ライフサイエンスコーパス: dietary cholesterol

1 s, and its activity is strongly modulated by dietary cholesterol.

2 total animal fat, saturated animal fat, and dietary cholesterol.

3 ial LDL-cholesterol elevation from the added dietary cholesterol.

4 dex and a greater intake of total energy and dietary cholesterol.

5 the role of LXR alpha as the major sensor of dietary cholesterol.

6 2013 for prospective studies that quantified dietary cholesterol.

7 e in regulating the percentage absorption of dietary cholesterol.

8 turated and polyunsaturated fatty acids, and dietary cholesterol.

9 turated and monounsaturated fatty acids, and dietary cholesterol.

10 apoB-containing lipoproteins in response to dietary cholesterol.

11 m cholesterol levels that can be restored by dietary cholesterol.

12 ation of new fat cells upon overfeeding with dietary cholesterol.

13 d by SREBP2, which responds to reductions in dietary cholesterol.

14 t the normal stimulation of CETP activity by dietary cholesterol.

15 reduced and declined further upon feeding of dietary cholesterol.

16 onse that prevents absorption of biliary and dietary cholesterol.

17 energy), saturated fatty acids (14.2%), and dietary cholesterol (492 mg/d) were similar to amounts s

18 The mass of dietary cholesterol absorbed (mg/d per 100 g body weight

19 inversely correlated with the percentage of dietary cholesterol absorbed (r = -0.99, P < 0.0008).

20 A plot of total daily mass of dietary cholesterol absorbed versus the percentage by we

21 dose-dependent decrease in the percentage of dietary cholesterol absorbed.

22 and inversely correlated with the percentage dietary cholesterol absorption (r = -0.63, P < 0.0001).

23 apolipoprotein E (apoE) in the regulation of dietary cholesterol absorption and biliary cholesterol e

24 no significant suppression of the percentage dietary cholesterol absorption and increased gallbladder

25 y therefore throw light on regulation of net dietary cholesterol absorption and lead to an advancemen

26 there is a molecular pathway that regulates dietary cholesterol absorption and sterol excretion by t

27 tion and physical-chemical factors affecting dietary cholesterol absorption have been extensively inv

28 es have suggested phospholipid inhibition of dietary cholesterol absorption through the gastrointesti

29 The regulation of dietary cholesterol absorption was examined in C57BL/6 a

30 Circulating cholesterol is the balance among dietary cholesterol absorption, hepatic synthesis and se

31 sing hepatic Abcg5/8 expression and limiting dietary cholesterol absorption, T39 deficiency inhibits

32 as originally thought to be its mediation of dietary cholesterol absorption.

33 sporters to participate in the regulation of dietary cholesterol absorption.

34 se changes correlated with the percentage of dietary cholesterol absorption.

35 erol into the bile and suppressed percentage dietary cholesterol absorption.

36 esterol-lowering drug that blocks intestinal dietary cholesterol absorption.

37 tary triglyceride is necessary for efficient dietary cholesterol absorption.

38 Dietary cholesterol also caused an increase in biliary c

39 Addition of dietary cholesterol also increased atherosclerosis (P<0.

40 Dietary cholesterol also statistically significantly inc

41 estern diet will contain about 250-500 mg of dietary cholesterol and about 200-400 mg of non-choleste

42 iet will contain approximately 250-500 mg of dietary cholesterol and approximately 200-400 mg of non-

43 a, lose their ability to respond normally to dietary cholesterol and are unable to tolerate any amoun

44 Dietary cholesterol and bile acids, particularly UDCA, i

45 Dietary cholesterol and cholate produced discrete gene e

46 nse of biliary cholesterol secretion to high dietary cholesterol and contributes to cholesterol galls

47 t, SREBP-1c gene expression was increased by dietary cholesterol and decreased by cholesterol depleti

48 d by the ability of bile acids to solubilize dietary cholesterol and essential nutrients and to promo

49 94 reporting quantitative data on changes in dietary cholesterol and fat and corresponding changes in

50 To study the effects of dietary cholesterol and fat upon expression of the human

51 ere its expression is regulated by estrogen, dietary cholesterol and fat, and controls murine plasma

52 n diet, consistent with predictions based on dietary cholesterol and fat.

