ライフサイエンスコーパス: differentiation pathway

1 for this branch point in the B-cell terminal differentiation pathway.

2 self-renewal by repressing a Bam-independent differentiation pathway.

3 g specifically upon entry into the T lineage differentiation pathway.

4 t antigenic specificity, correlates with the differentiation pathway.

5 whereby PKD1 signaling activates the p53-p21 differentiation pathway.

6 apoptosis increased progressively along this differentiation pathway.

7 and in clustering genes of the photoreceptor differentiation pathway.

8 self-renewal by repressing a Bam-independent differentiation pathway.

9 rophoblasts into progenitors of the invasive differentiation pathway.

10 stream target of Nkx6 genes in the endocrine differentiation pathway.

11 is involved in repressing a Bam-independent differentiation pathway.

12 inear naive --> effector --> T(EM) --> T(CM) differentiation pathway.

13 ing that patB acts downstream of them in the differentiation pathway.

14 hat inhibit the entry of pericytes into this differentiation pathway.

15 s with the CD27-defined CD4(+) T cell memory differentiation pathway.

16 and multiple other factors essential to this differentiation pathway.

17 d during sequential steps of the chondrocyte differentiation pathway.

18 as Sertoli cells, thus initiating the testis differentiation pathway.

19 h a restoration of the 'normal' granulocytic differentiation pathway.

20 allowing early myeloid precursors to enter a differentiation pathway.

21 yeloid blasts to enter into the granulocytic differentiation pathway.

22 cade and to propose a map for the islet cell differentiation pathway.

23 more direct role for CaBP in the trophoblast differentiation pathway.

24 e progression of cells along the chondrocyte differentiation pathway.

25 ifying mechanisms controlling this important differentiation pathway.

26 haps other genes involved in the chondrocyte differentiation pathway.

27 to represent distinct stages in the monocyte differentiation pathway.

28 red later to divert neurons along a specific differentiation pathway.

29 event progenitors from entering the neuronal differentiation pathway.

30 h a role for Mlps in myogenesis, late in the differentiation pathway.

31 ear to induce some aspects of the fiber cell differentiation pathway.

32 o the more general atonal-mediated proneural differentiation pathway.

33 onic cells are capable of following the VSMC differentiation pathway.

34 inase complex inhibitor in facilitating this differentiation pathway.

35 ast cells exit mitosis and enter the meiotic differentiation pathway.

36 to exit the stem cell state and to enter the differentiation pathway.

37 plays a key role in triggering the iNKT cell-differentiation pathway.

38 lation and the initiation of the plasma cell differentiation pathway.

39 versible initiation of the slender-to-stumpy differentiation pathway.

40 sical steroidogenic tissue, to a proallergic differentiation pathway.

41 onal hierarchy that directs this interneuron differentiation pathway.

42 it from the stem cell state and to enter the differentiation pathway.

43 to transcribe IFNG at each stage of the Th1 differentiation pathway.

44 ating a fundamental defect throughout the DC differentiation pathway.

45 gle cells at sequential stages in the B cell differentiation pathway.

46 eighbors to facilitate entry into a terminal differentiation pathway.

47 en the integrin/ILK adhesion complex and the differentiation pathway.

48 omote the UV cone fate by repressing the rod differentiation pathway.

49 tion dynamics in vitro by blocking exit into differentiation pathways.

50 multipotent cell types to regulate specific differentiation pathways.

51 elongated primary lens fibers via other lens differentiation pathways.

52 class II bHLH proteins to regulate distinct differentiation pathways.

53 resence or absence of tension with divergent differentiation pathways.

54 HoxA9 cooperation suppresses several myeloid differentiation pathways.

55 sensitive to small perturbation of neuronal differentiation pathways.

56 ating the molecular bases for their distinct differentiation pathways.

57 further differential expression of genes in differentiation pathways.

58 DCP-Mix cells along restricted and divergent differentiation pathways.

59 cell division with the rate of entrance into differentiation pathways.

60 ation of Raf-1, regulating proliferation and differentiation pathways.

61 numerous epithelial cell types with distinct differentiation pathways.

62 Fos implies that FBR v-Fos inhibits multiple differentiation pathways.

63 poiesis by regulating both proliferation and differentiation pathways.

