ライフサイエンスコーパス: dichloro

1 activity when the phenyl substituent was 3,4-dichloro.

2 ngation factor-b (P-TEFb) inhibitor DRB (5,6-dichloro 1-beta-d-ribofuranosylbenzinida-sole).

3 tion of a disulfide bond by oxidization with dichloro(1,10-phenanthroline)copper (II) (CuPh), or the

4 cy of a series of metallopeptides containing dichloro(1,10-phenanthroline)copper(II) and various orga

5 gs, such as bruceantin and LY2109761, and 2) dichloro(1,2-diaminocyclohexane)platinum(II) (DachPt).

6 ruthenacyclobutanes via the protonolysis of dichloro(1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinyl

7 mino)-2,2-dinitroethyl}diazene) (10), N1, N2-dichloro-1, 2-diazenedicarboximidamide (11), and (E,E)-N

8 2-Amino-N'-arylbenzamidines react with 4,5-dichloro-1,2,3-dithiazolium chloride (Appel salt) in the

9 -bromo-1,2-bis(trimethylsilyl)benzene or 4,5-dichloro-1,2-bis(trimethylsilyl)benzene with BBr3 in hex

10 rides occurs rapidly upon treatment with 3,3-dichloro-1,2-diphenylcyclopropene.

11 samples from 10 swimming pools and found 2,6-dichloro-1,4-benzoquinone (2,6-DCBQ) in all the pools at

12 o-3-methyl-1,4-benzoquinone (DCMBQ), and 2,6-dichloro-1,4-benzoquinone (DBBQ), were treated using a m

13 using formation potential (FP) tests for 2,6-dichloro-1,4-benzoquinone (DCBQ), 2,3,6-trichloro-1,4-be

14 Water samples containing four HBQs, 2,6-dichloro-1,4-benzoquinone (DCBQ), 2,3,6-trichloro-1,4-be

15 Four halobenzoquinones (HBQs), 2,6-dichloro-1,4-benzoquinone (DCBQ), 2,6-dichloro-3-methyl-

16 four HBQs were identified as 3-hydroxyl-2,6-dichloro-1,4-benzoquinone (OH-DCBQ) from DCBQ, 5-hydroxy

17 ,6-trichlorophenol (TCP) is converted to 2,6-dichloro-1,4-benzoquinone in a H2O2-dependent process.

18 of an electron-deficient reagent such as 2,6-dichloro-1,4-benzoquinone suppressed this isomerization

19 (2) will fully convert 1 equiv of TCP to 2,6-dichloro-1,4-benzoquinone, implicating the role of multi

20 -dibromo-1,4-benzoquinone or 2,5-diamino-3,6-dichloro-1,4-benzoquinone, proceeding through single-cry

21 to form 2,6-dibromo-1,4-benzoquinone and 2,6-dichloro-1,4-benzoquinone, respectively.

22 ave obtained a compound (5,8-diacetyloxy-2,3-dichloro-1,4-naphthoquinone) that provokes IR activation

23 ichlorocarbene to bicyclobutane to yield 1,1-dichloro-1,4-pentadiene.

24 ranosyl)benzimidazole (TCRB) and 2-bromo-5,6-dichloro-1-(beta-d-ribofuranosyl)benzimidazole (BDCRB) a

25 Amino acid ester prodrugs of 2-bromo-5,6-dichloro-1-(beta-d-ribofuranosyl)benzimidazole (BDCRB) w

26 the DNA encapsidation inhibitor 2-bromo-5,6-dichloro-1-(beta-d-ribofuranosyl)benzimidazole.

27 ching equilibrium with the carbinolamine 2,2-dichloro-1-(chloroamino)ethanol ( K(1) = 1.87 x 10(4) M(

28 Then, 2,2-dichloro-1-(chloroamino)ethanol underwent two parallel r

29 in-3-yl)-N'-cyanoguanidines furnished N-{2,2-dichloro-1-[N'-(substituted-pyridin-3-yl)-N''-cyanoguani

30 kinase and mRNA synthesis inhibitor DRB (5,6-dichloro-1-b-D-ribofuranosylbenzimidazole) induces the n

31 nslocation inhibitors alpha amanitin and 5,6-dichloro-1-beta-D-ribobenzimidazole (DRB) and an siRNA t

32 Treatment of neurons with 5, 6-dichloro-1-beta-D-ribobenzimidazole (DRB), an RNA Pol II

33 equires for activity the two-polypeptide 5,6-dichloro-1-beta-D-ribobenzimidazole-sensitivity inducing

