ライフサイエンスコーパス: differentiation potential

1 d allows the ranking of cells based on their differentiation potential.

2 the presence of close analogues with varying differentiation potential.

3 itor cells with self-renewal and multipotent differentiation potential.

4 eptor antagonist resulted in altered myeloid differentiation potential.

5 stem cells are considered to have a limited differentiation potential.

6 ither DPSC proliferation rate or multipotent differentiation potential.

7 ) cell derived SG-MSCs revealed multilineage differentiation potential.

8 hematopoietic progenitors and had bilineage differentiation potential.

9 on, exhibit differences in proliferation and differentiation potential.

10 mbryonic stem cell phenotype and pluripotent differentiation potential.

11 e proliferation ability, thus changing their differentiation potential.

12 hondria and require UCP2 repression for full differentiation potential.

13 in genome-wide DNA methylation profiles and differentiation potential.

14 ant proliferative, chemotaxis, adhesion, and differentiation potential.

15 e capacity for self-renewal and multilineage differentiation potential.

16 cells yet differ in molecular phenotype and differentiation potential.

17 yeloid progenitors (EMPs) that lack lymphoid differentiation potential.

18 sider implications for hESC pluripotency and differentiation potential.

19 but not their maintenance, proliferation or differentiation potential.

20 prethymic, age-related defects in T-lineage differentiation potential.

21 vels of endoglin (NCSC(CD105+)) had myogenic differentiation potential.

22 accelerates maturation and polarizes hES-NSC differentiation potential.

23 in Lmna(-/-) myoblasts resulted in increased differentiation potential.

24 er the JAK2 V617F-positive cells had altered differentiation potential.

25 derived stem cells (ADSCs) have multilineage differentiation potential.

26 -derived pluripotent stem cells with a broad differentiation potential.

27 mpaired differentiation kinetics and reduced differentiation potential.

28 enerated uncommitted cells with multilineage differentiation potential.

29 ed this compartment, but retain multilineage differentiation potential.

30 a transformed phenotype and disrupting their differentiation potential.

31 o establish new stage- or cell-type-specific differentiation potential.

32 developmental stage thymocytes lose this G/M differentiation potential.

33 planted into syngeneic rats to examine their differentiation potential.

34 played less CD45RA, and had little B-lineage differentiation potential.

35 an ongoing immune response, regardless of Th differentiation potential.

36 pRB(-/-) 3T3 cells exhibit defects in their differentiation potential.

37 cytic progenitor with intrinsic biphenotypic differentiation potential.

38 l, serial clonogenicity, and multigerm layer differentiation potential.

39 C) are cells with self-renewing multilineage differentiation potential.

40 clonogenic potential and increased B-lineage differentiation potential.

41 s (nephrogenic rests) which retain embryonic differentiation potential.

42 LMPP/MPP4 with loss of lymphoid priming and differentiation potential.

43 progenitor cell populations with restricted differentiation potential.

44 markers and demonstrated robust mineralizing differentiation potential.

45 ed MSCs for self-renewal, proliferation, and differentiation potential.

46 is regulated by progenitor availability and differentiation potential.

47 eased cell death or altered neural precursor differentiation potential.

48 blasts had approximately 50% lower adipocyte differentiation potential.

49 n (STAT) 3 signaling pathway, and osteogenic differentiation potential.

50 bryonic tissue while maintaining a versatile differentiation potential.

51 r cell duplication in populations with equal differentiation potential.

52 oth phenotypes and restored normal stem cell differentiation potential.

53 th preserved long-term in vivo lymphomyeloid differentiation potential.

54 ntify the lines exhibiting strong osteogenic differentiation potential.

55 population studied as HSPCs with multlineage differentiation potential.

56 fered in their metabolic characteristics and differentiation potential.

57 ssures favouring cell aneuploidy and loss of differentiation potential.

58 MSC marker profile and in vitro multilineage differentiation potential.

59 ughter cells with differing self-renewal and differentiation potentials.

60 either A-type lamins or emerin have impaired differentiation potentials.

61 fibroblasts possessed trilineage mesenchymal differentiation potentials.

