ライフサイエンスコーパス: dietary restriction

1 therefore does not explain the responses to dietary restriction.

2 athways that reveal a more genetic basis for dietary restriction.

3 ing full feeding and limits fecundity during dietary restriction.

4 p-7 and cup-4 mediate longevity increases by dietary restriction.

5 pan in Caenorhabditis elegans in response to dietary restriction.

6 n-like growth factor 1 (IGF-1) signaling and dietary restriction.

7 lterations in the insulin/IGF pathway and by dietary restriction.

8 ht/obese subjects undergoing weight-loss via dietary restriction.

9 anisms associated with lifespan extension by dietary restriction.

10 y reverse the longevity-extending effects of dietary restriction.

11 fasting (ADF) represent 2 different forms of dietary restriction.

12 ould increase with leptin administration and dietary restriction.

13 te can sometimes be altered, for example, by dietary restriction.

14 a possible link between the TOR pathway and dietary restriction.

15 greater increase in longevity in response to dietary restriction.

16 dy mass index, presumably indicating greater dietary restriction.

17 male SENCAR mice made vitamin A deficient by dietary restriction.

18 B6C3F1 mice are eliminated by apoptosis with dietary restriction.

19 ng protein-2 levels, a pattern suggestive of dietary restriction.

20 daptation to maintain barrier immunity under dietary restriction.

21 on in fly fat body cells that was delayed by dietary restriction.

22 This may operate by a mechanism similar to dietary restriction.

23 c progression that was further attenuated by dietary restriction.

24 a key metabolite that mediates longevity by dietary restriction.

25 onsistent gene expression changes induced by dietary restriction.

26 of long-lived eat-2 mutant worms, a model of dietary restriction.

27 germline signalling, sensory perception, or dietary restriction.

28 ons, including mitochondrial dysfunction and dietary restriction.

29 m line largely insensitive to the effects of dietary restriction.

30 echanism by which SIRT3 regulates IDH2 under dietary restriction.

31 may cause confusion and lead to unnecessary dietary restrictions.

32 use it has prognostic implications and eases dietary restrictions.

33 00 g peas each week for 12 wk, with no other dietary restrictions.

34 augmented in the livers of mice subjected to dietary restriction, a known longevity-extending regimen

35 Dietary restriction, a potent intervention associated wi

36 Dietary restriction activates skn-1 in these two neurons

37 However, whether and how dietary restriction affects hematopoietic malignancies i

38 s indicate that peptone deprivation mediated dietary restriction affects lifespan in C. elegans in a

39 sing various aspects of calorie restriction, dietary restriction, aging, longevity, life span, adipos

40 associated with insulin/IGF-1 signaling and dietary restriction allow us to understand longevity fro

41 Dietary restriction alone, similar to topical steroids,

42 Dietary restriction also increases life span and protect

43 Interestingly, dietary restriction also increases numbers of newly-gene

44 esembles the anti-ageing response induced by dietary restriction (also known as caloric restriction).

45 on with adequate nutrition (CRON) or without dietary restrictions (AMER).

46 We show that overall dietary restriction and amino acid deprivation cause ger

47 ism whereby cognitive stimulation, exercise, dietary restriction and antidepressant drugs preserve br

48 cifically required for lifespan extension by dietary restriction and by modulation of the TORC1 pathw

49 interleukin-6 were significantly reduced by dietary restriction and correlated with adipose interleu

50 In rodents, both dietary restriction and decreased nutrient-sensing pathw

51 agents that mimick the beneficial effects of dietary restriction and exercise.

52 If this were the case, long life under dietary restriction and high fecundity under full feedin

53 e mechanisms for mediating life extension by dietary restriction and hormesis.

54 longevity by a mechanism distinct from both dietary restriction and insulin-like signaling.

55 triction in Drosophila mimicks the effect of dietary restriction and is associated with decreased rep

56 s that coordinate the organismal response to dietary restriction and maintain homeostasis when nutrie

57 Treatment requires life-long dietary restriction and monitoring of branched-chain ami

58 studies involving exercise training without dietary restriction and no weight loss demonstrate that

59 ssential enzyme and are currently treated by dietary restriction and other strategies to replace the

60 ith physiological metabolic stress caused by dietary restriction and profoundly suppressed leukemogen

61 Dietary restriction and reduced activity of nutrient-sen

62 understanding of the molecular mechanism of dietary restriction and suggest a role for counterintuit

63 gh prevalence of anxiety before the onset of dietary restriction and support proposals that in AN, CR

