ライフサイエンスコーパス: difficult to

1 Glioblastoma (GB) is a highly aggressive, difficult to treat brain tumour.

2 Large gene networks can be dense and difficult to interpret in a biologically meaningful way.

3 olypeptides, building blocks of life, which are fragile and difficult to handle.

4 s and nanometers, position and orientation fluctuations are difficult to observe with common measurement technologies.

5 ypic variation, although the cause-effect relationships are difficult to discern, calling for additional complementary ap

6 to transform flat films into 3D complex structures that are difficult to achieve by conventional fabrication approaches.

7 ptical mapping for the analysis of genomic regions that are difficult to sequence.

8 shift changes between the conformational states, which are difficult to obtain in many situations.

9 Fingerprints may be difficult to grasp by visual analysis but could be learned fr

10 Within PAD populations, data from trials may be difficult to interpret due to differences among the studies w

11 ters that undergo such flexible adaptation has proven to be difficult to establish using simplified models that are based

12 azinamidase, however, the exact target of the drug has been difficult to determine.

13 Hepatitis B virus (HBV) is an important but difficult to study human pathogen.

14 a-bis(calix)-sapphyrins are relatively easier to reduce but difficult to oxidize.

15 m them; a group of patients variously designated as having 'difficult to treat', 'treatment-resistant' or 'refractory' RA

16 the tightest known binder of KRas, a protein implicated in difficult-to-treat cancers.

17 s indicate it is possible to conduct long scan protocols in difficult-to-scan populations and still achieve high-quality

18 eria in environments where growth substrate availability is difficult to quantify can have large downstream impacts on ou

19 derstanding of its pathophysiology, functional dyspepsia is difficult to treat and, in most patients, the condition is ch

20 It is difficult to believe that in about 1960 practically nothing w

21 Using traditional methods, it is difficult to disentangle modality-specific activation from mo

22 hand motor cortex (M1) as a model, but in this model it is difficult to separate out the relative contribution of cutane

23 t relatively weaker NDD than rare plants at local scales is difficult to reconcile with the maintenance of overall plant

24 Where transitions are diffuse, fire spread is difficult to predict, but should become increasingly predicta

25 s in microfluidic systems have been limited as this tool is difficult to implement on the nanoliter or smaller scale.

26 ified treatment effects by using the hazard ratio, which is difficult to interpret for a positive event, especially in th

27 limited overlap of reported p63-dependent genes has made it difficult to decipher the p63 gene regulatory network.

28 but the identical sequence of sister chromatids has made it difficult to determine how they topologically interact in rep

29 These measurement challenges make it difficult to assess the validity of concerns about different

30 resources for clinicians to use when circumstances make it difficult to provide ideal bereavement care.

31 hemicals that continually interact and transform, making it difficult to accurately evaluate associated toxicity response

32 ecombine in auditory and vestibular brain nuclei, making it difficult to ascribe resulting phenotypes solely to the inner

33 allenging to detect with fluorescence microscopy, making it difficult to determine whether actin filaments are directly a

34 inescence in the near-infrared spectral region is even more difficult to achieve as further nonradiative pathways come in

35 rrently showing great promise for systems that are normally difficult to target with small molecule therapies.

36 plied in the past decade to solve structures of notoriously difficult-to-study drug targets at room temperature, has now

37 e as a statistical necessity for radiomics studies is often difficult to achieve in prospective trials.

38 lex underlying formation dynamics are usually unobserved or difficult to describe.

39 bute to the understanding of reactions, which are otherwise difficult to study.

40 haride components of plant cell walls that are particularly difficult to assign by NMR correlation data alone.

41 The basis of this disease heterogeneity has proved difficult to resolve due to poor tumor cellularity and extens

42 However, such reactivity has proven difficult to reproduce in solution with man-made systems.

43 able" in a direct pharmacologic manner and thus have proven difficult to target in the clinic.

44 These are quite difficult to identify because they originate from the differe

45 onditions and within dynamic molecular regimes often remain difficult to ascertain.

46 However, tumors less than 1 cm in size still remain difficult to localize by conventional means because of the di

47 subsets of interest prior to analysis; however, it remains difficult to isolate and then single-cell sequence such popul

48 orized that brain stimulation is able to selectively target difficult-to-reach states, potentially aiding processing and

49 cted to replication in human cells and tissues, making them difficult to study in traditional animal models.

50 new therapeutic strategy and address an unmet need for this difficult to treat disease.See related article by Gonda et al