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1 men, and diencephalon (thalamus plus ventral diencephalon).
2 ired to maintain the appropriate size of the diencephalon.
3 es and few around the third ventricle in the diencephalon.
4 g centre for regional differentiation of the diencephalon.
5 ulation of wnt expression in the prospective diencephalon.
6 stablishing regional subdivisions within the diencephalon.
7 rd and a network in brainstem, midbrain, and diencephalon.
8 y inhibitory factors derived from the dorsal diencephalon.
9 iol were measured in the cerebral cortex and diencephalon.
10 rome-positive cells reside within the caudal diencephalon.
11  epithelial (CPe) cells of the hindbrain and diencephalon.
12  neurons, which also derive from the ventral diencephalon.
13 ime when the optic axons first grow over the diencephalon.
14 cephalic vesicle and an abnormally patterned diencephalon.
15 ew into the subpallium but did not enter the diencephalon.
16 ut most stopped growing without entering the diencephalon.
17 halon and the anterior-ventral region of the diencephalon.
18 utants lack SFRP-2 expression in the PSB and diencephalon.
19 e when they integrate homotopically into the diencephalon.
20 5, TACC1, and RA signaling in the developing diencephalon.
21 he dorsal thalamic association nuclei of the diencephalon.
22  part of the nerve cord corresponding to the diencephalon.
23 to restore left-sided gene expression in the diencephalon.
24 en turn and extend anteriorly in the ventral diencephalon.
25 n within aspects of the ventral midbrain and diencephalon.
26 ell migration begins in the developing chick diencephalon.
27 erate correct dorsoventral patterning in the diencephalon.
28  eye, in the optic stalk, and in the ventral diencephalon.
29 most alar regions of the newly formed murine diencephalon.
30 als crossed the midline to the contralateral diencephalon.
31 xpression domains in the embryonic zebrafish diencephalon.
32  cause ectopic lens formation in the ventral diencephalon.
33 ontact between this ectoderm and the ventral diencephalon.
34  and functional association with the ventral diencephalon.
35 ce Fgf8 expression in midbrain and posterior diencephalon.
36 destined to form the eyes, telencephalon and diencephalon.
37 induced in vivo by signals from the adjacent diencephalon.
38 d ventricular zones in the mesencephalon and diencephalon.
39 st two sequential inductive signals from the diencephalon.
40 t was also observed in other portions of the diencephalon.
41 rol retinal axon patterning in the embryonic diencephalon.
42 axons for guidance across the midline of the diencephalon.
43  in more than 50% of the clones in the chick diencephalon.
44 dentified as corresponding to the vertebrate diencephalon.
45 roepithelial domain in the alar plate of the diencephalon.
46 need-related phosphoprotein markers from the diencephalon.
47 prosomere organization of the alar and basal diencephalon.
48  part of the habenular complex in the dorsal diencephalon.
49  within the broader developing telencephalon/diencephalon.
50 fferent cell groups in the telencephalon and diencephalon.
51 telencephalic side of the TDJ but not in the diencephalon.
52 phalon and to more restricted regions of the diencephalon.
53 wo distinct progenitor domains in the caudal diencephalon.
54 le compartmental boundaries within the mouse diencephalon.
55 ent boundary between telencephalon and basal diencephalon.
56 gination of the neuroectoderm in the ventral diencephalon.
57  located within the alar plate of the caudal diencephalon.
58 odomain transcription factor, in the ventral diencephalon.
59 sed in the developing hippocampus and in the diencephalon.
60   CP forms in the hindbrain (4th ventricle), diencephalon (3rd ventricle) and dorsomedial telencephal
61 ious subdivisions are established within the diencephalon--a complex integration center and relay sta
62            The retina as an extension of the diencephalon accessible to in vivo microcopy with spectr
63                  [(123)I]ZIENT uptake in the diencephalon achieved transient equilibrium at 157 min.
64    It is still not known whether the ventral diencephalon acts as the initial inducer of pituitary de
65  expression in the ventral telencephalon and diencephalon and also appears to be unique for Dlx5 amon
66 ivity in microdissected regions of the basal diencephalon and amygdala of intact and castrated rams.
