ライフサイエンスコーパス: difficulty

1 slowed speech and mentation and word-finding difficulty).

2 tation and Rotation tasks after matching for difficulty.

3 umannii chosen to provide extreme diagnostic difficulty.

4 mple degree correlation (SDC) overcomes this difficulty.

5 g functional brain modulation in response to difficulty.

6 corresponds to a regime of maximum numerical difficulty.

7 rom probiotic bacteria could circumvent this difficulty.

8 CPPs within cells largely due to measurement difficulty.

9 await femtosecond lasers to be detected with difficulty.

10 mically important, is a prime source of this difficulty.

11 mory performance in the setting of increased difficulty.

12 emented (0 and 300 ms) in order to vary task difficulty.

13 us root tip displacement present significant difficulties.

14 d particularly females, would minimize these difficulties.

15 RNA-seq, hence bringing in new computational difficulties.

16 rely on overcoming conceptual and technical difficulties.

17 data, rather than insurmountable theoretical difficulties.

18 is rarely quantified due to the measurement difficulties.

19 optical devices are rare due to fabrication difficulties.

20 unexplored, in part due to sample collection difficulties.

21 aximized number of markers presents multiple difficulties.

22 uccess, and discuss remaining challenges and difficulties.

23 ly 10 kV/cm), resulting in various technical difficulties.

24 d recent advances developed to address these difficulties.

25 In an effort to overcome these difficulties, a previous study proposed a regularized re

26 Despite this difficulty, a growing body of independently measured plu

27 luronic acid, are anti-inflammatory but have difficulty achieving therapeutic levels in many tissues.

28 Difficulties adhering to a gluten-free diet have led to

29 rtex, was associated with word comprehension difficulties after factoring out object recognition.

30 ocial interaction to investigate interaction difficulties among people with BPD.

31 ort-duration episodes characterized by motor difficulties and altered consciousness.

32 Unfortunately, due to logistical difficulties and high cost, they tend to evaluate small

33 atobiliary tuberculosis can cause diagnostic difficulties and its possibility should be considered es

34 Six of the 7 patients had learning difficulties and psychomotor delay.

35 pig has not proven popular due to technical difficulties and time required in generating models with

36 udies, however these can be imprecise due to difficulty and cost of spatial modeling at the resolutio

37 ticipated analgesic interaction between task difficulty and pain intensity (p < 0.001).

38 The difficulty and viewing duration were controlled by the e

39 ed a new scaling technique to overcome these difficulties, and make accurate measurements of the rada

40 k attributes, including task precision, task difficulty, and stimulus exposure.

41 These difficulties are strongly predictive of functional outco

42 Contributing to this difficulty are the complex genetic organization of the H

43 ajor challenge in cancer treatment given the difficulties associated with directly inhibiting the KRA

44 Difficulties associated with handling H2 and CO in metal

45 nts, and other proteins, while circumventing difficulties associated with in vivo heterologous expres

46 There are many practical difficulties associated with subjects smoking in the mod

47 s to the clinic, in particular, the cost and difficulties associated with validation in multicenter c

48 h topochemical reactions are attractive, the difficulty associated with crystallization such as low y

49 not fully understood, owing, in part, to the difficulty associated with reconstituting enzyme activit

50 a quality, particularly in patients who have difficulty avoiding movement.

51 The item difficulties (between .25 and .73) and the item-total co

52 mand" (MD) network scales with comprehension difficulty, but also with cognitive effort across a wide

53 NA-ligand kinetics, we overcome the two main difficulties by applying a gradient-based coarse grainin

54 Here we overcome this difficulty by capitalizing on the variability of the ill

55 In wild-type mice, increasing task difficulty by introducing a long delay or by optogenetic

56 tween schizophrenia and social communication difficulties, by contrast, persisted across age, as obse

57 use was associated with intrusive body pain, difficulty climbing stairs and slower chair rise speed.