64 early embryogenesis to specify several major differentiation pathways.

65 at positively and negatively regulate myelin differentiation pathways.

66 ave an influence on these altered epithelial differentiation pathways.

67 ion factors of genes regulating various cell differentiation pathways.

68 of the complex mechanisms involved in B-cell differentiation pathways.

69 in human cancers to restore normal terminal differentiation pathways.

70 rk entropy also allows identification of key differentiation pathways.

71 (ESCs), Prdm4 regulates key pluripotency and differentiation pathways.

72 and Akt2 exert distinct effects on cellular differentiation pathways.

73 -renew or inhibit execution of preprogrammed differentiation pathways.

74 a role, by inducing apoptosis and/or through differentiation pathways.

75 ate choices, to build a map of immunological differentiation pathways.

76 y diverse and act through multiple, parallel differentiation pathways.

77 utes to induction of specific activation and differentiation pathways.

78 udies using seeded scaffolds may help define differentiation pathways.

79 g of pre-GMs, we identified distinct myeloid differentiation pathways: a pathway expressing the gene

80 ony-simulating factor), suggesting that cell differentiation pathways act as determinants of reactiva

81 anscription factors function in the neuronal differentiation pathway activated by the vertebrate neur

82 ated from maternal hearts recapitulate these differentiation pathways, additionally forming vascular

83 ngly, that it is specific for one fibroblast differentiation pathway (adipogenesis) relative to anoth

84 velopment and later SoxE genes influence the differentiation pathway adopted by migrating neural cres

85 d to their fates and the step(s) along their differentiation pathway affected by Hedgehog.

86 t acts at the terminal stage of the neuronal differentiation pathway and blocks the transcription of

87 e initial and the terminal stages of a given differentiation pathway and combines the statistically i

88 satory roles for MRF4 and MyoD in the muscle differentiation pathway and suggest that a threshold lev

89 nzymes that catalyse them modulate stem cell differentiation pathways and are essential for normal de

90 supporting these nonclassical megakaryocytic differentiation pathways and consider their relative str

91 d be used as a unique tool to study neuronal differentiation pathways and neuronal diseases that aris

92 inase family in distinct ES cell renewal and differentiation pathways and show that small-molecule SF

93 f pTalpha-expressing progenitors to distinct differentiation pathways and to the genealogy of mature

94 TNNB1, encoding beta-catenin in the Wnt cell-differentiation pathway, and expressed LHCGR and GNRHR,

95 s suggest that IKDCs may arise from a unique differentiation pathway, and one that diverges early fro

96 CD4+ T cells become primed to follow the Th2 differentiation pathway, and we show now that by 48 h of

97 helium is a cellular mosaic of different sex differentiation pathways, and displays extensive sex dif

98 ignals were enriched in neuronal genesis and differentiation pathways, and substantial genetic correl

99 ignals were enriched in neuronal genesis and differentiation pathways, and substantial genetic correl

100 erentiation genes and to override the muscle differentiation pathways, and they suggest that this app

101 n of NADPH oxidase, phagocyte activation and differentiation pathways, apoptosis, and interferon-gamm

102 s that two critical steps of the chondrocyte differentiation pathway are sensitive to Sox9 dosage.

103 ignaling pathways are well represented: most differentiation pathways are "off" and survival/growth p

104 linking mechanical forces to cell and tissue differentiation pathways are important for understanding

105 gest that endogenous stem cell signaling and differentiation pathways are maintained within distinct

106 Stem cell differentiation pathways are most often studied at the p

107 a cells, but the mechanisms leading to those differentiation pathways are mostly unknown.

