ライフサイエンスコーパス: dietary fat

1 ed nuts, or a control diet (advice to reduce dietary fat).

2 vs. white meat, and the interfering role of dietary fat.

3 eased energy intake and greater selection of dietary fat.

4 ring involved in the homeostatic response to dietary fat.

5 representing the direct storage pathway for dietary fat.

6 s secretion of CCK by I cells in response to dietary fat.

7 ated with higher intakes of total energy and dietary fat.

8 occurred with both unsaturated and saturated dietary fat.

9 k in their ability to absorb cholesterol and dietary fat.

10 consumption of >60 kcal x kg(-1) x d(-1) of dietary fat.

11 ic enzymes in order to control the uptake of dietary fat.

12 y acid profiles reflected the main source of dietary fat.

13 ion of endogenous cholesterol in response to dietary fat.

14 tegies to address the addictive potential of dietary fat.

15 g abnormalities may exist in the disposal of dietary fat.

16 c remodeling in hypoxia, but is prevented by dietary fat.

17 abdominal fat distribution were modified by dietary fat.

18 lipid deposition under conditions of excess dietary fat.

19 or extreme restriction in the consumption of dietary fat.

20 ave been implicated in the chemosensation of dietary fats.

21 bserved for palm oil compared with the other dietary fats.

22 ain differences in the metabolic handling of dietary fats.

23 Total dietary fat (34% of energy) and other macronutrients wer

24 ntestine, called lacteals, play key roles in dietary fat absorption and the gut immune response; howe

25 n of acylglycerols by DGAT1 is important for dietary fat absorption in the intestine.

26 triacylglycerol, a key process required for dietary fat absorption into the enterocytes of the small

27 Regulation of intestinal dietary fat absorption is critical to maintaining energy

28 drainage of interstitial fluids and reduced dietary fat absorption.

29 embrane bound acyltransferases implicated in dietary fat absorption.

30 association at the cellular membrane, blocks dietary fat-accelerated tumorigenesis in vivo Our findin

31 Dietary fat accumulates in lipid droplets or endolysosom

32 ate-limiting step in the transit of absorbed dietary fat across the enterocyte is the generation of t

33 , continuous access to an optional source of dietary fat (Ad Lib; n = 12), 1-h access to an optional

34 hat we previously reported following reduced dietary fat along with PEG-leptin and exendin-4 or FGF21

35 wild-type offspring under standard maternal dietary fat amounts to test the effects of low n-6/n-3 r

36 ROP (i.e., nontasters) like and consume more dietary fat and are prone to obesity.

37 nimals are remarkably efficient in absorbing dietary fat and assimilating this energy-dense nutrient

38 pidemiologic data on the correlation between dietary fat and breast cancer have been mixed, the Women

39 Epidemiologic studies of dietary fat and breast cancer risk are inconsistent, and

40 r prostate cancer with a special emphasis on dietary fat and carbohydrate intake for modulating progn

41 etes.In the present study, we tested whether dietary fat and carbohydrate intakes influenced the asso

42 weight loss, and this effect is dependent on dietary fat and carbohydrate intakes.

43 The associations between dietary fat and cardiovascular disease have been evaluat

44 dy is needed to clarify the relation between dietary fat and cataract risk.

45 present study, we have examined the role of dietary fat and cholesterol in the initiation and progre

46 Several lines of evidence suggest that dietary fat and cholesterol may play a role in the patho

47 Taken together, our data suggest that dietary fat and cholesterol play an important role in th

48 Hepatic and metabolic effects induced by dietary fat and cholesterol together were more than twic

49 and phospholipids, intestinal absorption of dietary fat and cholesterol, and gene expression were pe

50 variation in the response of serum LDL-C to dietary fat and cholesterol.

51 aimed to test the relative contributions of dietary fat and dietary cholesterol and their interactio

52 Dietary fat and dietary cholesterol interact synergistic

53 demiological evidence on the impact of total dietary fat and fat subtypes, measured pre- and/or postc

54 mediate the absorption of a major portion of dietary fat and fat-soluble vitamin esters.

