ライフサイエンスコーパス: dichloro

1 activity when the phenyl substituent was 3,4-dichloro.

2 ngation factor-b (P-TEFb) inhibitor DRB (5,6-dichloro 1-beta-d-ribofuranosylbenzinida-sole).

3 tion of a disulfide bond by oxidization with dichloro(1,10-phenanthroline)copper (II) (CuPh), or the

4 cy of a series of metallopeptides containing dichloro(1,10-phenanthroline)copper(II) and various orga

5 ruthenacyclobutanes via the protonolysis of dichloro(1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinyl

6 mino)-2,2-dinitroethyl}diazene) (10), N1, N2-dichloro-1, 2-diazenedicarboximidamide (11), and (E,E)-N

7 2-Amino-N'-arylbenzamidines react with 4,5-dichloro-1,2,3-dithiazolium chloride (Appel salt) in the

8 -bromo-1,2-bis(trimethylsilyl)benzene or 4,5-dichloro-1,2-bis(trimethylsilyl)benzene with BBr3 in hex

9 rides occurs rapidly upon treatment with 3,3-dichloro-1,2-diphenylcyclopropene.

10 also through a self-reaction of 2-amino-4,6-dichloro-1,3,5-triazine at similar conditions.

11 samples from 10 swimming pools and found 2,6-dichloro-1,4-benzoquinone (2,6-DCBQ) in all the pools at

12 o-3-methyl-1,4-benzoquinone (DCMBQ), and 2,6-dichloro-1,4-benzoquinone (DBBQ), were treated using a m

13 using formation potential (FP) tests for 2,6-dichloro-1,4-benzoquinone (DCBQ), 2,3,6-trichloro-1,4-be

14 Water samples containing four HBQs, 2,6-dichloro-1,4-benzoquinone (DCBQ), 2,3,6-trichloro-1,4-be

15 Four halobenzoquinones (HBQs), 2,6-dichloro-1,4-benzoquinone (DCBQ), 2,6-dichloro-3-methyl-

16 four HBQs were identified as 3-hydroxyl-2,6-dichloro-1,4-benzoquinone (OH-DCBQ) from DCBQ, 5-hydroxy

17 ,6-trichlorophenol (TCP) is converted to 2,6-dichloro-1,4-benzoquinone in a H2O2-dependent process.

18 (2) will fully convert 1 equiv of TCP to 2,6-dichloro-1,4-benzoquinone, implicating the role of multi

19 to form 2,6-dibromo-1,4-benzoquinone and 2,6-dichloro-1,4-benzoquinone, respectively.

20 ave obtained a compound (5,8-diacetyloxy-2,3-dichloro-1,4-naphthoquinone) that provokes IR activation

21 ichlorocarbene to bicyclobutane to yield 1,1-dichloro-1,4-pentadiene.

22 Hs namely 1,3,4,6,7,10-hexamethyl- 2 and 3,4-dichloro-1,6,7,10-tetramethylfluoranthene 3, benzo[k]flu

23 e experiments with the antiviral 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)-benzimidazole revealed

24 ranosyl)benzimidazole (TCRB) and 2-bromo-5,6-dichloro-1-(beta-d-ribofuranosyl)benzimidazole (BDCRB) a

25 Amino acid ester prodrugs of 2-bromo-5,6-dichloro-1-(beta-d-ribofuranosyl)benzimidazole (BDCRB) w

26 the DNA encapsidation inhibitor 2-bromo-5,6-dichloro-1-(beta-d-ribofuranosyl)benzimidazole.

27 2-Bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)indole (25) was also pr

28 in-3-yl)-N'-cyanoguanidines furnished N-{2,2-dichloro-1-[N'-(substituted-pyridin-3-yl)-N''-cyanoguani

29 kinase and mRNA synthesis inhibitor DRB (5,6-dichloro-1-b-D-ribofuranosylbenzimidazole) induces the n

30 nslocation inhibitors alpha amanitin and 5,6-dichloro-1-beta-D-ribobenzimidazole (DRB) and an siRNA t

31 Treatment of neurons with 5, 6-dichloro-1-beta-D-ribobenzimidazole (DRB), an RNA Pol II

32 equires for activity the two-polypeptide 5,6-dichloro-1-beta-D-ribobenzimidazole-sensitivity inducing

