ライフサイエンスコーパス: differentiation

1 d that ZFP521 regulates HSC self-renewal and differentiation.

2 b2 are required for EDN3 to prevent neuronal differentiation.

3 aintain TA cell proliferation and to inhibit differentiation.

4 rs modifies their granulocytic and erythroid differentiation.

5 degradation of Id proteins can regulate cell differentiation.

6 r essential for cell division, motility, and differentiation.

7 re differentially expressed in the course of differentiation.

8 tal-dielectric interface can perform spatial differentiation.

9 uniform CAR expression, and limited effector differentiation.

10 lular processes, including proliferation and differentiation.

11 KCbeta1, and p38 regulates the transition to differentiation.

12 ay in turn influence the outcome of cellular differentiation.

13 in NB cell proliferation and 16 also induced differentiation.

14 tubule-actomyosin interfaces during neuronal differentiation.

15 inhibited osteoblast-regualted osteoclastic differentiation.

16 which affects growth, development, and cell differentiation.

17 preferentially upregulated during Th17 cell differentiation.

18 n which bacterial symbionts undergo terminal differentiation.

19 an stem cells and cells at various stages of differentiation.

20 re known to be involved in proliferation and differentiation.

21 equently disrupting hypertrophic chondrocyte differentiation.

22 n the deleterious effect of IL-1beta on Treg differentiation.

23 e NLRP3 inflammasome and regulate osteoclast differentiation.

24 ine (DMOG) also significantly impaired iTreg differentiation.

25 ell migration but did not prevent fiber cell differentiation.

26 lls and tracked morphological changes during differentiation.

27 nvironment and promoter-bound TFs during ESC differentiation.

28 odulates TGF-beta/Smad3 signaling during SMC differentiation.

29 s such as cell migration, proliferation, and differentiation.

30 ntion to morphological changes indicative of differentiation.

31 -like peptides, which induce lamina neuronal differentiation.

32 y, inducing chromatin decondensation or cell differentiation.

33 o recruit Brd4 to enhancers activated during differentiation.

34 ement for subsequent initiation of erythroid differentiation.

35 stablished a role for lncRNAs in chondrocyte differentiation.

36 a species such as humans with low population differentiation.

37 g processes such as induced pluripotency and differentiation.

38 th efficient capability for self-renewal and differentiation.

39 wild type NSCs demonstrate delayed neuronal differentiation.

40 +) T cells are potentiated in Th17/Treg cell differentiation.

41 tion or sterol biosynthesis impaired myeloid differentiation.

42 tified genes important for human interneuron differentiation.

43 nact a gene expression program of melanocyte differentiation.

44 eductions in cell survival and myofibroblast differentiation.

45 reconstruct regulatory networks involved in differentiation.

46 ucleic acids (DNA vs. RNA), suggesting niche differentiation.

47 escent MuSCs express high levels of Myogenic Differentiation 1 (MyoD) transcript in vivo, whereas Myo

48 d basal-enriched molecules, while cluster of differentiation 44 (CD44) behaved in an opposite manner.

49 tracking analysis), and markers (clusters of differentiation 9, 63, and 81 by immunoblot) indicated t

50 tes significantly increases their adipogenic differentiation ability.

51 respectively; P < .001) and provided greater differentiation according to difference in median surviv

52 discriminatory, and reproducible method for differentiation among M. gallisepticum isolates.

53 Regulated retinal ganglion cell (RGC) differentiation and axonal guidance is required for a fu

54 issues, outline the factors that shape their differentiation and behavior and describe how macrophage

55 ion in epithelial and hepatic morphogenesis, differentiation and cell-type identity, depends on the f

56 It is essential for differentiation and early embryonic development in mice.

57 how that Shp2 is involved in oligodendrocyte differentiation and early myelination, but is not necess

58 proportion of loci showed strong patterns of differentiation and exhibited patterns of population str

59 Then, important genes related to cardiac differentiation and function were analyzed by real-time

60 me of T cells, thereby promoting stable Treg differentiation and functionality.

61 ntly considered major forces that drive cell differentiation and genome evolution in general, and suc

62 espread in surface oceans, presents ecotypic differentiation and has defied culturing efforts so far.