34 th the viral terminase inhibitor 2-bromo-5,6-dichloro-1-beta-d-ribofuranosyl benzimidazole riboside (

35 r herpesvirus genome maturation, 2-bromo-5,6-dichloro-1-beta-d-ribofuranosyl benzimidazole riboside (

36 (ii) DB particles recovered from 2-bromo-5,6-dichloro-1-beta-d-ribofuranosyl benzimidazole riboside (

37 ption of transcription by actinomycin D, 5,6-dichloro-1-beta-D-ribofuranosyl-benzimadazole or alpha-a

38 ments with two CKII-specific inhibitors, 5,6-dichloro-1-beta-d-ribofuranosyl-benzimidazole (DRB) and

39 Inhibition of P-TEFb kinase activity by 5,6-dichloro-1-beta-d-ribofuranosyl-benzimidazole (DRB) supp

40 Furthermore, 5,6-dichloro-1-beta-d-ribofuranosyl-benzimidazole, an inhibi

41 However, CTD kinase inhibitors, such as 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) and 1

42 rase II (Pol II) hyperphosphorylation by 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole (DRB) block

43 The selective CK2 inhibitors 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole (DRB) or 4,

44 of negative elongation factor (NELF) and 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole (DRB) sensi

45 ls or an extract is no longer sensitive to 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB), a co

46 uding the CDK9 pharmacological inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB), a do

47 first, infected cells were treated with 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole (DRB), a sp

48 Here, we demonstrate that 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole (DRB), an i

49 ors on HDV genome replication: amanitin, 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB), and

50 ibition of transcription elongation with 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB), comb

51 n of U0126, the mRNA synthesis inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB), or i

52 stein (a tyrosine kinase inhibitor), and 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB, a CK2

53 s well as by the gene expression blocker 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole administere

54 her serum-responsive factor knockdown or 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole altered rec

55 Inhibition of CKII activity by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole blocks the

56 scriptionally active, as incubation with 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole eliminated

57 tment with the casein kinase 2 inhibitor 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole had the opp

58 and by the inhibitor of gene expression 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole infused imm

59 ting this view, we found synergy between 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole riboside an

60 Negative elongation factor (NELF) and 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity

61 he cdk9 inhibitors Flavopiridol and DRB (5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole) allowed cd

62 to the well-known nucleoside analog DRB (5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole), and that

63 th CTD kinase inhibitors, including DRB (5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole), causes a

64 ycin, a tyrosine kinase inhibitor and by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole, a protein

65 ent with a nonspecific kinase inhibitor, 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole.

66 ow concentrations of the CDK9 inhibitor 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole.

67 alogenated benzimidazoles BDCRB (2-bromo-5,6-dichloro-1-beta-D-riborfuranosyl benzimidazole riboside)

68 Epoxide 2 was prepared from 3,4-dichloro-1-butene (1) by epoxidation with m-CPBA and sub

69 ics of the unimolecular rearrangement of 2,2-dichloro-1-methylenecyclopropane (1) to (dichloromethyle

70 We present a novel class of substituted 7,8-dichloro-1-oxo-beta-carbolines based on the distinct str

71 as synthesized by potassium reduction of 1,1-dichloro-1-silafluorene in refluxing THF.

72 lowing: 2,8-dichlorodibenzodioxin (4%), 4,5'-dichloro-[1,1'-biphenyl]-2,2'-diol (10%), 5-chloro-2-(4-

73 phosphorylation by the kinase inhibitors 5,6-dichloro-1beta-D-ribofuranosyl-benzimidazole and H8 bloc

74 aphtho[1,2-d]thiazol-2-ylamine (SKA-31), 6,7-dichloro-1H-indole-2,3-dione 3-oxime (NS309), and 1-ethy

75 imes more potent on K(Ca)2.1 than NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime), an unselective bu

76 (E)-3-(2-Carboxy-2-phenylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acid, 1, is a potent and

77 of 3-[2-(3-aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, 19, as a new poten

78 ll molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin ba

79 the preparation of the fluorescent dye 4',5'-dichloro-2',7'-dimethoxy-5(6)-carboxyfluorescein (JOE) i