58 y adjusted models of intrusive body pain and difficulty climbing stairs, but for chair rise speed the

59 of modulation in response to increasing task difficulty compared with epsilon4- individuals.

60 friendly formulations in LMICs and adherence difficulties contribute to acquired drug resistance duri

61 ormations, ophthalmologic anomalies, feeding difficulties, deafness, and subtle dysmorphic facial fea

62 , all known fungal enzymes tested have great difficulty degrading highly crystalline cellulosic subst

63 res of general vision, near activities, role difficulties, dependency, and color vision, with correla

64 ence, 11.6; 95% CI, 0.8-22.4; P = .04), role difficulties (difference, 17.3; 95% CI, 8.0-26.6; P < .0

65 erse effects on health, and some people have difficulty discontinuing their use of the drug.

66 However, this approach encountered difficulties due to the significantly reduced reactivity

67 tic factors influencing social communication difficulties during childhood versus later adolescence.

68 dysfunction experience subjective executive difficulties during menopause.

69 However, this mechanism has difficulty explaining the very localized, rather than wi

70 sessment of insomnia symptoms (restlessness, difficulty falling asleep, waking at night, trouble gett

71 ect connection between target discrimination difficulty, fixations, and reaction time (RT) measures.

72 of limited mechanistic insight, which poses difficulties for reliable distinction between true drive

73 R-CM is poorly characterized, which presents difficulties for the design of large-scale trials for ne

74 ental status change cases posed the greatest difficulty for student learners.

75 nitial process, but theoretical studies have difficulty growing the black hole fast enough.

76 PLpro function is observed to be essential, difficulty has been encountered in delineating the impor

77 dults from situations in which they may have difficulty hearing and communicating, which may contribu

78 Primary outcomes included item difficulty (how easy or difficult the question was), ite

79 (congenitally, or from a brain injury) have difficulty humming melodies but can be spared for singin

80 advocate for a broader perspective of social difficulties in ASD that considers both the individual's

81 Technological difficulties in assessing toxicity in deep-sea species h

82 nsors in different areas, although there are difficulties in controlling their responses.

83 cancer has been largely unexplored, owing to difficulties in detecting them in short-read sequencing

84 rocess is not well understood, partly due to difficulties in determining the specificity of P-TEFb to

85 spectrum of HEV-associated GBS, and discuss difficulties in diagnosing acute HEV infection.

86 ical niche models are still lacking owing to difficulties in evaluating forecasts using real-world da

87 otherwise require less support, face severe difficulties in everyday social interactions.

88 n array of phenotypes, such as hypotonia and difficulties in feeding during infancy and reduced energ

89 solid organ transplantation and can lead to difficulties in finding an underlying causative factor.W

90 Difficulties in generating and handling data for large v

91 Difficulties in generating nuclear data for polyploids h

92 applications, it has faced challenges due to difficulties in handling issues of statistical reliabili

93 ncomplete transcriptome characterization and difficulties in identifying orthologous phenotypes and c

94 Stressors often contribute to difficulties in maintaining behavior change following a

95 re both motor and non-motor skills, pre-date difficulties in more physically oriented daily activitie

96 alts the progression of BE, often because of difficulties in objectively proving an effective antiref

97 but are rarely performed in children due to difficulties in obtaining specimens.

98 postural control is limited by the technical difficulties in performing controlled experiments with c

99 tely calculate NOx levels, and concurrently, difficulties in performing direct NOx measurements in lo

100 ited by their complexity, heterogeneity, and difficulties in production.

101 teins, we hope our experiences with possible difficulties in purification of the proteins will facili

102 iously been studied in reconstitution due to difficulties in purification.

103 othesis remains inadequately tested owing to difficulties in reconstructing terrestrial paleoclimate.

