ライフサイエンスコーパス: diet-induced obesity

1 ddition, LDP enhances the effect of high-fat diet induced obesity.

2 n resistance, particularly in the context of diet-induced obesity.

3 f alternative splicing to the development of diet-induced obesity.

4 adipose remodeling and adipocyte survival in diet-induced obesity.

5 tained glucose tolerance and did not develop diet-induced obesity.

6 stance and as a novel therapeutic target for diet-induced obesity.

7 iR-155 (-5p and -3p) in female mice prevents diet-induced obesity.

8 7 also prevented kidney disease in mice with diet-induced obesity.

9 a central mechanism for beta cell failure in diet-induced obesity.

10 ate during and after development of high-fat diet-induced obesity.

11 oc in mice (Noc KO) results in resistance to diet-induced obesity.

12 itochondrial oxidation and susceptibility to diet-induced obesity.

13 rature and energy expenditure and preventing diet-induced obesity.

14 ivation precipitates vascular dysfunction in diet-induced obesity.

15 repression increased with aging and high-fat diet-induced obesity.

16 and, as adults, were protected from high fat diet-induced obesity.

17 display reduced adiposity and resistance to diet-induced obesity.

18 bitor decreased adipogenesis and ameliorated diet-induced obesity.

19 cient mice were also evaluated in a model of diet-induced obesity.

20 oding MGAT2 (Mogat2(-/-)) are protected from diet-induced obesity.

21 iture, decreased fat mass, and resistance to diet-induced obesity.

22 ficient to prevent both genetic and high-fat diet-induced obesity.

23 abolic derangements associated with high fat diet-induced obesity.

24 nsitivity and are more resistant to high fat diet-induced obesity.

25 PR-B signaling is important for the onset of diet-induced obesity.

26 oxidation and ketone body production during diet-induced obesity.

27 on and decreased BAT activity under high fat diet-induced obesity.

28 es fatty acid oxidation and protects against diet-induced obesity.

29 2 on effects of fibrates in a mouse model of diet-induced obesity.

30 Foxo1KO(Nkx2.1) mice are not protected from diet-induced obesity.

31 in resistance, but KO mice were resistant to diet-induced obesity.

32 the liver-related consequences of long-term diet-induced obesity.

33 e: ob/ob, GLUT4(+/-), and mice with high-fat diet-induced obesity.

34 hat mediate the resistance of female mice to diet-induced obesity.

35 pression in heart tissue in a mouse model of diet-induced obesity.

36 t and glucose homeostasis in mouse models of diet-induced obesity.

37 show that Dexras1 mediates adipogenesis and diet-induced obesity.

38 CHR1 are lean, hyperactive, and resistant to diet-induced obesity.

39 ed exercise tolerance and protection against diet-induced obesity.

40 inflammation in adipose tissue and prevents diet-induced obesity.

41 ntimal hyperplasia, which was exacerbated by diet-induced obesity.

42 ding a high-fat/high-sucrose diet, mimicking diet-induced obesity.

43 al temperature homeostasis and resistance to diet-induced obesity.

44 from pH1N1 infection using a mouse model of diet-induced obesity.

45 rvention protects offspring against high-fat diet-induced obesity.

46 high lipid content, and did not protect from diet-induced obesity.

47 rogenesis despite similar fat accretion with diet-induced obesity.

48 liver disease (NAFLD) and in mouse models of diet-induced obesity.

49 that lack functional SFRP5 were resistant to diet-induced obesity.

50 ro, in fasted mice, and in mice subjected to diet-induced obesity.

51 al white adipose tissue (WAT) in response to diet-induced obesity.

52 a marked increase in their susceptibility to diet-induced obesity.

53 2 diabetes, and C57BL/6J mice with high-fat diet-induced obesity.

54 d insulin resistance despite protection from diet-induced obesity.

55 lin and leptin receptors in animal models of diet-induced obesity.

56 ic reticulum contacts in POMC neurons during diet-induced obesity.

57 ylcholinesterase (BChE), in a mouse model of diet-induced obesity.

58 s control pancreatic dysfunction in high-fat-diet-induced obesity.

59 f Bmal1 also worsens chronic inflammation in diet-induced obesity.

60 deletion exerts a protective effect against diet-induced obesity.

61 increased oxygen consumption during high-fat-diet-induced obesity.