33 r herpesvirus genome maturation, 2-bromo-5,6-dichloro-1-beta-d-ribofuranosyl benzimidazole riboside (

34 (ii) DB particles recovered from 2-bromo-5,6-dichloro-1-beta-d-ribofuranosyl benzimidazole riboside (

35 th the viral terminase inhibitor 2-bromo-5,6-dichloro-1-beta-d-ribofuranosyl benzimidazole riboside (

36 ption of transcription by actinomycin D, 5,6-dichloro-1-beta-D-ribofuranosyl-benzimadazole or alpha-a

37 ments with two CKII-specific inhibitors, 5,6-dichloro-1-beta-d-ribofuranosyl-benzimidazole (DRB) and

38 Inhibition of P-TEFb kinase activity by 5,6-dichloro-1-beta-d-ribofuranosyl-benzimidazole (DRB) supp

39 Furthermore, 5,6-dichloro-1-beta-d-ribofuranosyl-benzimidazole, an inhibi

40 ol/L), an estrogen receptor antagonist; 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (10(-5) mol

41 However, CTD kinase inhibitors, such as 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) and 1

42 ferent drugs that inhibit polymerase II, 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) and a

43 rase II (Pol II) hyperphosphorylation by 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole (DRB) block

44 The transcriptional inhibitor 5, 6-dichloro-1-beta-d-ribofuranosylbenzimidazole (DRB) is an

45 The selective CK2 inhibitors 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole (DRB) or 4,

46 of negative elongation factor (NELF) and 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole (DRB) sensi

47 ymerase II and the large subunit of the 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) sensi

48 ls or an extract is no longer sensitive to 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB), a co

49 ly inhibited at the low concentration of 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole (DRB), a CT

50 uding the CDK9 pharmacological inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB), a do

51 first, infected cells were treated with 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole (DRB), a sp

52 Here, we demonstrate that 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole (DRB), an i

53 ors on HDV genome replication: amanitin, 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB), and

54 ibition of transcription elongation with 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB), comb

55 n of U0126, the mRNA synthesis inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB), or i

56 stein (a tyrosine kinase inhibitor), and 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB, a CK2

57 s well as by the gene expression blocker 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole administere

58 her serum-responsive factor knockdown or 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole altered rec

59 Inhibition of CKII activity by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole blocks the

60 scriptionally active, as incubation with 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole eliminated

61 tment with the casein kinase 2 inhibitor 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole had the opp

62 f transcription to the nucleotide analog 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole has led to

63 ting this view, we found synergy between 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole riboside an

64 Negative elongation factor (NELF) and 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity

65 Two of the proteins, 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole sensitivity

66 he cdk9 inhibitors Flavopiridol and DRB (5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole) allowed cd

67 to the well-known nucleoside analog DRB (5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole), and that

68 th CTD kinase inhibitors, including DRB (5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole), causes a

69 ycin, a tyrosine kinase inhibitor and by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole, a protein

70 ent with a nonspecific kinase inhibitor, 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole.

71 ow concentrations of the CDK9 inhibitor 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole.

72 alogenated benzimidazoles BDCRB (2-bromo-5,6-dichloro-1-beta-D-riborfuranosyl benzimidazole riboside)

73 Epoxide 2 was prepared from 3,4-dichloro-1-butene (1) by epoxidation with m-CPBA and sub

74 ics of the unimolecular rearrangement of 2,2-dichloro-1-methylenecyclopropane (1) to (dichloromethyle

75 We present a novel class of substituted 7,8-dichloro-1-oxo-beta-carbolines based on the distinct str

76 as synthesized by potassium reduction of 1,1-dichloro-1-silafluorene in refluxing THF.

77 lowing: 2,8-dichlorodibenzodioxin (4%), 4,5'-dichloro-[1,1'-biphenyl]-2,2'-diol (10%), 5-chloro-2-(4-

78 phosphorylation by the kinase inhibitors 5,6-dichloro-1beta-D-ribofuranosyl-benzimidazole and H8 bloc

79 aphtho[1,2-d]thiazol-2-ylamine (SKA-31), 6,7-dichloro-1H-indole-2,3-dione 3-oxime (NS309), and 1-ethy

80 imes more potent on K(Ca)2.1 than NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime), an unselective bu

81 (E)-3-(2-Carboxy-2-phenylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acid, 1, is a potent and