53 aceous glands have the capacity to sequester dietary cholesterol and fatty acids that may have import

54 as no association between egg consumption or dietary cholesterol and increased risk of incident T2D.

55 e in decreasing the percentage absorption of dietary cholesterol and increasing biliary cholesterol e

56 spectively examined the associations between dietary cholesterol and major fatty acids, and risk of P

57 Dietary cholesterol and monounsaturated and polyunsatura

58 Although eggs are important sources of dietary cholesterol and other nutrients, little is known

59 The positive relation between dietary cholesterol and serum total and low-density-lipo

60 mouse tissues in an LXR-dependent manner by dietary cholesterol and synthetic agonists for both LXR

61 he relative contributions of dietary fat and dietary cholesterol and their interaction on the develop

62 macrophage foam-cell formation, in absorbing dietary cholesterol, and in supplying cholesteryl esters

63 lgus monkeys, a species highly responsive to dietary cholesterol, and less responsive African green m

64 Pcsk9 expression is down-regulated by dietary cholesterol, and mutations in Pcsk9 have been as

65 ent a decline in dietary fat, saturated fat, dietary cholesterol, and serum cholesterol.

66 AT2 has an important role in the response to dietary cholesterol, and suggest that ACAT2 inhibition m

67 essure, smoking status, alcohol consumption, dietary cholesterol, and total calorie intake, a differe

68 These results suggest that, in response to dietary cholesterol, apoE may play a critical role in de

69 d here, intakes of saturated fatty acids and dietary cholesterol are generally positively correlated

70 AT2 with antisense oligonucleotides prevents dietary cholesterol-associated hepatic steatosis both in

71 aimed to establish a mouse model of reduced dietary cholesterol availability from maternal milk and

72 ic CYP39A1 mRNA do not change in response to dietary cholesterol, bile acids, or a bile acid-binding

73 cid synthesis, was elevated, unresponsive to dietary cholesterol, but repressed normally by dietary c

74 Second, we investigated whether dietary cholesterol caused an increase in brain choleste

75 s and females in this species responded to a dietary cholesterol challenge.

76 Dietary cholesterol consumption and intestinal cholester

77 and hepatic cholesterol levels to changes in dietary cholesterol content.

78 s paper, we elucidate the mechanism by which dietary cholesterol controls epithelial follicle stem ce

79 ontaining two large eggs per day with 581 mg dietary cholesterol/d also raised LDL- and HDL-cholester

80 aining 300 g shrimp/d, which supplied 590 mg dietary cholesterol/d, significantly increased low-densi

81 to compare the effect of an equal amount of dietary cholesterol derived from shrimp or egg on the pl

82 Dietary cholesterol did not statistically significantly

83 ough our data confirm previous findings that dietary cholesterol does not directly affect cholesterol

84 that inhibition of hepatic ACAT2 can prevent dietary cholesterol-driven hepatic steatosis in mice.

85 ene expression was not altered by changes in dietary cholesterol flux.

86 In contrast, increasing dietary cholesterol from 0.02% to 0.5% in C57BL/6 apoE k

87 Increasing dietary cholesterol from 0.02% to 0.5% in C57BL/6 wild-t

88 We show that dietary cholesterol had an adverse effect on memory reca

89 Furthermore, dietary cholesterol had comparable effects on total plas

90 Dietary cholesterol has been suggested to increase the r

91 al data and animal studies, both obesity and dietary cholesterol have been associated with coronary a

92 The hamster metabolizes and transports dietary cholesterol in a similar manner to humans, with

93 These findings emphasize the safety of dietary cholesterol in inflammatory diseases and point t

94 PCSK9 expression is regulated by dietary cholesterol in mice and cellular sterol levels i

95 newborn mice and decreases the absorption of dietary cholesterol in surviving adults.

