ライフサイエンスコーパス: dideoxycytidine

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1 ciated with 2'-C-cyano-2',3'-didehydro-2',3'-dideoxycytidine.

2 approved for human use: azidothymidine; 2'3'-dideoxycytidine; 2'3'-dideoxyinosine; 2', 3'-didehydro-3

3 ed series, L-3'-fluoro-2',3'-didehydro-2',3'-dideoxycytidine 24 and 5-fluorocytidine 26 showed highly

4 decyl-2-O-palmitoyl-1-thioglycerol (2) 2',3'-dideoxycytidine 5'-diphosphate-rac-1-S-octadecyl-2-O-pal

5 yphenyl ether, the target 4'-C-ethynyl-2',3'-dideoxycytidine analogue (rac-1h) was obtained after 13

6 ce of reverse transcriptase inhibitors 2',3'-dideoxycytidine and a tetrahydroimidazo[4,5,1-jk](1,4)-b

7 aused by HIV/AIDS antiretroviral [ddC (2',3'-dideoxycytidine)] and anticancer (oxaliplatin) chemother

8 In contrast, 2',3'-dideoxyinosine, 2',3'-dideoxycytidine, and 3'-azidothymidine, which are known

9 nti-human immunodeficiency virus agent 2',3'-dideoxycytidine (approximately 6-fold) and the anti-hepa

10 synthetic heteropolymeric RNA template with dideoxycytidine at its 3'-end, we examined de novo initi

11 On a dideoxycytidine-blocked synthetic RNA template derived f

12 20% of normal levels by treating with 2',3'-dideoxycytidine (ddC) and subsequently allowed recovery

13 2',3'-dideoxycytidine (ddC) is a synthetic pyrimidine nucleosi

14 odified cytosine analogs, Zalcitabine (2',3'-dideoxycytidine (ddC)) and Lamivudine (beta-d-(+)-2',3'-

15 idehydro-2',3'-dideoxythymidine (D4T), 2',3'-dideoxycytidine (ddC), (-)-beta-L-2',3'-dideoxy-3'-thiac

16 o the mtDNA depletion caused by beta-d-2',3'-dideoxycytidine (ddC), 2',3'-didehydro-2',3'-dideoxythym

17 de D-nucleoside analogs such as beta-D-2',3'-dideoxycytidine (ddC), beta-2'-fluoro-5-methyl-arabinofu

18 Dideoxycytidine (ddC), which is known to have a delayed

19 y activity, we used a nucleoside analog 2'3'-dideoxycytidine (ddC), which is phosphorylated to the ac

20 ally exhibited low-level resistance to 2',3'-dideoxycytidine (ddC).

21 -5-fluorocytidine (beta-L-FddCTP) and 2', 3'-dideoxycytidine (ddCTP), on DNA strand elongation by hum

22 ing resistance to tenofovir, abacavir, 2',3'-dideoxycytidine, dideoxyinosine, and stavudine.

23 2',3'-dideoxy-3'-thiocytidine > beta-d-2',3'-dideoxycytidine > beta-d-2',2'-difluorodeoxycytidine > b

24 3'-didehydro-5-fluorocytidine > beta-l-2',3'-dideoxycytidine > beta-l-2',3'-dideoxy-3'-thiocytidine >

25 d an 82-fold increase in the IC(50) to 2',3'-dideoxycytidine in Jurkat cells.

26 ited antinociception in a zalcitabine (2'-3'-dideoxycytidine) model of AIDS therapy-induced and tibia

27 The L-enantiomers of 5-fluoro-2',3'-dideoxycytidine monophosphate and triphosphate had IC50

28 olled in a prospective trial of zalcitabine (dideoxycytidine) monotherapy (Pediatric AIDS Clinical Tr

29 everse transcriptase inhibitor (NRTI), 2',3'-dideoxycytidine or 2',3'-dideoxyinosine, mtDNA depletion

30 othymidine therapy in combination with 2',3'-dideoxycytidine or 2',3'-dideoxyinosine.

31 ylated to the activated antimetabolite, 2'3'-dideoxycytidine triphosphate by cytoplasmic nucleoside k

32 I (Klentaq1) with a primer/template DNA and dideoxycytidine triphosphate, and that of a binary compl

33 ion therapy with zidovudine (AZT) plus 2',3'-dideoxycytidine was found to regain sensitivity to AZT a

34 ',3'-dideoxy-3'-thiacytidine) and ddC (2',3'-dideoxycytidine) were added to the cultures beginning at

35 V inhibition by azidothymidine (zidovudine), dideoxycytidine (zalcytibine), and hydroxyurea.

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