80 A series of methoxyl-substituted 3,3'-dichloro-2,2'-binaphthoquinones 2 were prepared and eval

81 ine (dmb, 2), 2,2'-bipyridine (bpy, 3), 4,4'-dichloro-2,2'-bipyridine (dclb, 4), and 4,4'-diethyleste

82 oxidase (BOD) "wired" with PAA-PVI-[Os(4,4'-dichloro-2,2'-bipyridine)(2)Cl](+/2+) (polymer II), havi

83 (N-vinylimidazole) complexed with [Os (4,4'-dichloro-2,2'-bipyridine)(2)Cl](+/2+), cross-linked on c

84 found with polychlorinated biphenyl or 1,1'-dichloro-2,2'-bis(4-chlorophenyl)ethylene levels and any

85 lyzed for polychlorinated biphenyls and 1,1'-dichloro-2,2'-bis(4-chlorophenyl)ethylene.

86 A novel class of pure antiestrogens, 1,1-dichloro-2,2,3-triarylcyclopropanes (DTACs), lack estrog

87 ons of polychlorinated biphenyl (PCB)-153; 1-dichloro-2,2-bis (p-chlorophenyl) ethylene (p,p'-DDE), a

88 ophenyl)ethane (DDT) and its metabolites 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane (DDD) and 1,1-dic

89 -2,2-bis(4-chlorophenyl)ethane (DDD) and 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (DDE), are ofte

90 potential of the antiandrogen, p,p -DDE [1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene], the most pre

91 l)ethane] and its metabolites, 4,4'-DDD [1,1-dichloro-2,2-bis(p-chlorophenyl)ethane] and 4,4'-DDE [1,

92 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), a persis

93 The main degradation product of DDT is 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), an antia

94 transformers and other applications, and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), the main

95 e to persistent organochlorines such as 1,1,-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p -DDE), pol

96 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) is a

97 t relating polychlorinated biphenyls and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene to time to preg

98 CBs (polychlorinated biphenyls) and DDE [1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene] reduces 6-mont

99 bis(p-chlorophenyl)ethane] and 4,4'-DDE [1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene], from an histo

100 ic assay for the determination of DDT [1,1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene].

101 WAY-161503 ((4aR)-8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxali

102 ithio-2,3,4,5-tetraphenylsilole (1) with 1,1-dichloro-2,3-diphenylcyclopropene (2) leads to the novel

103 deprotonated 2-oxa-6-azaadamantane with 2,6-dichloro-2,6-diazaadamantane.

104 yl)propyl)thio)benzoic acid (GRI977143), 4,5-dichloro-2-((9-oxo-9H-fluoren-2-yl)carbamoyl)benzoic aci

105 tions where, (1) it slowly dehydrated to 1,1-dichloro-2-(chloroimino)ethane ( k(2) = 1.09 x 10(-5) s(

106 logii, net CO(2) fixation was blocked by 3,3-dichloro-2-(dihydroxyphosphinoyl-methyl)-propenoate (a s

107 onse to its estrogenic isomer, o,p -DDE [1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl) ethylene]

108 epared from commercially available trans-1,4-dichloro-2-butene were converted to trans-disubstituted

109 e have previously shown that 4-(2-butyl-6, 7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid

110 4-(2-Butyl-6,7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid

111 phoenolpyruvate carboxylase (PEPCase) by 3,3-dichloro-2-dihydroxyphosphinoylmethyl-2-propenoate resul

112 In 3,3-dichloro-2-dihydroxyphosphinoylmethyl-2-propenoate-treat

113 Tris(1,3-dichloro-2-isopropyl) phosphate (TDCIPP) concentrations

114 loroisopropyl) phosphate (TCPP) and tris(1,3-dichloro-2-isopropyl) phosphate (TDCP)), four alkylated

115 Dicamba (3,6-dichloro-2-methoxybenzoic acid) is a widely used herbici

116 around aryl sulfonamide series led to N-(3,5-dichloro-2-methoxyphenyl)-3-(1-methylpiperidin-4-ylamino

117 nduced by our hit fragment compared with 4,6-dichloro-2-methyl-3-aminoethyl-indole (DCAI), a Ras liga

118 -(1,1-dimethylethyl)-3-(methylsulfonyl)-,6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline

119 ell as small molecule allosteric agonist 6,7-dichloro-2-methylsulfonyl-3-tert-butylaminoquinoxaline (

120 ide (Z)-6-O-(tert-butyldimethylsilyl)-1-(4,5-dichloro-2-nitrophenyl)-1,2-dideo xy-3,4-O-isopropyliden

121 ride, 2,4-dichloroaniline, and sea-nine (4,5-dichloro-2-octyl-3-isothiazolone)).