96 D36 KO exhibited significant accumulation of dietary cholesterol in the intestinal lumen at the end o

97 Absorption of dietary cholesterol in the proximal region of the intest

98 protein (NPC1L1) mediates the absorption of dietary cholesterol in the proximal region of the intest

99 reduced low-density lipoprotein response to dietary cholesterol in the setting of a moderate fat int

100 n, BMI, dietary intervention (in girls), and dietary cholesterol (in boys) were significant in determ

101 However, in both Het and Tg+KO mice, dietary cholesterol increased bile acid pool size (36% a

102 We confirmed previous findings that dietary cholesterol increased mouse Cyp7a1 activity in H

103 Whereas in wild-type mice, the increase in dietary cholesterol increased the hepatic excretion of b

104 However, whether dietary cholesterol increases inflammatory marker levels

105 Dietary cholesterol induced a significant 3-fold increas

106 Specifically we found that: 1) high dietary cholesterol induces aneuploidy in mice, satisfyi

107 ignaling pathway, combined with decreases in dietary cholesterol, induces the regression of atheroscl

108 est expression in adrenal gland with partial dietary cholesterol induction of CETP mRNA and plasma ac

109 To determine whether dietary cholesterol influenced the phosphorylation state

110 Our model suggests that dietary cholesterol initiates intestinal inflammation in

111 Dietary cholesterol, insoluble fiber, body mass index, a

112 liver is the central organ that responds to dietary cholesterol intake and facilitates the release a

113 a 10 cigarette/d smoking habit, and reducing dietary cholesterol intake by 100 mg/d on average would

114 When dietary cholesterol intake is kept constant, some long-c

115 Dietary cholesterol intake was associated with the risk

116 ed age, smoking status, total energy intake, dietary cholesterol intake, percentages of energy obtain

117 Dietary fat and dietary cholesterol interact synergistically to induce t

118 About 50-60% of the dietary cholesterol is absorbed and retained by the norm

119 Approximately 50-60% of dietary cholesterol is absorbed and retained by the norm

120 A reduction in dietary cholesterol is recommended to prevent cardiovasc

121 The molecular mechanisms by which dietary cholesterol is trafficked within cells are poorl

122 Reduction in dietary cholesterol is widely recommended for the preven

123 When challenged with excess dietary cholesterol, Lats2-CKO mice manifested more seve

124 Increased dietary cholesterol led to significant reductions in bra

125 ated in the ACAT2(-/-) mice, irrespective of dietary cholesterol level.

126 r to induce equivalent hypercholesterolemia, dietary cholesterol levels were 50% lower than was fed t

127 ly correlated with daily cholesterol intake, dietary cholesterol mass absorption, and liver cholester

128 There are limited data that dietary cholesterol may worsen macrophage accumulation i

129 gnaling pathway protects the body from toxic dietary cholesterol metabolites, and, by extension, PXR

130 In multivariate regression models, dietary cholesterol (milligrams per 1000 kilocalories),

131 al fat (negative), saturated fat (negative), dietary cholesterol (negative), polyunsaturated fat (pos

132 However, the effect of dietary cholesterol on adipose tissue has not been widel

133 review summarizes current evidence regarding dietary cholesterol on adipose tissue macrophage accrual

134 We investigated the effect of increasing dietary cholesterol on bile acid pool sizes and the regu

135 In general populations, the effects of dietary cholesterol on blood cholesterol concentrations

136 The effects of dietary cholesterol on brain amyloid precursor protein (

137 The authors examine the effects of dietary cholesterol on CVD risk in healthy adults by usi

138 e useful to identify the relative effects of dietary cholesterol on CVD risk.

139 raw any conclusions regarding the effects of dietary cholesterol on CVD risk.