64 ges were the only cell population reduced by dietary restriction and that CD11c/CD206 (M2-type) and C

65 ns, show that NAE abundance is reduced under dietary restriction and that NAE deficiency is sufficien

66 were compared between patients treated with dietary restriction and those that received topical ster

67 Fibrosis resolved following both dietary restriction and topical steroids (3/17 and 5/9 p

68 ified in 65% to 85% of the patients, so some dietary restrictions and endoscopies after food challeng

69 Numerous dietary restrictions and endoscopies limit the implement

70 ntake, which may be reinforced by prescribed dietary restrictions and inadequate monitoring of the pa

71 The lack of effectiveness of dietary restrictions and restrictions regarding social c

72 s, encompass an array of strategies (such as dietary restrictions and supplementations) aimed at opti

73 determinant of the sensitivity of tumours to dietary restriction, and activating mutations in the pat

74 ctively, the available data suggest the that dietary restriction, and physical and mental activity, m

75 The lower side effect burden, lack of dietary restrictions, and ease of use of venlafaxine and

76 Dietary restriction appears to act as a general non-gene

77 -4 in lifespan determination is specific for dietary restriction, because it is not required for the

78 or lactation, use of soy products, or infant dietary restrictions beyond 4-6 months has any effect on

79 span of the eat-2 mutant, a genetic model of dietary restriction, but has no effect on the life span

80 Other studies indicate that prolonged dietary restriction can attenuate many of the detrimenta

81 Even short-term dietary restriction can negatively impact physical activ

82 Severe dietary restriction, catabolic states and even short-ter

83 Adding essential amino acids to the dietary restriction condition increased fecundity and de

84 Compared with ad libitum feeding, dietary restriction consistently extends lifespan and de

85 opsies from individuals who underwent modest dietary restriction coupled with exercise also display s

86 Calorie or dietary restriction (CR) has attracted attention because

87 y decades of animal experiments showing that dietary restriction delays the aging process and decreas

88 Dietary restriction delays the incidence and decreases t

89 Very short-term caloric and saturated fat dietary restrictions do not lead to the same changes in

90 Dietary restriction does not affect a PTEN-null mouse mo

91 Intestinal FMO-2 is also activated by dietary restriction (DR) and is necessary for DR-mediate

92 Dietary restriction (DR) can extend lifespan and might i

93 in insulin/IGF signaling (IIS) pathways and dietary restriction (DR) can extend lifespan in model or

94 Although dietary restriction (DR) can increase lifespan and reduc

95 o activate DAF-16 (FOXO orthologue) or mimic dietary restriction (DR) effects, but selectively induce

96 Dietary restriction (DR) extends lifespan in multiple sp

97 e retarded when the mice are maintained on a dietary restriction (DR) feeding regimen resulting in an

98 nging from humans to Caenorhabditis elegans, dietary restriction (DR) grants numerous benefits, inclu

99 Dietary restriction (DR) has been shown to increase life

100 Dietary restriction (DR) has been shown to prolong longe

101 Dietary restriction (DR) improves health, delays tissue

102 ke growth factor I (IGF-I) is lowered during dietary restriction (DR) in both humans and rats.

103 ositive regulator of lifespan in response to dietary restriction (DR) in Caenorhabditis elegans.

104 Dietary restriction (DR) increases life-span in organism

105 Dietary restriction (DR) is a metabolic intervention tha

106 Dietary restriction (DR) is a well-established means of

107 Dietary restriction (DR) is a widely conserved intervent

108 This increase in longevity by dietary restriction (DR) is coupled to profound benefici

109 Lifelong dietary restriction (DR) is known to decrease spontaneou

110 Dietary restriction (DR) is the most effective environme

111 Dietary restriction (DR) reduces oxidative stress in sev

112 Dietary restriction (DR) without malnutrition encompasse

113 Dietary restriction (DR), a moderate reduction in food i

114 Dietary restriction (DR), a reduction in food intake wit

115 sm through brief restriction of food intake (dietary restriction, DR) prevents neuropathology in expe

116 erm 20 to 40% restriction in calorie intake (dietary restriction, DR), whose effects on cancer progre

117 Short-term dietary restriction drastically improved the survival ou

118 Dietary restriction elicits a genetically programmed res

119 This demonstrates that dietary restriction elicits robust compensatory changes

120 The mechanisms through which dietary restriction enhances health and longevity in div

121 Dietary restriction extends healthy lifespan in diverse

122 How dietary restriction extends life span may involve antici

123 Dietary restriction extends lifespan and retards age-rel

124 Dietary restriction extends longevity in diverse species

125 Dietary restriction extends the lifespan of numerous, ev

126 Mice were subjected to 40% dietary restriction for 3 weeks followed by induction of

127 pies are now established treatments, namely, dietary restriction for phenylketonuria and miglustat fo

128 Dietary restriction has been shown to have several healt

129 and the pathway that mediates the effects of dietary restriction have evolved to respond to the nutri

130 g insulin-like signaling and the response to dietary restriction, identified the cellular machineries

131 cytes, are required for life extension under dietary restriction in C. elegans.

