ライフサイエンスコーパス: differentiated cell

1 amination of what it means to be a stem or a differentiated cell.

2 e expression are established in a terminally differentiated cell.

3 o the Wnt-inactive inner bulge that contains differentiated cells.

4 or organizing noncentrosomal microtubules in differentiated cells.

5 ally facilitates malignant transformation of differentiated cells.

6 ttenuating the lipolysis pathway, but spared differentiated cells.

7 r knockout in hPSCs and in a wide variety of differentiated cells.

8 lst also facilitating egress of increasingly differentiated cells.

9 cells from primary cells, cancer cells, and differentiated cells.

10 ors as the initial step in the production of differentiated cells.

11 ansposons, rather than DNA methylation as in differentiated cells.

12 tion of HbF up to 30% of total hemoglobin in differentiated cells.

13 in subpopulations of both lineage-primed and differentiated cells.

14 e skin, where it is expressed in nondividing differentiated cells.

15 ss intensely in a small subset of these more differentiated cells.

16 early-stage stem cells, progenitors and more differentiated cells.

17 s contributes to emergence of novel types of differentiated cells.

18 o efficiently stimulate this pathway in well-differentiated cells.

19 ins, and did so to a much lesser extent with differentiated cells.

20 it is required for proper differentiation in differentiated cells.

21 ted poly(I:C) is markedly diminished in well-differentiated cells.

22 oducing the proper number and proportions of differentiated cells.

23 omote viral proliferation and spread between differentiated cells.

24 endolymphatic sacs demonstrates two types of differentiated cells.

25 l progenitors (INPs) and directly generating differentiated cells.

26 s to oxidative stress, is preactivated in de-differentiated cells.

27 e3 coexists with H3K27me3 in pluripotent and differentiated cells.

28 and silences the HIF-2alpha gene (EPAS1) in differentiated cells.

29 pes the epigenome and biological function of differentiated cells.

30 ctivities and distinguishes pluripotent from differentiated cells.

31 induces massive global DNA demethylation in differentiated cells.

32 toplasm in pluripotent P19 cells, but not in differentiated cells.

33 iation and became the main Panx expressed in differentiated cells.

34 esponse leading to aberrant proliferation of differentiated cells.

35 rogenitors and finally clonal populations of differentiated cells.

36 emotherapy-induced cell death less than more differentiated cells.

37 stem/progenitor cells, but not in terminally differentiated cells.

38 aberrant methylation spreading into CGIs in differentiated cells.

39 ansposon regulatory gene piwi, in terminally differentiated cells.

40 paring damage response pathways in hESCs and differentiated cells.

41 hPSC-derived lineage-specific stem cells or differentiated cells.

42 nic stem cells and mouse embryonic stem cell-differentiated cells.

43 ound to promote the degradation of ZFP809 in differentiated cells.

44 by assuring stable target gene repression in differentiated cells.

45 sable for maintaining cell identity genes in differentiated cells.

46 as suppression of markers for adult stem and differentiated cells.

47 and lymphoid lineages, ultimately leading to differentiated cells.

48 uced apoptosis of GSCs with little effect on differentiated cells.

49 relative to epiblast stem cells (EpiSCs) and differentiated cells.

50 expression and X-chromosome inactivation in differentiated cells.

51 le in embryonic cells but highly unstable in differentiated cells.

52 l cycle and the tissue-specific functions of differentiated cells.

53 estinal (GI) adenocarcinoma by reprogramming differentiated cells.

54 activity and maintenance of the identity of differentiated cells.

55 vels in proliferating KCs and high levels in differentiated cells.

56 or damaged histones in long-lived terminally differentiated cells.

57 rs and other post-transcriptional factors in differentiated cells.

58 t to more N-linked sialoglycoproteins in the differentiated cells.

59 tion of pluripotent stem cells and partially differentiated cells.

