ライフサイエンスコーパス: differentially methylated region

1 cant loss in the DNA methylation of the Peg3 differentially methylated region.

2 We generated mice with deletion of the 1A differentially methylated region.

3 and/or tumors the 5'-CpG island of LOT1 is a differentially methylated region.

4 1 and H3K9me3 binding were detected on their differentially methylated regions.

5 n primary and cancer cells revealed multiple differentially methylated regions.

6 .59 x 10(-6)) and CD8(+) (P = 2.10 x 10(-8)) differentially methylated regions.

7 We term these sequences gDMRs, for germline differentially methylated regions.

8 s cell carcinoma (OPSCC) samples to identify differentially methylated regions.

9 2R, could be associated with the neighboring differentially methylated regions.

10 rdant for alcohol use disorder and validated differentially methylated regions.

11 rmation among colocalized probes to identify differentially methylated regions.

12 ombines MeDIP-seq and MRE-seq data to detect differentially methylated regions.

13 and the epigenetically regulated silencer at differentially methylated region 1 (DMR1) of Igf2.

14 2/H19 imprinting control region (ICR), Igf2r differentially methylated region 2 (DMR2) and bacterial

15 eterm infants have altered 5mC at the linked differentially methylated region 2 (DMR2) of IGF2 and th

16 The differentially methylated region 2 of Igf2 was hypermeth

17 r reporter assays, revealed that within this differentially methylated region, a single CpG dinucleot

18 In particular, statistical identification of differentially methylated regions across different condi

19 These data suggest that the 2-kb differentially methylated region acts as a key regulator

20 els across CpG islands and a large number of differentially methylated regions adjacent to genes whic

21 We identify aging-associated differentially methylated regions (aDMRs) in whole blood

22 These age-associated differentially methylated regions also show marked enric

23 een promoter-proximal elements including the differentially methylated region and downstream elements

24 e, we report characterization of the WT1 ARR differentially methylated region and show that it contai

25 ile also introducing new methods for calling differentially methylated regions and detecting copy num

26 pression, respectively (P < 2.8 x 10(-6) for differentially methylated regions and P < 7.8 x 10(-10)

27 e genome-wide methylome analysis results for differentially methylated regions and their potential ef

28 Differentially methylated regions are hypomethylated and

29 ree DNA reveal many of the 51,259 identified differentially methylated regions are located in domains

30 offspring hippocampal DNA methylation showed differentially methylated regions as a result of both ME

31 Here, we characterize a differentially methylated region associated with the mou

32 d between-group analyses identified numerous differentially methylated regions associated with ASD.

33 omoter, and a decrease of DNA methylation in differentially-methylated regions associated with the Le

34 onstrate that deletions of a small noncoding differentially methylated region at 16q24.1, including l

35 ly derived targeted deletion of the germline differentially methylated region at exon 1A abolishes ti

36 The results establish that the differentially methylated region at exon 1A contains an

37 A differentially methylated region at the Ascl1 promoter,

38 plied to any biological settings to identify differentially methylated regions at the genomic scale.

39 olution genome-wide profiling, we identified differentially methylated regions between control and Dn

40 se methods differ in their ability to detect differentially methylated regions between pairs of sampl

41 ength in circulating cell-free DNA, identify differentially methylated regions between sample groups,

42 ) display epigenomic reprogramming with many differentially-methylated regions, both hypermethylated

43 n start site and mapped a cell-type-specific differentially methylated region bracketing the Bcl11b p

44 Methylation of differentially methylated regions can be restored coinci

45 hylomes identified 101,466 cancer-associated differentially methylated regions (cDMRs).

46 ination map based on 126 meiotically stable, differentially methylated regions covering 81.9% of the

47 led nearly three thousand cell-type specific differentially methylated regions (ctDMRs).

48 These differentially methylated regions did not occur at the l

49 Maternal deletion of the NESP55 differentially methylated region (DMR) (delNESP55/ASdel3

50 transmission leads to methylation of the H19 differentially methylated region (DMR) and silencing of

51 ly derived targeted deletion of the germline differentially methylated region (DMR) associated with t

52 marsupial genomes and the demonstration of a differentially methylated region (DMR) in the retrotrans

53 We have identified a 556 bp differentially methylated region (DMR) located approxima

54 Furthermore, loss of methylation at a differentially methylated region (DMR) of this locus, ex

55 and cohesins preferentially bind to the Gtl2 differentially methylated region (DMR) on the unmethylat

56 Genetic analyses demonstrate that the differentially methylated region (DMR) upstream of the H

57 escribed previously is hypermethylation of a differentially methylated region (DMR) upstream of the H

58 the H19 gene, and aberrant methylation of a differentially methylated region (DMR) upstream of the m

59 hylation pattern, the second CpG island is a differentially methylated region (DMR) with maternal met

60 gene 3 (Meg3) locus is regulated by the Meg3 differentially methylated region (DMR), but the mechanis

61 r allele-specific CpG methylation in the H19 differentially methylated region (DMR), Igf2 DMR0 or Igf

62 -associated hypermethylation at the upstream differentially methylated region (DMR), which also inclu

63 2 LOI correlates with hypomethylation at the differentially methylated region (DMR)-0.