132 espan extension induced by a novel method of dietary restriction in C. elegans.

133 rnal hatching, a phenotype closely linked to dietary restriction in C. elegans.

134 g the responses of lifespan and fecundity to dietary restriction in Drosophila.

135 Short-term dietary restriction in humans does appear to have benefi

136 lternate-day fasting is a feasible method of dietary restriction in nonobese humans and whether it im

137 netic requirements for lifespan extension by dietary restriction in the nematode Caenorhabditis elega

138 e, a universal cellular energy generator and dietary restriction in the regulation of organismal life

139 c1(/-) mice closely resembled the effects of dietary restriction in wild-type animals.

140 the role of oxalate, salt and animal protein dietary restrictions in the prevention of calcium stone

141 greatly inhibited in eat-2 worms, a model of dietary restriction, in daf-16/FOXO, sir-2.1, rsks-1 (ri

142 he role of environmental factors, other than dietary restriction, in developmental reprogramming thro

143 We found that dietary restriction increased fly lifespan independently

144 n ob/ob mice, both leptin administration and dietary restriction increased G5 and G8 protein and bili

145 Furthermore, dietary restriction increased lifespan without increasin

146 brought about by administration of leptin or dietary restriction increases biliary cholesterol excret

147 Prolonged dietary restriction increases the life span in rodents.

148 Reduced food intake as a result of dietary restriction increases the lifespan of a wide var

149 Dietary restriction increases the longevity of many orga

150 osapentaenoyl ethanolamide not only inhibits dietary-restriction-induced lifespan extension in wild-t

151 To determine whether dietary restriction induces apoptosis in GST-II-positive

152 Our results indicate a mechanism by which dietary restriction influences physiology and aging.

153 chanism underlying the beneficial effects of dietary restriction involves stimulation of the expressi

154 Dietary restriction is a robust means of extending adult

155 Thus, the conservation of copper during dietary restriction is highly organ specific.

156 Dietary restriction is limited in advanced stages of CKD

157 Dietary restriction is the most widely used intervention

158 In yeast, span extension from dietary restriction is thought to be mediated by the hig

159 interaction between nutrition and longevity, dietary restriction is typically based on medium dilutio

160 Dietary restriction largely prevented this declining tra

161 tion and suggest a role for counterintuitive dietary-restriction-like therapy for human progeroid gen

162 Dietary restriction long term does, however, have detrim

163 addressed in this article is whether or not dietary restriction long term is feasible or beneficial

164 trate a role for RNA splicing homeostasis in dietary restriction longevity and suggest that modulatio

165 The neurotrophic factors induced by dietary restriction may protect neurons by inducing the

166 y is sufficient to extend lifespan through a dietary restriction mechanism requiring PHA-4.

167 ning both gene mutations that interfere with dietary restriction-mediated lifespan extension and cons

168 -4 and SKN-1, miRNAs transduce the effect of dietary-restriction-mediated lifespan extension in C. el

169 st, consistent with action of this drug as a dietary restriction mimetic.

170 way may influence the response of cancers to dietary restriction-mimetic therapies.

171 Three reported dietary restriction mimetics are mainly effective across

172 Developing dietary restriction mimetics targeting energy metabolism

173 Upon dietary restriction, MLL-AF9-induced murine acute myeloi

174 We developed a novel dietary restriction model in the rat that allows us to s

175 Like DR (dietary restriction), modulation of genes in the insulin

176 l on a fasting day may make this approach to dietary restriction more acceptable.

177 Here we report that a dietary restriction of 30% tripled the median and maxima

178 Moreover, dietary restriction of AGE is an effective and feasible

179 aintain their weight loss, including greater dietary restriction of fat and higher physical activity

180 BACKGROUND & AIMS: Dietary restriction of fermentable carbohydrates (a low

181 In celiac disease, the dietary restriction of gluten is curative of the intesti

182 induced in 12 healthy adult men and women by dietary restriction of phylloquinone (40 microg/d, days

183 rsed the effects of minidose warfarin and of dietary restriction of phylloquinone on hemostasis and v

184 The increased survival following dietary restriction of serine and glycine in these model

185 The life-extending effect of dietary restriction on ageing in Drosophila has also bee

186 pathways and likely mediates the effects of dietary restriction on aging.