60 Unlike differentiated cells, adult stem cells are intrinsically

61 In differentiated cells, aging is associated with hypermeth

62 imal tubule clones expanded, suggesting that differentiated cells also contribute to tubule elongatio

63 Differentiated cells also expressed greater levels of th

64 ss the immature state of the cells, in vitro differentiated cells and adult human islets were compare

65 ome stem cells divide symmetrically into two differentiated cells and are replaced by a neighbor that

66 Podocytes are highly differentiated cells and critical elements for the filtr

67 However, TKIs primarily target differentiated cells and do not eliminate leukemic stem

68 lamic-like neurons accounted for over 90% of differentiated cells and exhibited transcriptional profi

69 normal oral epithelial cells is confined to differentiated cells and is lytic.

70 for its regulation of signaling processes in differentiated cells and its destructive activation in A

71 from stem cells, ensuring the generation of differentiated cells and preventing the formation of pro

72 skeleton as a component of the basal foot in differentiated cells and propose that the ZED tubulins a

73 ls the remarkable plasticity associated with differentiated cells and provides an unprecedented means

74 cal studies of 8 using mouse catecholamine A-differentiated cells and rat embryonic cortical neurons

75 orithms to separate the progenitors from the differentiated cells and reconstruct the lineage hierarc

76 the accumulation of polyubiquitin chains in differentiated cells and stabilized by the proteasome in

77 switch that modulates Polycomb regulation in differentiated cells and stabilizes repressed states.

78 of protection, poor protection by terminally differentiated cells and the importance of T cell migrat

79 crotubule dynamics and functions in vivo, in differentiated cells and tissues, remains under-explored

80 ting muscle progenitor cells into terminally differentiated cells and to develop new strategies that

81 eved in two ways: by proliferation of common differentiated cells and/or by deployment of specialized

82 rface of goblet cells compared with normally differentiated cells, and neutralization with anti-ST2R

83 tromeres is a general property of terminally differentiated cells, and the persistence of CenH3 incre

84 exhibited 4-5 layers of well-stratified and differentiated cells, and we successfully produced funct

85 data provide direct evidence that different differentiated cells are generated by different modes of

86 However, it is not clear how the two differentiated cells are generated from the ISC.

87 of PC12 cell differentiation, whereas fully differentiated cells are not affected.

88 nt tumor-associated macrophages, these newly differentiated cells are phenotypically distinct, and li

89 ng of many lineages into niche groups, where differentiated cells are pooled within each niche group.

90 f haematopoietic stem cells and multilineage-differentiated cells are reduced in iqcg-deficient embry

91 signatures differentiating between stem and differentiated cells are summarized and discussed.

92 he functions of this cytoskeletal network in differentiated cells, are resulting in a renaissance.

93 mans indicates that TSCM cells are minimally differentiated cells at the apex of the hierarchical sys

94 Reprogramming of a differentiated cell back to a naive pluripotent identity

95 luripotent, precursor, progenitor, and fully differentiated cells) based on changes in stage-dependen

96 epidermis and serve to replenish the loss of differentiated cells because of normal turnover or injur

97 tform can thus rapidly generate high quality differentiated cells, both neurons and potentially other

98 not affect cell proliferation or survival of differentiated cells but rather enhances the transition

99 tubules play an important role in polarizing differentiated cells, but little is known about how thes

100 regulates signals arising from the niche and differentiated cells by integrating the insulin-mediated

101 Moreover, terminally differentiated cells can be experimentally provoked to b

102 We investigated whether differentiated cells can give rise to SPEM using a nonge

103 addition, there are multiple routes by which differentiated cells can re-enter the pluripotent state.