62 ation of hepatic Dpp4 in young mice prone to diet-induced obesity.

63 nd appetitive motivation under conditions of diet-induced obesity.

64 tervention in dealing with the prevalence of diet-induced obesity.

65 is in the beta-cell compensatory response to diet-induced obesity.

66 tion prior to high calorie feeding prevented diet-induced obesity.

67 electrophysiological properties observed in diet-induced obesity.

68 des in adipocytes and protected animals from diet-induced obesity.

69 5(-/-) (double knock-out (DKO)) mice show HF diet-induced obesity, adipocyte hypertrophy, and present

70 Diet-induced obesity also affected the morphological pro

71 Thus, both food withdrawal and diet-induced obesity alter the sensitivity of vagal affe

72 Diet-induced obesity alters the biophysical, pharmacolog

73 he comorbidities of Pb exposure and high-fat diet-induced obesity amplify skeletal deficits independe

74 define whether activated calpains influence diet-induced obesity and adipose tissue macrophage accum

75 O) was sufficient to protect adult mice from diet-induced obesity and associated metabolic alteration

76 ctoside-binding lectin, accelerates high-fat diet-induced obesity and diabetes.

77 ve therapeutic potential in the treatment of diet-induced obesity and dyslipidemia.

78 R-378 and miR-378* are resistant to high-fat diet-induced obesity and exhibit enhanced mitochondrial

79 n this tissue are strongly protected against diet-induced obesity and exhibit increased energy expend

80 We engaged the model of diet-induced obesity and found that expression of C5aR w

81 t KLF3-null mice are lean and protected from diet-induced obesity and glucose intolerance.

82 The knock-out mice were resistant to diet-induced obesity and had abnormal lipid metabolism i

83 issues were resistant to developing high-fat diet-induced obesity and had significantly reduced white

84 ally reducing dietary BCAAs rapidly reverses diet-induced obesity and improves glucoregulatory contro

85 Importantly, loading relieves diet-induced obesity and improves glucose tolerance.

86 tivation of Hh signaling suppresses high-fat-diet-induced obesity and improves whole-body glucose tol

87 However, in wild-type mice with high-fat-diet-induced obesity and in ob/ob mice, the marked downr

88 In addition, diet-induced obesity and insulin resistance are exacerba

89 nd adipose tissue mass and were resistant to diet-induced obesity and insulin resistance due to a com

90 NSG mice were completely protected from diet-induced obesity and insulin resistance with signifi

91 homeostasis in a preclinical murine model of diet-induced obesity and insulin resistance, making the

92 ound, lymphocytes, and cytokine signaling in diet-induced obesity and insulin resistance.

93 roved metabolic profiles and protection from diet-induced obesity and insulin resistance.

94 for 15 weeks, after which the mice exhibited diet-induced obesity and insulin resistance.

95 Mice lacking PEMT are protected against diet-induced obesity and insulin resistance.

96 e tissue browning, and protects mice against diet-induced obesity and insulin resistance.

97 ACF was found to prevent diet-induced obesity and insulin resistance.

98 ncreased in the skeletal muscle of mice with diet-induced obesity and insulin resistance.

99 ial fatty acid oxidation, thereby preventing diet-induced obesity and insulin resistance.

100 ion of Tst in adipocytes protected mice from diet-induced obesity and insulin-resistant diabetes.

101 teries is an early event that coincides with diet-induced obesity and IR in primates.

102 e deficient for Akt1 exhibit protection from diet-induced obesity and its associated insulin resistan

103 epresents a promising approach to ameliorate diet-induced obesity and leptin resistance.

104 y regulated in white and brown fat depots of diet-induced obesity and leptin-deficient ob/ob mouse mo

105 geted activation of Hh signaling ameliorates diet-induced obesity and may be explored for pharmaceuti

106 endothelial dysfunction, occurs early during diet-induced obesity and may serve as a mediator of athe

107 crobial community structure can protect from diet-induced obesity and metabolic disease.

108 potential therapeutic targets for combating diet-induced obesity and metabolic disease.

109 dy suggests that blocking of CB1 ameliorates Diet-Induced Obesity and metabolic disorder by modulatin

110 KKbeta-deficient mice were also resistant to diet-induced obesity and metabolic disorders.

111 egulated microbiota protect BALB/c mice from diet-induced obesity and metabolic dysfunction.

