ライフサイエンスコーパス: dibasic

1 Analytes studied include the dibasic acid methylphosphonic acid (MPA) and its monoaci

2 tes studied include methylphosphonic acid (a dibasic acid), the monoisopropyl ester of ethylphosphoni

3 oactivation via proteolytic processing after dibasic amino acid cleavage recognition sites.

4 Here, we report that a dibasic amino acid convertase, furin, directly cleaves p

5 myristoylation reaction occurs internally at dibasic amino acid doublets of proteins such as alpha-TN

6 These isolates had a dibasic amino acid motif in the fusion protein cleavage

7 A dibasic amino acid motif was present at the predicted F

8 Alanine mutations to either of two dibasic amino acid motifs in the G2 cytoplasmic domain c

9 Lack of conservation of other dibasic amino acid residues whose cleavage by prohormone

10 We demonstrated that the dibasic amino acid-rich region in bZIP28 is involved in

11 ied a small region in bZIP28 that is rich in dibasic amino acids and proximal to the transmembrane do

12 in renal tubular and intestinal transport of dibasic amino acids that results in elevated urinary exc

13 arbamyl-phosphate synthase (CPS), as well as dibasic aminoacidurias hyperammonemia-hyperornithinemia-

14 psin L occurred by proteolytic processing at dibasic and monobasic prohormone-processing sites.

15 ge of their respective precursor proteins at dibasic and monobasic sites, which is consistent with th

16 data imply that MPII specificity mimics the dibasic Arg downward arrowArg cleavage motif of furin-li

17 that this vitamin-K-dependent protein has a dibasic Arg-Arg sequence at the propeptide cleavage site

18 ries of piperidinylalkyl groups provided the dibasic benzimidazoles 55-62.

19 cium phosphate (CaP) phases (hydroxyapatite, dibasic calcium phosphate dihydrate, dibasic calcium pho

20 patite, dibasic calcium phosphate dihydrate, dibasic calcium phosphate, monobasic calcium phosphate,

21 is the first zinc metalloproteinase with the dibasic cleavage preferences, suggesting a high level of

22 onobasic cleavage sites rather than a single dibasic cleavage site at the amino-terminal end of the p

23 missense mutation, R236G, which disrupts the dibasic cleavage site between beta melanocyte-stimulatin

24 tion of Ebo-GP despite the conservation of a dibasic cleavage site in all filoviral envelope glycopro

25 secretion for the cassettes with the mutated dibasic cleavage site in C-prM.

26 ed an assay in which processing at the C-prM dibasic cleavage site is abolished by Lys-->Gly conversi

27 nesis was used to disrupt putative mono- and dibasic cleavage sites.

28 previously described mouse arginine-specific dibasic cleaving enzyme (dynorphin converting enzyme) is

29 rting enzyme) is the homologue of N-arginine dibasic convertase (NRDc) isolated from rat testis.

30 ptor showed it to be identical to N-arginine dibasic convertase (NRDc), a metalloendopeptidase of the

31 al oncogene homolog 1 (ErbB1) and N-arginine dibasic convertase (NRDc).

32 proteolysis by metalloproteinase N-arginine dibasic convertase 1 (NRD1) and leads to the significant

33 es as physiological modulators of N-arginine dibasic convertase is considered.

34 Nardilysin (N-arginine dibasic convertase, EC 3.4.24.61) was first identified o

35 eals no obvious conserved acceptor motifs or dibasic doublets.

36 Previous work identified a dibasic endoplasmic reticulum retrieval signal in the cy

37 ulation factor Xa, and the Bacillus subtilis dibasic endoproteinase subtilisin A through different me

38 Suppressor mutations in a putative dibasic ER retention signal, located within the cytoplas

39 cleavage occurs at a site distinct from the dibasic juxtamembrane motif that had been suggested prev

40 rase cleaved at tetrabasic (RRKR) but not at dibasic (KR) sites.

41 Compound 1 is a dibasic lipophilic molecule that is predicted to accumul

42 We also identified a novel dibasic motif (-KXHXX-COOH) in the cytoplasmic tails of

43 viously, we reported the identification of a dibasic motif (KxHxx) in the cytoplasmic tail of the SAR

44 Another dibasic motif (residues Arg-47, Arg-50) in the repeat 1

45 ng site-directed mutagenesis, we created the dibasic motif (RR or RK; R = arginine, K = lysine), a ta

46 study, we demonstrate that introduction of a dibasic motif adjacent to a subdominant determinant enha

47 This dibasic motif also retained a reporter protein in the ER

48 und O-acyltransferase family and possesses a dibasic motif at its C terminus that is likely responsib

49 tion with beta-COP was reduced by mutating a dibasic motif at Lys(54) in the Na,K-ATPase alpha-subuni

50 The dibasic motif bound the coatomer complex I (COPI) in an

51 so show that prosegments lacking an internal dibasic motif can act as autoinhibitors and prevent acti

52 We reported previously that the RXR-type dibasic motif in the distal C-terminal tail of an HIV co

53 In support of this, we found that the dibasic motif on the SARS S protein was required for its

54 Mutational analysis identified a dibasic motif, reminiscent of furin-like protease proces

55 erminal 11-amino acid propeptide ending in a dibasic motif, suggesting cleavage by a furin-like propr