63 as useful models for investigating cellular differentiation and human embryogenesis.

64 cally inactive form of METTL3, inhibits cell differentiation and increases cell growth.

65 latin zymography to determine the effects of differentiation and inhibitor concentration on protease

66 hiatric disorders, including dopamine neuron differentiation and innate immune response.

67 Notch is a critical regulator of T cell differentiation and is activated through proteolytic cle

68 ulation, independent of HCV, caused monocyte differentiation and M2 MPhi polarization.

69 ed for retinogenesis, as well as patterning, differentiation and maintenance of specific retinal cell

70 ds to aberrations in proliferation, neuronal differentiation and migration in the embryonic mouse cer

71 evealed a major defect in the proliferation, differentiation and mineralization abilities of patDp/+

72 is an important mediator of oligodendrocyte differentiation and myelination, both during development

73 supports efficient and reproducible in vitro differentiation and positive selection of conventional h

74 unter spatially restricted cues critical for differentiation and selection of a functional, self-tole

75 e, and suggest a compelling architecture for differentiation and separate parsing of inputs within th

76 otubule-associated protein tau regulates the differentiation and survival of mDANs during embryonic d

77 face polysaccharides that affect NCR-induced differentiation and survival of rhizobia in nodule cells

78 impact on monocyte identity regarding their differentiation and susceptibility for the full lytic cy

79 ple signaling pathways underlying taste cell differentiation and taste stem/progenitor cell prolifera

80 ar pathways that govern the induction of TH2 differentiation and the critical role of GATA-3 in this

81 s involvement in keratinocyte proliferation, differentiation, and migration and in epidermal wound he

82 down regulation of genes involved in neural differentiation, and that the transcription factor OLIG2

83 required for both myoblast proliferation and differentiation, and the control of Brg1 phosphorylation

84 cesses, including cell growth, survival, and differentiation, and were established early on as proto-

85 D8(+) T cell terminal effector versus memory differentiation are incompletely understood.

86 se quiescence, activation, self-renewal, and differentiation are influenced by oxygen supply, an envi

87 c acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5), which are cruc

88 l over the decision between self-renewal and differentiation at the transcriptional, post-transcripti

89 Depending on their origin and level of differentiation at which they are harvested, stem cells

90 specific manner, and many ISGs decrease upon differentiation, at which time cells become IFN responsi

91 an smooth muscle cells undergoing osteogenic differentiation attenuated matrix mineralization, cytosk

92 Moreover, such sensitivity enables differentiation between cell types.

93 the role of diffusion-weighted MR imaging in differentiation between Graves' disease and painless thy

94 However, genetic differentiation between groups in Papua New Guinea is mu

95 RTE can play an important role in the differentiation between malignant and benign breast mass

96 other (overall FST=0.23), and the degree of differentiation between S and NS populations was similar

97 These techniques allow for biological differentiation between visual communication and noncomm

98 ecome open for transcription during terminal differentiation, blocking the action of a promiscuous ac

99 over, these subsets are not fixed in lineage differentiation but can undergo transcriptional reprogra

100 methyltransferase activity in regulating ESC differentiation but not self-renewal and suggests the ex

101 mat(M)) that 'preferentially' disrupted TH17 differentiation but not thymocyte development.

102 defects in Napa(hyh/hyh) signaling and Treg differentiation, but not IL-2 expression.

103 uran inhibits NSC proliferation and neuronal differentiation by altering TGF-beta signaling.

104 the author show that caspase-1 promotes TAMs differentiation by attenuating medium-chain acyl-CoA deh

105 latory pathways with new roles in hepatocyte differentiation by identifying cellular processes that r

106 e importance of PLCgamma2 in osteoclast (OC) differentiation by modulating inositol 1,4,5-trisphospha

107 gene expression, migration, and melanocytic differentiation by reducing Sox10 activity.