62 ogenic assays were used to investigate their differentiation potentials.

63 are defined by self-renewal and multilineage differentiation potentials.

64 teoblastogenic, chondrogenic, and adipogenic differentiation potentials.

65 iple BM populations have intrinsic T lineage differentiation potential, a small subset of multipotent

66 mice, displaying increased proliferation and differentiation potentials (adipogenesis, osteogenesis a

67 marrow cells containing lymphoid-restricted differentiation potential after i.v. transplantation.

68 ulated young mice, and retained multilineage differentiation potential after multiple rounds of seria

69 aracteristics in vitro and proliferative and differentiation potential after transplantation into adu

70 gramming event to acquire a remarkably broad differentiation potential and ability to migrate through

71 parthenogenesis and demonstrated their wide differentiation potential and applicability for genetic

72 om hESCs (hESCd-MSCs) that have multilineage differentiation potential and are capable of producing f

73 teoclasts from BgnFmod KO mice having higher differentiation potential and being more active compared

74 oid progenitors exhibiting CD14-dependent DC differentiation potential and CD14(+)CD1a+ DC precursors

75 ryonic progenitor cells with hemangioblastic differentiation potential and conclude that embryonic pr

76 These progenitor cells demonstrated bipotent differentiation potential and could generate endothelial

77 cells differ from each other with respect to differentiation potential and fates.

78 prisingly, GPx2-suppressed cells also lacked differentiation potential and formed slow-growing undiff

79 Understanding the differentiation potential and function of these cells ma

80 monocyte subpopulations, understanding their differentiation potential and function.

81 on therapies by virtue of their multilineage differentiation potential and immunogenicity; however, r

82 ntense investigation in HCT because of their differentiation potential and immunomodulatory propertie

83 al, and had normal transcriptional profiles, differentiation potential and karyotypes.

84 ells, with which they share gene expression, differentiation potential and lineage restriction.

85 n knockout cells decreased proliferation and differentiation potential and recapitulated the WT pheno

86 tant in defining cellular properties such as differentiation potential and responsiveness to developm

87 iding with a reduction in both smooth muscle differentiation potential and TGFbeta1 responsiveness.

88 cific stem/precursor cells that retain broad differentiation potential and, more importantly, develop

89 in an intermediate state with bidirectional differentiation potential, and found the balance between

90 rbor an appropriate gene edit, pluripotency, differentiation potential, and genomic stability are typ

91 re the most proliferative, hold the greatest differentiation potential, and have the lowest rate of c

92 ity of the hemangioma stem cells, diminishes differentiation potential, and inhibits the vasculogenic

93 h passage 11 for phenotype, gene expression, differentiation potential, and karyotype.

94 at histone H3 serine 10 (H3S10P), decreased differentiation potential, and premature cellular senesc

95 e have distinct patterns of gene expression, differentiation potential, and response to environmental

96 itors are hyperproliferative, show decreased differentiation potential, and show increased self-renew

97 + CD38- progenitor cells have a multilineage differentiation potential, and that Tpo promotes prolong

98 itor populations with granulocyte/macrophage differentiation potential are efficiently immortalized i

99 rs that regulate cancer stem-like cell (CSC) differentiation potential are largely unknown.

100 rs did not restrict, but rather switch their differentiation potential as they developed.

101 scaffolds exhibit an increase in osteogenic differentiation potential, as evidenced by increased alk

102 enitors had a combined myeloid and erythroid differentiation potential, as well as capacity for prolo

103 progenitor populations for T cell growth and differentiation potential, as well as for clonogenic T o

104 riability of their osteogenic and adipogenic differentiation potential, as well as their ability to m

105 rimitive human progenitors with multilineage differentiation potential, as well as to evaluate future

106 the dissociated cells retained their normal differentiation potentials, as shown by their capabiliti

107 ested that bone marrow cells possess a broad differentiation potential, being able to form new liver

108 ndrogenic potential assays revealed retained differentiation potentials between transduced and wild-t

109 ariability in frequency, immunophenotype and differentiation potential, both between and even within

110 ers of haematopoietic stem cells with normal differentiation potential, but loss of cell-autonomous s