82 of 3-[2-(3-aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, 19, as a new poten

83 ll molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin ba

84 the preparation of the fluorescent dye 4',5'-dichloro-2',7'-dimethoxy-5(6)-carboxyfluorescein (JOE) i

85 A series of methoxyl-substituted 3,3'-dichloro-2,2'-binaphthoquinones 2 were prepared and eval

86 ine (dmb, 2), 2,2'-bipyridine (bpy, 3), 4,4'-dichloro-2,2'-bipyridine (dclb, 4), and 4,4'-diethyleste

87 oxidase (BOD) "wired" with PAA-PVI-[Os(4,4'-dichloro-2,2'-bipyridine)(2)Cl](+/2+) (polymer II), havi

88 (N-vinylimidazole) complexed with [Os (4,4'-dichloro-2,2'-bipyridine)(2)Cl](+/2+), cross-linked on c

89 found with polychlorinated biphenyl or 1,1'-dichloro-2,2'-bis(4-chlorophenyl)ethylene levels and any

90 lyzed for polychlorinated biphenyls and 1,1'-dichloro-2,2'-bis(4-chlorophenyl)ethylene.

91 A novel class of pure antiestrogens, 1,1-dichloro-2,2,3-triarylcyclopropanes (DTACs), lack estrog

92 ons of polychlorinated biphenyl (PCB)-153; 1-dichloro-2,2-bis (p-chlorophenyl) ethylene (p,p'-DDE), a

93 ophenyl)ethane (DDT) and its metabolites 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane (DDD) and 1,1-dic

94 -2,2-bis(4-chlorophenyl)ethane (DDD) and 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (DDE), are ofte

95 potential of the antiandrogen, p,p -DDE [1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene], the most pre

96 l)ethane] and its metabolites, 4,4'-DDD [1,1-dichloro-2,2-bis(p-chlorophenyl)ethane] and 4,4'-DDE [1,

97 For determination of whether plasma 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) pesticide

98 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), a persis

99 The main degradation product of DDT is 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), an antia

100 transformers and other applications, and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), the main

101 e to persistent organochlorines such as 1,1,-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p -DDE), pol

102 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) is a

103 t relating polychlorinated biphenyls and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene to time to preg

104 The metabolite, DDE (1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene), has been link

105 CBs (polychlorinated biphenyls) and DDE [1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene] reduces 6-mont

106 bis(p-chlorophenyl)ethane] and 4,4'-DDE [1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene], from an histo

107 ic assay for the determination of DDT [1,1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene].

108 They detected elevated levels of 1,1-dichloro-2,2-bis-(p-chorophenyl)ethylene and organophosp

109 WAY-161503 ((4aR)-8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxali

110 ithio-2,3,4,5-tetraphenylsilole (1) with 1,1-dichloro-2,3-diphenylcyclopropene (2) leads to the novel

111 ee conformational polymorphs of dimethyl-3,6-dichloro-2,5-dihydroxyterephthalate are studied by solid

112 riedel-Crafts alkylation of toluene with 2,5-dichloro-2,5-dimethylhexane 6.

113 deprotonated 2-oxa-6-azaadamantane with 2,6-dichloro-2,6-diazaadamantane.

114 yl)propyl)thio)benzoic acid (GRI977143), 4,5-dichloro-2-((9-oxo-9H-fluoren-2-yl)carbamoyl)benzoic aci

115 logii, net CO(2) fixation was blocked by 3,3-dichloro-2-(dihydroxyphosphinoyl-methyl)-propenoate (a s

116 h excised shoots of wild-type plants fed 3,3-dichloro-2-(dihydroxyphosphinoyl-methyl)-propenoate, an

117 onse to its estrogenic isomer, o,p -DDE [1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl) ethylene]

118 wed by alpha,alpha-dialkylation with cis-1,4-dichloro-2-butene to form polymer-bound 3-phenylsulfonyl

119 epared from commercially available trans-1,4-dichloro-2-butene were converted to trans-disubstituted

120 4-(2-Butyl-6,7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid

121 e have previously shown that 4-(2-butyl-6, 7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid

122 phoenolpyruvate carboxylase (PEPCase) by 3,3-dichloro-2-dihydroxyphosphinoylmethyl-2-propenoate resul