112 Finally, moderate alcohol prevented high-fat diet-induced obesity and metabolic dysfunction.

113 the discovery of new molecular therapies for diet-induced obesity and metabolic syndrome.

114 ockout of Maf1 in mice confers resistance to diet-induced obesity and nonalcoholic fatty liver diseas

115 Egr-1 null mice were protected from diet-induced obesity and obesity-associated pathologies

116 ing a foothold in the pathways that regulate diet-induced obesity and offering the potential for ther

117 lacking hepatic ZFP36L1 were protected from diet-induced obesity and steatosis.

118 HFD-fed TG mice rapidly developed diet-induced obesity and systemic insulin resistance, bu

119 DZ-RhoGEF-deficient mice were protected from diet-induced obesity and T2D.

120 results of VSG surgery applied to mice with diet-induced obesity and targeted genetic disruption of

121 ver, the transgenic mice were protected from diet-induced obesity and type 2 diabetes.

122 Shp inactivation may be beneficial to combat diet-induced obesity and uncover that hepatic SHP is nec

123 a therapeutic target for insulin resistance, diet-induced obesity, and associated metabolic dysfuncti

124 proves insulin sensitivity, protects against diet-induced obesity, and elicits the browning of white

125 at they were protected from atherosclerosis, diet-induced obesity, and insulin resistance.

126 ic insulin resistance and hepatosteatosis in diet-induced obesity are associated with various metabol

127 Mice lacking LR11 are protected from diet-induced obesity associated with an increased browni

128 ong reduction of adiposity and resistance to diet-induced obesity, associated with overall better met

129 confers long-term metabolic protection from diet-induced obesity at the cost of moderate skin oxidat

130 Since diet-induced obesity attenuates the responsiveness of ga

131 effector protein SMAD3 are protected against diet-induced obesity because of browning of their white

132 Following diet-induced obesity, biochemical analysis of livers rev

133 ting) and excessive energy storage (high-fat diet-induced obesity) blunt the effect of leptin.

134 lin resistance and insulin resistance due to diet-induced obesity both depend on muscle TRIB3.

135 The 16 week HF/HS diet induced obesity, but did not significantly affect t

136 ansfer in mice suppressed the development of diet-induced obesity, but did not affect pre-existing ad

137 om brain cells is known to protect mice from diet-induced obesity, but the effects on HCD-induced inf

138 ient mice have been shown to be resistant to diet-induced obesity, but the mechanism behind this rema

139 knockdown in WAT and liver protects against diet-induced obesity by augmenting cellular energy expen

140 mproves insulin sensitivity substantially in diet-induced obesity by both peripheral and central mech

141 sociated with obesity, we induced long-term, diet-induced obesity by challenging mice to high-fat die

142 -PAR2 signaling in adipocytes contributes to diet-induced obesity by decreasing metabolism and energy

143 ight a protective effect of NT-PGC-1alpha on diet-induced obesity by enhancing diet-induced thermogen

144 se tissue LPL improves glucose metabolism in diet-induced obesity by improving the adipose tissue phe

145 in proopiomelanocortin neurons and prevented diet-induced obesity by increasing WAT browning and ener

146 esults implicate a new class of compounds in diet-induced obesity-C18 epoxide and diol oxylipins.

147 Diet-induced obesity can induce low-level inflammation a

148 eered mice on different diets, we found that diet-induced obesity caused a loss of guanylin expressio

149 Diet-induced obesity causes chronic macrophage-driven in

150 In diet-induced obesity, cellular Ca(2+) handling propertie

151 Diet-induced obesity compromises the excitability and re

152 We hypothesized that diet-induced obesity could lead to alterations of the NR

153 In this study, we show that diet-induced obesity did not impact the maintenance of p

154 s to identify the pathologic consequences of diet induced obesity (DIO) on the lymphatic system.

155 C57BL/6J mice with diet-induced obesity (DIO mice) displaying a cardiac phe

156 PDE10A-deficient mice are resistant to diet-induced obesity (DIO) and associated metabolic dist

157 ed metabolic abnormalities both in mice with diet-induced obesity (DIO) and in leptin-deficient (ob/o

158 Global deletion of Ip6k1 protects mice from diet-induced obesity (DIO) and insulin resistance, but t

159 dipose tissue (VAT), thereby contributing to diet-induced obesity (DIO) and insulin resistance.