104 The principle that differentiated cells can revert to an embryonic state an

105 In differentiated cells, chromosomes are packed inside the

106 ble to self-renew, proliferate, and generate differentiated cells, consistent with a progenitor/stem

107 Compared with differentiated cells, constitutive Noxa levels were sign

108 Free microtubule minus ends, found in many differentiated cells, contribute to polarized motility.

109 d that the gene expression profiles of these differentiated cells could reveal the identities of gene

110 eep was unrelated to epigenetic age and late differentiated cell counts, but was related to a decline

111 ges, the continuous production of functional differentiated cells depends on the maintenance of proge

112 We found that differentiated cells derived from isogenic iPSCs and nt-

113 ng beta-galactosidase in PW1(+) cells and in differentiated cells derived from PW1(+) cells.

114 Thus, differentiated cells derived from syngeneic iPSCs do not

115 function of mitochondria; however, in fully-differentiated cells, determining the structure of more

116 As apparently terminally differentiated cells embedded in a mineralized extracell

117 ed genes that are already up-regulated in de-differentiated cells, even in the absence of oxidative d

118 Post-mitotic, differentiated cells exhibit a variety of characteristic

119 Differentiated cells exhibited expression of myogenic ma

120 Differentiated cells exhibited greater F-actin density a

121 he endogenous MIR520G locus is methylated in differentiated cells, exposure of DAOY cells to 5-aza-2'

122 e robust inflammatory responses in naturally differentiated cells, failed to activate NF-kappaB, the

123 m and progenitor cells and maintained in one differentiated cell fate but lost in others.

124 Regulators of differentiated cell fate can offer targets for managing

125 hanisms that drive neural progenitors into a differentiated cell fate in the nervous system.

126 ipotent stem cells are a promising source of differentiated cells for developmental studies, cell tra

127 alternatives for generating patient-specific differentiated cells for disease modeling and preclinica

128 ion in weak tissues, targeting both stem and differentiated cells for elimination.

129 cell population and can give rise to all the differentiated cells found in the normal tissue.

130 Stem and differentiated cells frequently differ in their response

131 Constitutive PERK-Nrf2 signaling protects de-differentiated cells from chemotherapy by reducing ROS l

132 low signal variability is needed to prevent differentiated cells from de-differentiating.

133 s measured by using quantitative PCR in TH17-differentiated cells from healthy women (n = 13) and men

134 Differentiated cells from human embryonic stem cells (hE

135 molecular and functional characteristics of differentiated cells from human PSCs are primarily attri

136 homeostasis requires the production of newly differentiated cells from resident adult stem cells.

137 Differentiated cells from various tumors, or medium cond

138 and let-7f expression was decreased in TH17-differentiated cells from women compared with men.

139 we report the critical role of PRMT5 in GBM differentiated cells (GBMDC) grown in serum and GBM neur

140 abnormalities and preclinical application of differentiated cells generated by different reprogrammin

141 icating an intercellular signal arising from differentiated cells governing circadian clock-dependent

142 These highly differentiated cells had the ability to inhibit viral sp

143 generating iMS cells from primary terminally differentiated cells has significant scope for applicati

144 Differentiated cells have evolved mechanisms to adapt th

145 mable, with an active transcriptome, whereas differentiated cells have stiffer nuclei and condensed c

146 To investigate the mechanisms that maintain differentiated cells, here we inducibly delete the histo

147 In pluripotent and differentiated cells HP1beta is differentially localized

148 As in differentiated cells, hypermethylated sequences were enr

149 The plasticity of differentiated cells in adult tissues undergoing repair

150 ellular dynamics as stem cells transition to differentiated cells in extinct and extant taxa [11].

151 Lineage conversion of differentiated cells in response to hormonal feedback ha

152 fferentiated cell marker LHX9, and a loss of differentiated cells in somatic cell lineages.

153 e also observed accelerated reprogramming of differentiated cells in the absence of Kdm5b, demonstrat

154 reversing the genetic sex of progenitors or differentiated cells in the fly intestine dramatically a

155 g action of mtROS and inflammasomes in fully differentiated cells in the retina, the removal of the d

156 Whether differentiated cells in the secretory complex are mainta

157 The unremitting demand to replenish differentiated cells in tissues requires efficient mecha

158 his paper reports the role of CYCA1;2/TAM in differentiated cells in vegetative organs.