123 In 3,3-dichloro-2-dihydroxyphosphinoylmethyl-2-propenoate-treat

124 loroisopropyl) phosphate (TCPP) and tris(1,3-dichloro-2-isopropyl) phosphate (TDCP)), four alkylated

125 Dicamba (3,6-dichloro-2-methoxybenzoic acid) is a widely used herbici

126 around aryl sulfonamide series led to N-(3,5-dichloro-2-methoxyphenyl)-3-(1-methylpiperidin-4-ylamino

127 ell as small molecule allosteric agonist 6,7-dichloro-2-methylsulfonyl-3-tert-butylaminoquinoxaline (

128 ide (Z)-6-O-(tert-butyldimethylsilyl)-1-(4,5-dichloro-2-nitrophenyl)-1,2-dideo xy-3,4-O-isopropyliden

129 ride, 2,4-dichloroaniline, and sea-nine (4,5-dichloro-2-octyl-3-isothiazolone)).

130 All four diastereomers of 3,4-dichloro-2-pentanol were synthesized by anti-dichlorinat

131 -2-ethylhexyl phosphate (TEHP), and tris-1,3-dichloro-2-propyl phosphate (TDCPP) were coated on (NH4)

132 TDCIPP and TPHP metabolites (bis(1,3-dichloro-2-propyl) phosphate (BDCIPP) and diphenyl phosp

133 The current study measured levels of bis(1,3-dichloro-2-propyl) phosphate (BDCIPP), bis(1-chloro-2-pr

134 asured five urinary PFR metabolites [bis(1,3-dichloro-2-propyl) phosphate (BDCIPP), diphenyl phosphat

135 ponding to maxima dust for the pairs bis(1,3-dichloro-2-propyl) phosphate (BDCIPP)-tris(1,3-dichloro-

136 course of 3 months and analyzed for bis(1,3-dichloro-2-propyl) phosphate (BDCPP) and diphenyl phosph

137 Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) has been frequentl

138 oroisopropyl) phosphate (TCIPP), or tris(1,2-dichloro-2-propyl) phosphate (TDCIPP).

139 ate (DPP), metabolites of the OPFRs tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosp

140 )phosphate (TCIPP; max: 14500 ng/L), bis(1,3-dichloro-2-propyl)phosphate (BDCIPP; max: 4550 ng/L), tr

141 uptake and elimination of TDCPP and bis(1,3-dichloro-2-propyl)phosphate (BDCPP, the primary metaboli

142 magnitude concentration increase in tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) and tri-m-cresyl ph

143 flame retardants (PFRs), including tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) and triphenyl phosp

144 ncluded triphenyl phosphate (TPHP), tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) and tris(2-chloroet

145 Tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) is a high-productio

146 lhexyl) tetrabromophthalate (TBPH), tris(1,3-dichloro-2-propyl)phosphate (TDCIPP), and triphenyl phos

147 phosphate (BDCIPP; max: 4550 ng/L), tris(1,3-dichloro-2-propyl)phosphate (TDCIPP; max: 3150 ng/L) and

148 osphate flame retardants (ClOPFRs), tris(1,3-dichloro-2-propyl)phosphate (TDCPP or TDCIPP), tris(1-ch

149 ondensation of 2,5-dihydroxyquinone with 4,5-dichloro-, 2,6-dichloro-, and 4,5-dibromo-1,2-phenylened

150 d with equal potency to human COX-2 with 2,6-dichloro-, 2,6-dimethyl-, or 2-chloro-6-methyl-substitut

151 polymerization (SSP) does not occur for 2,5-dichloro-3,4-ethylenedioxythiophene (DCEDOT), and requir

152 pound, (Me2NH2)2[Fe2L3].2H2O.6DMF (LH2 = 2,5-dichloro-3,6-dihydroxo-1,4-benzoquinone) was previously

153 much less toxic dihydroxylation product, 2,5-dichloro-3,6-dihydroxy-1,4-benzoquinone (chloranilic aci

154 tion of the redox-active bridging ligand 2,5-dichloro-3,6-dihydroxy-1,4-benzoquinone (LH2) with Fe(II

155 obenzoquinone and fully converted to the 2,5-dichloro-3-(indol-3-yl)benzoquinone targets by DDQ or Ag

156 ls is always the alkoxy anion of 2-cyano-5,6-dichloro-3-hydroxy-1,4-benzoquinone, whether the final D