187 anner that may overlap with known effects of dietary restriction on longevity.

188 e to flies in holidic medium and, similar to dietary restriction on oligidic food, amino acid dilutio

189 The impact of dietary restriction on physiologic function in humans is

190 es have shown that the beneficial effects of dietary restriction on the brain result in part from inc

191 hought to be a chronic illness that requires dietary restriction or chronic medical therapy.

192 Here we demonstrate that under conditions of dietary restriction or growth factor starvation, where P

193 irect role for endocannabinoid signalling in dietary restriction or lifespan determination has yet to

194 are achieved without developing significant dietary restrictions or clinical metabolic or nutritiona

195 gned to receive either conventional therapy (dietary restriction) or intensive therapy (either sulfon

196 Although insulin/IGF-1 signaling and dietary restriction pathways are currently viewed as bei

197 Dietary restriction per se is unlikely to emerge as a fe

198 f gammaH2AX DNA damage foci, indicating that dietary restriction preserves genome function by allevia

199 Our study also showed that dietary restriction prevented the age-related increase i

200 tants (insulin/insulin-like growth factor-1, dietary restriction, protein translation, mitochondrial

201 eir side effects and prescription-associated dietary restrictions reduce their suitability as a first

202 al models of these disorders have shown that dietary restriction (reduced calorie intake or intermitt

203 Our recent studies have shown that dietary restriction (reduced calorie intake) can increas

204 Genetic epistasis analyses suggest that dietary restriction, reduced 60S subunit abundance, and

205 Dietary restriction reduces gut pathology in aging femal

206 otypes in which peptone deprivation mediated dietary restriction reduces lifespan.

207 epithelial carcinogenesis and this method of dietary restriction reduces many circulating proteins, i

208 A dietary restriction regimen, known to extend life span,

209 associated with the salutary effects of this dietary restriction regimen.

210 intermittent fasting (alternate-day fasting) dietary-restriction regimen their overall food intake is

211 Dietary restriction regimens, including fasting, have be

212 ver, the mechanisms underlying the effect of dietary restriction remain elusive.

213 However, the degree of dietary restriction required to achieve success may be q

214 cancer cell line, is sufficient to convert a dietary-restriction-resistant tumour into one that is di

215 Cancer cells that form dietary-restriction-resistant tumours carry mutations th

216 The dietary restriction response in Ercc1(/-) mice closely r

217 Mice undergoing dietary restriction retained 50% more neurons and mainta

218 Treatments such as enriched environment, dietary restriction, running and anti-depressants increa

219 with few food triggers, avoiding unnecessary dietary restrictions, saving endoscopies, and shortening

220 estriction-resistant tumour into one that is dietary-restriction-sensitive.

221 These data suggest that dietary-restriction stimulates NPY release resulting in

222 anisms such as yeast and rodents is reduced (dietary restriction), they live longer than organisms fe

223 E9 to E12 must be included within the 9-day dietary restriction to yield the expanded field.

224 Dietary restrictions to control serum phosphorus, which

225 extension observed in wild-type N2 worms by dietary restriction using bacterial dilution is prevente

226 e-mRNA splicing with age that are reduced by dietary restriction via splicing factor 1 (SFA-1; the C.

227 d old animals fed ad libitum or subjected to dietary restriction, we find defects in global pre-mRNA

228 FOB tests were not rehydrated and dietary restrictions were imposed only for retesting bor

229 endent delay in anaphase onset, and inducing dietary restriction when the checkpoint is impaired incr

230 ghly sensitive to the anti-growth effects of dietary restriction, whereas others are resistant.

231 A dietary restriction which exceeds the limited capability

232 such as reduced insulin/IGF-1 signaling and dietary restriction, which are critical in determining t

233 to recapture the full potential benefits of dietary restriction, which humans can find difficult to

234 Dietary restriction, which is known to retard aging and

235 Dietary restriction, which reduces the level of insulin-

236 ssible to obtain the benefits to lifespan of dietary restriction without incurring a reduction in fec

237 his relation is of concern and suggests that dietary restrictions without attention to a possible res

238 The best avenue for humans to benefit from dietary restriction would be for pharmacological or bioa

239 y, we tested whether the loss of fat mass by dietary restriction would remove the major source of the