55 nce, glucose tolerance, and tissue uptake of dietary fat and glucose were assessed.

56 Low intake of dietary fat and high intake of soy foods have been sugge

57 We hypothesized that, by examining dietary fat and its food sources classified according to

58 intracellular signaling pathway that senses dietary fat and leads to fat storage remains elusive.

59 maintenance, due to the constant exposure to dietary fat and mechanical strain, and efficient uptake

60 Earlier studies indicated that high dietary fat and obesity are associated with an increased

61 uscle, brain, spinal cord, and tongue, while dietary fat and overnight fasting had differential effec

62 o differential exposure duration and timing, dietary fat and phytoestrogen content, or lack of sophis

63 suggest that there is no association between dietary fat and prostate cancer risk.

64 on types of dietary fat than total amount of dietary fat and recommend replacing SFAs with unsaturate

65 The association between dietary fat and risk of prostate cancer was assessed by

66 The authors examined the associations of dietary fat and specific types of fat with risk of coron

67 e association between the amount and type of dietary fat and subsequent weight change (follow-up weig

68 nt association between the amount or type of dietary fat and subsequent weight change in this large p

69 erminant of energy metabolism in response to dietary fat and suggest that the inhibition of this enzy

70 2) has a crucial role in the assimilation of dietary fat and the accretion of body fat in mice.

71 The quality of dietary fats and carbohydrates consumed is more crucial

72 isk has renewed debate over the link between dietary fats and CHD.

73 n Heart Association presidential advisory on dietary fats and CVD reviews and discusses the scientifi

74 tive was to investigate associations between dietary fats and early kidney disease.

75 randial events involved in the absorption of dietary fats and the subsequent metabolism of diet-deriv

76 Ks in fat cell maturation, storage of excess dietary fat, and body weight (BW) gain, we studied a gen

77 ny changes in symptoms of anxiety, intake of dietary fat, and exercise behavior at a mean (+/-SD) of

78 associations between total fat, subtypes of dietary fat, and food sources rich in saturated fatty ac

79 toxin (lipopolysaccharides) that occurs with dietary fat, and oral IAP supplementation prevents as we

80 ria, but neither total nor other subtypes of dietary fat are associated with high albuminuria or eGFR

81 Dietary fats are important triggers of this process, ind

82 Dietary fats are not created equally, slight differences

83 ount and the type and source of prepregnancy dietary fats are related to risk of GDM.

84 in A-I, lipoprotein(a), and body weight when dietary fats are replaced with carbohydrates.

85 fficiently incorporates and rapidly secretes dietary fat as chylomicrons (lipoprotein particles compr

86 strongly implicates chronic inflammation and dietary fats as risk factors for cancer, the mechanisms

87 in regulating the absorption and storage of dietary fats, as well as in the development of obesity a

88 The authors examined the relation of dietary fat, assessed by repeated questionnaires, to inc

89 the animal-based diet support a link between dietary fat, bile acids and the outgrowth of microorgani

90 isingly, these mice absorb normal amounts of dietary fat but increase their energy expenditure.

91 Together these data show that dietary fats, by promoting changes in host bile acid com

92 Exogenous dietary fat can induce obesity and promote diabetes, but

93 ell established, it is still unclear whether dietary fat can modulate cancer risk in a predisposed po

94 luable to our understanding of the role that dietary fat can play in disease management and preventio

95 s context, an intriguing possibility is that dietary fats can incorporate into membrane lipids to reg

96 e cellular and molecular mechanisms by which dietary fat causes obesity and diabetes is of paramount

97 dy was to investigate how the differences in dietary fat composition affect survival and bacterial lo

98 how these effects may be altered by varying dietary fat composition and exercise.

99 an adipose tissue is affected differently by dietary fat composition and general overfeeding in a ran

100 Dietary fat composition can affect ectopic lipid accumul

101 The importance of dietary fat composition for ectopic fat storage in human

102 notype is however variable and influenced by dietary fat composition, with the APOE4 allele associate

103 metabolism and adapts rapidly to changes in dietary fat composition.