157 TDF) the required intermediate, 3-[4-[1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-5-iodopyrazolo]

158 ituted pyrazine C-nucleosides, including 2,6-dichloro-3-iodo-5-(beta-D-ribofuranosyl)pyrazine and 2-b

159 to form additional HBQs, such as TriCBQ, 2,6-dichloro-3-methyl-(1,4)benzoquinone (DCMBQ), and 2,3,5,6

160 ), 2,6-dichloro-1,4-benzoquinone (DCBQ), 2,6-dichloro-3-methyl-1,4-benzoquinone (DCMBQ), 2,3,6-trichl

161 2,3,6-trichloro-1,4-benzoquinone (TCBQ), 2,6-dichloro-3-methyl-1,4-benzoquinone (DCMBQ), and 2,6-dibr

162 2,3,6-trichloro-1,4-benzoquinone (TCBQ), 2,6-dichloro-3-methyl-1,4-benzoquinone (DCMBQ), and 2,6-dich

163 oquinone (OH-DCBQ) from DCBQ, 5-hydroxyl-2,6-dichloro-3-methyl-1,4-benzoquinone (OH-DCMBQ) from DCMBQ

164 alogues of 3'-chloro-, 4'-chloro-, and 4,4''-dichloro-3alpha-(diphenylmethoxy)tropanes were synthesiz

165 trifluoromethyl-4-nitrophenol (TFM) and 2',5-dichloro-4'-nitrosalicylanilide (niclosamide) are direct

166 Analogues of penclomedine (PEN, 3,5-dichloro-4,6-dimethoxy-2-(trichloromethyl)pyridine) and

167 3)) and a non-liver-targeted TR agonist, 3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)phenylacetic ac

168 is of the targeted 2-chloro- and 2-bromo-6,7-dichloro-4-(beta-d-ribofuranosyl)quinolines (18and 21, r

169 We proposed to synthesize 2-halo-6,7-dichloro-4-(beta-d-ribofuranosyl)quinolines as 6 + 6 bic

170 used structure-based design to discover 2,6-dichloro-4-cyanophenyl and (1R,2R)-2-fluorocyclopropylam

171 s prepared in 10 steps from pyrazole and 3,5-dichloro-4-fluorobenzotrifluoride.

172 PEN and 4-DMPEN (3,5-dichloro-4-hydroxy-6-methoxy2-(trichloromethyl)pyridine

173 renylindole)tin in coupling with a bromo-2,5-dichloro-4-indolylbenzoquinone gives the demethylasterri

174 hanamine, was prepared by first coupling 2,5-dichloro-4-nitroaniline with 2-mercapto-N,N-dimethylbenz

175 3-[4-[1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazolo]]-3-(trifluoro

176 The structures of the bound dichloro (5) and dimethyl (12) analogue complexes indica

177 enes have been synthesized starting from 6,9-dichloro-5,10-diaza[5]helicene, which was prepared from

178 The use of a combination of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and beta-pin

179 hloromethane, followed by oxidation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) generates a

180 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) is a highly

181 enes and isochromenes react quickly with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) to form pers

182 followed by oxidative aromatization with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone produced the funct

183 Q-mediated dehydrogenation reaction (DDQ=2,3-dichloro-5,6-dicyano-1,4-benzoquinone).

184 kinetics of the hydride abstractions by 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) from 13 C-H hy

185 Reactions of 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) with silyl eno

186 t the sp-hybridized C2, with either DDQ (2,3-dichloro-5,6-dicyano-p-benzoquinone) or TBHP (tert-butyl

187 When the oxidant was replaced by 2,3-dichloro-5,6-dicyano-p-benzoquinone, which is frequently

188 with various styrenes in the presence of 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) was promoted by B

189 FeCl(3), CuCl(2), [Co(NH(3))(5)Cl]Cl(2), 2,3-dichloro-5,6-dicyanobenzoquinone, or ceric ammonium nitr

190 of two target compounds, (RS)-2-amino-3-(3,4-dichloro-5-(5-hydroxypyridin-3-yl)phenyl)propanoic acid

191 e reaction of the commercially available 4,6-dichloro-5-aminopyrimidine 1 with isothiocyanates.

192 A highly selective monodechlorination of 2,6-dichloro-5-fluoronicotinic acid was discovered to afford

193 group of 1a led to 1c, which contains a 2,4-dichloro-5-methoxy-substituted aniline.

