ライフサイエンスコーパス: differentiation state

1 o modulate liposarcoma cell survival and ASC differentiation state.

2 reas hiPSC-derived RPE cells are in a unique differentiation state.

3 ain their expression, thereby locking in the differentiation state.

4 r CD57, a finding consistent with an earlier differentiation state.

5 according to the stage of the cell cycle and differentiation state.

6 o transition from a proliferative state to a differentiation state.

7 lls progress from a naive to a primed/memory differentiation state.

8 Id1 degradation are independent of myogenic differentiation state.

9 that pigpen helps regulate endothelial cell differentiation state.

10 expression depends on cell type and cellular differentiation state.

11 rdless of host species, tissue of origin, or differentiation state.

12 llular signals causing phenotypic changes in differentiation state.

13 t correlated with cell cycle distribution or differentiation state.

14 on on EVT, presumably representing a further differentiation state.

15 with the latter independently of the T cell differentiation state.

16 tion at the ECM and governed by the cellular differentiation state.

17 ression are modified by cellular context and differentiation state.

18 ith sensitivity to DNA damage, was linked to differentiation state.

19 choring mechanisms depending on the neuronal differentiation state.

20 e from which MCs may be derived and/or their differentiation state.

21 nes regardless of the somatic cell source or differentiation state.

22 loss in DLBCL is associated with an altered differentiation state.

23 exhausted CD8 T cells become fixed in their differentiation state.

24 ion by interfering with the mature beta-cell differentiation state.

25 ytokine cascades that correlate with each Th differentiation state.

26 tionship between the replication program and differentiation state.

27 the stability and reversibility of cellular differentiation states.

28 genes in the proliferation and post-mitotic differentiation states.

29 te immune cell epigenomes to engage specific differentiation states.

30 its expression in different B cell lineages/differentiation states.

31 s similarly made up of cells in a variety of differentiation states.

32 onal signatures that define and regulate CTL differentiation states.

33 6 and subplate neurons maintain an immature differentiation state, abnormally expressing these genes

34 ctivity of TGF-beta is modulated by the cell differentiation state and by the presence of inflammator

35 g drives distinct responses depending on the differentiation state and context of CD8(+) T cells.

36 flect the cellular proliferative ability and differentiation state and deserve further studies as pot

37 posite effect, perturbing maintenance of the differentiation state and facilitating reprogramming to

38 pe, mechanics, and deformability change with differentiation state and have been likewise implicated

39 s a prominent role for syk in regulating the differentiation state and invasive phenotype of PDAC cel

40 ays an active role to reinforce the impaired differentiation state and promote malignancy.

41 The differentiation state and regulatory pathways that enabl

42 ated GLI2 levels, thereby regaining the full differentiation state and restoring normoglycemia in tra

43 oblastoma prognosis is dependent on both the differentiation state and stromal content of the tumor.

44 cence mimics a cell cycle-dependent drift in differentiation state and that propagation of HDF in his

45 , underlying the significance of chondrocyte differentiation state and the factors regulating normal

46 eosome stability and PTMs across cell types, differentiation state and throughout the cell-cycle in c

47 effector subsets is contingent on both their differentiation state and tissue localization.

48 lved in the regulation of breast cancer cell differentiation state and tumorigenicity.

49 CD8(+) T cells retain terminal effector (TE) differentiation states and fail to mature into protectiv

50 analyses of markers associated with cellular differentiation states and genotypic alterations in huma

51 ve accuracy of SLICE in determining cellular differentiation states and reconstructing cell different

52 xhibit both heterogeneity and instability of differentiation states and varying sensitivities of thes

53 We therefore determined the lineage, differentiation state, and functional potential of FL-in

54 The activation state, differentiation state, and functions of liver lymphocyte

55 We investigated the existence, differentiation state, and neoplastic potential of CD66(

56 at Lbx1 expression defines a basal GABAergic differentiation state, and Tlx3 acts to antagonize Lbx1

57 ith replicative age, chronological age, cell differentiation state, and/or overall worm physiological

58 signatures that represent specific lineages, differentiation states, and functions.

59 calization within tissues is linked to their differentiation states, and this may identify anatomical

60 ature, suggesting that programs that control differentiation state are key determinants of spatiotemp

61 s in tissue culture is dependent both on the differentiation state as well as exposure to soluble med

62 s (RAGE), promote chondrocyte hypertrophy, a differentiation state associated with matrix catabolism.

63 ctor, and transplanted similarly at the same differentiation state, at the same time and location, in

64 d into three subtypes, on the basis of their differentiation states: basal, intermediate, and differe

65 cRNA-seq) to quantitatively measure cellular differentiation states based on single cell entropy and

66 s thought to involve a compromised beta cell differentiation state, but the mechanisms underlying thi

67 ated role for methyltransferases in cellular differentiation states by direct posttranslational modif

68 This differentiation state can be modulated by preexisting me

69 Their differentiation state can be regulated by serum response

70 en, cytotoxic CD8(+) T cells develop diverse differentiation states characterized by function, locali

71 o activate transcription in a cell type- and differentiation state-dependent manner.