104 , genetic background (C57BL/6 vs. A/J mice), dietary fat concentration (27% vs. 5%), and time (2, 5,

105 In the mouth, dietary fat constituents such as mono- and diunsaturated

106 To test the hypothesis that parental dietary fat consumption during gestation and lactation i

107 bserve significant association between total dietary fat content and T2D (P-trend = 0.24), but intake

108 es to fuel interest in the potential role of dietary fat content in reducing breast cancer risk.

109 Dietary fat content probably influences both NAFLD and i

110 yl-CoAs derived from the diet, even when the dietary fat content was low.

111 Dietary fats could affect glucose metabolism and obesity

112 n = 12), 1-h access to an optional source of dietary fat daily (Daily; n = 12), or 1-h access to an o

113 over this approximately 6-week time period, dietary fats did not substantially affect responses to p

114 triglyceride lipase (PNLIP) is essential for dietary fat digestion in children and adults, whereas a

115 te functional PLRP2 and may have inefficient dietary fat digestion, particularly when breastfeeding i

116 bjective was to investigate abnormalities in dietary fat disposal in the pathogenesis of hypertriacyl

117 on of provitamin A carotenoids to vitamin A, dietary fat effects, and the effect of genotype on the a

118 In vivo, dietary fat emulsions contain fatty acids as a result of

119 ogenous lipid mediator that is released when dietary fat enters the small intestine.

120 Dietary fat exerts a potent stimulatory effect on feedin

121 he dose of beta-carotene, and the amounts of dietary fat, fiber, vitamin A, and other carotenoids in

122 nce in underreporting error was explained by dietary fat (g), BMI, and sex.

123 In addition to its high caloric density, dietary fat has a hyperphagic effect, in part as a resul

124 Although dietary fat has been associated with prostate cancer ris

125 Apart from being an important macronutrient, dietary fat has recently gained much prominence for its

126 Health effects of dietary fats have been extensively studied for decades.

127 atory evidence suggests a plausible role for dietary fat in breast cancer pathophysiology.

128 k is a material contributor of vitamin D and dietary fat in children.

129 interaction between APOA5 gene variation and dietary fat in determining plasma fasting TGs, remnant-l

130 Erk1 or Calhm1 genes impaired preference for dietary fat in mice.

131 Dietary fat in midlife has not been associated with brea

132 a statistically significant interaction with dietary fat in relation to WC and SAT (P-interaction = 0

133 uvenile gut, suggesting a potential role for dietary fat in shaping commensal microbial communities i

134 nt, some clarification regarding the role of dietary fat in T2D incidence could be provided.

135 Lipid absorption involves hydrolysis of dietary fat in the lumen of the intestine, followed by t

136 oportion of total energy intake derived from dietary fat in the symptomatic group was higher than tha

137 stasis, immune trafficking and absorption of dietary fats in the human body.

138 studies in adult and weanling rats show that dietary fat, in close association with circulating lipid

139 In conclusion, polyunsaturated dietary fat increased both survival and efficiency of ba

140 The dietary fat increased the bioaccessibility of capsaicin

141 r protein deleter mice, which fail to absorb dietary fat, increased in peroxisome proliferator activa

142 Here we show in mice that excess dietary fat induced MKP-1 overexpression in skeletal mus

143 d defects of DA and 5HT neurotransmission in dietary fat induced obese animals.

144 ts high in soy protein may help prevent high dietary fat-induced bone impairments; and the molecular

145 ion was markedly reduced in both genetic and dietary fat-induced obesity and diabetes.

146 of adipocyte LRP1 resulted in resistance to dietary fat-induced obesity and glucose intolerance.

147 on of PKCbeta expression could contribute to dietary fat-induced obesity and related disorders.

148 We sought to determine whether dietary fat-induced secretion of CCK is directly mediate

149 d glucose intolerance in genetic (db/db) and dietary fat-induced type 2 diabetic mice as well as in s

150 ses their recruitment and in the presence of dietary fat induces hepatosteatosis.