108 Ps promote progenitor patterning or neuronal differentiation by their activation of different type I

109 In vitro differentiation can trigger the development of the infla

110 antified with excellent single-base-mismatch differentiation capability by this non-enzymatic, amplif

111 EC differentiation, capillary engraftment, reduced capillar

112 ntification of four cell-specific cluster of differentiation (CD) proteins used to count cells by flo

113 fates makes a quantitative understanding of differentiation challenging.

114 ibitor could effectively redirect the mating differentiation, confirming the causative role of Fus3 d

115 ssion of genes associated with cholangiocyte differentiation (cytokeratin 19, connexin 43, integrin b

116 fferentiation of neuroprogenitors, mimicking differentiation defects of Mcph1-knockout neuroprogenito

117 r and tongue epithelia also display specific differentiation defects that are mimicked by loss of the

118 We previously showed that the differentiation-dependent cellular transcription factors

119 ges of development: gonad development, gonad differentiation, development of secondary sex characteri

120 ial population responses to climate (genetic differentiation due to past divergent climatic selection

121 mental role in somatic and reproductive cell differentiation during early anther development in Arabi

122 onads, but the mechanisms that control their differentiation during gonad development remain elusive.

123 The first cellular differentiation event in mouse development leads to the

124 he timing of mitosis in relation to multiple differentiation events for bipolar cells (BCs) in the ze

125 tumor-suppressive mode of action for growth-differentiation factor 11 (GDF11) and an unusual mechani

126 roBNP, high-sensitive troponin-T, and growth-differentiation factor 15) at the time of study inclusio

127 actor needed for Fshb induction (e.g. growth differentiation factor 9).

128 vity in the pluripotent state and during PSC-differentiation for several of the CBX3 subfragments.

129 Differentiation from bronchial asthma is also important.

130 nd knockout of HBL1 increased, cardiomyocyte differentiation from hiPSCs.

131 lated pro-B cell cultures revealed a reduced differentiation from large pre-B cells to small B cells

132 younger beta-cells join the islet following differentiation from post-embryonic progenitors.

133 rovides a framework to infer the dynamics of differentiation from single cell transcriptomics data an

134 above 2 g/cm(2) did not enhance osteoblastic differentiation further but significantly inhibited oste

135 It represses the mammary differentiation gene GATA3 involving DNMT3b and Rb.

136 g contrast, the regulation of cell-cycle and differentiation gene programs by MEF2C was antagonistic

137 deletion of pab1 overcomes the repression of differentiation genes in cells overexpressing TORC1.

138 ced expression of a large number of terminal differentiation genes.

139 During differentiation, Gnas(+/p-) cells showed diminished pCRE

140 within population (Hs), coefficient of gene differentiation (Gst) and level of gene flow (Nm) reveal

141 lecules to control stem cell self-renewal or differentiation has arrived at natural product-based age

142 important for balancing effector and memory differentiation; however, the epigenetic regulator(s) un

143 ndent nuclear IYO accumulation triggers cell differentiation in Arabidopsis.

144 ies on the genetic origin of gene expression differentiation in Caenorhabditis elegans, which could n

145 endent drop in proliferation and increase in differentiation in etoposide-treated neurospheres.

146 on of sequential gene regulation for somatic differentiation in pre-meiotic anthers.

147 that CD4(+) T(Pam3) cells are capable of Th1 differentiation in the presence of TGF-beta, suggesting

148 rescue keratinocyte adhesion and biochemical differentiation in these mice.

149 Here, we show that IRF8 is required for Th9 differentiation in vitro and in vivo.

150 vidence that neutrophils can undergo subtype differentiation in vitro in response to bacterial pathog

151 Macrophage motility, phagocytosis, and differentiation in vivo are thus coupled.

152 mitive neuroectodermal tumors with divergent differentiation including osteosarcoma.

153 APC/C inactivation severely inhibits retinal differentiation independently of cell-cycle defects.

154 In this study, we show that epithelial cell differentiation induces LMP1 expression by increasing ex

155 ), which mediated both cancer-inhibition and differentiation-induction effects of ZNF750.

