ライフサイエンスコーパス: dicentric

1 t from a chromatid dicentric to a chromosome dicentric.

2 pTRS-63, have been indicated for most of the dicentric 14q21q and 13q14q translocations that have bee

3 sequences downstream of c-myc, generating a dicentric (15;12) chromosome as an amplification interme

4 For construction of dicentrics, a modified B-9 chromosome was used, B-9-Dp9.

5 of nonlethal stable translocations to lethal dicentric aberrations be unity and not change with radia

6 trast analysis of the cellular response upon dicentric activation reveals that the majority of cells

7 Dicentric anaphase chromatin bridges and structurally al

8 , at the same time reducing the frequency of dicentric and abnormal chromosomes.

9 ely 1-5 kb) frequently fuse to form unstable dicentric and acentric chromosomes.

10 s we show rob(15;21)c to be constitutionally dicentric and breakage-fusion-bridge cycles generate dic

11 type aberrations, including gaps and breaks, dicentrics and radial formations, following exposure to

12 earance of chromosome aberrations (including dicentrics and ring forms) in peripheral blood lymphocyt

13 omeric fusions, resulting in translocations, dicentrics, and circular chromosomes.

14 tic septa pinch the nucleus, suggesting that dicentrics are severed after actomyosin ring contraction

15 the duplicated region gives a chromatid-type dicentric B-9 that subsequently initiates a chromatid-ty

16 ning chromosomes normally display occasional dicentric behavior, suggesting that bWD has centromeric

17 "Healing" of broken chromosomes produced by dicentric breakage accounted for much of the dicentric l

18 In all cases, dicentric breakage requires anaphase exit, ruling out st

19 c fragment is lost when cells divide and the dicentric breaks, transmitting a chromosome that has los

20 gH DSBs in progenitor B cells and that these dicentrics can be propagated developmentally into mature

21 isms, we find that attempts to segregate the dicentric chromatid frequently result not in breakage, s

22 etochore protein dephosphorylation regulates dicentric chromatid segregation.

23 nverted region results in the formation of a dicentric chromatid, which usually breaks or is stretche

24 eproduction theory," where a complete set of dicentric chromatids is synthesized during gametogenesis

25 We find that cell survival after dicentric chromosome activation requires the MT-binding

26 able chromosome to induce the formation of a dicentric chromosome and an acentric, telomere-bearing,

27 The nilgai karyotype contains an apparent dicentric chromosome as evidenced by the sites of 1.715

28 Centromeres on the same chromatid of a dicentric chromosome attach to opposite poles approximat

29 Suppression of dicentric chromosome breakage reflects loss of kinetocho

30 ated sequence and a telomere, suggesting the dicentric chromosome breaks and repairs by recombination

31 sister chromatids following the rupture of a dicentric chromosome during mitosis.

32 ient to completely inhibit radiation-induced dicentric chromosome formation had no effect on the freq

33 ption readthrough phenotype and stabilizes a dicentric chromosome fragment in two assays for kinetoch

34 ced between two centromeres on a conditional dicentric chromosome in budding yeast cells and made vis

35 Using a conditionally functional dicentric chromosome in vivo, we demonstrate that kineto

36 ethodology also involves the generation of a dicentric chromosome intermediate, which subsequently un

37 rted repeats in budding yeast fuse to form a dicentric chromosome intermediate, which then rearranges

38 ty, we introduced a conditionally functional dicentric chromosome into yeast.

39 Activation of a facultative, dicentric chromosome provides a unique opportunity to in

40 yKU70, yKU80, or SIR2, a 10-kb region of the dicentric chromosome stretched along the spindle axis to

41 matin relaxation following the breakage of a dicentric chromosome subjected to microtubule-based spin

42 al centromere is activated, the functionally dicentric chromosome undergoes double-stranded DNA break

43 The fate of the dicentric chromosome was evaluated in the mitotic cells

44 When two copies of the dicentric chromosome with one active and one inactive ce

45 4 chromosomes, monosomy 7, the presence of a dicentric chromosome, or both predicted a worse EFS but

46 to collapse and buckle in the presence of a dicentric chromosome.

47 phila melanogaster by breakage of an induced dicentric chromosome.

48 ce of telomerase but not after breakage of a dicentric chromosome.

49 lacO region in response to activation of the dicentric chromosome.

50 tions at M1 and the end fusions that produce dicentric chromosomes and breakage-fusion cycles.

51 stream of c-myc on chromosome 15, generating dicentric chromosomes and c-myc amplification via a brea

52 Dicentric chromosomes are unstable products of erroneous

53 atid exchange between inverted FRTs produced dicentric chromosomes at a high rate.

54 the response did not result from breakage of dicentric chromosomes at mitosis.

55 ore reproduction theory are: (i) breakage of dicentric chromosomes between centromere pairs forms acr

56 We found that dicentric chromosomes break in mitosis, and the broken f

57 Apoptosis was not due to rupture of dicentric chromosomes formed by end-to-end fusion, indic

58 rise through TREX1-mediated fragmentation of dicentric chromosomes formed in telomere crisis.

59 The resulting dicentric chromosomes have been proposed to drive genome

60 This analysis shows that dicentric chromosomes have recombination breakpoints tha

61 n arrest, and are resolved into acentric and dicentric chromosomes in G2.

62 o an unusual mechanism for the processing of dicentric chromosomes in mammalian oogenesis.

63 two kinetochores of engineered, unreplicated dicentric chromosomes in Saccharomyces cerevisiae bi-ori

64 We investigated the fate of dicentric chromosomes in the mitotic divisions of Drosop

65 s to wheat, often leading to the presence of dicentric chromosomes in the subsequent progeny.