67 monkey with [18F]1 showed high uptake in the diencephalon and brainstem with peak uptake achieved at
68  continuation of the alar territories of the diencephalon and brainstem, according to the prosomeric
69 abnormal joining of the telencephalon to the diencephalon and defined the medial limit of the dorsal
70 rlapping domains, with pitx2c in left dorsal diencephalon and developing gut and pitx2a in left heart
71 ns differentiate normally but scatter in the diencephalon and fail to properly gather close to the th
72 al thalamic axons extending down through the diencephalon and growing out through the internal capsul
73 ry for nonradial cell migration in the chick diencephalon and have provided a system to further explo
74 innervation patterns of RGC axons within the diencephalon and implicate the Slits as components of th
75 ye development, CE2 drives expression in the diencephalon and in the developing heart tube where Pax6
76 lsewhere in the dorsal telencephalon, in the diencephalon and in the ventral telencephalon, mutant ce
77     The mammalian thalamus is located in the diencephalon and is composed of dozens of morphologicall
78 region is topologically rostral to the basal diencephalon and is composed of the tuberal (rostral) an
79 urons have descending projections beyond the diencephalon and isthmus.
80 ft2 are expressed asymmetrically in the left diencephalon and left lateral plate respectively, sugges
81 The commonality of regions of mesencephalon, diencephalon and limbic/paralimbic areas involved in pri
82 stablishing regional subdivisions within the diencephalon and may also play a role in the development
83  Fgf15 shows Shh-dependent expression in the diencephalon and may participate in this interaction, at
84 cerebellum, as well as in cell bodies in the diencephalon and metencephalon.
85 th of both ventral and dorsal regions of the diencephalon and midbrain in early somite-stage mouse em
86  the hypothalamus and related regions of the diencephalon and midbrain was studied with retrograde an
87                            Similarly, in the diencephalon and midbrain, prominent LAMP labeling was o
88 d survival of dorsal cell populations in the diencephalon and midbrain.
89 progenitors in the floor plate of the caudal diencephalon and midbrain.
90 ressed in the telencephalon, and fkh5 in the diencephalon and more posterior neurectoderm.
91 the developing embryo, except for within the diencephalon and olfactory bulb.
92 active cells were spread widely in the ovine diencephalon and overlapped with the known distribution
93  hFOXA2 in the neural tube, third ventricle, diencephalon and pancreas.
94 entral midbrain, the majority of the ventral diencephalon and parts of the telencephalon.
95 ich is expressed only in the rostral ventral diencephalon and pituitary gland, commencing on e11.5, m
96 as first expressed in groups of cells in the diencephalon and pretectum.
97 3 in mice causes abnormal development of the diencephalon and Rathke's pouch, the progenitor of the a
98 8); then in more caudal basal regions of the diencephalon and rostral mesencephalon (substantia nigra
99 and protein throughout the telencephalon and diencephalon and some mesencephalic structures of A. bur
100 forebrain, because the major features of the diencephalon and telencephalon were normal in the null m
101 C axons expressed in specific regions of the diencephalon and telencephalon, help regulate optic trac
102 l and retinal axons cross the midline of the diencephalon and telencephalon.
103 tral regions of CNS including the hindbrain, diencephalon and telencephalon.
104 instead forms tissue with characteristics of diencephalon and telencephalon.
105 urons situated at the midline of the ventral diencephalon and that function as intermediate targets f
106 s necessary for the formation of the rostral diencephalon and that Six3 activity is required for the
107  effect was statistically significant in the diencephalon and the cerebellum, while it was absent in
108 halic progenitors that integrated within the diencephalon and the mesencephalon continued to express
109  rax expression is restricted to the ventral diencephalon and the optic vesicles.
110      Shh is expressed throughout the ventral diencephalon and the oral ectoderm, but its expression i
111 the telencephalon and dorsal identity in the diencephalon and the retina.
112 elencephalon near to its boundaries with the diencephalon and the ventral telencephalon, mutant cells
113 ate in dorsal thalamus, project ventrally in diencephalon and then dorsolaterally in ventral telencep
114  ventrally from their position in the dorsal diencephalon and then turn and extend anteriorly in the
115 nglion cells (RGCs) within the embryonic rat diencephalon and whether the slits can account for a rep
116 xpression in the dorsal midbrain and ventral diencephalon, and at the midbrain-hindbrain junction.
117 nd protein were present in cortex, brainstem-diencephalon, and cerebellum.