104 timum control groups, loss to follow-up, and difficulties in recruitment of representative samples of

105 y online comprehensive 2D-LC: undersampling, difficulties in refocusing, and lack of flexibility in t

106 However, difficulties in relating sound levels to abundance have

107 , nature's proficiency conceals the inherent difficulties in replicating this contra-thermodynamic tr

108 l sometimes hampered by low productivity and difficulties in scaling up.

109 Difficulties in social communication are part of the phe

110 The difficulties in staffing a ward with an 8h day shift pat

111 However, there are still major difficulties in terms of acquisition speed, poor spatial

112 Due to difficulties in the expression of hClC-Kb in heterologou

113 gions, which may increase risk for emotional difficulties in the long term.

114 pread nature of peri-implant bone loss poses difficulties in the management of biological complicatio

115 ive decline in his daily routine due to gait difficulties in the past year.

116 er, mecC-harboring MRSA strains pose special difficulties in their detection.

117 wever, they often suffer from high cost, and difficulties in their development, production and storag

118 h no history of executive dysfunction report difficulties in this domain during the menopause transit

119 Difficulties in visualizing and studying nanotubes withi

120 Presenting symptoms were difficulties in walking, pain during exercise, delayed m

121 earm) and visual attention tasks of titrated difficulty in 20 healthy subjects.

122 or individuals reporting moderate or greater difficulty in any of the aforementioned tasks.

123 A major difficulty in applying computational design methods to n

124 The results highlight the difficulty in applying such models to realistic media un

125 have received much less attention given the difficulty in assessing detailed molecular-level informa

126 of methyl NMR has often been limited by the difficulty in assigning the methyl resonances.

127 This finding highlights the difficulty in characterizing the structure-activity rela

128 nt for spinal cord injury is hindered by the difficulty in conducting clinical trials, which to date

129 inhibitory control by the prefrontal cortex, difficulty in controlling intrusive thoughts is also ass

130 ems, however, remains challenging due to the difficulty in creating structurally controlled macromole

131 ed symbiotic or parasitic lifestyle, but the difficulty in culturing representative members constrain

132 herin function in mESCs is compounded by the difficulty in delineating the structural and signalling

133 (MD worse than -12 dB) loss, but had greater difficulty in detecting early (MD better than -6 dB) los

134 A difficulty in developing 5-HT2C agonists is that most li

135 (HF) in older individuals, owing in part to difficulty in diagnosis.

136 clinic; however, [(18)F]FDG-PET often faces difficulty in differentiating malignant tissues from cer

137 In males, variances were small and there was difficulty in discriminating between additive maternal a

138 However, the difficulty in forming the unstable diazo compound partne

139 evelopment of heterogeneous catalysts is the difficulty in identifying active sites.

140 The difficulty in identifying what behaviors qualify as new

141 ing because of its varied manifestations and difficulty in interpretation of serological tests used t

142 The difficulty in isolating and propagating functional prima

143 been hampered by its slow growth in culture, difficulty in isolating it, and lack of commercial molec

144 Difficulty in isolation and purification procedures, tox

145 comparative epidemiological studies, and the difficulty in keeping the review up to date with the pac

146 bubble size distributions is limited by the difficulty in measuring bubble sizes over wide spatial o

147 One difficulty in measuring dicarboxylic acid emissions is t

148 se intermediates is severely hampered by the difficulty in obtaining well-diffracting crystals of tra

149 into consideration the infiltrative nature, difficulty in obtaining wide margins, high recurrence ra

150 higher scores indicates more ability or less difficulty in performing activities), and comparison of

151 e, numerous factors related to the intrinsic difficulty in performing AR research, and economic force

152 due to the scarcity of clinical isolates and difficulty in performing susceptibility tests to determi

153 (i.e., number of free associates produced or difficulty in performing the free associate task).

154 nt of such gastroresident electronics is the difficulty in powering millimeter-sized electronics devi

155 ive role to re-challenge, it illustrates the difficulty in producing a vaccine in a young, immunologi

156 ong patients with Alzheimer disease leads to difficulty in providing clinical counseling and diminish

157 ion efficiency, lack of reproducibility, and difficulty in providing linear quantification.