122 All four diastereomers of 3,4-dichloro-2-pentanol were synthesized by anti-dichlorinat

123 of 3-chloropropane-1,2-diol (3-MCPD) and 1,3-dichloro-2-propanol (1,3-DCP) were found in domestically

124 -2-ethylhexyl phosphate (TEHP), and tris-1,3-dichloro-2-propyl phosphate (TDCPP) were coated on (NH4)

125 TDCIPP and TPHP metabolites (bis(1,3-dichloro-2-propyl) phosphate (BDCIPP) and diphenyl phosp

126 The current study measured levels of bis(1,3-dichloro-2-propyl) phosphate (BDCIPP), bis(1-chloro-2-pr

127 asured five urinary PFR metabolites [bis(1,3-dichloro-2-propyl) phosphate (BDCIPP), diphenyl phosphat

128 ponding to maxima dust for the pairs bis(1,3-dichloro-2-propyl) phosphate (BDCIPP)-tris(1,3-dichloro-

129 course of 3 months and analyzed for bis(1,3-dichloro-2-propyl) phosphate (BDCPP) and diphenyl phosph

130 Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) has been frequentl

131 oroisopropyl) phosphate (TCIPP), or tris(1,2-dichloro-2-propyl) phosphate (TDCIPP).

132 ate (DPP), metabolites of the OPFRs tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosp

133 )phosphate (TCIPP; max: 14500 ng/L), bis(1,3-dichloro-2-propyl)phosphate (BDCIPP; max: 4550 ng/L), tr

134 uptake and elimination of TDCPP and bis(1,3-dichloro-2-propyl)phosphate (BDCPP, the primary metaboli

135 magnitude concentration increase in tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) and tri-m-cresyl ph

136 flame retardants (PFRs), including tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) and triphenyl phosp

137 ncluded triphenyl phosphate (TPHP), tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) and tris(2-chloroet

138 Tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) is a high-productio

139 Tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) is a high-productio

140 lhexyl) tetrabromophthalate (TBPH), tris(1,3-dichloro-2-propyl)phosphate (TDCIPP), and triphenyl phos

141 phosphate (BDCIPP; max: 4550 ng/L), tris(1,3-dichloro-2-propyl)phosphate (TDCIPP; max: 3150 ng/L) and

142 osphate flame retardants (ClOPFRs), tris(1,3-dichloro-2-propyl)phosphate (TDCPP or TDCIPP), tris(1-ch

143 ondensation of 2,5-dihydroxyquinone with 4,5-dichloro-, 2,6-dichloro-, and 4,5-dibromo-1,2-phenylened

144 d with equal potency to human COX-2 with 2,6-dichloro-, 2,6-dimethyl-, or 2-chloro-6-methyl-substitut

145 catechol metabolite, 4,5-di-OH-PCB 11 (3',5-dichloro-3,4-dihydroxybiphenyl), were unambiguously iden

146 polymerization (SSP) does not occur for 2,5-dichloro-3,4-ethylenedioxythiophene (DCEDOT), and requir

147 atalyzes a second hydroxylation, forming 2,6-dichloro-3,5-dihydroxybenzoic acid.

148 NH(2))(2)[M(2)L(3)] (M = Zn, Mn; H(2)L = 2,5-dichloro-3,6-dihydroxo-1,4-benzoquinone) undergo linker

149 pound, (Me2NH2)2[Fe2L3].2H2O.6DMF (LH2 = 2,5-dichloro-3,6-dihydroxo-1,4-benzoquinone) was previously

150 much less toxic dihydroxylation product, 2,5-dichloro-3,6-dihydroxy-1,4-benzoquinone (chloranilic aci

151 tion of the redox-active bridging ligand 2,5-dichloro-3,6-dihydroxy-1,4-benzoquinone (LH2) with Fe(II

152 SO(4))(2) (Cl(2) dhbq(n-) = deprotonated 2,5-dichloro-3,6-dihydroxybenzoquinone) (2-SO(4)), are shown

153 obenzoquinone and fully converted to the 2,5-dichloro-3-(indol-3-yl)benzoquinone targets by DDQ or Ag

154 xygenase BbdD transforming 2,6-DCBA into 2,6-dichloro-3-hydroxybenzoic acid.