160 genic enzymes and spare lipogenic enzymes in diet-induced obesity (DIO) are obscure.

161 The development of diet-induced obesity (DIO) can potently alter multiple a

162 d that the increase in leptin levels seen in diet-induced obesity (DIO) drives an increase in BP in r

163 Diet-induced obesity (DIO) has been shown to alter the b

164 th regular chow, increased susceptibility to diet-induced obesity (DIO) in males but not in females,

165 meostasis centers of the hypothalamus during diet-induced obesity (DIO) in rodent models, but the cha

166 ought to establish whether the propensity to diet-induced obesity (DIO) is associated with addictive-

167 ic distribution, 17- to 18-week-old lean and diet-induced obesity (DIO) mice were studied.

168 In db/db or diet-induced obesity (DIO) mice, hepatic expression of A

169 Here we use a diet-induced obesity (DIO) mouse model and compare metab

170 lates development of insulin resistance in a diet-induced obesity (DIO) mouse model by ameliorating l

171 reduces obesity and insulin resistance in a diet-induced obesity (DIO) mouse model.

172 HGA(273-301)) by investigating the effect of diet-induced obesity (DIO) on insulin sensitivity of the

173 The effects of diet-induced obesity (DIO) on tau pathology remain unkno

174 Impaired adipogenic differentiation during diet-induced obesity (DIO) promotes adipocyte hypertroph

175 t received low perinatal n-6/n-3 ratios were diet-induced obesity (DIO) resistant and had a lower pos

176 und that withaferin-A treatment of mice with diet-induced obesity (DIO) resulted in a 20-25% reductio

177 hat STAT4(-/-)C57Bl6/J mice develop high-fat diet-induced obesity (DIO) similar to wild-type controls

178 laboratory demonstrated earlier that in the diet-induced obesity (DIO) state, the appetite-suppressi

179 Here, diet-induced obesity (DIO) studies in mice with genetic

180 oregulatory role of GIP in a murine model of diet-induced obesity (DIO) using the long-acting GIP ana

181 ever, when females were fed a high-fat diet, diet-induced obesity (DIO) wild-type (DIO-WT) mice were

182 essential for weight gain in mouse models of diet-induced obesity (DIO), but the pathways that cause

183 gh behavioural rhythmicity was maintained in diet-induced obesity (DIO), gene expression profiling re

184 othelial explants excised from mice modeling diet-induced obesity (DIO), in which they were fed a "We

185 Thus in diet-induced obesity (DIO), lack of GH action on the MPh

186 a cannabinoid receptor 1 (CB1) antagonist on Diet-Induced Obesity (DIO), specifically whether such a

187 in resistance in C57Bl6/J mice with high-fat diet-induced obesity (DIO), using JD5037, a peripherally

188 TNF receptor-associated factors (TRAFs), in diet-induced obesity (DIO).

189 H NPY mRNA expression is observed only after diet-induced obesity (DIO).

190 hyperphagic conditions such as lactation and diet-induced obesity (DIO).

191 We found that rats susceptible to diet-induced obesity displayed heightened conditioned ap

192 We show that diet-induced obesity does not impair NRG1 signalling in

193 Diet-induced obesity drove early production of interleuk

194 d muscle glucose metabolism and resistant to diet-induced obesity due to increased energy expenditure

195 deterioration of glucose homeostasis during diet-induced obesity, due to enhanced resistance to insu

196 dipose tissue development, but its effect on diet-induced obesity during postnatal life is not known.

197 PQQ, provided prenatally in a mouse model of diet-induced obesity during pregnancy, could protect obe

198 and suggest a novel mechanism through which diet-induced obesity during puberty imposes its long-las

199 In primates with diet-induced obesity, endothelial inflammatory activatio

200 exercise on type II diabetes risk under a HF diet-induced obesity environment.

201 control region mice on a high fat diet with diet-induced obesity following single oral doses of 3 an

202 ascularization, including leptin deficiency, diet-induced obesity, genetic ablation of the secreted f

203 Whey protein has been indicated to curb diet-induced obesity, glucose intolerance and delay the

204 ke receptor 4 expression was observed in the diet-induced obesity HCC animal model.