159 onocytes parallels the distribution found in differentiated cells in vitro, and that gene-specific 5-

160 ar that a radical change of cell identity of differentiated cells in vivo, triggered by injury or oth

161 modulates DNA methylation patterns in normal differentiated cells in vivo.

162 ail of Cx32, a Cx expressed in polarized and differentiated cells, in regulating gap junction assembl

163 em, were previously thought to be terminally differentiated cells, incapable of altering their gene e

164 ial component for caveola assembly in highly differentiated cells, including adipocytes, smooth muscl

165 plifying cells, and the expected spectrum of differentiated cells, including goblet and endocrine cel

166 sdifferentiation and retrodifferentiation of differentiated cells, increases tumor heterogeneity.

167 cer-binding protein-alpha (C/EBPalpha), with differentiated cells increasingly secreting adiponectin,

168 The ability to reprogram differentiated cells into a pluripotent state has reveal

169 Reprogramming differentiated cells into induced pluripotent stem cells

170 The reprogramming of differentiated cells into induced pluripotent stem cells

171 ered an irreversible process, meaning that a differentiated cell is thought to be unable to return to

172 e for the demonstration that the identity of differentiated cells is not irreversibly determined but

173 the generation of essential sphingolipids in differentiated cells is not well understood.

174 Characterization of differentiated cells is performed via flow cytometry and

175 ld belief that DNA methylation of terminally differentiated cells is permanent and essentially immuta

176 Furthermore, endocytic capacity in fully differentiated cells is rapidly modulated by changes in

177 Normally, the cellular phenotype of such differentiated cells is remarkably stable and resists di

178 ting stem or progenitor cells and terminally differentiated cells is unclear.

179 FBP1 is barely detectable in normal differentiated cells; its overexpression in HCC tumors w

180 to a significant reduction in the number of differentiated cells leading to tissue pathology, but th

181 int determines the proliferative capacity of differentiated cell lineages by restricting the reservoi

182 t stem cells, and direct conversions between differentiated cell lineages represent powerful approach

183 similar levels of efficacy and contained all differentiated cell lineages.

184 Overexpression of miR-215 in poorly differentiated cell lines causes a decrease in clonogeni

185 olon tumors and used them to generate stably differentiated cell lines.

186 However, in differentiated cells, loss of HP1beta has the opposite e

187 for nucleotide analogues to inhibit HIV-1 in differentiated cells low in dNTPs.

188 These cells gain expression of de-differentiated cell markers CD44 and cytokeratin 5 (CK5)

189 This specialized set of pre-existing differentiated cells may be highly suitable for cell-bas

190 ids can exhibit some spatial organization of differentiated cells, methods that generate embryoid bod

191 In comparison to more differentiated cells, naive ES cells utilize both glucos

192 In de-differentiated cells, Nrf2 is not activated by oxidation

193 ittle is known about how progenitor cell and differentiated cell numbers and proportions are maintain

194 mex3-1 was required for generating differentiated cells of multiple lineages, while restric

195 Podocytes are terminally differentiated cells of the kidney glomerulus that are e

196 re T cells inhibit the proliferation of less-differentiated cells of the same specificity.

197 sted but was undetectable in fully quiescent differentiated cells or senescent cells.

198 ual identity as they are reprogrammed into a differentiated cell, or risk tumorigenesis.

199 goblet cells was greater than from normally differentiated cells (P < 0.01), and IL-33 stimulated ap

200 ase from goblet cells, but not from normally differentiated cells (P < 0.01).

201 NSG-3GS mice reflects an expanded output of differentiated cells per STRC rather than an increase in

202 ession as highly correlated with that of the differentiated cell phenotype.

203 ome, RNAs isolated from undifferentiated and differentiated cell populations of normal, spontaneously

204 evated in undifferentiated cells relative to differentiated cell populations, and interfering with it

205 Microorganisms form biofilms containing differentiated cell populations.

206 tynereis dumerilii, with a rich diversity of differentiated cells present in relatively low number.