194 d 1 (SKI-606, bosutinib), a 7-alkoxy-4-[(2,4-dichloro-5-methoxyphenyl)amino]-3-quinolinecarbonitrile,

195 A 2,4-dichloro-5-methoxyphenylamino group at C-7 provided supe

196 eta-D-ribofuranosyl)pyrazine and 2-bromo-3,5-dichloro-6-(beta-D-ribofuranosyl)pyrazine, were obtained

197 photocycloaddition of crystalline trans-2,4-dichloro-6-styrylpyrimidine to produce the corresponding

198 racterization of one of these compounds, 2,4-dichloro-6-{(E)-[(3-methoxyphenyl)imino]methyl}phenol (D

199 l)[1,4]benzoquinone and 2,5-dihydroxy-3-(4,6-dichloro-7-farnesyl-1H-indol-3-yl)[1,4]benzoquinone, are

200 dro-2 H-pyran, an alcohol, and catalytic 1,5-dichloro-9,10-anthraquinone with use of visible light.

201 containing the fluorogenic substrate 9H-(1,3-dichloro-9,9-dimethylacridin-2-on-7-yl) beta-D-galactosi

202 te of beta-galactoside and 7-hydroxy-9H-(1,3-dichloro-9,9-dimethylacridin-2-one) (DDAO), is not only

203 aved by beta-gal to produce 7-hydroxy-9H(I,3-dichloro-9,9-dimethylacridin-2-one) (DDAO).

204 sulfatase-activated probe, 7-hydroxy-9H-(1,3-dichloro-9,9-dimethylacridin-2-one)-sulfate, that detect

205 One substrate, 9H-(1,3-dichloro-9,9-dimethylacridin-2-one-7-yl) beta-d-galactop

206 ent substrate of beta-galactosidase (9H-{1,3-dichloro-9,9-dimethylacridin-2-one-7-yl} beta-D-galactop

207 ion (3b) was synthesized by reduction of 9,9-dichloro-9-germafluorene (4b) with sodium/potassium allo

208 2,6-Dichloro-9-thiabicyclo[3.3.1]nonane is especially useful

209 Herein we introduce 2-((3-(3,6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl)amino)-2-(hyd

210 Asymmetric hydration of alpha,alpha-dichloro aldehydes and alpha-halo enals via a NHC-cataly

211 The 2',5'-dichloro analogue 8 showed selectivity ratios (IC(50) ag

212 2,3-Dichloro- and 2,3-dibromopyridines have been shown to re

213 d and optimized to give 80-90% yields of 2,6-dichloro- and 2,6,7-trichloro-3-(2,3-dideoxy-2,3-didehyd

214 Dichloro- and phenylchlorocarbene (CCl2 and PhCCl) add t

215 s possible to conclude that at least 2 HAAs (dichloro- and trichloroacetic acids, DCAA and TCAA) are

216 nic matter (DOM) had no measurable effect on dichloro- and trichlorobiphenyls, but did contain about

217 2,4,5-Trichloro-, 2-bromo-4,5-dichloro-, and 2,4,5-tribromoimidazole nucleosides were

218 2,5-dihydroxyquinone with 4,5-dichloro-, 2,6-dichloro-, and 4,5-dibromo-1,2-phenylenediamine, followe

219 analogues (2-amino-benzimidazole and 1-(3,4-dichloro-benzyl)-2-amino-benzimidazole) in complex with

220 is of the alternative binding mode of 1-(3,4-dichloro-benzyl)-2-amino-benzimidazole, derivatives were

221 the bis-pyridinium derivative 4,4'-bis-[(2,6-dichloro-benzyloxy-imino)-methyl]-1,1'-propane-1,3-diyl-

222 The corresponding alpha,alpha-dichloro-beta-hydroxyketones were obtained by treatment

223 lization promoted by the 1:1 complex of o,o'-dichloro-BINOL and SbCl(5).

224 on on the oxygenated phenyl ring, e.g., 4,4'-dichloro-biphenyl-2,5-diol, 3,6,4'-trichloro-biphenyl-2,

225 repared, 6-chloro-biphenyl-3,4-diol and 6,4'-dichloro-biphenyl-3,4-diol.