155 TDF) the required intermediate, 3-[4-[1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-5-iodopyrazolo]

156 to form additional HBQs, such as TriCBQ, 2,6-dichloro-3-methyl-(1,4)benzoquinone (DCMBQ), and 2,3,5,6

157 ), 2,6-dichloro-1,4-benzoquinone (DCBQ), 2,6-dichloro-3-methyl-1,4-benzoquinone (DCMBQ), 2,3,6-trichl

158 2,3,6-trichloro-1,4-benzoquinone (TCBQ), 2,6-dichloro-3-methyl-1,4-benzoquinone (DCMBQ), and 2,6-dibr

159 2,3,6-trichloro-1,4-benzoquinone (TCBQ), 2,6-dichloro-3-methyl-1,4-benzoquinone (DCMBQ), and 2,6-dich

160 oquinone (OH-DCBQ) from DCBQ, 5-hydroxyl-2,6-dichloro-3-methyl-1,4-benzoquinone (OH-DCMBQ) from DCMBQ

161 trifluoromethyl-4-nitrophenol (TFM) and 2',5-dichloro-4'-nitrosalicylanilide (niclosamide) are direct

162 Analogues of penclomedine (PEN, 3,5-dichloro-4,6-dimethoxy-2-(trichloromethyl)pyridine) and

163 3)) and a non-liver-targeted TR agonist, 3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)phenylacetic ac

164 is of the targeted 2-chloro- and 2-bromo-6,7-dichloro-4-(beta-d-ribofuranosyl)quinolines (18and 21, r

165 We proposed to synthesize 2-halo-6,7-dichloro-4-(beta-d-ribofuranosyl)quinolines as 6 + 6 bic

166 used structure-based design to discover 2,6-dichloro-4-cyanophenyl and (1R,2R)-2-fluorocyclopropylam

167 s prepared in 10 steps from pyrazole and 3,5-dichloro-4-fluorobenzotrifluoride.

168 PEN and 4-DMPEN (3,5-dichloro-4-hydroxy-6-methoxy2-(trichloromethyl)pyridine

169 renylindole)tin in coupling with a bromo-2,5-dichloro-4-indolylbenzoquinone gives the demethylasterri

170 hanamine, was prepared by first coupling 2,5-dichloro-4-nitroaniline with 2-mercapto-N,N-dimethylbenz

171 3-[4-[1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazolo]]-3-(trifluoro

172 The structures of the bound dichloro (5) and dimethyl (12) analogue complexes indica

173 enes have been synthesized starting from 6,9-dichloro-5,10-diaza[5]helicene, which was prepared from

174 lization of 4-arylpent-4-enoic acid with 1,3-dichloro-5,5-dimethylhydantoin (DCDMH), is revealed to b

175 The use of a combination of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and beta-pin

176 hloromethane, followed by oxidation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) generates a

177 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) is a highly

178 enes and isochromenes react quickly with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) to form pers

179 followed by oxidative aromatization with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone produced the funct

180 (2)Cl(2) followed by oxidation with DDQ (2,3-dichloro-5,6-dicyano-1,4-benzoquinone) and alumina colum

181 Q-mediated dehydrogenation reaction (DDQ=2,3-dichloro-5,6-dicyano-1,4-benzoquinone).

182 kinetics of the hydride abstractions by 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) from 13 C-H hy

183 Reactions of 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) with silyl eno

184 t the sp-hybridized C2, with either DDQ (2,3-dichloro-5,6-dicyano-p-benzoquinone) or TBHP (tert-butyl

185 When the oxidant was replaced by 2,3-dichloro-5,6-dicyano-p-benzoquinone, which is frequently

186 with various styrenes in the presence of 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) was promoted by B

187 anyl azaBODIPY was in situ oxidized with 2,3-dichloro-5,6-dicyanobenzoquinone and either reacted with

188 FeCl(3), CuCl(2), [Co(NH(3))(5)Cl]Cl(2), 2,3-dichloro-5,6-dicyanobenzoquinone, or ceric ammonium nitr

189 of two target compounds, (RS)-2-amino-3-(3,4-dichloro-5-(5-hydroxypyridin-3-yl)phenyl)propanoic acid

190 e reaction of the commercially available 4,6-dichloro-5-aminopyrimidine 1 with isothiocyanates.

