ライフサイエンスコーパス: diazonamide

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1 A brief introduction into the chemistry of diazonamide A (1) is followed by first-generation sequen

2 rminal residue, the revised architecture for diazonamide A (1) provided an even more challenging mole

3 toward the originally proposed structure of diazonamide A (1).

4 an analog of the antimitotic marine peptide diazonamide A (both the analog and diazonamide A are pot

5 ng the course of studies on the synthesis of diazonamide A 1, an unusual O-aryl into C-aryl rearrange

6 A biotinylated form of diazonamide A affinity purifies ornithine delta-amino tr

7 ver, the remaining biochemical properties of diazonamide A and its analog differ markedly from those

8 If the latter is correct, diazonamide A and its oxygen analog should have uniquely

9 te studies regarding the chemical biology of diazonamide A and its structural congeners, and more ful

10 n the latter system, the interaction between diazonamide A and OAT is regulated by RanGTP.

11 oid and dolastatin 10 binding sites, or that diazonamide A and the analog bind weakly to unpolymerize

12 These observations indicate either that diazonamide A and the analog have a unique binding site

13 Both diazonamide A and the oxygen analog are potent inhibitor

14 fragment of the marine secondary metabolite diazonamide A are described, all of which feature dirhod

15 e peptide diazonamide A (both the analog and diazonamide A are potent inhibitors of tubulin assembly)

16 anced intermediate in the first synthesis of diazonamide A by Nicolaou et al.

17 Diazonamide A causes cells to arrest in mitosis, and, af

18 the right-hand heteroaromatic macrocycle of diazonamide A features C16-C18 bond formation in the Suz

19 cially unique target for chemical synthesis, diazonamide A has the potential to be constructed throug

20 synthesis of a biologically active analog of diazonamide A in which a single nitrogen atom was replac

21 Diazonamide A is highly effective at blocking spindle as

22 Neither diazonamide A nor the analog inhibited the binding of [3

23 preparation of DZ-2384; a refined analog of diazonamide A slated for clinical development as a cance

24 cle, we detail our second total synthesis of diazonamide A through a sequence entirely distinct from

25 cell death, the effects largely phenocopying diazonamide A treatment in these cell lines.

26 tail the first successful total synthesis of diazonamide A, an endeavor which not only verified its p

27 e organism for the complex cytotoxic peptide diazonamide A.

28 occurring small-molecule antimitotic called diazonamide A.

29 and functional analog of the natural product diazonamide A.

30 method to synthesize the core macrolactam of diazonamides is described.

31 ) that sets C10 configuration in a potential diazonamide precursor.

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