226 Reaction of the dichloro-bridged dimers [(C'N(2)Ir(mu-Cl)(2)Ir(C'N)(2)]

227 on battery system, the electrolyte is of the dichloro complex (DCC) solution family, Mg(AlCl2BuEt)2/T

228 Surprising differences were seen between the dichloro complex 2b with isopropyl groups on phosphorus,

229 Dichloro complexes (L(1) = L(2) = Cl, 2a-2c,2e) showed i

230 from ca. 20 pg/L (part-per-quadrillion) for dichloro-congeners down to ca. 0.2 pg/L for higher-molec

231 Log K(POM) values ranged from ca. 4.6 for dichloro-congeners to ca. 7.0 for octachloro-congeners a

232 Chlorination of anthracimycin gives a dichloro derivative that retains activity against Gram-p

233 tereomeric separation by substitution of the dichloro derivative with a chiral amine has been shown.

234 timicrobial activity and revealed simplified dichloro derivatives that are equally potent against sev

235 traphenylmetallole dianion and corresponding dichloro(dialkyl)silanes.

236 s as well as a fluorescent dye, carboxy-H(2)-dichloro-dihydrofluorescein diacetate (carboxy-H(2)-DCFD

237 and rhodizonic acids, dihydroxybenzoquinone, dichloro-dihydroxy-p-benzoquinone, or benzene decorated

238 sistance of these species to the insecticide dichloro-diphenyl-trichloroethane (DDT).

239 l- channel antagonists, niflumic acid (NFA), dichloro-diphenylamine 2-carboxylic acid (DCDPC) and dii

240 The dichloro form of the drug exists in equilibrium with at

241 ely converts the aquated species back to the dichloro form of the parent drug so that a single molecu

242 rect vinylogous aldol addition of alpha,beta-dichloro gamma-butyrolactones and gamma-butyrolactams wi

243 substitution at the C3 position remains 3,4-dichloro > 2-naphthyl > 4-fluoro > phenyl.

244 4]) > chloral hydrate (165% [161-176]) > 2,2-dichloro- > 2-chloro approximately 2,2,2-trifluoroethano

245 The dichloro(heteroaryl)borane primary products can be prote

246 Hpg, 3,5-dichloro-Hpg, and 3,5-dichloro-hydroxybenzoylformate are

247 Hpg, 3,5-dichloro-Hpg, and 3,5-dichloro-hydroxybenzoylformate are unusual building bloc

248 zine privileged structures (2-methoxy vs 2,3-dichloro) influenced bias when the thienopyridine hetero

249 chloro-2-propyl) phosphate (BDCIPP)-tris(1,3-dichloro-isopropyl) phosphate (TDCIPP) and bis(2-chloroe

250 e additive flame retardants (FRs), tris (1,3-dichloro-isopropyl) phosphate (TDCPP) and Firemaster((R)

251 The reaction of dichloro ketones with azide anions provides acyl azides,

252 ion of 7-chloro-L-tryptophan to generate 6,7-dichloro-L-tryptophan.

253 ntially on free L-tryptophan to generate 6,7-dichloro-L-tryptophan.

254 cts (water, methanol, ethyl acetate, hexane, dichloro-methane) of fenugreek seeds were investigated i

255 A second compound, NT-9-21, which contains dichloro moieties in place of the 3,5-dibromo substituen

256 .08, or 0.16 mg/kg) and D2/D3 antagonist 3,5-dichloro-N-(1-ethylpyrrolidin-2-ylmethyl)-2-hydroxy-6-me

257 three most potent compounds: 918013 (1; 2,4-dichloro-N-(3-fluorophenyl)-5-(4-morpholinylsulfonyl) be

258 olus injections of 11C-raclopride (S-(-)-3,5-dichloro-N-[(1-ethyl-2-pyrrolidinyl)]methyl-2-hydroxy-6-

259 Taking advantage of 3,5-dichloro-N-[1-(2,2-dimethyl-tetrahydro-pyran-4-ylmethyl)

260 t not by the kappa agonist trans-(1S,2S)-3,4-dichloro-N-mathyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benze

261 ,D-Leu5]-enkephalin (DADLE), trans-(+/-)-3,4-dichloro-N-methyl-N-(2-[1-pyrrolidinyl]cyclohexyl) benze

262 nt with the kappa agonist U50,488 (trans-3,4-dichloro-N-methyl-N-[2-(1-pyrolytinil)-cyclohexyl]-benze

263 lic [D-Pen2-D-Pen5]-enkephalin, or trans-3,4-dichloro-N-methyl-N-[2-(1-pyrolytinil)-cyclohexyl]-benze