151 t type 2 diabetes for participants with high dietary fat intake >/=37% (GG vs. AA/AG, OR 2.36 [1.02-5

152 Dramatic changes in dietary fat intake (-61%; P<0.001 versus controls) and p

153 between the APOA5 rs964184 polymorphism and dietary fat intake (low compared with high) in the deter

154 and follow-up in anxiety symptoms (P=0.80), dietary fat intake (P=0.89), or exercise behavior (P=0.6

155 We assessed the relation of dietary fat intake (total, subtypes, and selected food s

156 There is growing evidence suggesting that dietary fat intake affects the development and progressi

157 ciations between total and specific types of dietary fat intake and 1) hormone concentrations and 2)

158 amined prospectively the association between dietary fat intake and cataract extraction in adult wome

159 study was to examine the association between dietary fat intake and CHD incidence in American Indians

160 previous studies on the association between dietary fat intake and coronary heart disease (CHD) inci

161 etary lipids and interaction effects between dietary fat intake and genetic variation on risk of GA.

162 eractions between APOE genotype and habitual dietary fat intake and modulations of fat intake on meta

163 f gamma-tocopherol was related positively to dietary fat intake and negatively to multivitamin use.

164 correlate with sugar intake, independent of dietary fat intake and obesity.

165 No significant differences in dietary fat intake and physical activity levels were not

166 ctive was to examine the association between dietary fat intake and semen quality among 701 young Dan

167 atal growth modifies the association between dietary fat intake and serum cholesterol concentration i

168 to examine the association between long-term dietary fat intake and the prevalence of age-related nuc

169 ine the relative contributions of changes in dietary fat intake and use of cholesterol-lowering medic

170 was a marker of total partially hydrogenated dietary fat intake and was not associated with outcomes

171 ndings suggest that enterostatin may inhibit dietary fat intake by blocking dopamine reuptake transpo

172 Excessive dietary fat intake causes systemic metabolic toxicity, m

173 As body mass index (BMI) and dietary fat intake differed between the groups (P < 0.05

174 High dietary fat intake has been associated with increased en

175 inconsistent epidemiologic evidence whether dietary fat intake is associated with future weight chan

176 Increasing dietary fat intake is expected to improve alpha-tocopher

177 In addition, dietary fat intake may also increase circulating adropin

178 Dietary fat intake may contribute to non-Hodgkin lymphom

179 long-term changes in energy expenditure, and dietary fat intake may modify the genetic effects.

180 The effect of change in dietary fat intake on concentrations of total cholestero

181 However, the short-term effect of dietary fat intake on the expression of these genes has

182 e, fruit, and fiber intake and a decrease in dietary fat intake reduces the risk of recurrent and new

183 Increased dietary fat intake results in high plasma levels of trig

184 In summary, manipulation of dietary fat intake shows promise in the prevention and t

185 for an increment of 5% of energy from total dietary fat intake was 0.98 (95% confidence interval: 0.

186 Dietary fat intake was estimated with the use of country

187 had the greatest liver tumor incidence while dietary fat intake was not associated with tumorigenesis

188 Dietary fat intake was significantly lower in the dietar

189 ostatin, an endogenous pentapeptide inhibits dietary fat intake when administered peripherally and ce

190 here was little evidence for associations of dietary fat intake with NHL overall or by subtype.Previo

191 Oral sensory signals drive dietary fat intake, but the neural mechanisms underlying

192 differences were attributable to changes in dietary fat intake, physical activity levels, or statin

193 coneogenesis that is elevated by obesity and dietary fat intake.

194 ted whether this association was modified by dietary fat intake.

195 is association was modified by adiposity and dietary fat intake.

196 t and vegetables, sodium intake, energy, and dietary fat intake.

197 cular disease (CVD) prevention than is total dietary fat intake.

198 ariant and glucose tolerance is modulated by dietary fat intake.