56 rmini of ZP1, ZP2, and ZP3 lie upstream of a dibasic motif, which is part of, but distinct from, a pr

57 ymes suggested that the naturally processed, dibasic motif-marked epitope may not always correspond p

58 ombinatorial, non-exchangeable dileucine and dibasic motifs located in a defined sequence context in

59 An end-group effect of the dibasic N-terminal Lys of TP in the open-chain TP and it

60 N-Arginine dibasic (NRD) convertase is a recently described peptida

61 ch band occurring at ~1080 cm(-1) versus the dibasic (-OPO(3)(2-)) band measured at ~980 cm(-1) in bo

62 ncoding region is flanked by the appropriate dibasic or monobasic cleavage processing sites.

63 greater increase in soil solution P than the dibasic oxalic acid, likely due to the rapid degrading o

64 ved that an aromatic residue adjacent to the dibasic pair (i.e., Phe-Arg-Lys) could alter the cleavag

65 (8) M(-)(1) min(-)(1) for cleavage between a dibasic pair in dynorphin B-13.

66 ty to cleave peptides containing an arginine dibasic pair, i.e., Arg-Arg or Arg-Lys.

67 (2) Ile or Val produced cleavage between the dibasic pair.

68 Analyses of peptides spanning each of the 12 dibasic PE cleavage sites illustrated differences in H-D

69 Such dibasic peptides are less prone to cellular degradation.

70 othreonine are assigned to the monobasic and dibasic phosphate groups, respectively.

71 ary precursor to the intracellular mammalian dibasic processing endoproteinases.

72 suggests differential utilization of typical dibasic processing sites and atypical processing sites C

73 ate the relative accessibilities of multiple dibasic processing sites of PE by peptide amide hydrogen

74 AP-A presequence indicated the presence of a dibasic protease (Kex2/furin) processing site motif 6-8

75 These findings suggest that the dibasic protease cleavage sites of the PE prohormone wit

76 ng of proenkephalin by cathepsin V occurs at dibasic residue sites to generate enkephalin-containing

77 end two amino acids upstream of a conserved dibasic residue that is part of, but distinct from, the

78 otein motif consisting of a cluster of three dibasic residues ((356)RR(357), (359)KK(360), and (362)K

79 cleaving after sequences having consecutive dibasic residues (namely, at the P1 and P2 substrate pos

80 in convertase 1/3 (PC1) cleave substrates at dibasic residues along the eukaryotic secretory/endocyti

81 ecretory granules, where they are cleaved at dibasic residues by copackaged proprotein convertases.

82 that normally includes two sets of flanking dibasic residues), they offer insights into understandin

83 in convertases (PCs) cleave precursors after dibasic residues, and carboxypeptidases remove basic res

84 c protease which hydrolyzes peptides between dibasic residues.

85 Proteins with dibasic retention motifs are subject to retrograde trans

86 Both alpha4 and delta subunits contain dibasic retention motifs in homologous positions.

87 II-associated invariant chain Iip35 exhibits dibasic retention, carries a release motif, and shows mu

88 Substitution of the dibasic RK(841) and KR(845) sequences within this peptid

89 of all cell types tested, but cleavage of a dibasic sequence was detected only intracellularly and o

90 nce at the propeptide cleavage site, where a dibasic sequence would normally be expected.

91 The dibasic signal was shown to be important for concentrati

92 cleavage of the precursor at its Lys-Arg-Gly dibasic site by the protease.

93 ytoplasmic trafficking motifs: an N-terminal dibasic site that binds beta-COP to hold channels in ER

94 ed to regions of the NH(2) and COOH domains (dibasic sites 2, 3, and 9-11, respectively).

95 The mid-domain cleavage sites (dibasic sites 4-8) exhibited greater accessibility to th

96 molecule is processed by proteases at three dibasic sites found in the pro domain to form mature NGF

97 When a mutant form of pro-TRH, which has the dibasic sites of initial processing mutated to glycines,

98 lcium-dependent cleavage enzymes that act on dibasic sites of various peptide/protein substrates.

99 roenkephalin (PE) is a prohormone containing dibasic sites that are cleaved by proteases to generate

100 mutations in the pro domain at the other two dibasic sites, we found the stability of proNGF to incre

101 , the major form of catestatin is cleaved at dibasic sites, while smaller carboxyl-terminal forms als

102 m, human chromogranin A(340-372), bounded by dibasic sites.

103 in to insulin occurs via cleavage at the two dibasic sites: Arg31-Arg32, B chain-C-peptide (BC) junct

104 or the Y104D/I107E double mutation into the dibasic specific enzyme failed to generate the processed

105 peptidase B (OPB) is a serine peptidase with dibasic substrate specificity.

106 Dibasic substrates such as the piperizines are likely co

107 Dibasic tetrahydropyran-based compounds such as 6 and 21

108 es attributed to protonation of -OPO(3)(2-) (dibasic) to -OPO(3)H(-) (monobasic).