207 Differentiated cells produce albumin and apolipoprotein

208 liferation in response to IL-7, whereas more differentiated cells proliferated poorly.

209 thylation increased during aging in MSCs and differentiated cells, providing a new avenue for the ide

210 iver and pancreas, relies on self-renewal of differentiated cells rather than a stem cell pool.

211 s highlights a continued need to explore how differentiated cells regulate microtubule geometry in vi

212 unogenicity of more therapeutically relevant differentiated cells remains unexplored.

213 defense at the start of a lytic infection in differentiated cells, remains in the cytoplasm.

214 Moreover, Oct4 induction in various differentiated cells represses their lineage identity in

215 In contrast, differentiated cells require oxidative damage to activat

216 n signature of genes that remain bivalent in differentiated cells resolves into a cell cycle-independ

217 required for MT dynamics in the precursor or differentiated cells, respectively.

218 pathway prevents the removal of these poorly differentiated cells, resulting in the retention of cell

219 tural information for all cell lines tested: differentiated cells reveal pronounced structural orient

220 al males and hermaphrodites to address how a differentiated cell sex-specifically changes its morphol

221 Differentiated cells showed induction of Elovl6 (2-fold)

222 neal endothelial cells (CECs) are terminally differentiated cells, specialized in regulating corneal

223 nt a general principle of the inheritance of differentiated cell states.

224 er replenishment capacity compared with late differentiated cells (such as most CMV-specific cells).

225 ed to their memory phenotype, in which early differentiated cells (such as most M. tuberculosis-speci

226 embers of the TAF family of proteins work in differentiated cells, such as motor neurons or brown fat

227 he active chromatin mark H3K4me1 in stem and differentiated cells, suggesting this is a cell type-ind

228 nome-wide profiling of pluripotent cells and differentiated cells suggests global chromatin remodelli

229 tem cells is important for the production of differentiated cells suitable for transplantation.

230 it more changes in expression in the one-day-differentiated cells than in Nanog-negative cells.

231 podocytes are highly specialized terminally differentiated cells that act as a filtration barrier in

232 a powerful and unlimited source to generate differentiated cells that can be used to study disease b

233 cell division to self-renew and give rise to differentiated cells that comprise mature tissue.

234 al endothelial cells (HCEnCs) are terminally differentiated cells that have limited regenerative pote

235 duce multiple outer cell layers of partially differentiated cells that show sporadic expression of al

236 In differentiated cells, the centrosome is often attenuated

237 pite ubiquitous expression of lamin A in all differentiated cells, the HGPS mutation results in organ

238 Unlike terminally differentiated cells, the impact of epigenetic dysregula

239 ing stem cells were engulfed by neighbouring differentiated cells through a draper-myoblast city-Rac1

240 xistence of cellular memory that persists in differentiated cells through many cell generations and c

241 cal basis for the ability to transition from differentiated cell to totipotent zygote is unknown.

242 b inactivation promotes the reprogramming of differentiated cells to a pluripotent state.

243 n alternate approach is to induce terminally differentiated cells to dedifferentiate into multipotent

244 ated the potential and circumstances of more differentiated cells to generate glioma development.

245 stem cells divide to self-renew and generate differentiated cells to maintain homeostasis.

246 multicellular organisms requires terminally differentiated cells to preserve their lineage specifici

247 Re-expression of p44/wdr77 caused terminally differentiated cells to re-enter the cell cycle.

248 tion of stem cells, or to cause reversion of differentiated cells to stem cells.

249 s and metazoa have the capacity to reprogram differentiated cells to stem cells.

