ライフサイエンスコーパス: difficult to

1 results reported in the literature are highly disparate and difficult to structure, a new format of organizing, visualizi

2 rder states, such as bound biexcitons, are possible but are difficult to identify unambiguously using linear optical spec

3 On the other hand, alpha-sulfinyl chlorides are difficult to prepare with high levels of enantiopurity and ar

4 ened species the rate and drivers of population decline are difficult to assess accurately: species' surveys are typicall

5 These patterns of atypical development are difficult to explain with existing models that emphasize stre

6 es and functional role of these intracellular hydrogels are difficult to study, primarily due to technical challenges in

7 wever, they, as all other protein-protein interactions, are difficult to target by small molecules.

8 e effects of anti-epileptic drugs on individual neurons are difficult to separate from their network-level actions.

9 ogy, but current solutions are costly, not versatile or are difficult to deploy.

10 such as monolignol oxidation and lignin polymerization are difficult to study in intact trees.

11 or small-scale societies for which reliable age records are difficult to acquire.

12 racterization and that global peptide-S/N relationships are difficult to identify.

13 Complex DNA sequences are difficult to detect and profile, but are important contributo

14 Such transient species are difficult to study experimentally, but it has proven valuable

15 are targets of most available pharmaceuticals, but they are difficult to produce recombinantly, like many other aggregati

16 ant species leading to the generation of datasets which are difficult to compare.

17 factants, macromolecules, and even nanoparticles, which are difficult to deploy in harsh reservoir conditions and where f

18 W chromosomes in species with female heterogamety (ZW), are difficult to sequence and assemble.

19 to the ovary and produce hybrids that, otherwise, would be difficult to obtain.

20 ect evidence for the precise synaptic localization has been difficult to achieve due to the lack of adequate optical micr

21 neonatal hematopoiesis, a developmental stage that has been difficult to analyze to date.

22 For such a complex reaction with membranes, it has been difficult to uncover the molecular process that underlies its

23 n of removal fluxes (e.g., crop uptake, leaching) have been difficult to estimate.

24 erivatives are desirable for a variety of applications, but difficult to access with modern C-C bond-forming reactions.

25 This makes it extremely difficult to evaluate the relative added value of each new tr

26 se pathogenesis, diagnosis, and therapeutic intervention in difficult-to-treat subjects.

27 nd that many diversification shifts occur after WGDs, it is difficult to consider diversification and duplication to be t

28 However, it is difficult to predict their properties based on macroscopic th

29 Because at present it is difficult to tell where sign stops and gesture begins, we sug

30 The rapid non-linear increase in heat-related morbidity is difficult to quantify, hindering the attribution of direct ef

31 e oneself as separate from other individuals and objects is difficult to investigate in non-human animals.

32 bular joint (TMJ) ankylosis is a refractory disease that is difficult to predictably treat.

33 quality of the predictions produced by the various tools is difficult to quantify.

34 conflicting theories require experimental support which is difficult to obtain from the living eye.

35 tant is highly variable over time and space, which makes it difficult to assess the average agronomic and economic impact

36 ce evolutionary relatedness in plant communities, making it difficult to generalize responses of this major feature of bi

37 ients generalize fear to nonfearful fear stimuli, making it difficult to regulate anxiety.

38 and response selection are strongly interactive: it is more difficult to repeat a response in the context of a changing t

39 The gain arises when a saved seed is allocated to a node difficult to reach via diffusion.

40 rial infections associated with biofilm formation are often difficult to resolve without extended courses of antibiotic t

41 f urban segregation that would be otherwise easy to miss or difficult to quantify.

42 ion, heterogeneity, and severity in patients with severe or difficult-to-treat asthma.

43 ltaneous acquisition of two high-resolution views otherwise difficult to obtain due to steric constraints at high numeric

44 MRSA is particularly difficult to treat when it invades host cells and survive ins

45 , but the precise nature of the protective effecthas proved difficult to define as G6PD deficiency has multiple allelic v

46 agricultural transition, although these changes have proved difficult to characterize at a global scale.

47 manifests as prolonged excruciating pain, which has proven difficult to treat.

48 However, the nature of this state has remained difficult to characterize.

49 membrane interactions, yet such information is surprisingly difficult to obtain at the molecular level.

50 ltra-flat aromatic structure of SN-38, it is typically very difficult to produce sub-100nm, SN-38-encapsulated nanopartic