199 NHL risk associated with total and specific dietary fat intake.We evaluated associations within the

200 se homeostasis; however, studies on habitual dietary fat intakes and gestational diabetes mellitus (G

201 rformed with semen variables as outcomes and dietary fat intakes as exposure variables, adjusted for

202 dium intakes with BP and of added sugars and dietary fat intakes with blood lipids.

203 fat diet group (P = 0.02), although the gene-dietary fat interaction became nonsignificant (P = 0.30)

204 we found statistically significant genotype-dietary fat interaction on the change in total abdominal

205 Genotype-dietary fat interaction was also examined.

206 wer risk.In a Mediterranean trial focused on dietary fat interventions, baseline intake of saturated

207 However, entry of dietary fat into the circulation occurs at a reduced rat

208 The absorption of dietary fat involves the re-esterification of digested t

209 ntake is normal in MGAT2-deficient mice, and dietary fat is absorbed fully.

210 sity and associated metabolic disorders when dietary fat is abundant.

211 anisms underlying oro-gustatory detection of dietary fat is critical for the prevention and treatment

212 important for fatty acid esterification when dietary fat is in excess.

213 nexposed F4 male descendants to obesity when dietary fat is increased.

214 ovascular disease events, and the quality of dietary fat is known to influence serum concentrations o

215 absorption and extraintestinal metabolism of dietary fat is less clear.

216 The absorption of dietary fat is of increasing concern given the rise of o

217 erweight or obese and consume a diet high in dietary fat, it is critical to examine the consequences

218 Excessive intake of dietary fats leads to diminished brain dopaminergic func

219 ntestinal ultrastructure was not affected by dietary fat level or probiotic inclusion.

220 modified the oxidation of the 2 most common dietary fats, likely through a better trafficking and up

221 various equations suggested that changes in dietary fat made minimal contributions to the observed t

222 sitivity of fasting triglycerides and CRP to dietary fat manipulation in those with an APOE3/E4 genot

223 The response of plasma lipids to dietary fat manipulation is highly heterogeneous, with s

224 rmine the plasma long-chain PUFA response to dietary fat manipulation.

225 Dietary fat may affect lens cell membrane composition an

226 diture (REE) have suggested that the type of dietary fat may alter energy expenditure (EE).

227 hese findings reveal new mechanisms by which dietary fat may alter mesolimbic circuit function and re

228 ory and novelty-seeking behaviors induced by dietary fat may be mediated by enhanced nicotinic cholin

229 Dietary fats may be proinflammatory.

230 al studies have suggested that the intake of dietary fat might be a contributing factor in the etiolo

231 It is not known how dietary fats might directly affect arterial LDL-CE uptak

232 bolic complications responded differently to dietary fat modification, being more susceptible to a he

233 However, little is known about whether dietary fat modulates this association.

234 include vitamin D insufficiency, unhealthful dietary fat, obesity, increased hygiene, and the timing

235 ntial mechanism for the extensive effects of dietary fat on health and disease.

236 ines response to the quantity and quality of dietary fat on MetS risk factors, which suggests that ta

237 c alterations in the quality and quantity of dietary fat on MetS risk factors.

238 12), or 1-h access to an optional source of dietary fat on Monday, Wednesday, and Friday (MWF; n = 1

239 t-induced obesity to investigate the role of dietary fat on myofibroblast differentiation in the mamm

240 en the CETP TaqIB polymorphism and intake of dietary fat on plasma HDL concentration.

241 This study evaluated the effect of dietary fat on prostate cancer development by using the

242 We studied the influence of the amounts of dietary fat on the effectiveness of carotene-rich plant

243 effect of substituting PO for other primary dietary fats on blood lipid-related markers of coronary

244 Dietary fat overconsumption leads to myocardial lipid ac

245 We did not detect a change in labeled dietary fat oxidation after 6 mo of CLA supplementation

246 Dietary fat oxidation as a percentage of fat consumed wa

247 expenditure, macronutrient utilization, and dietary fat oxidation in overweight adults after 6 mo of

248 Dietary fat oxidation was determined from the percentage

249 Dietary fat oxidation was measured by using stable isoto

250 expenditure (AEE) is a major determinant of dietary fat oxidation, which is a central component of f

251 This study explored 2 major dietary fats, palmitate and oleate, in supporting endoge

252 Our data do not support the idea that dietary fat per se promotes ectopic adiposity and cardio

253 The response to dietary fat plays a key role in metabolic health.

254 wild-type mice on food intake, body weight, dietary fat preference, and glucose tolerance.