111 Ps, with very limited granulocyte/macrophage differentiation potential, but they can differentiate in

112 ssemble HC variable region genes and assayed differentiation potential by recombination activating ge

113 n impaired, however, in determining cellular differentiation potentials by a lack of short-term funct

114 7, and CD94 cell surface expression, lineage differentiation potentials, capacity for cytokine produc

115 ogeneous, and displays distinct multilineage differentiation potential, cell cycle profile, prolifera

116 ibited increased TRPV4 activity and enhanced differentiation potential compared with normal human lun

117 d from TRPV4-knockout mice showed diminished differentiation potential compared with wild-type mice.

118 e less quiescent, and exhibit myeloid-biased differentiation potential compared with young HSC.

119 ple distinct subsets that display growth and differentiation potential consistent with being canonica

120 ervoir of CD45-CD34(+) EPCs with endothelial differentiation potential, containing a mean of 263 time

121 yed differences in fate-regulating genes and differentiation potential depending on their rostrocauda

122 lls affected by BRAF mutation had a range of differentiation potentials depending on exogenous signal

123 the sequential loss of erythroid and then GM differentiation potential during early hematopoiesis.

124 genitors are protean and able to alter their differentiation potential during embryogenesis and after

125 oietic cells are tightly restricted in their differentiation potential during mouse embryo developmen

126 rm self-renewing capacities and multilineage differentiation potential during physiological and regen

127 pression for protecting stem cells and their differentiation potential during viral infection.

128 ation capacity and restricted cardiovascular differentiation potentials during cardiac transdifferent

129 pacity in vivo but completely lacked myeloid differentiation potential either in vivo or in vitro.

130 n upon which TSCs are cultured changes their differentiation potential from TGCs to multinucleated sy

131 g progenitor cells, and possess multilineage differentiation potential generating functional prostati

132 To this end, we examined differentiation potential, global gene expression patter

133 culture and transplantation assays to assess differentiation potential have led to extraordinary prog

134 id cell lines with neutrophil and macrophage differentiation potential in about 50% of the infected c

135 potent stem cells (hiPSCs) with wide lineage differentiation potential in culture.

136 anscription factors and surface markers, and differentiation potential in embryoid body formation and

137 ts expression levels correlate with fat cell differentiation potential in humans.

138 Single BASCs had bronchiolar and alveolar differentiation potential in lung endothelial cell cocul

139 amycin targets the self-renewal and vascular differentiation potential in patient-derived hemangioma

140 CD29(low) luminal progenitors with enhanced differentiation potential in vitro and in vivo.

141 FP mice and evaluate their proliferative and differentiation potential in vitro.

142 ted long-term proliferation and multilineage differentiation potential in vitro.

143 perties in vitro and their proliferative and differentiation potential in vivo after transplantation

144 rogenitor cells; however, their identity and differentiation potential in vivo remain poorly characte

145 Lymphoid-specified MPPs have low myeloid differentiation potential in vivo, but potently differen

146 inocyte subpopulations with increased growth/differentiation potential, including clonal growth capab

147 ely impact either clonogenic or multilineage differentiation potential, indicating a selective depend

148 pe and possessing unlimited self-renewal and differentiation potential, induced pluripotent stem cell

149 bility with respect to CHCHD2 expression and differentiation potential is caused by clonal variation

150 Their migration pattern and differentiation potential is distinct from anterior fore

151 impact of genetic modifications on relative differentiation potential, it is now evident that a bias

152 Cell clones were evaluated for their O/C differentiation potential, metabolic activity, and expre

153 To evaluate their differentiation potential, NEPECs were heritably marked

154 tential in myoblasts, the augmented myogenic differentiation potential observed is likely the result

155 The differentiation potential of 17 human embryonic stem (hE

156 r, the EVE had no effect on proliferation or differentiation potential of adipose stem cells.

157 se model can be a valuable tool to study the differentiation potential of adult human stem cells.