108 molecular complexity in which many possible differentiation pathways are primed, providing one possi

109 ams, and correspondingly, all three terminal differentiation pathways are suppressed when Tcf3 is ind

110 These data suggest that a linear differentiation pathway, as defined by the transition fr

111 body response to identify the sites and cell differentiation pathways at early and late stages of the

112 ep transplantation experiments established a differentiation pathway between conventional lymphoid pr

113 ine skin revealed that while GRHL3 regulates differentiation pathways both during development and dur

114 anglion cells develop following two separate differentiation pathways--Brn-3b dependent and Brn-3b in

115 Thus, Isl1 is required for engaging bipolar differentiation pathways but not for general bipolar cel

116 Here, we delineate a macrophage differentiation pathway by which a persistent Toll-like

117 female determined state and activates female differentiation pathways by directing the female-specifi

118 lities of forward and reverse engineering of differentiation pathways by manipulation of transcriptio

119 implicates deregulation of developmental and differentiation pathways, cell fate misspecification, in

120 the NOD2 ligand-induced, IL-32-dependent DC differentiation pathway contributes a key and specific m

121 PL that interfere with the proliferation and differentiation pathways controlled by both RAR and thei

122 ion conditions blocked entry into the muscle differentiation pathway, countered endogenous REST/NRSF-

123 tween the initial and terminal stages of the differentiation pathway, coupled with "if-then" rules (B

124 nses to viral infection can undergo distinct differentiation pathways, depending on the timing of Ag

125 This Ag-independent T cell differentiation pathway did not result in up-regulation

126 cating a G-protein-coupled receptor-mediated differentiation pathway distinct from the one activated

127 nerated from multiple pathways and that some differentiation pathways do not require transit through

128 f the cellular origin of B-CLL cells and the differentiation pathways down which we believe these cel

129 and fruitless-independent branch of the sex differentiation pathway downstream of transformer.

130 o choose between a mesodermal and a neuronal differentiation pathway during gastrulation; Tbx6 is ess

131 ated epithelial apoptosis, proliferation and differentiation pathways during gastric carcinogenesis,

132 ads neuronal progenitor cells to distinctive differentiation pathways during human brain development.

133 oncoproteins block complementary subsets of differentiation pathways, establishing a more complete d

134 r 2 weeks of culture, progresses through the differentiation pathway exhibited by chondrocytes in the

135 Our findings thus identify a new differentiation pathway for DN regulatory T cells and un

136 Our observations define a new differentiation pathway for peripheral T cells and sugge

137 ion and differentiation, we identified a new differentiation pathway for the conversion of CD4(+) T c

138 intrinsic mechanism that specifies alternate differentiation pathways for stratified squamous epithel

139 Our findings establish a novel LC differentiation pathway from BDCA-1(+) blood DCs with po

140 s that T(EM) and T(CM) cells follow a linear differentiation pathway from naive T cells to effector T

141 tly coexpressed with Tbr1, and in the direct differentiation pathway from radial glia --> postmitotic

142 s that, in turn, induce type I IFN-dependent differentiation pathway functioning in T cells.

143 Despite increasing evidence that differentiation pathway genes are frequently mutated in

144 ypermethylation of MITF and its co-regulated differentiation pathway genes corresponded to decreased

145 Its role in differentiation pathways has been highlighted by its pot

146 Mapping physiological differentiation pathways has now led to opposite conclus

147 The underlying differentiation pathways have been well characterized in

148 At later times cells continue along the differentiation pathway in a manner which is RA and RAR

149 newal by directly repressing a Bam-dependent differentiation pathway in GSCs.

150 receptor signaling, a key proliferation and differentiation pathway in mast cells.

151 nd introduce a major component of the sexual differentiation pathway in Plasmodium that may provide n

152 te that B. fragilis co-opts the Treg lineage differentiation pathway in the gut to actively induce mu

153 s the autocrine IL-6- and IL-21-induced Th17 differentiation pathways in autoreactive CD4 T cells, hi

154 These results suggest that the differentiation pathways in Cdk4-overexpressing cells re

155 al development by balancing self-renewal and differentiation pathways in CNC progenitors.

156 e that LMP2A greatly affects cell growth and differentiation pathways in epithelial cells, in part th

157 been defined, the factors that control these differentiation pathways in humans are not well understo

158 green soil alga, shares common ancestry with differentiation pathways in land plants.

159 g points for reverse genetic analyses of the differentiation pathways in petal and stamen development

160 show genetic abnormalities of lung-specific differentiation pathways in the development of lung canc

161 1 expression may contribute to WT1-dependent differentiation pathways in the kidney and potentially t

162 a useful model to further define the complex differentiation pathways in the normal gut as well as th

163 -renewal signaling pathway or stimulation of differentiation pathways in the NPC decreased glycolytic

164 enhancements in IL-6- and IL-21-induced Th17 differentiation pathways in these T cells.