205 We developed a diet-induced obesity HCC mouse model and examined TnC ex

206 lays a protective role in the progression of diet-induced obesity, hepatosteatosis, and atheroscleros

207 wild-type and Itch(-/-) mice in a context of diet-induced obesity (high-fat diet [HFD]).

208 nhanced leptin signaling and protection from diet-induced obesity; however, whether additional signal

209 eficient mice are more resistant to high-fat diet-induced obesity, hyperleptinemia, and glucose intol

210 This study evaluates the role of cafeteria diet-induced obesity/hyperlipidemia (CAF) on alveolar bo

211 In a context of diet-induced obesity, IL-21 KO mice, compared with WT an

212 Diet-induced obesity impaired AT1-ILC killing ability.

213 MH-specific inhibition of TBK-1 in mice with diet-induced obesity impaired glucose metabolism and AKT

214 nfirmed in both serum and liver of mice with diet-induced obesity, implying that such a metabolic alt

215 ggerated the detrimental effects of maternal diet-induced obesity in adipose tissue.

216 We investigated the effect of diet-induced obesity in C57BL6J mice upon rhythmic trans

217 Diet-induced obesity in mice demonstrated that IL-6 expr

218 Here we show that diet-induced obesity in mice is associated with persiste

219 Pharmacological inhibition of CBR1 in diet-induced obesity in mice results in more marked gluc

220 To test the role of JNK, we examined diet-induced obesity in mice with targeted ablation of J

221 rotein produces a phenotype of resistance to diet-induced obesity in mice, we hypothesized that this

222 and deletion of theNrf2gene protects against diet-induced obesity in mice.

223 on of Id1 causes age-associated and high-fat diet-induced obesity in mice.

224 odulates traits of the metabolic syndrome in diet-induced obesity in mice.

225 mide N-methyltransferase (NNMT)-ASO prevents diet-induced obesity in mice.

226 AL) in a skeletal muscle model system and in diet-induced obesity in mice; however, potential functio

227 4 is a negative regulator of inflammation in diet-induced obesity, in part through regulation of macr

228 Maternal diet-induced obesity increased miR-126 expression howeve

229 Diet-induced obesity increased the expression of MHC II

230 In mice with a GSNOR deletion, diet-induced obesity increases lysosomal nitrosative str

231 According to our previous results, diet-induced obesity induces epigenetic modifications to

232 nvestigated the effects of Lcn2 depletion on diet-induced obesity, inflammation, and PDAC development

233 y, microbial and dietary factors incurred by diet-induced obesity influence underlying innate and ada

234 Here, we demonstrate that resistance to diet-induced obesity inNrf2(-/-)mice is associated with

235 w that intestinal PPARdelta protects against diet-induced obesity, insulin resistance and dyslipidemi

236 he fDsbA-L mice also displayed resistance to diet-induced obesity, insulin resistance, and hepatic st

237 tion, transgenic mice were protected against diet-induced obesity, insulin resistance, and inflammati

238 Additionally, in mice with diet-induced obesity, INT-767 prevented mitochondrial dy

239 High-fat diet-induced obesity is a major risk factor for osteoart

240 Diet-induced obesity is associated with strong circadian

241 Diet-induced obesity leads to devastating and common chr

242 Previous studies have shown that maternal diet-induced obesity leads to increased risk of type 2 d

243 tion protected homozygous mice from high fat diet-induced obesity, likely by promoting enhanced energ

244 Moreover, there is emerging evidence that diet-induced obesity locks the phenotype of vagal affere

245 During high fat diet-induced obesity, macrophages are activated by lipid

246 suggest that the memory-impairing effects of diet-induced obesity may potentially be mediated by neur

247 We studied C57BL/6 mice with diet-induced obesity, MC4R-deficient mice, and mice that

248 our unique gut microbiota with resistance to diet-induced-obesity-mediated alteration of the gut micr

249 ce but increased over time in overweight and diet-induced obesity mice, suggesting CR obviates epigen

250 We used a diet-induced obesity model to show that Thy1-null mice g

251 e metabonomics data and microbiome data in a diet-induced obesity model using C57BL/6 mice.

252 Using a diet-induced obesity model, we show that TLR3-deficient

253 Diet-induced obesity modulates the excitability and resp

254 ose at 30 mg/kg in a streptozotocin-treated, diet-induced obesity mouse pharmacodynamic assay and blu

255 recapitulates the leanness and resistance to diet-induced obesity of RIIbeta KO mice.