118 gination of the neuroectoderm in the ventral diencephalon, and defects in the formation of the distin
119 lized to neurons, was enriched in forebrain, diencephalon, and hindbrain during prenatal and postnata
120 on propagates between cortex, basal ganglia, diencephalon, and hippocampus in genetically susceptible
121 loping limbic structures of the cerebrum and diencephalon, and in the medulla of the brain stem.
122 of the infundibulum, a region of the ventral diencephalon, and Rathke's pouch, a derivative of oral e
123 talk and nerve, the optic chiasm and ventral diencephalon, and the anterior midline zones that abut d
124 ains of BMP and FGF signaling in the ventral diencephalon, and the second mechanism is the restrictio
125 f their production in neurons of the rostral diencephalon, and their axonal localization in brain sit
126 eta species in the hippocampus and brainstem/diencephalon ( approximately 1.5-fold).
127                                           In diencephalon, AptCB1R RNA probe weakly stained the centr
128 tein into the anterior midbrain or posterior diencephalon are consistent with it being at least part
129 ion in which the embryonic hindbrain and the diencephalon are flattened out, allowing a birds-eye vie
130                   Several brain areas in the diencephalon are involved in the activation and expressi
131 ei, indicating that laterality of the dorsal diencephalon arises in a step-wise fashion.
132           We identify a DA cell group in the diencephalon as a common source for innervation of both
133 key, radioactivity was reduced by 39% in the diencephalon at 101 min following injection of citalopra
134 ell proliferation or death in the developing diencephalon at embryonic day 10.5 (e10.5) or e11.5.
135 Fgf8 and Wnt3a expression are induced in the diencephalon at the ZLI, reminiscent of the Fgf8/Wnt1-ex
136 t, and that antagonizing its function in the diencephalon attenuates thalamic specification.
137 rted to be detected only in the midbrain and diencephalon, become elevated.
138 Olg genes are expressed at the telencephalon-diencephalon border and adjacent to the floor plate, a s
139 en the medial temporal lobe (MTL) and medial diencephalon, both of which are critical for episodic me
140 ically specific nuclei in the basal ganglia, diencephalon, brainstem and cerebellum, with restricted
141 sion of gnih was particularly evident in the diencephalon, but also in the olfactory bulbs/cerebral h
142 GC axon pathfinding and targeting within the diencephalon by regulating their fasciculation, preventi
143 ex above the basal ganglia, cortex above the diencephalon], caudate-putamen, basal forebrain, hypotha
144         Previous work has shown that ventral diencephalon CD44/stage-specific embryonic antigen (SSEA
145                                      Lateral diencephalon cell conditioned medium inhibits growth of
146 it reduced growth in the presence of lateral diencephalon cell membranes.
147 cantly different between groups overall; and diencephalon, cerebral white matter, cerebellum and glob
148 n had greater 3alpha,5alpha-THP formation in diencephalon compared to other groups.
149 pe results from loss of GAP-43 in RGCs or in diencephalon components such as CD44/SSEA axons, wild-ty
150  dorsal and ventral hypothalamus) and caudal diencephalon, confirming results of Garcia-Fernandez et
151                        In older mutants, the diencephalon contained fewer cells than normal.
152 e co-cultures in which a region of embryonic diencephalon containing the ZI is maintained adjacent to
153                               The teleostean diencephalon contains a relatively large number of dopam
154 ate here that Gbx2-expressing cells in mouse diencephalon contribute to the entire thalamic nuclear c
155 , lefty1 and pitx2 are expressed in the left diencephalon; cyclops, lefty2 and pitx2 are expressed in
156 that the separation of the telencephalon and diencephalon depends on interactions between Shh and Gli
157                                          The diencephalon-derived optic stalk (OS) and neural retina
158 n was investigated in Alligator during early diencephalon development.
159     The pattern of cell proliferation in the diencephalon differed from that observed in the rhombenc
160  As in the mammalian telencephalon and chick diencephalon, dispersion among clonally related cells in
161 lly, while T/ebp is expressed in the ventral diencephalon during forebrain formation, it is not expre
162           Noggin is expressed in the ventral diencephalon during Rathke's pouch induction, in the und
163 ssed in VT retina, as well as in the ventral diencephalon during the formation of the optic chiasm.
164 ce paced mating but younger rats had greater diencephalon E(2) than did middle-aged rats.