264 The agonist (-)(trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidiny)-cyclohexyl]benzen

265 Treatment with the agonist (-)-(trans)-3,4- dichloro-N-methyl-N-[2-(1-pyrrolidiny)cyclohexyl]benzene

266 analgesic effect of the agonist (trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl] benz

267 -Pen(5)]-enkephalin (1 microm) and trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benze

268 of the KOR agonist U50,488 [(+/-)-trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benze

269 ersion caused by the kappa agonist trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benze

270 hydrochloride) and U50488H (trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(pyrrolidinyl)cyclohexyl] benzene

271 infusion of the kappa-OR agonist (trans)-3,4-dichloro-N-methyl-N-[2-1-pyrrolidinyl)-cyclo-hexyl] benz

272 hemBridge, San Diego, CA; ID5128535) and 2,4-dichloro-N-{4-[(1,3-thiazol-2-ylamino)sulfonyl]phenyl}be

273 N,N-dichloro-o-nitrobenzenesulfonamide (2-NsNCl2) was found

274 zes 2,4,5-trichlorophenol (2,4,5-TCP) to 2,5-dichloro-p-benzoquinone, which is chemically reduced to

275 1,4-diene, Bu3SnD, and pyridine.BD3 with 2,5-dichloro-p-benzoquinone.

276 oquinone, which is chemically reduced to 2,5-dichloro-p-hydroquinone (2,5-DiCHQ).

277 trichloro-p-hydroquinone (TriCH) and then to dichloro-p-hydroquinone (DiCH) in the PCP degradation pa

278 PcpA (2,6-dichloro-p-hydroquinone 1,2-dioxygenase) from Sphingobiu

279 It converted 2,4,5-trichlorophenol to 2,5-dichloro-p-quinol and then to 5-chlorohydroxyquinol but

280 converted 2,4,6-trichlorophenol only to 2,6-dichloro-p-quinol as the final product.

281 echanisms of the reactions of p-quinone, 2,5-dichloro-p-quinone, 2,3,4,5-tetrachloro-p-quinone (chlor

282 The reaction employs readily available N,N-dichloro-p-toluenesulfonamide (TsNCl(2)) and acetonitril

283 ulfonate, chlorodicarbonylrhodium (I) dimer, dichloro(pentamethylcylcopentadienyl)rhodium (III) dimer

284 es of 0.92 and 0.37 for 4-Cl-Ph-O-dG and 2,6-dichloro-Ph-O-dG (DCP-O-dG), respectively.

285 and sites of activator actions of 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nico

286 igated the mechanisms of action of 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nico

287 h [(3)H]SR141716A [5-(4-chlorophenyl)-1-(2,4-dichloro-phenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazo l

288 e 2 agonists such as PD-118057 [2-(4-[2-(3,4-dichloro-phenyl)-ethyl]-phenylamino)-benzoic acid] atten

289 One example is PD-118057 (2-{4-[2-(3,4-dichloro-phenyl)-ethyl]-phenylamino}-benzoic acid) which

290 Diaminocyclohexane(trans-diacetato)(dichloro) platinum(IV) (DAP), a platinum-based coordinat

291 vel alpha4beta2 NNR agonist (ABT-894 (3-(5,6-dichloro-pyridin-3-yl)-1(S),5 (S)-3,6-diazabicyclo[3.2.0

292 The 1:1 complex of o,o'-dichloro-R-BINOL and SbCl5 initiates the enantioselectiv

293 esis more efficiently than the commonly used dichloro-ruthenium complexes, indicating that its utilit

294 Subsequent reduction of these dichloro-species afforded unprecedented four-membered gr

295 group, the mutations reduced binding of 2,4-dichloro-substituted compounds more than 4-chloro-substi

296 r 2-pyridylphenylamide and 2-methoxy- or 2,3-dichloro-substituted phenylpiperazines to measure the im

297 les in a doped quantum magnet (bromine-doped dichloro-tetrakis-thiourea-nickel, DTN).

298 le, 2, was synthesized from the reduction of dichloro(tetraphenyl)germole with 2 equivs of Li.

299 hium salts of tetraphenylsilole dianion with dichloro(tetraphenyl)germole.

300 itative calibration was simplified by adding dichloro- to hexachlorobiphenyl internal standards chose