158 ing question in part because of the inherent difficulty in quantifying plutonic volumes.

159 the general key factors and highlighting the difficulty in quantitatively determining SERS performanc

160 ients reported higher levels of alexithymia (difficulty in recognizing and expressing emotions) compa

161 mpound identification due to matrix effects, difficulty in separating isomer and isobaric ions, and l

162 not been well documented due to the inherent difficulty in separating their effects.

163 However, experimental methods have difficulty in solving disordered PPIs and existing prote

164 uirements imposes substantial complexity and difficulty in the design and fabrication of these polyme

165 Difficulty in the simulation and memory tasks also incre

166 However, the difficulty in transferring large-scale data to clients a

167 Previous studies attributed the notorious difficulty in treating this state to strong double excit

168 But there exists much difficulty in using BMSCs as a clinical therapy.

169 The study demonstrates the difficulty in using such structures to infer a mechanism

170 tion is a significant contributor to weaning difficulty in ventilated critically ill patients.

171 ionships that were more stressful, and these difficulties, in turn, related to worse asthma control a

172 Difficulties include inefficient polarization in water,

173 pausal women with midlife onset of executive difficulties include modulation of insular and DLPFC rec

174 The difficulties inherent in such controls cast doubt on how

175 ample sizes, a necessity given the technical difficulty inherent in simultaneous intracellular record

176 in part due to the analytical complexity and difficulty involved in distinguishing silver ion release

177 This difficulty is intricately linked to the varying (and sti

178 The difficulty is particularly severe when the network is de

179 hnologies come with considerable expense and difficulty, limiting the possibility of wider clinical a

180 Autism Spectrum Disorder (ASD) seem to have difficulties looking others in the eyes, but the substra

181 This difficulty mainly stems from amounts of organic carbon (

182 ion involves more than one person and social difficulties may arise not just from people with ASD the

183 These difficulties mean that basic questions remain unanswered

184 populations suggest that pregnant women have difficulty meeting all their nutritional requirements th

185 Sleep difficulties might be a contributory causal factor in th

186 response, and postural instability and gait difficulty motor PD subtype in linear regression analysi

187 , excessive administrative responsibilities, difficulty obtaining extramural funding, and desire for

188 The inherent difficulties of antagonizing physiological effects of dr

189 erging climate disturbance and highlight the difficulties of anticipating novel disturbance processes

190 at we hypothesize compound the developmental difficulties of children with unique reading disability

191 raining, support and assessment policies and difficulties of implementing them.

192 This public health response illustrates the difficulties of investigating botulism in correctional f

193 nderstood and modeled in part because of the difficulties of looking inside the "black box" constitut

194 These problems come in addition to the difficulties of making precise measurements within a liv

195 Due to scarcity of biological material and difficulties of the tsetse fly as an experimental system

196 ng compared with other complex traits is the difficulty of accessing the relevant tissue.

197 RATIONALE: Difficulty of asthma ascertainment and its associated me

198 size requirements and increases the cost and difficulty of conducting successful clinical trials.

199 ch logic circuits was rather poor due to the difficulty of controlling spin waves in the input juncti

200 tools in plant biology has been hindered by difficulty of delivering high quantities of biologically

201 (2017) now present data suggesting that the difficulty of detecting RNAi in virus-infected mammalian

202 reduction rates, is still lacking due to the difficulty of directly probing the electrochemical inter

203 The inherent difficulty of discovering new and effective antibacteria

204 on of morphogen signaling is hampered by the difficulty of disentangling endogenous signaling from ex

205 ely difficult to control due to the inherent difficulty of doping a strictly two-dimensional material

206 The main difficulty of exploiting aoQM in synthesis is that they

207 Increased difficulty of females finding mates as male density decl

208 ant but not top-ranked, which was due to the difficulty of identifying smoking history from search te