156 (Wt1), fetal EPDC activation and subsequent differentiation into coronary smooth muscle, and restore

157 ial cells within the same culture to undergo differentiation into either lens fiber cells or myofibro

158 and mesenchymal lineages, with preferential differentiation into fibroblast-like cells but not into

159 In vitro differentiation into fibroblasts and smooth muscle cells

160 nd MAFB were critical regulators of monocyte differentiation into mo-DCs and mo-Macs, respectively.

161 strated that HCV infection leads to monocyte differentiation into polarized MPhis that mediate stella

162 ibitor dibenzazepine (DBZ) to drive cellular differentiation into secretory cell lineages, we show th

163 We show that the differentiation into such a hub neuron involves the sex-

164 However, we have largely ignored how the differentiation into the NKT cell subsets is regulated.

165 Muscle differentiation is a complex process in which muscle pro

166 Differentiation is important from other diseases in whic

167 ming or skew clonal recruitment and effector differentiation is not known.

168 Its expression during erythroid differentiation is regulated by alternative pre-mRNA spl

169 Lymphocyte differentiation is set to produce myriad immune effector

170 .Ser219Gly)) and vascular smooth muscle cell differentiation (LMOD1, rs2820315).

171 We find that during embryonic stem cell differentiation loss of HMGNs leads to down regulation o

172 emokine-related pathways but also osteoclast differentiation may be involved in the effects observed.

173 s been implicated as a key regulator of cell differentiation, migration, and proliferation.

174 To answer these questions, we tested for differentiation, movement and expansion in four elevatio

175 L19 abolished oligodendrocyte precursor cell differentiation observed in patients with high remyelina

176 PERK is essential for the survival and differentiation of activated satellite cells into the my

177 hypertrophy of existing cells and increased differentiation of adipocyte precursors (hyperplasia).

178 The osteogenic differentiation of adipose-derived stem cells (ASCs) was

179 mouse ears markedly enhanced the adipogenic differentiation of ADSCs, leading to dermal augmentation

180 s suggestive of OSPW seepage, but conclusive differentiation of anthropogenic and natural sources rem

181 ss-catenin effector Lef1 is required for the differentiation of anxiolytic hypothalamic neurons in ze

182 , the equiaxial load induced region-specific differentiation of ASCs within the inner and outer regio

183 We assessed differentiation of B cells in bone marrow and spleen and

184 anscription factor Irf4 is essential for the differentiation of Bcl6-expressing Tfh and Blimp-1-expre

185 omega-3 PUFAs exerted similar effects on the differentiation of CD4+ T cells isolated from human peri

186 Tcra gene in the presence of antigen drives differentiation of cells with a distinct agonist-selecte

187 tly improved potential for odonto/osteogenic differentiation of DPSCs both in vivo and in vitro.

188 ess of IFN-gamma-regulated odonto/osteogenic differentiation of DPSCs.

189 scribe an analogous Foxa2+ population during differentiation of embryonic stem cells.

190 matic cell lineage that later contributes to differentiation of gametes, and the second restricts the

191 Differentiation of glioblastoma stem-like cells drives t

192 functions, from pathogen containment to the differentiation of helper T cells, yet the cues that pos

193 cr4 desensitization is critical for lymphoid differentiation of HSPCs, and its impairment is a key me

194 ein, we analyzed the role of exosomes in the differentiation of HT29 cells.

195 by 6.4-fold during IL-13-induced goblet cell differentiation of human bronchial epithelial cells.

196 ro environment and growth factors can direct differentiation of human pluripotent stem cells into org

197 namics and regulatory mechanisms that govern differentiation of individual human neural precursor cel

198 uncover the immunological heterogeneity and differentiation of Langerhans cells, delineate the signa

199 Differentiation of lineage-committed cells from multipot

200 The hormone prolactin promotes lactational differentiation of mammary epithelial cells (MECs) via i

201 ethylases (KDMs) have been implicated in the differentiation of mesenchymal stem cells into various c

202 that describes how to initiate the in vitro differentiation of mouse and human PSCs into cardiac pro

203 P300-ZNF384 and CREBBP-ZNF384 fusion altered differentiation of mouse hematopoietic stem and progenit

204 TRX80 also promotes the differentiation of mouse peritoneal and human macrophage

205 ing activity is required for the odontogenic differentiation of MSCs.