64 eg3 is predicted to be regulated by the Peg3-differentially methylated region (DMR).

65 ifferentially methylated region [the exon 1A differentially methylated region (DMR)] that is methylat

66 Multiple differentially methylated regions (DMR) could be identif

67 We identified 3,506 cancer-specific differentially methylated regions (DMR) in human breast

68 examined allele-specific methylation of the differentially methylated regions (DMR) of IGF2 and H19

69 we have discovered two previously unreported differentially methylated regions (DMR): one in the prom

70 sters including virtually all known germline differentially methylated regions (DMRs) and 23 previous

71 ytes, and placenta, and identify 795 hap-ASM differentially methylated regions (DMRs) and 3,082 stron

72 A total of 853 significantly differentially methylated regions (DMRs) and 963 differe

73 We analyzed an additional 11 differentially methylated regions (DMRs) and found that,

74 fy predominately hypermethylated T2D-related differentially methylated regions (DMRs) and replicate t

75 thylated promoters in prostate tissues, 2481 differentially methylated regions (DMRs) are cancer-spec

76 Furthermore, many of the Gsk-3-dependent, differentially methylated regions (DMRs) are identical t

77 Differentially methylated regions (DMRs) are stable epig

78 the aim of identifying previously unreported differentially methylated regions (DMRs) associated prim

79 We identified 1027 differentially methylated regions (DMRs) associated with

80 encing analysis of methylated DNA identified differentially methylated regions (DMRs) associated with

81 n the methylation status of specific CpGs in differentially methylated regions (DMRs) at affected but

82 e are still 5,000 to 20,000 context-specific differentially methylated regions (DMRs) between any two

83 d cytosines (mCs) in a sample, and to detect differentially methylated regions (DMRs) between paired

84 We show here that single differentially methylated regions (DMRs) correlate with

85 ependent and maps only to imprinting control differentially methylated regions (DMRs) established in

86 n smoothing approach (called ABBA) to detect differentially methylated regions (DMRs) from whole-geno

87 Of 811 differentially methylated regions (DMRs) identified in A

88 we found to significantly overlap with known differentially methylated regions (DMRs) in colon tumors

89 cape in human pancreatic islets, to identify differentially methylated regions (DMRs) in diabetic isl

90 Differentially methylated regions (DMRs) in each methyla

91 sulfite sequencing we identified hundreds of differentially methylated regions (DMRs) in humans compa

92 ts have not been identified, and the role of differentially methylated regions (DMRs) in Igf2 has not

93 was reprogrammed after fertilization in two differentially methylated regions (DMRs) in Igf2, and wa

94 4K12, H2AK5, H2BK12, H2BK16 and H2BK46 at 11 differentially methylated regions (DMRs) in reciprocal m

95 The differentially methylated regions (DMRs) in the reprogra

96 ctive X-chromosome and in tumors, as well as differentially methylated regions (DMRs) in the vicinity

97 gene promoters, 4% of which reside in known Differentially Methylated Regions (DMRs) including repro

98 So it is more desirable to identify differentially methylated regions (DMRs) instead of DMPs

99 The detection of differentially methylated regions (DMRs) is a necessary

100 nism in gene regulation and the detection of differentially methylated regions (DMRs) is enthralling

101 The gene contains three differentially methylated regions (DMRs) located upstrea

102 o parthenogenetic mouse embryos, to identify differentially methylated regions (DMRs) methylated spec

103 ration of normal DNA methylation patterns in differentially methylated regions (DMRs) of affected loc

104 onders from nonresponders, we identified 167 differentially methylated regions (DMRs) of DNA at basel

105 blastocysts display hypermethylation in the differentially methylated regions (DMRs) of Peg3 and Gna

106 DNA methylation profiling reveals important differentially methylated regions (DMRs) of the genome t

107 conserved sequences between human and mouse differentially methylated regions (DMRs) of the IGF2 gen

108 In addition, differentially methylated regions (DMRs) often contain s

109 wide studies discovered that tissue-specific differentially methylated regions (DMRs) often overlap t

110 Eleven age-associated differentially methylated regions (DMRs) passed Bonferro

111 e to cigarette smoking on methylation at two differentially methylated regions (DMRs) regulating Insu