165             TCF4 is expressed in the ventral diencephalon early in pituitary development, rostral to
166 neural differentiation within the developing diencephalon, emphasizing the contribution of recent lar
167 ebral cortex, striatum, basal forebrain, and diencephalon express the dopamine D5 receptor.
168 irst phase, the BMP4 signal from the ventral diencephalon, expressing BMP4, Wnt5a, and FGF8, represen
169                                   Within the diencephalon, Fgf3 and Fgf8 act synergistically to patte
170 oping axons of the fasciculus retroflexus, a diencephalon fiber tract associated with limbic function
171  In addition, in the Foxd1 deficient ventral diencephalon, Foxg1 invades the Foxd1 domain, Zic2 and I
172         We provide evidence that the ventral diencephalon from 2- to 4-day-old chick embryos is able
173     Finally, we demonstrate that the ventral diencephalon from e9.5-e11.5 mouse embryos is also an ef
174  hypothalamus, and the more caudally located diencephalon [from rostral to caudal: the prethalamus, t
175                                The embryonic diencephalon gives rise to the vertebrate thalamus and h
176                                       In the diencephalon, Gly-ir neurons were observed in the pretha
177                                              Diencephalon: high densities were detected in the medial
178 t of the NMDA-R is widely distributed in the diencephalon, implicates it in a wide variety of functio
179 bed the acoustic pathway from the ear to the diencephalon in a sound-producing fish (Pollimyrus) base
180 e ventral midbrain and dorsal midline of the diencephalon in Gbx2-deficient mice.
181           Nevertheless, damage to the medial diencephalon in humans is associated with both retrograd
182 t the ventral midline of the spinal cord and diencephalon in the developing rodent CNS, respectively.
183 alar hypothalamus was located rostral to the diencephalon in the secondary prosencephalon and represe
184 ene, zic2a, during formation of the anterior diencephalon in zebrafish.
185 alis (SP) in the midbrain, almost the entire diencephalon including nucleus dorsomedialis posterior t
186 ensively expressed in the developing ventral diencephalon, including the infundibulum and the posteri
187 n of ligand binding sites in the fetal sheep diencephalon indicated that the highest levels of bindin
188 disruption of the normal architecture of the diencephalon indicating nonradial cell migration is nece
189 P and WNT signals emanating from the ventral diencephalon influence pouch growth and development.
190 n the retina, gene expression in the ventral diencephalon influences chiasm formation.
191 ch and by inductive signals from the ventral diencephalon/infundibulum.
192 ry appears normal, patterning in the ventral diencephalon is disrupted; Bmp4 activity is expanded res
193 urons from either the cerebral cortex or the diencephalon is largely lacking.
194 ion in the PSB, but Wnt-7b expression in the diencephalon is preserved.
195 Nodal signaling within the developing dorsal diencephalon is required for determining the direction o
196  the 15- to 17-somite stage, the prospective diencephalon is the most-anterior structure in the Six3-
197 rojections from field CA1 to the interbrain (diencephalon) is analyzed here with the Phaseolus vulgar
198 ral thalamus (vTh), two major regions of the diencephalon, is characterized by their parcellation int
199 pretoral nucleus, contralateral NC, tectum), diencephalon (lateral preglomerular, central posterior,
200 itional deletion of Lhx6 from the developing diencephalon leads to decreases in both NREM and REM sle
201    They show reciprocal connections with the diencephalon (mainly the thalamus), project to the midbr
202 central progestogen formation in midbrain or diencephalon may contribute to some variability in expre
203 eminence and dorsal hypothalamic area in the diencephalon; medial region of the superior colliculus,
204 NS (olfactory bulbs, pallium, basal ganglia, diencephalon, mesencephalic tegmentum, rhombencephalon,
205 f these isoforms were found in the thalamus, diencephalon, mesencephalon, and brainstem.
206 ndrograms from the secondary prosencephalon, diencephalon, mesencephalon, and isthmus showed some dev
207 ze proliferation zones in the telencephalon, diencephalon, mesencephalon, and rhombencephalon that we
208 mRNA is expressed in discrete regions of the diencephalon, mesencephalon, and rhombencephalon.