140 In the adult mouse, dietary cholesterol or colestipol induce cholesterol 7al

141 vels rise following increased consumption of dietary cholesterol or saturated and trans-monounsaturat

142 y dimorphic and do not change in response to dietary cholesterol or to changes in bile acid pool size

143 l conditions, including diabetes, feeding of dietary cholesterol, or statin treatment.

144 018 mmol/L for each 10 mg/4.2 MJ decrease in dietary cholesterol (P<.05).

145 atty acids; intake of complex carbohydrates; dietary cholesterol; plasma triacylglycerol; and age wer

146 ein kinase C delta with ATP, suggesting that dietary cholesterol reduced the expression of this prote

147 Thus, in Tg+KO mice, dietary cholesterol regulates bile acid pool size, fecal

148 Dietary cholesterol regulation of cholesterol 7alpha-hyd

149 These results challenge the notion that dietary cholesterol regulation of Cyp7a1 is a major dete

150 Tissue-specific expression and dietary cholesterol response of CETP mRNA were determine

151 C57BL/6 animals, feeding 0.02 to 1% (wt/wt) dietary cholesterol resulted in a dose-dependent decreas

152 olecular mechanisms regulating the amount of dietary cholesterol retained by the body, as well as the

153 olecular mechanisms regulating the amount of dietary cholesterol retained in the body as well as the

154 olecular mechanisms regulating the amount of dietary cholesterol retained in the body, as well as the

155 ium and intakes of total and animal protein, dietary cholesterol, saturated fats, and heme iron and h

156 f hepatic free cholesterol concentrations by dietary cholesterol, seen only in cynomolgus monkeys, re

157 Dietary cholesterol statistically significantly increase

158 Upon feeding, dietary cholesterol stimulates S6 kinase-mediated phosph

159 Dietary cholesterol supplementation improves systemic bi

160 Dietary cholesterol suppressed hepatic 3-hydroxy-3-methy

161 e significantly more responsive to change in dietary cholesterol than concentrations in children with

162 6 wild-type mice decreased the percentage of dietary cholesterol that is absorbed by 25%, and this de

163 the amount of endogenous biliary as well as dietary cholesterol that is retained, thereby influencin

164 In addition, at high levels of dietary cholesterol the mRNA encoding SREBP-2 declined a

165 mendations for total fat, saturated fat, and dietary cholesterol, the vast majority continued to exce

166 Dietary cholesterol therapy improved sterol profiles in

167 elate partly to a limited ability to convert dietary cholesterol to bile acid.

168 cilitates the delivery of significantly more dietary cholesterol to the liver than is the case in mal

169 ssion of NCoRDeltaID in mouse liver improves dietary cholesterol tolerance in an LXRalpha-independent

170 lipid infusion and significant reduction of dietary cholesterol transport into the lymph.

171 rption in the intestine, the primary site of dietary cholesterol uptake in humans, can have profound

172 ed a novel protein in C. elegans involved in dietary cholesterol uptake, which we have named ChUP-1.

173 1-like 1 gene NPC1L1, which is essential for dietary cholesterol uptake.

174 ntestinal cells have been shown to transport dietary cholesterol via apoB-independent pathways, such

175 Reduction in dietary cholesterol was achieved primarily by substantia

176 Dietary cholesterol was associated with statistically si

177 st differences occurring in situations where dietary cholesterol was elevated.

178 In a secondary analysis, dietary cholesterol was not associated with incident dia

179 Dietary cholesterol was not statistically significantly

180 The fractional absorption of dietary cholesterol was reduced by about 50%, and biliar

181 lator of the hypercholesterolemia induced by dietary cholesterol was studied.

182 Corresponding RRs (95% CIs) for dietary cholesterol were 1.00 (reference), 1.08 (0.84, 1

183 fat, saturated fat, polyunsaturated fat, and dietary cholesterol were observed from 1988-1994 to 2007

184 s of cholesterol and eggs, a major source of dietary cholesterol, with carotid intima-media thickness

185 s of cholesterol and eggs, a major source of dietary cholesterol, with the risk of cognitive decline