181 as well as the site in the ether complex for diazo decomposition and subsequent metal carbene reactio

182 of reactions, triggered by Rh(II)-catalyzed diazo decomposition followed by a vinylogous N-H inserti

183 The cascade proceeds through diazo decomposition, carbene/alkyne metathesis, and C-H

184 ent nonmetal alternative to X-H insertion by diazo decomposition.

185 ManDiaz, which is a diazo derivative of N-acetylmannosamine, is found to end

186 The cascade reaction of alpha-diazo dihydroindolinone 21 proceeded in high yield with

187 ation/cycloaddition cascade of several alpha-diazo dihydroindolinones have been carried out as an app

188 The photochemistry of a p-biphenylyl diazo ester (BpCN2CO2CH3) and diazo ketone (BpCN2COCH3)

189 The rate of disappearance of diazo ester 1 catalyzed by several representative Rh(II)

190 othesis that steric interactions between the diazo ester and adjacent silyloxy group can play an impo

191 Proper stereoelectronic alignment of the diazo ester and the departing hydroxyl group is necessar

192 of a urea catalyst and an alpha-nitro-alpha-diazo ester gives rise to a reactive species able to und

193 amidobenzenesulfonyl azide affords the alpha-diazo ester in good yield.

194 llowed the alternative use of an alpha-cyano diazo ester in the process, leading to alpha-cyano cyclo

195 used to study the photochemistry of a vinyl diazo ester PhCH=CHCN2CO2CH3 (1) in solution.

196 The diazo ester produces singlet carbene with greater quantu

197 ted phenoxypyrimidine and 3 mol equiv of the diazo ester.

198 nterceptive [4 + 1] annulation strategy with diazo esters (DEs).

199 stituted, N-Boc imines react with both alpha-diazo esters and alpha-diazo-N-acyloxazolidinones to giv

200 of cyclic gamma-silyloxy-beta-hydroxy-alpha-diazo esters provided tethered aldehyde ynoate intermedi

201 omethanes, trimethylsilyldiazomethane, alpha-diazo esters, and disubstituted diazo compounds are cove

202 al-catalyzed reactions of alkynes with alpha-diazo esters, can be utilized directly in carbozincation

203 ceptor carbenoids derived from unsubstituted diazo esters.

204 is easy to prepare gram quantities of alpha-diazo esters.

205 lkyl-substituted allylic sulfides) and alpha-diazo esters.

206 I)-catalyzed reaction of cyclopropanols with diazo esters.

207 The decay of the diazo excited state correlates with the growth of single

208 The diazo excited state fragments to form fluorenylidene (Fl

209 The optical yields of diazo excited states produced by photolysis of p-bipheny

210 o a complex cyclopentadiene to introduce the diazo function.

211 y gold in which the terminal nitrogen of the diazo functional group adds to the central carbon of the

212 cationic gold complexes are initiated at the diazo functional group to form a gold carbene whose subs

213 es subject to further transformations of the diazo functional group; (2) [3+n]-cycloadditions (n = 1-

214 of enoldiazo compounds with retention of the diazo functionality to furnish alpha-cyclic-alpha-diazo

215 ate into several aldehydes, oxidation of the diazo functionality, and diastereoselective alkyl transf

216 We introduce a stabilized diazo group as a reporter for chemical biology.

217 There its diazo group can undergo a 1,3-dipolar cycloaddition with

218 e to the greater nucleophilic character of a diazo group compared to that of an azido group, which ca

219 The diazo group has attributes that complement those of the

220 de insights into the chemoselectivity of the diazo group in 1,3-dipolar cycloadditions.

221 The metallo carbenoid derived from the D/A diazo group is preferentially formed and undergoes selec

222 of a nucleophile and an electrophile to the diazo group, has been realized in the intramolecular ami

223 A novel mode of reactivity for the diazo group, the 1,3-addition of a nucleophile and an el

224 Thus, the diazo group, which is approximately half the size of an

225 l angucycline ring system substituted with a diazo group.

226 olely with the pi-donor rather than with the diazo group.

227 Notably, these advantages of diazo groups are amplified in water.

228 > 497 nm) of the isomeric diazo compounds, 1-diazo-hexa-2,4-diyne (2) or 2-diazo-hexa-3,5-diyne (3),

229 o compounds, 1-diazo-hexa-2,4-diyne (2) or 2-diazo-hexa-3,5-diyne (3), generates triplet carbene 1.

230 erated from the Rh(II)-catalyzed reaction of diazo imides, on the other hand, undergo successful intr

231 of the stemofoline alkaloids from an acyclic diazo imine intermediate.

232 mical instability cyclizing to form a unique diazo-imine.

233 ation/cycloaddition cascade of several alpha-diazo indolo amido esters have been carried out as an ap

234 The Cu(II)-catalyzed reaction of an alpha-diazo indolo diester that contains a tethered oxa-penten

235 lar [3+2]-cycloaddition reaction of an alpha-diazo indoloamide which delivers the pentacyclic skeleto

236 on experiments demonstrate the presence of a diazo intermediate and methyl acetate in all photochemic

237 f the substrate is due to the formation of a diazo intermediate which encounters a nucleophilic attac

238 f rearrangement/lactonization of these alpha-diazo intermediates provided cis-fused gamma-lactones ef

239 sertion reactions of the delta-hydroxy-alpha-diazo intermediates.