112 Identification of differentially methylated regions (DMRs) revealed that D

113 of cell types within a sample by leveraging differentially methylated regions (DMRs) specific to cel

114 , this pattern of expression is regulated by differentially methylated regions (DMRs) that are establ

115 early childhood lead exposure can alter the differentially methylated regions (DMRs) that control th

116 and identified four genome-wide significant differentially methylated regions (DMRs) using a bump hu

117 DNA methylation at 12 differentially methylated regions (DMRs) was analyzed in

118 Differentially methylated regions (DMRs) were identified

119 rinting control regions (ICRs) and secondary differentially methylated regions (DMRs) were identified

120 n transcription factor binding and to reveal differentially methylated regions (DMRs) with context-sp

121 identified 40, 66 and 2136 genes containing differentially methylated regions (DMRs) with negative c

122 sue and cell type specific, the detection of differentially methylated regions (DMRs) with small effe

123 significance is established at the level of differentially methylated regions (DMRs), and bootstrapp

124 single methylation polymorphisms and 2485 CG differentially methylated regions (DMRs), both of which

125 Three differentially methylated regions (DMRs), each with diff

126 YY1 binding sites are located within several differentially methylated regions (DMRs), including Xist

127 res are limited to imprinted genes and their differentially methylated regions (DMRs), whereas broad

128 The Dlk1-Gtl2 locus carries three differentially methylated regions (DMRs), which are meth

129 erentially methylated positions (DMPs) and 5 differentially methylated regions (DMRs), which we study

130 ngly, the oocyte contributes a unique set of differentially methylated regions (DMRs)--including many

131 Zea mays) inbred lines were used to discover differentially methylated regions (DMRs).

132 methylation at the Igf2 P2 promoter and Igf2 differentially methylated regions (DMRs).

133 rinted genes based on their association with differentially methylated regions (DMRs).

134 recovered using an existing method based on differentially methylated regions (DMRs).

135 ost imprinted loci marked by the presence of differentially methylated regions (DMRs).

136 to all other regions, and showed over 16 000 differentially methylated regions (DMRs).

137 gical contexts, with the goal of identifying differentially methylated regions (DMRs).

138 We identified 2,130 differentially methylated regions (DMRs; <5% false disco

139 novel computational pipeline that identifies differentially methylated regions efficiently.

140 der, we now report deletions that remove the differentially methylated region encompassing exon NESP5

141 y note to genome-wide searches on the use of differentially methylated regions for the identification

142 the computational approaches for identifying differentially methylated regions from high-throughput b

143 cessing, quality assessment and detection of differentially methylated regions from the kilobase to t

144 asses of genes associated with these gametic differentially methylated regions (gDMRs), namely those

145 Methylation at several imprinted differentially methylated regions (GRB10 ICR, H19 ICR, K

146 etected are found highly consistent with the differentially methylated regions identified by using pu

147 Differentially methylated regions identified when compar

148 At least one cis-element, the intergenic differentially methylated region (IG-DMR) is required fo

149 An intergenic differentially methylated region (IG-DMR) located 13 kb

150 we identified an intergenic germline-derived differentially methylated region (IG-DMR) that is a cand

151 ouse brain DNA methylation, we found a novel differentially methylated region in a CpG island located

152 variation in DNA methylation at the VTRNA2-1 differentially methylated region in healthy Caucasian an

153 We identified a differentially methylated region in the ankyrin 1 (ANK1)

154 We identified a differentially methylated region in the promoter of the

155 We validated 11 of the differentially methylated regions in an independent set

156 A core set of differentially methylated regions in APL was identified.

157 ught stress, there were negligible conserved differentially methylated regions in drought-exposed lin

158 Differentially methylated regions in Igf2 and H19 contai

159 basis for the recognition and methylation of differentially methylated regions in imprinted genes, in

160 k of genomic imprinting and parent-of-origin differentially methylated regions in Nasonia, together w

161 have searched for parent-of-origin dependent differentially methylated regions in order to identify n

162 egrative epigenomic approach revealed 10,504 differentially methylated regions in regulatory elements

163 methylation analysis identified a number of differentially methylated regions in TET2-deficient vers

164 formation capture technique to show that the differentially methylated regions in the imprinted genes

165 approach, we were able to identify specific differentially methylated regions in the parental genome

166 apped to 23 chromosomal regions, and 12 were differentially methylated regions in uniparental tissues

167 orders, our findings suggest that the Nesp55 differentially methylated region is an additional princi

168 The imprinted Kcnq1 domain contains a differentially methylated region (KvDMR) in intron 11 of

169 nal allele-specific methylation (LOM) of the differentially methylated region KvDMR1.