165 is suggested enriched cellular proliferation/differentiation pathways in truck drivers and proinflamm

166 pair, and aberrant activation of alternative differentiation pathways in vascular disease.

167 of a series of distinct steps in the dermal differentiation pathways, including a unique cell type c

168 have focused on tyrosine kinase inhibition, differentiation, pathway inhibition, and immunotherapy.

169 of LMP7-specific inhibition on major Th cell differentiation pathways involved in the progression of

170 Thus, the T(FH) differentiation pathway is co-opted by T(reg) cells to c

171 for neurofibromin in which the survival and differentiation pathway is constitutively active.

172 The CD46-mediated differentiation pathway is defective in several chronic

173 Because the Flt3 ligand-mediated differentiation pathway is important during homeostasis,

174 However, we found that the cartilage differentiation pathway is initiated in mice as seen by

175 ormally specific for cells on the stalk cell differentiation pathway, is expressed throughout the pre

176 estis from which sperm arise by means of the differentiation pathway known as spermatogenesis.

177 Together, this work underlines the differentiation pathways leading to Fv3-susceptible and

178 in granulosa cells blocks the granulosa cell differentiation pathway, leading to the persistence of a

179 w) B cells were blocked in their plasma cell differentiation pathway, maintained high expression of t

180 Thus, alternate differentiation pathways may be used to produce innate e

181 t in adult mice, although alternative T-cell differentiation pathways may exist.

182 ial pathogen-mediated stimulation of myeloid differentiation pathways may provide a means for rapid r

183 hich can help to direct cells along opposing differentiation pathways, may in fact be reflected in pa

184 mutations of genes encoding molecules in the differentiation pathway mediated by Tshz3.

185 f the phenotypes depends on the stage in the differentiation pathway of a given lineage in which the

186 ent manner, respectively, thus following the differentiation pathway of alphabeta and not gammadelta

187 ed on these data, we propose a model for the differentiation pathway of alphabeta TCR thymocytes that

188 ses Eomes expression, thereby regulating the differentiation pathway of CD8(+) T cells.

189 The magnitude, phenotypic activation, and differentiation pathway of CD8+ T cells were similarly i

190 alized dentin have the ability to affect the differentiation pathway of embryonic muscle fibroblasts

191 A two-branched differentiation pathway of five fibroblastic subtypes wa

192 spectives generated by this newly identified differentiation pathway of HSCs.

193 We describe a distinct "helper" differentiation pathway of human CD56+CD3- NK cells into

194 r population in the erythroid/megakaryocytic differentiation pathway of humans, and implicate an eryt

195 The differentiation pathway of iNKT cells branches off from

196 The differentiation pathway of iNKT cells positively selecte

197 BMPs likely promote a hair follicle-type differentiation pathway of keratinocytes while suppressi

198 Our data demonstrate the origin and differentiation pathway of MAIT-cells from a naive type-

199 ons only, and the second class had a default differentiation pathway of neurons and astrocytes.

200 immortalized: the first class had a default differentiation pathway of neurons only, and the second

201 C-like properties, they also unveil a unique differentiation pathway of neutrophils into neutrophil-D

202 The differentiation pathway of peptide-induced IL-10 T reg c

203 eratinocytes while suppressing the sebaceous differentiation pathway of skin epithelium.

204 as been whether these factors can direct the differentiation pathway of uncommitted precursors or whe

205 here advances our ability to understand the differentiation pathways of naive T cells into antigen-s

206 ommon, evolutionarily conserved, link in the differentiation pathways of skeletal and cardiac muscle.

207 Fundamental processes in determining the differentiation pathways of stem cells remain to be eluc

208 , at a clonal level, the immunophenotype and differentiation pathways of the earliest progenitors in

209 self-renewal by repressing a Bam-independent differentiation pathway possibly through regulating tran

210 otent and multipotent stem cells to distinct differentiation pathways, proliferation and maturation o

211 meiosis in S. cerevisiae is a paradigm of a differentiation pathway regulated by signal transduction

212 DNT origin and differentiation pathways remain controversial.

213 ally specialized lineages, whose origins and differentiation pathways remain incompletely defined.