240 a p-biphenylyl diazo ester (BpCN2CO2CH3) and diazo ketone (BpCN2COCH3) were studied by ultrafast time

241 We propose that the initially formed alpha-diazo ketone 3a fragments into the simple alpha-diazomet

242 zide gave, in addition to the expected alpha-diazo ketone 3a, the dihydropyrazole 3c and its oxidatio

243 Both diazo ketone excited states decompose in less than 300 f

244 The key ring-forming reaction, in which a diazo ketone is converted into a bridged bicyclic ether,

245 hane in the outer chamber, and the resulting diazo ketone is finally converted to the halo ketone wit

246 The alpha-diazo ketone is produced from the mixed anhydride and di

247 ction of a metal carbenoid, generated from a diazo ketone, with an ether to produce an ylide-like int

248 al or photochemical Wolff rearrangement of a diazo ketone.

249 arrangement (WR) in the excited state of the diazo ketone.

250 the tether connecting the ether to the alpha-diazo ketone.

251 The derived alpha-aryl-alpha-diazo ketones cyclize efficiently with Rh catalysis to g

252 Some long chain alpha-aryl alpha-diazo ketones under Rh catalysis cyclize efficiently to

253 The photochemistry of two isomeric aryl diazo ketones was investigated by fs time-resolved UV-vi

254 n based on the reaction of cyclobutenones or diazo ketones with N-propargyl-substituted ynamides proc

255 d based on the reaction of beta'-bromo-alpha-diazo ketones with rhodium carboxylates.

256 al carbene chemistry without using hazardous diazo ketones.

257 The diazo-linker of UiO-abdc possesses local site disorder,

258 y host-guest interaction between beta-CD and diazo-linker works as a gatekeeper to control the releas

259 diazirine 2 produces quantitative yields of diazo Meldrum's acid.

260 r/acceptor (D/A) and acceptor/acceptor (A/A) diazo moieties in the same molecule was examined using 3

261 ty at the alpha-position with respect to the diazo moiety, here referred to as lambda(5)-phosphorus-c

262 Indeed, thanks to the high reactivity of the diazo moiety, PCDCs can be induced to undergo a wide var

263 react with both alpha-diazo esters and alpha-diazo-N-acyloxazolidinones to give trisubstituted azirid

264 Photolysis of alpha-diazo-N-methoxy-N-methyl (Weinreb) beta-ketoamides deriv

265 ons of MEDAM imines and three representative diazo nucleophiles has been studied using ONIOM(B3LYP/6-

266 ls that photoisomerization from diazirine to diazo occurs within a few picoseconds of the laser pulse

267 of alpha-oximino ketenes derived from alpha-diazo oxime ethers provides 2H-azirines bearing quaterna

268 For metalated diazo-oxochlorins, these products compete with intramole

269 ((1)2) is produced from the excited state of diazo precursor (1*).

270 r is believed to reflect the geometry of the diazo precursor, as enforced by the rigid matrix.

271 roach of substrates to carbenes from acyclic diazo precursors may be relatively slow due to a steric

272 ohols with N-alkyl-N-hydroxyl amides to give diazo precursors, which upon intramolecular cyclopropana

273 opropanation with the acceptor/acceptor-type diazo reagent alpha-cyanodiazoacetates.

274 alyzed arylation of a Meldrum's acid-derived diazo reagent with electron-rich arenes is described.

275 the products were derivatized using a novel diazo reagent.

276 ment reaction involving allylic sulfides and diazo reagents (Doyle-Kirmse reaction) is reported.

277 ocol that can effectively utilize donor-type diazo reagents for asymmetric olefin cyclopropanation.

278 Donor-substituted diazo reagents, generated in situ from sulfonyl hydrazon

279 other similar acceptor-acceptor-substituted diazo substrates instead produce mixtures of C-H inserti

280 mical alternative to the strategies based on diazo substrates.

281 Diazo sulfonylamidines readily undergo enantioselective

282 CH3) occurs competitively and conversion of diazo to ketene occurs catalytically as well as stoichio

283 lladium-catalyzed cyclization (39-->37), and diazo transfer (37-->53).

284 Under diazo transfer conditions in the presence of a base in a

285 tic studies show the reaction proceeds via a diazo transfer mechanism.

286 Diazo transfer of the benzoylated ester utilizing p-acet

287 Direct diazo transfer proceeds smoothly with alpha-aryl ketones

288 the juglone derivative 61, cyclization, and diazo transfer provided the advanced diazofluorene 63, w

289 Diazo transfer reactions on Behera's amine and its next-

290 ation, Bamford-Stevens-type elimination, and diazo transfer reactions.

291 methylene compounds as well as deformylative diazo transfer reagent.

292 vides a considerable advantage over existing diazo transfer reagents in terms of impact stability, co

293 Diazo transfer to beta-keto sulfoxides to form stable is

294 were successfully explored as substrates for diazo transfer.

295 en sulfate salt as the reagent of choice for diazo transfer.

296 and salts thereof are valuable reagents for diazo-transfer reactions, most particularly conversion o

297 ic scaffold of the natural product, and mild diazo-transfer to a complex cyclopentadiene to introduce

298 he resin-bound peptide to selective on-resin diazo transformation of a Lys into the Nle(epsilon-N3) o

299 Placing the carbene producing 21-diazo/triazolo moiety of the photoprobe in the vicinity

300 n the basis of hypervalent alpha-aryliodonio diazo triflate salts 1A, 2A, and 3A, the corresponding h