191 A highly selective monodechlorination of 2,6-dichloro-5-fluoronicotinic acid was discovered to afford

192 d 1 (SKI-606, bosutinib), a 7-alkoxy-4-[(2,4-dichloro-5-methoxyphenyl)amino]-3-quinolinecarbonitrile,

193 A 2,4-dichloro-5-methoxyphenylamino group at C-7 provided supe

194 he nucleophilic aromatic substitution of 4,6-dichloro-5-nitrobenzofuroxan 1 with eight aliphatic amin

195 photocycloaddition of crystalline trans-2,4-dichloro-6-styrylpyrimidine to produce the corresponding

196 racterization of one of these compounds, 2,4-dichloro-6-{(E)-[(3-methoxyphenyl)imino]methyl}phenol (D

197 l)[1,4]benzoquinone and 2,5-dihydroxy-3-(4,6-dichloro-7-farnesyl-1H-indol-3-yl)[1,4]benzoquinone, are

198 dro-2 H-pyran, an alcohol, and catalytic 1,5-dichloro-9,10-anthraquinone with use of visible light.

199 containing the fluorogenic substrate 9H-(1,3-dichloro-9,9-dimethylacridin-2-on-7-yl) beta-D-galactosi

200 te of beta-galactoside and 7-hydroxy-9H-(1,3-dichloro-9,9-dimethylacridin-2-one) (DDAO), is not only

201 aved by beta-gal to produce 7-hydroxy-9H(I,3-dichloro-9,9-dimethylacridin-2-one) (DDAO).

202 sulfatase-activated probe, 7-hydroxy-9H-(1,3-dichloro-9,9-dimethylacridin-2-one)-sulfate, that detect

203 One substrate, 9H-(1,3-dichloro-9,9-dimethylacridin-2-one-7-yl) beta-d-galactop

204 ent substrate of beta-galactosidase (9H-{1,3-dichloro-9,9-dimethylacridin-2-one-7-yl} beta-D-galactop

205 2,6-Dichloro-9-thiabicyclo[3.3.1]nonane is especially useful

206 Herein we introduce 2-((3-(3,6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl)amino)-2-(hyd

207 Asymmetric hydration of alpha,alpha-dichloro aldehydes and alpha-halo enals via a NHC-cataly

208 The 2',5'-dichloro analogue 8 showed selectivity ratios (IC(50) ag

209 2,3-Dichloro- and 2,3-dibromopyridines have been shown to re

210 d and optimized to give 80-90% yields of 2,6-dichloro- and 2,6,7-trichloro-3-(2,3-dideoxy-2,3-didehyd

211 Dichloro- and phenylchlorocarbene (CCl2 and PhCCl) add t

212 s possible to conclude that at least 2 HAAs (dichloro- and trichloroacetic acids, DCAA and TCAA) are

213 nic matter (DOM) had no measurable effect on dichloro- and trichlorobiphenyls, but did contain about

214 2,4,5-Trichloro-, 2-bromo-4,5-dichloro-, and 2,4,5-tribromoimidazole nucleosides were

215 2,5-dihydroxyquinone with 4,5-dichloro-, 2,6-dichloro-, and 4,5-dibromo-1,2-phenylenediamine, followe

216 y with the dipole moments of chloro-, nitro- dichloro-, and dinitro- (o-, m-, and p-) benzene guests.

217 analogues (2-amino-benzimidazole and 1-(3,4-dichloro-benzyl)-2-amino-benzimidazole) in complex with

218 is of the alternative binding mode of 1-(3,4-dichloro-benzyl)-2-amino-benzimidazole, derivatives were

219 the bis-pyridinium derivative 4,4'-bis-[(2,6-dichloro-benzyloxy-imino)-methyl]-1,1'-propane-1,3-diyl-

220 The corresponding alpha,alpha-dichloro-beta-hydroxyketones were obtained by treatment

221 lization promoted by the 1:1 complex of o,o'-dichloro-BINOL and SbCl(5).

222 on on the oxygenated phenyl ring, e.g., 4,4'-dichloro-biphenyl-2,5-diol, 3,6,4'-trichloro-biphenyl-2,

223 repared, 6-chloro-biphenyl-3,4-diol and 6,4'-dichloro-biphenyl-3,4-diol.