66 We observed that dicentric chromosomes invariably persisted through mitos

67 Thus, dicentric chromosomes may be an important precipitant of

68 Breakage of the resulting dicentric chromosomes results in nonreciprocal transloca

69 Immunostaining on dicentric chromosomes reveals that an inactive centromer

70 c and breakage-fusion-bridge cycles generate dicentric chromosomes somatically.

71 ome tumour cells, like senescent cells, have dicentric chromosomes that may arise as a result of telo

72 Mutations in chl4/mcm17/ctf17 segregate dicentric chromosomes through successive cell divisions

73 alpha-satellite-rich inactive centromeres of dicentric chromosomes together suggest that CENP-A assoc

74 protein has been reported to be recruited to dicentric chromosomes under tension, and such chromosome

75 Dicentric chromosomes undergo a breakage-fusion-bridge c

76 Dicentric chromosomes undergo breakage in mitosis, resul

77 Cells initially tolerated dicentric chromosomes without dying, but eventually, a c

78 tative changes (a shift from TAs to TAs plus dicentric chromosomes) and quantitative changes (an incr

79 lect a cycle of T-TF formation (resulting in dicentric chromosomes), followed by chromosome breakage.

80 B is found at inactive centromeres on stable dicentric chromosomes, and also mitotically stable chrom

81 of numerous chromosome aberrations including dicentric chromosomes, chromatid breaks, and double minu

82 rrations, including increases in aneuploidy, dicentric chromosomes, chromatid exchanges and chromosom

83 long lasting and transmissible induction of dicentric chromosomes, nucleoplasmic bridges, micronucle

84 ents within palindromes that create unstable dicentric chromosomes, resulting in infertility, sex rev

85 d to the formation and sometimes breakage of dicentric chromosomes, thus starting a devastating break

86 This inverted repeat fusion reaction forms dicentric chromosomes, which are well-known intermediate

87 hing between nearby inverted repeats to form dicentric chromosomes.

88 TAs preceded and were more numerous than dicentric chromosomes.

89 gh TAs before additional shortening leads to dicentric chromosomes.

90 ycle was examined for the presence of stable dicentric chromosomes.

91 end of the chromosome, and the formation of dicentric chromosomes.

92 omosome of maize has been used in a study of dicentric chromosomes.

93 emergence of chromosomal fusions (including dicentrics) coincided with onset of deletions and comple

94 ventually, a combination of too many TAs and dicentrics/complex chromosomal rearrangements resulted i

95 chromosomes were recovered from an unstable dicentric containing large and small versions of the B c

96 a model explaining the formation of inverted dicentric dimers by intermolecular single-strand anneali

97 to this model, anaphase breakage of inverted dicentric dimers leads to gross chromosomal rearrangemen

98 The dicentrics form anaphase bridges that subsequently break

99 We propose that dicentrics formed by joining V(D)J recombination-associa

100 By using dicentrics from dispensable chromosomes, centromere inac

101 In budding yeast, dicentrics generated by telomere fusion break at the fus

102 Here, we examine the fate of dicentric human chromosomes in telomere crisis.

103 The three cytologically dicentric i(Xq)s had breakpoints distal to DXS423E in Xp

104 this study, we map chromosome break sites of dicentrics in Saccharomyces cerevisiae by a mitotic reco

105 that the arrest represents surveillance of a dicentric induced aberration.

106 structures observed suggest involvement of a dicentric intermediate and break-induced replication wit

107 further results in intact segregation of the dicentric into one of the meiotic products, where it can

108 repeats, resulting in the formation of large dicentric inverted dimers.

109 st cases had deletions of 9p, add/der(9p), a dicentric involving chromosome arm 9p, and/or balanced t

110 me that is subsequently replicated to form a dicentric isochromosome.

111 ants, potential dicentric translocations and dicentric isochromosomes were associated with cell cycle

112 Here, we observed that dicentrics lacking telomere fusion preferentially break

113 there was no specific developmental time for dicentric loss.

114 dicentric breakage accounted for much of the dicentric loss.

115 Fusion of nearby inverted repeats to form dicentrics may be a major cause of instability in yeast

116 at the minichromosome segregation defect and dicentric minichromosome stabilization, both characteris

117 d neck, explaining how cytokinesis can sever dicentrics near centromeres.

118 complex chromosomal abnormalities including dicentrics, rings and fragments.

119 Most Robertsonian translocations are dicentric, suggesting that the location of chromosomal b

120 The dicentric t(8;11) in ZR-75-1 carries multiple rearrangem

121 In the presence of dicentrics, the cytokinetic septa pinch the nucleus, sug

122 to one pole and converts it from a chromatid dicentric to a chromosome dicentric.

123 e second pollen mitosis, which sends the B-9 dicentric to one pole and converts it from a chromatid d

124 d in telomerase-defective mutants, potential dicentric translocations and dicentric isochromosomes we

125 We have analyzed the structure of 36 dicentric translocations, using several repetitive DNA p

126 As expected, the new dicentric undergoes the chromosome-type breakage-fusion-

127 ficiency leads to formation of chromosome 12 dicentrics via recombination-activating gene-initiated I

128 n the root cells of plants with a chromosome dicentric was studied during the first 10 wk of developm

129 A large number of plants with chromosome dicentrics were produced in this way.

130 eakpoints of cytogenetically monocentric and dicentric Xq isochromosomes (i(Xq)) from Turner syndrome