158 o the mammary epithelial hierarchy, the true differentiation potential of adult MaSCs remains unclear

159 The multilineage differentiation potential of adult tissue-derived mesenc

160 Impaired lymphoid differentiation potential of aged LMPP/MPP4 is not rescu

161 We examined the differentiation potential of an adult liver stem cell li

162 f B-ALL and suggest that engaging the latent differentiation potential of B-ALL cells may provide new

163 reduction in the frequency and self-renewal/differentiation potential of basal MaSCs.

164 The differentiation potential of BECs and LECs in vivo and i

165 itutive Notch activity suppresses the acinar differentiation potential of CACs.

166 rs influence the epigenetic conformation and differentiation potential of cells during reprogramming

167 Here, we examined the differentiation potential of cells expressing such linea

168 ells; however, CTGF is down-regulated as the differentiation potential of committed pre-osteoblasts i

169 3 is required for both the proliferative and differentiation potential of developmentally mature kera

170 ted gene expression to the proliferation and differentiation potential of early human bone marrow lym

171 egies should concentrate on manipulating the differentiation potential of endogenous or exogenous pre

172 The phenotype characteristics and differentiation potential of enriched cells were analyze

173 Acute deletion of BAF250a disrupted the differentiation potential of ES cells by altering the ex

174 C self-renewal, but significantly alters the differentiation potential of ESCs, particularly along th

175 The differentiation potential of GRP cells is retained throu

176 The B cell differentiation potential of HNF1A(-/-) common lymphoid

177 the retinoblastoma protein and enhances the differentiation potential of hPSCs across all germ layer

178 The self-renewal and differentiation potential of human embryonic stem cells

179 nted here offer new tools for harnessing the differentiation potential of human ESCs.

180 f this study was to characterize the cardiac differentiation potential of human iPS cells generated u

181 mmunophenotype, transcriptional profile, and differentiation potential of individual MEP cells.

182 or formation and a determinant of the growth/differentiation potential of keratinocyte subpopulations

183 layed differentiation kinetics and decreased differentiation potential of lamin A/C-deficient and eme

184 e expression of premarked genes and enhanced differentiation potential of Lsh(-/-) iPS cells toward t

185 The differentiation potential of mouse embryonic stem cells

186 beta-catenin in mouse osteoblasts alters the differentiation potential of myeloid and lymphoid progen

187 r observe enhanced unbiased lineage-specific differentiation potential of naive hESCs converted in NC

188 The differentiation potential of NCC varies according to the

189 We tested the growth and differentiation potential of NCSCs at approximately 5% O

190 challenged by reports that showed a broader differentiation potential of neural stem cells, in vitro

191 When the differentiation potential of NG2+ cells in vitro was exa

192 rferons modulate the function and growth and differentiation potential of normal myeloid cells and pr

193 ciated previously with the proliferation and differentiation potential of OPs.

194 sion seems to correlate with neuroectodermal differentiation potential of pluripotent stem cells.

195 ce and differentiation, we have analyzed the differentiation potential of progenitors derived from em

196 l blood indices, and corrected the defective differentiation potential of progenitors in the erythroi

197 etic progenitor assays demonstrated that the differentiation potential of PV was already skewed towar

198 To examine the self-renewal and differentiation potential of Rad-NSCs in vivo, Rad-NSCs

199 The ability to quantify differentiation potential of single cells is a task of c

200 In this study, we analyzed the differentiation potential of single thymocytes from wild

201 rm-free mice display reduced proportions and differentiation potential of specific myeloid cell proge

202 The differentiation potential of stem cells is influenced by

203 ether an open chromatin is necessary for the differentiation potential of stem cells, and which molec

204 e demonstrate the in vitro proliferative and differentiation potential of stem/progenitor cells, adul

205 The differentiation potential of T lineage cells becomes res

206 In short, slower proliferation and abnormal differentiation potential of tetraploid ESCs might be tw

207 g the dKO-nmMSCs with dKO-MPCs, the myogenic differentiation potential of the dKO-MPCs was reduced.

208 nce even low vector expression may alter the differentiation potential of the iPSCs or induce maligna

209 The viability, proliferation rate, and differentiation potential of the labelled cells were the

210 The relatively uniform differentiation potential of the Wnt(high) and Wnt(low)

211 The origin and growth/differentiation potential of these c-kit-positive cells

212 decreasing average mechanical compliance and differentiation potential of these cells, although expre

213 han nonpolar progenitors, leading to a lower differentiation potential of these cells.