170 ndem array of YY1 binding sites of Peg3-DMR (differentially methylated region) led us to identify thr

171 SA) hormone revealed numerous stress-induced differentially methylated regions, many of which were in

172 binations further showed that these parental differentially methylated regions most likely mediate th

173 ating phenotype ensues, with 79% of the 2966 differentially methylated regions observed involving dem

174 served for the frequency of CpG sites in the differentially methylated regions of 12 maternally impri

175 tting of the EGC DNA was used to analyze the differentially methylated regions of Igf2 and H19.

176 he differential DNA methylation found on the differentially methylated regions of imprinted genes, an

177 ited abnormal patterns of methylation at the differentially methylated regions of the IGF2/H19 or IGF

178 H2A1 deposition levels at the ICRs and other differentially methylated regions of these domains are a

179 by bringing repressive histone marks on the differentially methylated regions of these three direct

180 We identify 19 differentially methylated regions on chromosome 6 harbor

181 genes with significant methylation changes, differentially methylated regions or differentially meth

182 eristics of prenatal malnutrition-associated differentially methylated regions (P-DMRs) is lacking in

183 vation that a 45-bp sequence (DMR45) in this differentially methylated region positively influenced p

184 iPSCs share megabase-scale differentially methylated regions proximal to centromere

185 We identified hundreds of differentially methylated regions proximal to genes invo

186 For several of these 'differentially methylated regions', recent studies estab

187 accompanied by changes in DNA methylation of differentially methylated regions related to these loci.

188 dicated that EC-enriched gene promoters with differentially methylated regions replicate early in S-p

189 We identified 52,095 differentially methylated regions (representing 1% of th

190 modifications in somatic tissue, and a sperm differentially methylated region (sDMR; sperm not equal

191 m-derived dermal fibroblasts, to identify SE differentially methylated regions (SE-DMRs).

192 The differentially methylated regions show enrichment for bi

193 DNA methylomes, 95.7 % of the age-associated differentially methylated regions showed the same direct

194 The top psychosis-associated, differentially methylated region, significantly hypometh

195 ntially binds to the methylated paternal H19 differentially methylated region, suggesting a mechanism

196 In protein-coding genes, tissue-specific differentially methylated regions (T-DMRs) were preferen

197 dentifying 223 new candidate tissue-specific differentially methylated regions (T-DMRs).

198 rate of linkage disequilibrium decay amongst differentially methylated regions targeted by RNA-direct

199 rehensive genome-wide set of tissue-specific differentially methylated regions (tDMRs) that may play

200 Tissue specific differentially methylated regions (TDMRs) were identifie

201 the results presented here, tissue-specific differentially methylated regions (TDMs) were first iden

202 dentified a novel parent-of-origin dependent differentially methylated region that has no apparent as

203 OPSCCs and identified a specific pattern of differentially methylated regions that critically depend

204 Neonatal immune cells harbored 589 differentially methylated regions that distinguished IIS

205 e and unique sequences, the latter including differentially methylated regions that regulate expressi

206 s in a human genome and identify hundreds of differentially methylated regions that were previously u

207 oter is unmethylated, but is downstream of a differentially methylated region [the exon 1A differenti

208 An intergenic, parental-origin-specific differentially methylated region, the IG-DMR, which is u

209 lignment with ENCODE data, we also found the differentially methylated regions to be enriched with CC

210 undergoing EMT and translated the identified differentially methylated regions to human breast cancer

211 ing maternal-allele-specific deletion of the differentially methylated region, to maintain hematopoie

212 Although differentially methylated regions, transcript number of

213 icant over-representation of tissue-specific differentially methylated regions (TS-DMRs) observed at

214 overage, we identify 302,864 tissue-specific differentially methylated regions (tsDMRs) and estimate

215 A differentially methylated region upstream of H19 (H19-DM

216 validation, the authors characterized these differentially methylated regions using personality trai

217 ndependent validation of selected cord blood differentially methylated regions, using bisulfite ampli

218 ode within the network of asthma-associated, differentially methylated regions, was selectively incre

219 Differentially methylated regions were associated with c

220 Among asthmatic patients, 11 differentially methylated regions were associated with h

221 ies using similar methodology, many of these differentially methylated regions were associated with l

222 Importantly, differentially methylated regions were enriched at cis-e

223 l line, NT2, we previously demonstrated that differentially methylated regions were located in intron

224 s and 24 matched controls were conducted and differentially methylated regions were validated.

225 In response to SA, transposon-associated differentially methylated regions, which were accompanie

226 in each of 3 diagnostic categories), and 54 differentially methylated regions with P < .01 were iden

227 nd/or cohesin bind to a majority but not all differentially methylated regions, with preferential bin

228 d 19-82 years, we identify 71 age-associated differentially methylated regions within the linkage dis