209 gnals over much of the turkey telencephalon, diencephalon, mesencephalon, cerebellum, pituitary, and
210 labeling over much of the rat telencephalon, diencephalon, mesencephalon, cerebellum, spinal cord, an
211 n the nervous system is predominantly in the diencephalon, midbrain and neural tube.
212 nantly in the olfactory bulbs/telencephalon, diencephalon, midbrain tegmentum, retina, and gonads.
213 d, contributing to diverse structures in the diencephalon, midbrain, and brainstem and extensively po
214 eled receptors throughout the telencephalon, diencephalon, midbrain, and brainstem, with a similar di
215 on of sleep and wake in the basal forebrain, diencephalon, midbrain, and pons of the minke whale, a m
216 ed to sleep and wake in the basal forebrain, diencephalon, midbrain, and pons of the river hippopotam
217 branes from brain stem, cortex, hippocampus, diencephalon, midbrain, and spinal cord, but not basal g
218 brate ancestor of the vertebrates included a diencephalon, midbrain, hindbrain, and spinal cord.
219 rea and in the periventricular region at the diencephalon/midbrain junction.
220 e eye to the optic stalk (OS), and cross the diencephalon midline at the optic chiasm en route to the
221                         Tumor locations were diencephalon (n = 58), cerebral hemisphere (n = 3), and
222 of the cholinergic tone to the brainstem and diencephalon necessary for physiological arousal.
223 g cells failed to move anteriorly, a ventral diencephalon never formed, and the eyes remained fused.
224 placeable brain uptake (i.e., V3"=[brainstem-diencephalon-occipital]/occipital), a measure proportion
225 measure Mecp2e1 and Mecp2e2 abundance in the diencephalon of adult mice, demonstrating significantly
226 ctor influencing brain development, then the diencephalon of Alligator may be built differently from
227 ed with the idea of a common bauplan for the diencephalon of anamniote and amniote vertebrates from f
228  absent from the rostral midbrain and caudal diencephalon of embryos carrying a dominant-negative tra
229 ctions, we localized the NR2B subunit in the diencephalon of the adult male rat using immunoperoxidas
230  the lateral plate mesoderm (LPM) and dorsal diencephalon of the brain.
231                                       In the diencephalon of the mutant, Bmp4 expression is maintaine
232 donor retinal tissues were grafted onto host diencephalons of all three genotypes, and graft axon gro
233                                       In the diencephalons of the adult zebrafish brain, all catechol
234 val or transplant replacement of the lateral diencephalon optic tract entry zone in GAP-43-deficient
235 cortical axons (TCAs) also fail to leave the diencephalon or abnormally project toward the amygdala.
236 system, resulting in venous ischaemia to the diencephalon or mesial temporal lobes and to TGA.
237  and not in cellular elements of the ventral diencephalon or transition zone.
238                                   The dorsal diencephalon (or epithalamus) of larval zebrafish displa
239 sfunction or injury involving the brainstem, diencephalon, or cerebral cortex and are associated with
240                                       In the diencephalon, overlap was observed in several hypothalam
241 sion to portions of the ventral midbrain and diencephalon, overlaps both temporally and spatially wit
242 ease in the number of dividing cells in male diencephalon (p < 0.05, Kruskal-Wallis test).
243 support the idea that there are distinct MTL-diencephalon pathways that subserve differing memory pro
244                           In wild-type E14.5 diencephalon, Pax-6, Dlx-2 and Wnt-3 are expressed in di
245                                       In the diencephalon, Pax6 and Pax7 were distinct in the alar an
246                                       In the diencephalon, PITX2 is expressed in neurons of the zona
247 s of the adult cerebral cortex, hippocampus, diencephalon, pons/medulla, and cerebellum.
248  position of the optic chiasm on the ventral diencephalon (presumptive hypothalamus) and in ipsilater
249 ebellar cell populations were located in the diencephalon (pretectum and thalamus), mesencephalon (re
250 organisms, and in a small domain in the left diencephalon, providing the first observation of asymmet
251 whereas ventral midline cells of the rostral diencephalon (RDVM cells) appear to be induced by the du
252 oop with FGF8/FGF10 signaling in the ventral diencephalon, required to prevent induction of multiple