250 Such an approach can produce differentiated cells to study physiology or pathophysiol

251 ulation that progressively contributes newly differentiated cells to the most posterior end of the em

252 nents absent or misregulated in the in vitro differentiated cells, to probe the components involved i

253 ect of changing the plasticity of terminally differentiated cells toward pluripotency has completely

254 modules of co-expressed genes that represent differentiated cells, transit-amplifying cells, and resi

255 Unlike normal differentiated cells, tumor cells metabolize glucose via

256 These results indicate that a terminally differentiated cell type derived from HSCs contributes t

257 Conversion of one terminally differentiated cell type into another (or transdifferent

258 osure to morphogens, or by conversion of one differentiated cell type into another by enforced expres

259 Osteocytes are the terminally differentiated cell type of the osteoblastic lineage and

260 As an exemplar differentiated cell type, we showed that directing early

261 essed together and specifically in a primary differentiated cell type: muscle.

262 l for probing developmental questions, while differentiated cell types allow the development of novel

263 t is adapted to the specialized functions of differentiated cell types and opens new research avenues

264 The formation of differentiated cell types from pluripotent progenitors i

265 ntity is continuously maintained in specific differentiated cell types long after sex determination o

266 rentiation and model human diseases, but the differentiated cell types obtained from iPSCs may become

267 organoid, we detect diverse progenitors and differentiated cell types of neuronal and mesenchymal li

268 To this end, comparisons between differentiated cell types produced in vitro and their in

269 neity of stem cells, which generates diverse differentiated cell types required for organogenesis, ar

270 , induced-pluripotent stem cells (iPSCs) and differentiated cell types using MNase-seq.

271 c expression of marker genes associated with differentiated cell types was observed in E11.5 progenit

272 natal differentiation where fully functional differentiated cell types with limited lifespans arise.

273 d differentiation of numerous progenitor and differentiated cell types, and although SOX9 haploinsuff

274 ed for the production and maintenance of all differentiated cell types, including the germline.

275 hyla to evolve tissue-level organization and differentiated cell types, such as neurons and muscle [9

276 ch mechanisms operate in postmitotic, highly differentiated cell types, such as neurons in vivo.

277 reveal structural details of stem cells and differentiated cell types.

278 resulting in complete dosage compensation in differentiated cell types.

279 gulation across conditions, environments, or differentiated cell types.

280 mise for cell therapy as a source of diverse differentiated cell types.

281 wn hierarchy of pluripotent, multipotent and differentiated cell types.

282 otubules (MTs) are poorly understood in many differentiated cell types.

283 Collectively, these results indicate that de-differentiated cells up-regulate MDR genes via PERK-Nrf2

284 hes, which have revealed that, although some differentiated cells utilize conserved strategies to rem

285 nitors (HSC/Ps) and thereby downregulated in differentiated cells via asymmetric division.

286 cell culture and can also be reactivated in differentiated cells via nuclear reprogramming.

287 demonstrated that the increased stiffness of differentiated cells was due to the increased membrane-c

288 ch is a non-limiting enzyme of glycolysis in differentiated cells, was tightly regulated in stem cell

289 key transcriptional regulators play in adult differentiated cells, we examined the effects of depleti

290 In these differentiated cells, we find that the genome-wide patte

291 Among the miRNAs overrepresented in differentiated cells, we focused on microRNA-21 (miR-21)

292 otion of chromatin inside the nuclei of live differentiated cells, we present a hydrodynamic theory-t

293 Exons included in differentiated cells were characterized by particularly

294 After 14 days, differentiated cells were exposed to IL-33 for 24 h.

295 riched within exons, unlike the situation in differentiated cells, where it binds heterochromatic sat

296 tical for cell cycle reentry of postmitotic, differentiated cells, whereas an increase is required fo

297 ic phenotypes that are reminiscent of normal differentiated cells, whereas others reflect the phenoty

298 Second, stem cells are vastly outnumbered by differentiated cells, which have a higher mutation rate-

299 idered a homogenous population of terminally differentiated cells with a well-defined and highly cons

300 t conversion of skin biopsies into iPSCs and differentiated cells with minimal manual intervention.