209 onducted exclusively in male mice due to the difficulty of initiating attack behavior directed toward

210 Too often, however, the difficulty of installing these fragments surpasses the c

211 to studying this phenomenon in plants is the difficulty of isolating certain types of cells at define

212 We acknowledge the evolutionary difficulty of large genetic divergence among well-connec

213 such as the Antarctic ice sheet, due to the difficulty of locating and interrogating suitable archiv

214 ting neural regeneration are hindered by the difficulty of manipulating desired neural fates in the b

215 impacts remain poorly understood due to the difficulty of manipulating pCO2 at the ecosystem level t

216 s far limited to in vitro studies due to the difficulty of measurement in the natural context of the

217 However, the difficulty of measuring nanometric displacements with an

218 The difficulty of measuring very large contact angles (>150

219 ogy and diagnosis of this enteropathy is the difficulty of obtaining information about the primary si

220 legans are limited by low throughput and the difficulty of performing longitudinal monitoring of agin

221 The difficulty of predicting individual mutation effects, an

222 he overall instability of the domain and the difficulty of producing reagents.

223 s involved in bnAb generation, including the difficulty of quantifying antigen-specific GC Tfh cells

224 ce engineering trimers can be limited by the difficulty of rationally predicting beneficial mutations

225 n demonstrated experimentally because of the difficulty of realizing CNT-encapsulated molecules as pa

226 that catalytic promiscuity, and the ease or difficulty of remodeling and building onto existing prot

227 ding of metastatic disease is limited due to difficulty of sampling as prostate cancer mainly metasta

228 ave been largely restricted by the technical difficulty of separating VLVs from mature virions.

229 nal (2D) cell culture and are limited by the difficulty of simulating three-dimensional physiological

230 s efficiency was consistent across levels of difficulty of the same task.

231 We suggest that the difficulty of the spatial tasks rests on the neocortex a

232 ifying antigen-specific GC Tfh cells and the difficulty of tracking GC in human and non-human primate

233 nts reported significantly greater cognitive difficulties on the FACT-Cog total score and four subsca

234 30 days, dementia, anxiety disorder, hearing difficulty, or history of drug abuse were excluded.

235 aily living (ADLs), defined as self-reported difficulty performing 1 or more ADLs, assessed every 2 y

236 dominant (TD) and postural instability/gait difficulty (PIGD) subtype patients during a motor task.

237 To alleviate this difficulty, pipelines are commonly employed.

238 History A 63-year-old man with learning difficulties presented to the Accident and Emergency Dep

239 targeting functioning, or who have comorbid difficulties preventing them from doing so.

240 dsRNA in chloroplasts overcomes many of the difficulties previously encountered.

241 but their usage is limited due to synthetic difficulties, process complexities and prohibitive costs

242 ion and treatment of children with ADHD-type difficulties provides an opportunity to improve long-ter

243 disorder characterized by ptosis, swallowing difficulties, proximal limb weakness and nuclear aggrega

244 d child; scale, 1-10), and the strengths and difficulties questionnaire (SDQ).

245 Well-Being Assessment and the Strengths and Difficulties Questionnaire (SDQ).

246 the child was 7 years old, the Strengths and Difficulties Questionnaire was completed by the parents.

247 motional behavioural problems (Strengths and Difficulties Questionnaire) at ages 5 years, 7 years, an

248 Variability in fluid resuscitation and difficulty recognizing early sepsis are major barriers t

249 Theoretical difficulties regarding image acquisition and scan tolera

250 spectroelectrochemistry should overcome some difficulties related to direct measurements in complex m

251 e functions itself and/or the methodological difficulties related to its evaluation.

252 n to addiction faster and experience greater difficulties remaining abstinent.

253 jor challenges GxE studies have faced (e.g., difficulties replicating findings and high false discove

254 cted under harsh conditions; hence, the main difficulty resides in generating stable catalysts.