206 ncoded transcription factor PLZF directs the differentiation of multiple innate and innate-like cell

207 eported to promote proliferation and inhibit differentiation of myoblast cells, whereas miR-30c targe

208 The differentiation of naive CD8 T cells into effector cytot

209 ctopic expression of Cdh1 leads to premature differentiation of neuroprogenitors, mimicking different

210 Here, we show that differentiation of new taste bud cells, but not progenit

211 mbrane and clemastine fumarate can stimulate differentiation of oligodendrocyte precursor cells in vi

212 Regeneration of CNS myelin involves differentiation of oligodendrocytes from oligodendrocyte

213 studies show that autophagy is required for differentiation of other blood cell lineages, its functi

214 regulate MOR gene expression during neuronal differentiation of P19 cells, suggesting a conserved rol

215 roliferation of these RP progenitors and for differentiation of pituitary cell types.

216 In vitro differentiation of progenitors transduced with a known T

217 atic fibrosis, and is characterized by trans-differentiation of quiescent HSCs to HSC myofibroblasts,

218 leads to reduced proliferation and premature differentiation of radial glial cells and aberrant posit

219 chanisms that support long-term survival and differentiation of repair cells will help identify, and

220 Current ASTs rely on time-consuming differentiation of resistance and susceptibility after i

221 Finally, plasma cell differentiation of sorted LPS-stimulated MZ B cells was

222 eurogenesis in adult mice and humans through differentiation of Sox2- and PLP1-expressing cells, whic

223 s autophagy, inflammation, proliferation and differentiation of stem cell, cell survival/death, and c

224 thrombopoietin (TPO) signaling and therefore differentiation of stem cells into megakaryocytes.

225 netic mechanisms play a critical role during differentiation of T cells by contributing to the format

226 riptional repressor that is required for the differentiation of T follicular helper (TFH) cell popula

227 ntrast, Tcf1 long isoforms were required for differentiation of T follicular helper (TFH) cells, but

228 consequently, are constantly replenished by differentiation of taste stem cells.

229 This consequently blocked the differentiation of TH17 cells by antagonizing the functi

230 ey factor required for sex determination and differentiation of the follicular cell progenitors, but

231 iction and subsequent restudy-should lead to differentiation of the item's neural representation from

232 Sexual differentiation of the malaria parasite is a pre-requisi

233 he Notch signalling pathway regulate further differentiation of the progenitors into endothelial line

234 tension gradients can lead to patterning and differentiation of tissues through mechanoregulation of

235 Elevated MPV was associated with tumor differentiation (p < 0.001).

236 s the autocrine IL-6- and IL-21-induced Th17 differentiation pathways in autoreactive CD4 T cells, hi

237 ntitative assessment of the self-renewal and differentiation patterns of these cells in a myeloablati

238 To prevent somatic differentiation, PGCs must transiently silence their gen

239 ockdown of RIMA causes delayed onset of cell differentiation, phenocopying the effects of IYO knockdo

240 This differentiation platform provides a basis for generating

241 The ability to quantify differentiation potential of single cells is a task of c

242 d allows the ranking of cells based on their differentiation potential.

243 ks the innate defense protein MyD88 (myeloid differentiation primary response gene 88), or after supe

244 morphism alters the functions of the myeloid differentiation primary response protein 88 (MyD88)-IRAK

245 Myogenic differentiation proceeds through a highly coordinated ca

246 marrow myeloid progenitor cells by a complex differentiation process that culminates in fusion of mon

247 otal regulators of several lineage-selective differentiation programs.

248 e or deliver cues to retain stemness, direct differentiation, promote reprogramming, manipulate the g

249 in mouse embryonic stem cells, and in vitro differentiation promotes only partial development of thi

250 lineages, the positive relationship between differentiation rate and speciation rate is robust to sp

251 Although population differentiation rate explains relatively little of the v

252 estingly, increased expression of osteogenic differentiation-related genes, including OSX, DMP1, and

253 e macrophages, compared it to the LD adipose differentiation-related protein (Adrp)/perilipin 2 (Plin

254 ious cellular events, their functions in SMC differentiation remain largely unknown.

