ライフサイエンスコーパス: diazomethane

1 inimizing the handling of the toxic reagent, diazomethane.

2 s that avoids the use of toxic and explosive diazomethane.

3 would yield isobaric species with unlabeled diazomethane.

4 s types of (3 + 2) cycloadditions, including diazomethane 1,3-dipolar cycloadditions, a thermally pro

5 to generate two conformers of (o-cyanophenyl)diazomethane 11 (2079 and 2075 cm(-1)), followed by (o-c

6 o as "trimethylation enhancement using (13)C-diazomethane" ((13)C-TrEnDi), which results in the methy

7 ree-step reaction including isomerization of diazomethane, a C-C or N-C coupling, and a formal cycloa

8 cerophospholipids to an ethereal solution of diazomethane and acid, derivatizing them to contain a ne

9 cycloaddition between lithium(trimethylsilyl)diazomethane and alpha,beta-unsaturated esters.

10 orin was synthesized from sclerotiorin using diazomethane and fed to B. bassiana.

11 ates the need to store, transport, or handle diazomethane and produces alpha-halo ketone building blo

12 The best results were obtained with diazomethane and substituted diazomethane reagents, whic

13 borane sites upon exposure to a solution of diazomethane at -17 degrees C.

14 ng the O(2)-protonated diazeniumdiolate with diazomethane, both yield mixtures of O(1)- and O(2)-meth

15 ex) = 308 nm) of p-biphenylyltrifluoromethyl diazomethane (BpCN2CF3) releases singlet p-biphenylyltri

16 -demand generation of anhydrous solutions of diazomethane (CH2N2) avoiding distillation methods is pr

17 CH3NNOH, and further eliminate water to form diazomethane, CH2NN.

18 referentially inhibited when competed with a diazomethane-conjugated inhibitor, Z-FA-CHN(2), demonstr

19 Simple diazomethane derivatives afford N-unsubstituted indazole

20 rfaces upon exposure to a dilute solution of diazomethane (DM) and ethyl diazoacetate (EDA) in ether

21 double additions with lithium(trimethylsilyl)diazomethane, effectively generating various molecular f

22 purification followed by derivatization with diazomethane (either manual or robotic); GC-MS analysis;

23 ture and the amount of lithio(trimethylsilyl)diazomethane employed, which led to the development of o

24 The use of isotopically labeled diazomethane enabled the distinction of modified PE and

25 The compound belongs to the peptidyl-diazomethane family (cysteine protease inhibitor 1, term

26 ast photolysis of 2-fluorenyltrifluoromethyl diazomethane (FlCN2CF3) and therefore cannot be associat

27 erted to the acid chlorides and reacted with diazomethane, followed by 48% HBr to generate the alpha-

28 Derivatization of phosphoric acid with diazomethane generates trimethyl phosphate.

29 Once the diazomethane generator has been assembled, processing 96

30 To this end, we have designed a custom diazomethane generator that can safely withstand high fl

31 e acetals, allylsilanes, enamino esters, and diazomethanes have been studied in CH3CN and CH2Cl2 solu

32 direct derivatization of organic acids using diazomethane in a 96-sample format.

33 ride is subsequently combined with anhydrous diazomethane in a tube-in-tube reactor.

34 one is produced from the mixed anhydride and diazomethane in the outer chamber, and the resulting dia

35 tone with 1.2 equiv of lithio(trimethylsilyl)diazomethane in THF resulted in the formation of the cor

36 egy is the in situ generation of substituted diazomethanes in a two-step sequence from the correspond

37 ized by the killing of the parasite with the diazomethane inhibitor Z-Phe-Ala-CHN(2) (where Z is benz

38 Diazomethane is a highly reactive gas that readily forms

39 Though volatile, toxic, and unstable, diazomethane is an indispensable one-carbon reagent with

40 In this procedure, diazomethane is generated in situ and used concurrently

41 Diazomethane is generated in the inner tube in an aqueou

42 Diazomethane is produced by base-mediated decomposition

43 xes with the lithium salt of (trimethylsilyl)diazomethane, Li[Me3SiCN2], gave products formulated as

44 By passing ethereal diazomethane over peptides on strong cation exchange res

45 In addition, larger scales (1.8 g diazomethane per hour) could be obtained via paralleliza

46 culture and is the most likely target of the diazomethane protease inhibitor Z-Phe-Ala-CHN(2) in T. b

47 e obtained with diazomethane and substituted diazomethane reagents, which provided cyclopentenone pro

48 bacteriopyropheophorbide a methyl ester with diazomethane resulted in the formation of bacterioverdin

49 ized cyclopentenones were synthesized by the diazomethane ring expansion of cyclobutanones, produced

50 The syntheses were achieved via the diazomethane route, and the regioisomeric distribution o

51 However, diazomethane's reactivity and explosive potential make i

52 ner tube in an aqueous medium, and anhydrous diazomethane subsequently diffuses through the permeable

53 protected mixed anhydrides were reacted with diazomethane to lead to the alpha-amino diazoketones, wh

54 r 9-fluorenylmethyloxycarbonyl-tyrosylalanyl-diazomethane was found to inhibit growth of the breast c

55 the [4+2+1] cycloaddition of (trimethylsilyl)diazomethane with alkynes tethered to dienes has been de