214 The differentiation potential of these MSCs combined with ex

215 that cellular origin influences the in vitro differentiation potentials of iPSCs into embryoid bodies

216 howed a direct correlation between DDIT4 and differentiation potentials of MSC.

217 lations often have reduced proliferation and differentiation potential, or have become immortalized c

218 expressed EphB4 in cell lines of restricted differentiation potential promoted megakaryocytic differ

219 g and comparing the hiPSC clonal and/or line differentiation potential provides a tool for large scal

220 ed-HSCs (iHSCs), possess clonal multilineage differentiation potential, reconstitute stem/progenitor

221 een claimed to possess an unexpectedly broad differentiation potential (referred to here as plasticit

222 To test whether these changes in Th cell differentiation potential rendered Grb2(fl/fl) CD4cre(tg

223 Finally, to confirm the differentiation potential, reporter human iPS clones wer

224 ic cells are expected to possess high growth/differentiation potential, required for organ morphogene

225 g-term engrafting potential and multilineage differentiation potential resided within the Rh123lo-mid

226 Furthermore, CCR9(+) MPPs possess differentiation potential similar to that of ETPs, with

227 en their unique function in self-renewal and differentiation potential, stem cells might be used to r

228 tion defect with minimal effect on erythroid differentiation potential, suggesting the mechanism of a

229 neurons, the two hESC lines exhibit distinct differentiation potentials, suggesting that they are pre

230 eir genomic instability and diminishes their differentiation potential, supporting the notion that ac

231 enewing progenitor with limited multilineage differentiation potential termed the erythromyeloid prog

232 intain a latent granulocyte/macrophage (G/M) differentiation potential that can be initiated by signa

233 However, they maintain a latent myeloid differentiation potential that can be initiated by stimu

234 sively without obvious senescence or loss of differentiation potential, they may be an ideal cell sou

235 that become increasingly restricted in their differentiation potential through oligopotent and then u

236 t nuclear reprogramming can restore terminal differentiation potential to human-derived cancer cells,

237 elopmental plasticity, thereby expanding the differentiation potential to include the neuronal lineag

238 F4 or FGF2 together with heparin rescued the differentiation potential to neural progenitors and furt

239 l brain tumors are similar in appearance and differentiation potential to neural stem and progenitor

240 (termed R-NSCs), a novel NSC type with broad differentiation potential toward CNS and PNS fates and c

241 In addition, these SCs show differentiation potential toward mesenchymal lineages, a

242 d both neuronal and glial progeny, but their differentiation potential toward multiple region-specifi

243 erative medicine has been to direct the wide differentiation potential toward the derivation of a spe

244 Although early pro-B cells have lost myeloid differentiation potential, transplantation experiments d

245 during hematopoiesis, with stepwise loss of differentiation potential ultimately resulting in lineag

246 helial SCs, their tissue location, and their differentiation potential under physiological conditions

247 scence and maintained their multipotency and differentiation potential until passage 11 and beyond.

248 Thus, IRF8 not only bestows monocyte and DC differentiation potential upon mononuclear phagocyte pro

249 ght, we assessed relative tumorigenicity and differentiation potential via xenotransplantation.

250 Differentiation potential was evaluated by injecting cel

251 Differentiation potential was examined for changes in ph

252 Monocytic cell differentiation potential was retained in left-shifted b

253 Differentiation potential was tested in novel, single-ce

254 Six imidazole derivatives with high kinase differentiation potential were identified.

255 D repopulating cells (SRC) with multilineage differentiation potential were maintained in FL-SCF-IL-7

256 ing fibrocytes, with greater myofibroblastic differentiation potential, were observed in patients wit

257 previously showed that they acquire broader differentiation potential when cultured under embryonic-

258 cdpk3- ookinetes maintain their full genetic differentiation potential when microinjected into the mo

259 rogenitors (CLPs), maintain a latent myeloid differentiation potential, which can be initiated by sti