253    We conclude that proper maturation of the diencephalon requires ZLI-derived Hh signalling.
254      CE2 is shown to be autoregulated in the diencephalon, responding to absence of Pax6.
255  patterning along the dorsal-ventral axis of diencephalon: retinal axons grow in a compact bundle ove
256 ebrain (including both the telencephalon and diencephalon) revealed a unique role for Isl1 in diencep
257                                In the future diencephalon, several genes with patterned expression ha
258        At the time RGC axons extend over the diencephalon, slit1 and slit2 are expressed in hypothala
259                                       In the diencephalon, substantial secondary olfactory projection
260 cord, hindbrain, rostral midbrain and caudal diencephalon, suggesting that multiple transcriptional r
261 lls appeared in the hypothalamus and rostral diencephalon (suprachiasmatic, posterior recess and post
262  (M), medial striatum (MSt), septum, Area X, diencephalon, telencephalic subventricular zone (SVZ), a
263 e nucleus, globus pallidus plus putamen, and diencephalon (thalamus plus ventral diencephalon).
264 crete neuroepithelial domains, including the diencephalon, the insertion of the eminentia thalami int
265 duced in frontal cortex and cortex overlying diencephalon, the olfactory bulbs, caudate-putamen, hipp
266 rating the eyes, and formed ventral anterior diencephalon, the presumptive hypothalamus.
267 ess also induced activation of mast cells in diencephalon, the site where most mast cells are found i
268 er, the border between the telencephalon and diencephalon, the telencephalic/diencephalic junction (T
269 issue is located in a small region of caudal diencephalon-this region is necessary to retain response
270 -negative GABAergic progenitors in the early diencephalon through sequential waves of tangential migr
271  The remaining axons converge in the lateral diencephalon to form a fourth fascicle, the marginal opt
272 from each eye sort in the developing ventral diencephalon to project to ipsi- or contralateral target
273 ed from their various sites of origin in the diencephalon to the synaptic termination sites on differ
274 ry periphery and brainstem) to sensorimotor (diencephalon) to motor (forebrain) components of a behav
275 nd place, in both the retina and the ventral diencephalon, to be able to influence RGC axon guidance.
276 ptake in the diencephalon, which resulted in diencephalon-to-cerebellum ratios of 2.12 at 190 min.
277 in the vertebrate forebrain that bisects the diencephalon transversely, expresses the secreted factor
278 hh is a direct target of Six3 in the rostral diencephalon ventral midline (RDVM).
279 nregulation of Shh expression in the rostral diencephalon ventral midline, the alobar phenotype is ca
280 preoptic areas and medial preoptic nucleus), diencephalon (viz., subincertal nucleus, zona incerta as
281 Beck Depression Inventory, bilateral ventral diencephalon volume, and expression levels of the RNF123
282 d transverse and longitudinal borders of the diencephalon was investigated in Alligator embryos begin
283 ucleus of the ansa lenticularis in the avian diencephalon was renamed the subthalamic nucleus, both f
284  of adenosine A(2A) receptors in fetal sheep diencephalon, we have used a receptor autoradiographic t
285                        Steroid levels in the diencephalon were altered by age mainly in females, and
286 l, posterior cingulate, thalamus and ventral diencephalon were independently associated with telomere
287 )I-FP-CIT binding ratios in the midbrain and diencephalon were significantly higher 2 h after injecti
288  in the patterning of the developing ventral diencephalon where the optic chiasm forms.
289 ereby helping define the site in the ventral diencephalon where the optic chiasm forms.
290     Forebrain labeling was restricted to the diencephalon, where distinctive terminal fields were obs
291                         Cells in the ventral diencephalon, where Sox3 is usually highly expressed, ha
292 l correlates, of structures in brainstem and diencephalon which regulate the sleep-wake cycle, and of
293 rodevelopmental gene mostly expressed in the diencephalon, which contains a region previously reporte
294 The medial habenular nuclei of the zebrafish diencephalon, which lie bilateral to the pineal complex,
295 to monoamine transporters in the midbrain or diencephalon, which may reflect predominantly serotonin
296 al lamination, and cell death in the ventral diencephalon, which resulted in cyclopia.
297 emonstrated high [(123)I]ZIENT uptake in the diencephalon, which resulted in diencephalon-to-cerebell
298 ound to be widely distributed in the ventral diencephalon, with high densities in the preopticoseptal
299 sed on the left side of the embryonic dorsal diencephalon, within a region corresponding to the presu
300                                           In diencephalon, WNT2b expression is restricted to medial d

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