256 f increased susceptibility to the effects of diet-induced obesity on amygdala function.

257 nockout (ob/ob) obese mice, and in mice with diet-induced obesity, orexinergic neurons receive predom

258 tatively contributing to protection from the diet-induced obesity phenotype.

259 y robust to alter the effects of fibrates on diet-induced obesity phenotypes.

260 e long-term impact of transient peripubertal diet-induced obesity (ppDIO, induced between 4 and 10 we

261 oreover, betaine administration to mice with diet-induced obesity prevents the development of impaire

262 by increased intestinal permeability during diet-induced obesity promotes insulin resistance in mice

263 Male Long-Evans rats with diet-induced obesity received AGB implantation or sham s

264 iated downregulation of miR-34a in mice with diet-induced obesity reduced adiposity, improved serum p

265 zed to receive a CR, overweight-inducing, or diet-induced obesity regimen (n = 27/group).

266 Relative to the overweight and diet-induced obesity regimens, CR decreased body weight,

267 TTR-ASO treatment of mice with genetic or diet-induced obesity resulted in an 80-95% decrease in c

268 lantation of subcutaneous fat into mice with diet-induced obesity showed a loss of metabolic benefit

269 ific Fxr-null (Fxr(DeltaIE)) mice show lower diet-induced obesity, similar to tempol-treated wild-typ

270 In a rat model of breast cancer driven by diet-induced obesity, STAT3 blockade suppressed the CSC-

271 ficient (Mfge8(-/-)) mice are protected from diet-induced obesity, steatohepatitis and insulin resist

272 Moreover, this function of SphK1 in diet-induced obesity suggests a potential role for SphK1

273 Recent studies revealed that diet-induced obesity suppressed guanylin and uroguanylin

274 Our study indicates that, in diet-induced obesity, these circadian fluctuations in ga

275 We used a mouse model of maternal-diet induced obesity to define predictive correlations b

276 l of individual susceptibility to junk-foods diet-induced obesity to determine whether there are pre-

277 the current study, we used a mouse model of diet-induced obesity to identify putative cellular mecha

278 use models of a regular diet and of high-fat-diet-induced obesity to investigate the role of dietary

279 Maternal diet-induced obesity, together with androgen excess, aff

280 In a model of diet-induced obesity, Tregs from the visceral adipose ti

281 ssels as a basis for vascular dysfunction in diet-induced obesity via a mechanism involving type 2 pr

282 The effect of adjunctive diet-induced obesity was defined.

283 Here, a rat model of diet-induced obesity was used to explore changes in brai

284 Here, using a murine model of diet-induced obesity, we determined that obesity causes

285 he consequences of hepatic BIM deficiency in diet-induced obesity, we generated liver-specific BIM-kn

286 In a mouse model of diet-induced obesity, we show that adipose tissue macrop

287 and the metabolic complications of high fat diet-induced obesity were dependent on C1q.

288 ceptor 4 mutant mice (C3H/HeJ) with high-fat-diet-induced obesity were not protected against insulin

289 mice have increased food intake and greater diet-induced obesity when fed high-fat diet.

290 ptive response is the complete resistance to diet-induced obesity when POLG mice are placed on a high

291 In mice, diet-induced obesity, which decreases insulin sensitivit

292 ssions in the mutant pedigrees and mice with diet-induced obesity, which showed that each obesity mou

293 er show that loss of Sln predisposes mice to diet-induced obesity, which suggests that Sln-mediated N

294 pha in the MeA partially prevented mice from diet-induced obesity, while chemogenetic activation of S

295 ator (SRA) (SRAKO) are resistant to high fat diet-induced obesity with a phenotype that includes impr

296 Our findings suggest that the combination of diet-induced obesity with other risk factors may increas

297 ale mice results in protection from high fat diet-induced obesity, with a preferential loss of s.c. f

298 SRA(-/-) mice are resistant to high fat diet-induced obesity, with decreased fat mass and increa

299 duces WAT lipolysis in vivo but also reduces diet-induced obesity without affecting LPL activity.

300 ote tumorigenesis, we examined the effect of diet-induced obesity, without ongoing high fat diet, on