255 treated with a radiation dose </= 54 Gy had difficulty swallowing solids (40% v 89%; P = .011) or ha

256 genetic architecture of social communication difficulties that enhance the understanding of autism sp

257 is includes analyses of social communication difficulties that share, depending on their developmenta

258 lamocortical circuits partially underpin the difficulty that elderly adults experience with respect t

259 In view of these difficulties, the search for a novel, NPC1-specific biom

260 switches did not always engender processing difficulties: the switch cost was reduced or eliminated

261 get executive function or adapt the level of difficulty throughout training.

262 He experienced swallowing difficulties, tinnitus, and fecal incontinence, and he h

263 phospholipids, has been hindered due to its difficulties to be resolved from its structural isomer (

264 e oil production as well as spills and cause difficulties to efficient remediation practice.

265 ur findings reveal that patients have marked difficulties to exploit facial social cues elicited by a

266 ations affect SNARE zippering, partly due to difficulties to quantify the energetics and kinetics of

267 rnover/resting state measurements, i.e., the difficulty to design a suitable reference state against

268 ibiotics, the formation of a biofilm and the difficulty to eradicate it.

269 ODMAP diet; the diets had similar degrees of difficulty to follow.

270 per nm(2)) are at the origin of the apparent difficulty to functionalize the surface of CIS NCs obtai

271 cal devices in real-life applications is the difficulty to mass-fabricate nano-optical antennas in pa

272 lexity of the mass spectra and therefore the difficulty to specifically and precisely detect analytes

273 There was no difficulty to use genioplasty templates.

274 tide exhibited signs of steric hindrance and difficulty translocating.

275 cy dropped to chance levels for intermediate difficulty trials and to 25% for high difficulty trials,

276 relative heights on approximately 70% of low difficulty trials, corroborating previous findings for j

277 ediate difficulty trials and to 25% for high difficulty trials, regardless of the listener's sightedn

278 clinics report substantially more cognitive difficulties up to 6 months after treatment with chemoth

279 To overcome these difficulties, we present here a statistical framework fo

280 To overcome this difficulty, we synthesized solenopsin analogs which bioc

281 hildren who have moderate to high myopia and difficulties wearing glasses or contact lenses.

282 Social communication difficulties were measured in typically-developing youth

283 hildren aged 5-12 years referred for anxiety difficulties were randomly allocated (1:1), via a secure

284 age-invariant modulation in response to task difficulty, whereas APOEepsilon4+ individuals showed age

285 ve put elimination within reach, but several difficulties will need to be navigated on the path to el

286 On multivariable analysis, the number of difficulties with activities of daily living (odds ratio

287 o their often pleiotropic phenotypes and the difficulties with distinguishing primary effects (i.e. o

288 In addition, difficulties with interpretation of respiratory viral te

289 st a further 5% of children have substantial difficulties with overactivity, inattention, and impulsi

290 ecline in her gait with parkinsonism, visual difficulties with restricted vertical gaze, slowed horiz

291 he present study found that OCD patients had difficulties with the deactivation of DMN even when the

292 not from inorganic nanomaterials because of difficulties with the replication of spherical tiling.

293 , often had comorbid conditions, and 16% had difficulty with >/=1 activities of daily living.

294 ssessed by comorbidity burden, self-reported difficulty with activities of daily living and prior hos

295 ercentile) were more impaired by gait speed, difficulty with Instrumental Activities of Daily Living,

296 ardiovascular disease, dementia, disability (difficulty with one or more activities of daily living)

297 tio [OR], 1.3; 95% CI, 1.0-1.6), anticipated difficulty with postoperative self-care (OR, 1.6; 95% CI

298 function that may result from risk carriers' difficulty with top-down initiated responses caused by d

299 ent (FNVI) was defined as at least "moderate difficulty" with either reading newsprint or near work.

300 One strategy for resolving this difficulty would be to target downstream components of t