72 ion that is essential for the cell cycle and differentiation state-dependent onset of human cytomegal

73 the importance of this molecular switch for differentiation state-dependent regulation of IE gene ex

74 rogenitor cell-derived LC-type DCs exhibit a differentiation state-dependent susceptibility to CMV in

75 substantially up-regulated in a cortisol and differentiation-state-dependent manner.

76 into epithelial-mesenchymal interactions and differentiation state differences within the RA biosynth

77 ies suggest that the maintenance of the vein differentiation state during pupal development involves

78 e distinct BC subtypes on the basis of their differentiation states, each harboring a unique tumor-in

79 orm of thymic selection or as an alternative differentiation state for Ag-exposed T cells.

80 000 normal breast cells, which identified 11 differentiation states for normal luminal cells.

81 diversity of cell types that are defined by differentiation states, genetic mutations and altered ep

82 e transcriptional regulation of other T cell differentiation states has provided critical information

83 chanism of cellular communication, roles for differentiation state heterogeneity in pigment cell inte

84 al that T cell subsets can synchronize their differentiation state in a process similar to quorum sen

85 ancreas are not static, but can change their differentiation state in response to injury or stress.

86 nitor cells and remained expressed until the differentiation state in the mature plant, suggesting a

87 able proliferation and transition to earlier differentiation states in CONV.

88 prolonged Ag stimulation in programming this differentiation state, including local stimulation via c

89 An abnormal differentiation state is common in BRCA1-deficient mamma

90 Glomerular podocyte differentiation state is critical for filtration barrier

91 ization and understanding of this macrophage differentiation state is needed in order to efficiently

92 mbinations of factors that, depending on the differentiation state, might collaborate with MRFs.

93 receptors, Ptger4, was sufficient to drive a differentiation state morphologically and transcriptiona

94 age (CD8 > CD4) and a function of the memory differentiation state (naive T cells < central memory T

95 emonstrating a novel correlation between the differentiation state of a CD8(+) T cell and its abundan

96 t with the hypothesis that the activation or differentiation state of a monocyte may have a substanti

97 as a model system to investigate whether the differentiation state of a polarized model epithelium af

98 gonist or by alteration of the activation or differentiation state of a susceptible cell such as a ma

99 ring PD-1/PD-L1 inhibition are linked to the differentiation state of a T cell.

100 Thus, the differentiation state of adult neurons is under the cont

101 pigenetic regulators may influence the final differentiation state of an osteosarcoma.

102 bal effect that HIV has on the activation or differentiation state of CD8 cells that are responsive t

103 The differentiation state of CD8+ T cells has emerged as a c

104 microenvironment exerts supremacy over prior differentiation state of cells in directing position-spe

105 Understanding the lineage and differentiation state of each cell is fundamentally impo

106 , we show that CD4(+) T cells can modify the differentiation state of EBV-transformed LCL.

107 f functional TGase 1 forms, depending on the differentiation state of epidermal keratinocytes.

108 E2 expression positively correlated with the differentiation state of epithelia.

109 , by targeting multiple genes regulating the differentiation state of GNPs, Atoh1 collaborates with t

110 ks, we established a method to influence the differentiation state of hPSCs with a CRISPR-associated

111 motionless and foggy affect the number and differentiation state of hypothalamic DA, telencephalic

112 Remarkably, the differentiation state of individual BC progenitors at mi

113 The differentiation state of individual HCs in a test set co

114 (TOF-SIMS) data can be used to identify the differentiation state of individual hematopoietic cells

115 latory activity of IL-21 is modulated by the differentiation state of its target cells as well as by

116 m the Raman spectra can be used as marker of differentiation state of mES cells.

117 teractions as a mechanism for regulating the differentiation state of migrating cells.

118 found to change dynamically depending on the differentiation state of neural precursor cells.

119 We further show that the differentiation state of normal cells-of-origin is a str

120 The differentiation state of osteosarcomas has therefore bec

121 with the effects of E2F4, which enhances the differentiation state of PC12 cells without affecting ce

122 at mitosis is not arbitrary but matches the differentiation state of post-mitotic BCs in their surro

123 Exit from the cell cycle into a pre-differentiation state of post-mitotic growth arrest was

124 st that the effects of Ras signalling on the differentiation state of Schwann cells may be important

125 We therefore investigated its effects on the differentiation state of Schwann cells.

126 esis, and it plays a role in maintaining the differentiation state of secretory stage ameloblasts by

127 iated hESCs and fibroblasts to determine the differentiation state of stem-cell-derived RPE cells.