224 Reaction of the dichloro-bridged dimers [(C'N(2)Ir(mu-Cl)(2)Ir(C'N)(2)]

225 on battery system, the electrolyte is of the dichloro complex (DCC) solution family, Mg(AlCl2BuEt)2/T

226 Surprising differences were seen between the dichloro complex 2b with isopropyl groups on phosphorus,

227 Dichloro complexes (L(1) = L(2) = Cl, 2a-2c,2e) showed i

228 from ca. 20 pg/L (part-per-quadrillion) for dichloro-congeners down to ca. 0.2 pg/L for higher-molec

229 Log K(POM) values ranged from ca. 4.6 for dichloro-congeners to ca. 7.0 for octachloro-congeners a

230 Chlorination of anthracimycin gives a dichloro derivative that retains activity against Gram-p

231 tereomeric separation by substitution of the dichloro derivative with a chiral amine has been shown.

232 timicrobial activity and revealed simplified dichloro derivatives that are equally potent against sev

233 traphenylmetallole dianion and corresponding dichloro(dialkyl)silanes.

234 s as well as a fluorescent dye, carboxy-H(2)-dichloro-dihydrofluorescein diacetate (carboxy-H(2)-DCFD

235 and rhodizonic acids, dihydroxybenzoquinone, dichloro-dihydroxy-p-benzoquinone, or benzene decorated

236 sistance of these species to the insecticide dichloro-diphenyl-trichloroethane (DDT).

237 l- channel antagonists, niflumic acid (NFA), dichloro-diphenylamine 2-carboxylic acid (DCDPC) and dii

238 The dichloro form of the drug exists in equilibrium with at

239 ely converts the aquated species back to the dichloro form of the parent drug so that a single molecu

240 rect vinylogous aldol addition of alpha,beta-dichloro gamma-butyrolactones and gamma-butyrolactams wi

241 4]) > chloral hydrate (165% [161-176]) > 2,2-dichloro- > 2-chloro approximately 2,2,2-trifluoroethano

242 The dichloro(heteroaryl)borane primary products can be prote

243 zine privileged structures (2-methoxy vs 2,3-dichloro) influenced bias when the thienopyridine hetero

244 chloro-2-propyl) phosphate (BDCIPP)-tris(1,3-dichloro-isopropyl) phosphate (TDCIPP) and bis(2-chloroe

245 e additive flame retardants (FRs), tris (1,3-dichloro-isopropyl) phosphate (TDCPP) and Firemaster((R)

246 The reaction of dichloro ketones with azide anions provides acyl azides,

247 ion of 7-chloro-L-tryptophan to generate 6,7-dichloro-L-tryptophan.

248 ntially on free L-tryptophan to generate 6,7-dichloro-L-tryptophan.

249 cts (water, methanol, ethyl acetate, hexane, dichloro-methane) of fenugreek seeds were investigated i

250 A second compound, NT-9-21, which contains dichloro moieties in place of the 3,5-dibromo substituen

251 therapy-specifically 2-quinoxalinamine, 6,7-dichloro-N-(1,1-dimethylethyl)-3-(methylsulfonyl)-,6,7-d

252 The 3,4-dichloro-N-(1-(dimethylamino)cyclohexyl)methyl benzamide

253 .08, or 0.16 mg/kg) and D2/D3 antagonist 3,5-dichloro-N-(1-ethylpyrrolidin-2-ylmethyl)-2-hydroxy-6-me

254 three most potent compounds: 918013 (1; 2,4-dichloro-N-(3-fluorophenyl)-5-(4-morpholinylsulfonyl) be

255 olus injections of 11C-raclopride (S-(-)-3,5-dichloro-N-[(1-ethyl-2-pyrrolidinyl)]methyl-2-hydroxy-6-

256 Taking advantage of 3,5-dichloro-N-[1-(2,2-dimethyl-tetrahydro-pyran-4-ylmethyl)

257 ice and a panselective T-channel blocker 3,5-dichloro-N-[1-(2,2-dimethyltetrahydro-pyran-4-ylmethyl)-

258 t not by the kappa agonist trans-(1S,2S)-3,4-dichloro-N-mathyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benze

259 ,D-Leu5]-enkephalin (DADLE), trans-(+/-)-3,4-dichloro-N-methyl-N-(2-[1-pyrrolidinyl]cyclohexyl) benze

260 f this finding, the N-methylated analog, 2,5-dichloro-N-methyl-N-(2-methyl-4-nitrophenyl)benzenesulfo

261 nt with the kappa agonist U50,488 (trans-3,4-dichloro-N-methyl-N-[2-(1-pyrolytinil)-cyclohexyl]-benze

262 lic [D-Pen2-D-Pen5]-enkephalin, or trans-3,4-dichloro-N-methyl-N-[2-(1-pyrolytinil)-cyclohexyl]-benze