255 Dietary fat promotes pathological insulin resistance thr

256 rs9364628, showed moderate interaction with dietary fat quality and a consistent direction of effect

257 Dietary fat quality and fat replacement are more importa

258 esults support dietary guidelines to improve dietary fat quality by replacing intake of SFAs with n-6

259 Dietary fat quality may influence skeletal muscle lipid

260 However, the impact of dietary fat quality on brain function, behavior, and sle

261 sible interaction between PARK2 variants and dietary fat quality on serum LDL-cholesterol concentrati

262 ify the variation in serum lipid response to dietary fat quality.

263 ruitment approach to determine the effect of dietary fat quantity and composition on both lipid and n

264 Dietary fat (r = 0.643, P = 0.004), carbohydrate (r = -0

265 We conclude that dietary fat reduction delays transition from mPIN to inv

266 age breast cancer tested the hypothesis that dietary fat reduction would increase the relapse-free su

267 tween quintiles of total fat and subtypes of dietary fat (saturated, monounsaturated, polyunsaturated

268 To date, dietary fats seem to be most promising and have been the

269 onoenoic and dienoic fatty acid component of dietary fat selectively initiates endocannabinoid mobili

270 At 6 months, dietary fat significantly modified genetic effects on ch

271 Ingestion of dietary fat stimulates production of the small-intestina

272 that spillover, a measure of inefficiency in dietary fat storage, is inversely associated with lower

273 iacin provides a model for acutely improving dietary fat storage, perhaps by suppressing lipolysis in

274 t source of FFA and reflects inefficiency in dietary fat storage.

275 with a severely impaired pathway for direct dietary fat storage.

276 a diet with rice bran oil (1/3 of the total dietary fat) substituted for an oil blend that had a fat

277 objectives were to assess whether intakes of dietary fat, subtypes of fat, and fat from animal produc

278 other as well as facilitates the clearing of dietary fats, such as triglycerides, from the blood.

279 Americans place greater emphasis on types of dietary fat than total amount of dietary fat and recomme

280 ese patients, prior to bypass, ingest excess dietary fat that can produce hyperphagic steatorrhea.

281 rats to identify fatty-acid constituents of dietary fat that might be responsible for triggering sma

282 ycerides (TGs) are the major transporters of dietary fats throughout the bloodstream.

283 l absorption can be modulated by structuring dietary fat to modulate postprandial lipemia and lipid b

284 aimed to motivate and support reductions in dietary fat, to increase consumption of vegetables and f

285 There was no significant association between dietary fat (total, saturated, monounsaturated, and poly

286 n apparently results in more partitioning of dietary fat toward energy dissipation rather than toward

287 uggest that IMCL content is not modulated by dietary fat type but by total fat intake and that reduci

288 A study was undertaken to relate dietary fat types to cognitive change in healthy communi

289 s studied in the absence and presence of two dietary fat types.

290 The proportion of dietary fat uptake into the three depots did not differ

291 cells led to lacteal regression and impaired dietary fat uptake.

292 cholesterol responses to the manipulation of dietary fat vary widely between persons.

293 Dietary fat was assessed by repeated food frequency ques

294 Until recently, dietary fat was considered to be tasteless, and its prim

295 es are dynamically modulated by the types of dietary fat we consume.

296 HDL intravascular processing attributable to dietary fat were small.

297 0 y of follow-up, neither total nor specific dietary fats were significantly associated with NHL risk

298 rred when PO was substituted for the primary dietary fats, whereas only favorable changes occurred wh

299 associated with either measure of BP nor was dietary fat with blood lipids.

300 This review explores what happens to dietary fat within the enterocyte.