128 he antigenic signal and the developmental or differentiation state of the B cell, antigen receptor si

129 ggests that TCR usage is associated with the differentiation state of the CD8+ T cell response to YFV

130 at assaults on the beta cell that impact the differentiation state of the cell have clear implication

131 rs of transcription, varying by promoter and differentiation state of the cell.

132 ng on the nature of the signal and/or on the differentiation state of the cell.

133 y regulate caspase activation depends on the differentiation state of the cell.

134 differentially depending on cell type and/or differentiation state of the cell.

135 thway; this cross-regulation depended on the differentiation state of the cell: Akt activation inhibi

136 nges in [Ca2+]in levels) depends on both the differentiation state of the cells and concomitant engag

137 pidermal architecture, and the maturation or differentiation state of the cells.

138 However, we knew little about the differentiation state of the cultured granule cells that

139 e presence of blood flow correlates with the differentiation state of the developing pancreatic epith

140 ) from the melanoma cells that increased the differentiation state of the fibroblasts, an affect asso

141 BMP2 and BMP4 expression, independent of the differentiation state of the flanking chondrocytes.

142 llomavirus (HPV) life cycle is linked to the differentiation state of the host cell.

143 irus life cycle is intimately coupled to the differentiation state of the infected epithelium.

144 n state of tumors did not correlate with the differentiation state of the lineage of origin.

145 lation through CD28 or LFA-1, as well as the differentiation state of the lymphocyte, explaining how

146 effect of OxLDL on SR-BI is dependent on the differentiation state of the monocyte/macrophage.

147 ne expression, is influenced markedly by the differentiation state of the muscle cell.

148 heir release, but also on the activation and differentiation state of the neighboring immune cells.

149 tion differed significantly depending on the differentiation state of the phagocyte, providing furthe

150 le for CD4+ T cells in disease; however, the differentiation state of the responsible T cells is uncl

151 To evaluate the differentiation state of the sinonasal epithelium in CRS

152 ling pathway are secondary to changes in the differentiation state of the surrounding mesenchyme.

153 through the same receptor, depending on the differentiation state of the T cell.

154 tumour proliferation rate, host response and differentiation state of the tumour.

155 ve, reflecting the developmental lineage and differentiation state of the tumours.

156 ion and histological osteoid production, the differentiation state of tumors did not correlate with t

157 The lineage-specific differentiation states of cells from these four subpopul

158 orrelate with the distinct proliferation and differentiation states of chondrocyte zones.

159 s express markers corresponding to the major differentiation states of epithelial cells in the breast

160 onses and may influence the proliferation or differentiation states of epithelial cells.

161 using limited numbers of CD antigens enables differentiation states of immune system cells to be dete

162 SLICE successfully measured the differentiation states of single cells and reconstructed

163 n in the perichondrium correspond to altered differentiation states of the flanking chondrocytes.

164 e the progenitor cell niche, we examined the differentiation states of two progenitor cell subtypes i

165 The role of cell differentiation state on hepatitis B virus (HBV) replica

166 ly infection events and the role of the cell differentiation state on such events.

167 n which they can function as a group to mark differentiation states or individually as bona fide onco

168 ogeneity of functionally discrete and stable differentiation states, or conversely may be readily rev

169 It has been assumed that the somatic differentiation state provides a barrier for efficient r

170 athways mediating the switch between the two differentiation states remain unclear.

171 delay in the transition between the distinct differentiation states required to support peripheral ne

172 ue-resident memory (Trm) CD8(+) T cells to a differentiation state resembling inflationary effector r

173 n became linked to N-cadherin complexes in a differentiation-state specific manner.

174 We identified discrete cell-type and differentiation state-specific DNA methylation and gene

175 ets of normal human mammary cells could have differentiation state-specific functions and long-term c

176 eased autoantigen expression correlates with differentiation state, such that myositis autoantigen ex

177 protein degradation depends on the myogenic differentiation state (t 1/2 approximately 2 h in prolif

178 keratin 14 (KRT14) marks the most primitive differentiation state that precedes KRT5 and KRT20 expre

179 ntieth century, the dominant model of sexual differentiation stated that genetic sex (XX versus XY) c

180 oid cells by HSV-1 in vitro depends on their differentiation state; the outcome in vivo is unknown.

181 Related to differentiation states they have specific phenotypes and

182 transition from an epithelial-to-mesenchymal differentiation state through a process known as epithel

183 e cancer cell state (stem cell-like state vs differentiation state) to control the cancer stem cell (

184 Depending on their differentiation state, vertebrate neurones can commit su

185 Expression of this aberrant differentiation state was suppressed by GA.

186 visions, but is a function of the CD8 T cell differentiation state, which is genetically controlled i

187 rm cells, exhibit a wide range of histologic differentiation states with varying clinical behaviors.

188 e that CD66(high) cells have an intermediate differentiation state, with a cellular milieu connected

189 rectly from activated precursors in multiple differentiation states, with subset heterogeneity maximi