263 Treatment with the agonist (-)-(trans)-3,4- dichloro-N-methyl-N-[2-(1-pyrrolidiny)cyclohexyl]benzene

264 analgesic effect of the agonist (trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl] benz

265 -Pen(5)]-enkephalin (1 microm) and trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benze

266 of the KOR agonist U50,488 [(+/-)-trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benze

267 ersion caused by the kappa agonist trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benze

268 hydrochloride) and U50488H (trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(pyrrolidinyl)cyclohexyl] benzene

269 infusion of the kappa-OR agonist (trans)-3,4-dichloro-N-methyl-N-[2-1-pyrrolidinyl)-cyclo-hexyl] benz

270 hemBridge, San Diego, CA; ID5128535) and 2,4-dichloro-N-{4-[(1,3-thiazol-2-ylamino)sulfonyl]phenyl}be

271 N,N-dichloro-o-nitrobenzenesulfonamide (2-NsNCl2) was found

272 flow reactor or nucleophilic substitution of dichloro (oxa)helicenes with alkanethiolates were used i

273 zes 2,4,5-trichlorophenol (2,4,5-TCP) to 2,5-dichloro-p-benzoquinone, which is chemically reduced to

274 1,4-diene, Bu3SnD, and pyridine.BD3 with 2,5-dichloro-p-benzoquinone.

275 oquinone, which is chemically reduced to 2,5-dichloro-p-hydroquinone (2,5-DiCHQ).

276 trichloro-p-hydroquinone (TriCH) and then to dichloro-p-hydroquinone (DiCH) in the PCP degradation pa

277 PcpA (2,6-dichloro-p-hydroquinone 1,2-dioxygenase) from Sphingobiu

278 It converted 2,4,5-trichlorophenol to 2,5-dichloro-p-quinol and then to 5-chlorohydroxyquinol but

279 converted 2,4,6-trichlorophenol only to 2,6-dichloro-p-quinol as the final product.

280 echanisms of the reactions of p-quinone, 2,5-dichloro-p-quinone, 2,3,4,5-tetrachloro-p-quinone (chlor

281 The reaction employs readily available N,N-dichloro-p-toluenesulfonamide (TsNCl(2)) and acetonitril

282 ulfonate, chlorodicarbonylrhodium (I) dimer, dichloro(pentamethylcylcopentadienyl)rhodium (III) dimer

283 es of 0.92 and 0.37 for 4-Cl-Ph-O-dG and 2,6-dichloro-Ph-O-dG (DCP-O-dG), respectively.

284 and sites of activator actions of 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nico

285 igated the mechanisms of action of 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nico

286 h [(3)H]SR141716A [5-(4-chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazo l

287 e 2 agonists such as PD-118057 [2-(4-[2-(3,4-dichloro-phenyl)-ethyl]-phenylamino)-benzoic acid] atten

288 One example is PD-118057 (2-{4-[2-(3,4-dichloro-phenyl)-ethyl]-phenylamino}-benzoic acid) which

289 Diaminocyclohexane(trans-diacetato)(dichloro) platinum(IV) (DAP), a platinum-based coordinat

290 vel alpha4beta2 NNR agonist (ABT-894 (3-(5,6-dichloro-pyridin-3-yl)-1(S),5 (S)-3,6-diazabicyclo[3.2.0

291 The 1:1 complex of o,o'-dichloro-R-BINOL and SbCl5 initiates the enantioselectiv

292 esis more efficiently than the commonly used dichloro-ruthenium complexes, indicating that its utilit

293 Subsequent reduction of these dichloro-species afforded unprecedented four-membered gr

294 ying 2,6-difluoro, 2-chloro-6-fluoro, or 2,6-dichloro substituted benzyl moieties.

295 group, the mutations reduced binding of 2,4-dichloro-substituted compounds more than 4-chloro-substi

296 r 2-pyridylphenylamide and 2-methoxy- or 2,3-dichloro-substituted phenylpiperazines to measure the im

297 les in a doped quantum magnet (bromine-doped dichloro-tetrakis-thiourea-nickel, DTN).

298 le, 2, was synthesized from the reduction of dichloro(tetraphenyl)germole with 2 equivs of Li.

299 hium salts of tetraphenylsilole dianion with dichloro(tetraphenyl)germole.

300 itative calibration was simplified by adding dichloro- to hexachlorobiphenyl internal standards chose