255 ties of patDp/+ osteoblasts while osteoclast differentiation remained unchanged compared to controls.

256 iocyte gene expression are determined during differentiation remains poorly understood.

257 and invasion, cancer stem cell viability and differentiation, resistance to anoikis, epithelial-to-me

258 y cell retention, and connective tissue cell differentiation, respectively.

259 In the absence of TLR2, TLR4, myeloid differentiation response gene 88, or TRIF, the clinical

260 (MAPK) cascade and triggers a dose-dependent differentiation response.

261 easome activity in CD8+ T cells early during differentiation resulted in acquisition of terminal effe

262 However, germ cell differentiation resumed after ceasing the ablation proto

263 In a third phase, cardiac precursor differentiation resumes and contributes to SHF-derived r

264 Thus, the balance of GMP and MDP differentiation shapes the myeloid cell repertoire durin

265 on factor Prep1 is a repressor of adipogenic differentiation since its down-regulation (DR) in both e

266 27me3, which are involved in stable cellular differentiation, specifically in cardiomyocytes from phy

267 dy, we outline the role of Dll4 in Treg cell differentiation, stability, and function in RSV infectio

268 o modulate liposarcoma cell survival and ASC differentiation state.

269 etition arising from differences in cellular differentiation status, thus providing a physiological m

270 ally important molecules required for T cell differentiation, such as JAK2 and IL12RB2, are regulated

271 transcriptional activation during epidermal differentiation suggested a cis-regulatory mechanism via

272 ieve this, antibodies are used to antagonize differentiation, survival and polarization signals or to

273 sses by controlling a neuronal proliferation/differentiation switch of ID-bHLH factors.

274 coma are classified according to the line of differentiation that these neoplastic cells most closely

275 lation of cell proliferation, migration, and differentiation, these data reveal a novel role for Osr2

276 is required for osteoblast proliferation and differentiation through transcriptional enhancer associa

277 -trans-retinoic acid (ATRA)-induced AML cell differentiation, through regulating expression of target

278 ssive state to cancer by promoting Treg cell differentiation, thus offering a potential therapeutic t

279 tches Ras activation from promoting cellular differentiation to aggressive cellular proliferation.

280 sferred into antigen-free mice revealed that differentiation to memory cells was coupled to erasure o

281 increase proliferation, followed by lineage differentiation to replenish damaged cells.

282 the genes are involved in directing the cell differentiation to that particular cell type.

283 f M-CSFR, and low numbers of cells underwent differentiation toward macrophages.

284 ics of early mouse embryonic stem (mES) cell differentiation, uncovering discrete transitions across

285 t activated mammary carcinomas with squamous differentiation was accompanied by a significantly reduc

286 Efficient lineage-specific differentiation was confirmed by uniform NCAM1 and myosi

287 Functional cholangiocyte differentiation was demonstrated via increased acetylate

288 TH1, TH17, and CD8(+) memory T-cell differentiation was significantly reduced, and T cells d

289 s, which are involved in alveolar epithelial differentiation, was demonstrated.

290 Upon their differentiation, we found hematopoietic phenotypes of gr

291 To study the spectrum of T cell differentiation, we have analyzed an infection with mous

292 ILC3 cytokine production, proliferation, and differentiation were determined by means of flow cytomet

293 lastic and osteoblast-regulated osteoclastic differentiation were enhanced at 2 g/cm(2).

294 at transcriptomes during early cardiomyocyte differentiation were highly concordant between hiPSCs an

295 ingly, reduced GATA1 expression and impaired differentiation were limited to megakaryocytes, consiste

296 Osteoblast viability and differentiation were not negatively affected by the AMP.

297 y mechanism through induction of itBreg cell differentiation, which takes place in palatine tonsils i

298 ifically inhibited mouse and human Th17 cell differentiation while promoting the generation of Foxp3(

299 down of either Cbx3 or Med26 inhibits neural differentiation while up-regulating genes involved in me

300 ds to impaired activation of HoxA genes upon differentiation, while knockdown of a long noncoding RNA