214 receptor expression by ECs reflects distinct differentiation pathways remains to be established.

215 nd which transcription factors control these differentiation pathways remains unknown.

216 Commitment to a neuronal differentiation pathway results in increased levels of A

217 ulated by chemical design to direct cellular differentiation pathways such as angiogenesis and vascul

218 th hypoxia and TGF-beta1 modulated adipocyte differentiation pathways such as the insulin-, peroxisom

219 egatively regulate alternative T helper cell differentiation pathways such as the Th2 and Th17 fates.

220 functional importance and well-characterized differentiation pathways, T and B lymphocytes are ideal

221 The independent differentiation pathways targeted by Hoxa9 and Meis1a pr

222 is an important cytokine signature of the TH differentiation pathway TH17.

223 live infected organs and revealed a complex differentiation pathway that facilitates bacterial persi

224 ults suggest a specific role for Hoxb13 in a differentiation pathway that gives the ventral prostate

225 ng epithelial cells through a neuroendocrine differentiation pathway that is a feature of small-cell

226 nding suggests possible abnormalities in the differentiation pathway that leads to uterine invasion.

227 ate both pathways, allowing cells to enter a differentiation pathway that results in tubule formation

228 2 cells have already become polarized to the differentiation pathway that they will follow.

229 olarity, directional cell migration and cell differentiation, pathways that extend the complexity of

230 brates and vertebrates by inhibiting certain differentiation pathways, thereby permitting cells to ei

231 ECP induces normal monocytes to enter the DC differentiation pathway, this phenomenon is independent

232 nstrate that microRNAs control the stem cell differentiation pathway through regulating Bam, the down

233 e selection of an adipocyte or myofibroblast differentiation pathway through SAPK/JNK signaling.

234 FGF9 in the early embryonic RPE switched its differentiation pathway to a neuronal fate, resulting in

235 Our analysis suggests a common differentiation pathway to an intermediate state followe

236 ly express HLA class II molecules during the differentiation pathway to granulocytes and macrophages.

237 rate viral exploitation of the normal B cell differentiation pathway to maintain latency.

238 n also co-opt the Bcl-6-dependent follicular differentiation pathway to migrate into B-cell follicles

239 llective output of neoblasts transit through differentiation pathways to produce specific cell types.

240 s1a cooperates with Hoxa9 by blocking viable differentiation pathways unaffected by Hoxa9 alone.

241 ggest that EBV harnesses the B-cell terminal differentiation pathway via XBP-1s as a physiological si

242 However, this differentiation pathway was limited to mesenchyme-derive

243 of the bipotent precursor cell whose default differentiation pathway was neurons only.

244 sential for several steps of the chondrocyte differentiation pathway, we asked whether Ctgf (Ccn2) is

245 assess the ability of SF-1 to regulate this differentiation pathway, we ectopically expressed SF-1 i

246 insights into the role of Nurr1 in the final differentiation pathway, we have examined the fate of do

247 l system to gain insight into the mesodermal differentiation pathway, we have isolated a set of mutan

248 To clarify the Th1 differentiation pathway, we performed ablation studies u

249 n cell growth and proliferation, and myeloid differentiation pathways were among the most significant

250 a marker for the entry of myoblasts into the differentiation pathway, were detected first during myog

251 n cells that have further advanced along the differentiation pathway, whereas Mad1 is primarily expre

252 RNA interference promotes and accelerates a differentiation pathway, which also affects and slowdown

253 age-associated hotspots targeting stem-cell differentiation pathways, which we validate in independe

254 Understanding when to manipulate the cell's differentiation pathway with the application of single o

255 ption factor Id1 coordinates cell growth and differentiation pathways within mammalian cells and has

256 Id proteins coordinate cell growth and differentiation pathways within mammalian cells and have

257 r the antigen-presenting dendritic cell (DC) differentiation pathway, within a single day, without ad

258 eported ability to suppress multiple myeloid differentiation pathways, would provide a strong selecti

259 of gene expression is a hallmark of cellular differentiation pathways, yet the mechanisms controlling