ライフサイエンスコーパス: difficulty in *ing

1 f increasing neck pain on the right side and difficulty in swallowing.

2 g with a higher frequency of eye redness and difficulty in swallowing.

3 routine in research because of the technical difficulty in constructing 3D tissue models.

4 A difficulty in developing 5-HT2C agonists is that most li

5 gated individual OPKA activities, indicating difficulty in achieving a multi-valent vaccine targeting

6 , the extent of genomic instability, and the difficulty in acquiring a large sample size in a rare tu

7 n the rate of appropriate use highlights the difficulty in developing a standardized definition that

8 Given the difficulty in finding a cure for HIV/AIDS, a promising p

9 or treating periodontitis effectively is the difficulty in finding a target that can inhibit bone los

10 eptide (MIP), fall asleep normally, but have difficulty in maintaining a sleep-like state.

11 or limitation of the sensor, however, is its difficulty in measuring a broad concentration range of t

12 Parkinson's disease (PD) patients have difficulty in performing a dual-task.

13 o criterion, more errors made, and a greater difficulty in performing a reversal learning task relati

14 ive role to re-challenge, it illustrates the difficulty in producing a vaccine in a young, immunologi

15 Difficulty in being able to use this information to opti

16 conventional introns, however, also portends difficulty in generating accurate gene models and highli

17 ent to tuberculosis control in Africa is the difficulty in diagnosing active tuberculosis (TB), parti

18 evelopment of heterogeneous catalysts is the difficulty in identifying active sites.

19 higher scores indicates more ability or less difficulty in performing activities), and comparison of

20 higher scores indicates more ability or less difficulty in performing activities), and comparison of

21 Many genetic manipulations are limited by difficulty in obtaining adequate levels of protein expre

22 lar macrophages, target non-specificity, and difficulty in combining aerodynamic properties with effi

23 Difficulty in obtaining air pollutant emission permits a

24 lar studies has thus far been slowed down by difficulty in obtaining amplifiable DNA.

25 The difficulty in developing an immunoassay that is specific

26 graduates from 2008 to 2012 report increased difficulty in identifying an HPB-focused practice versus

27 Patients with salivary hypofunction exhibit difficulty in chewing and swallowing foods, tooth decay,

28 This poorer response may reflect patients' difficulty in forming and maintaining attachments, inclu

29 rsity in protein function and the consequent difficulty in gauging and comparing rates of protein fun

30 This specific difficulty in identifying and distinguishing the feeling

31 The difficulty in isolating and propagating functional prima

32 The difficulty in organizing and mining this unprecedented a

33 This adds to the difficulty in predicting and identifying combinations th

34 resolution limit of light microscopy and the difficulty in preserving and analyzing ultrastructure wi

35 ients reported higher levels of alexithymia (difficulty in recognizing and expressing emotions) compa

36 recently had become painful and was causing difficulty in speaking and swallowing.

37 ajor obstacle in the quest for a cure is the difficulty in targeting and measuring latently infected

38 ific antioxidant target(s), and the inherent difficulty in delivering antioxidants where they are nee

39 lating LDL-C has been challenging due to the difficulty in accessing appropriate cells from affected

40 nd fetal safety, ethical considerations, the difficulty in designing appropriate trials to assess the

41 application and approval dates, and level of difficulty in obtaining approval.

42 e, numerous factors related to the intrinsic difficulty in performing AR research, and economic force

43 African Americans and Latinos highlights the difficulty in replicating associations in admixed popula

44 This is a challenging undertaking given the difficulty in defining asthma and the lack of supportive

45 e pathways contributing to exposure, and the difficulty in assessing behavioral determinants of expos

46 Difficulty in differentiating between tissue types commo

47 In males, variances were small and there was difficulty in discriminating between additive maternal a

48 Difficulty in distinguishing between effects of ongoing

49 But there exists much difficulty in using BMSCs as a clinical therapy.

50 The difficulty in delineating brain tumor margins is a major

51 vivo has not been elucidated because of the difficulty in monitoring brain Abeta oligomers in living

52 bubble size distributions is limited by the difficulty in measuring bubble sizes over wide spatial o

53 e dimensions are stable, thus overcoming the difficulty in exploring by experiment or simulation the

54 A major difficulty in treating cancer is the inability to differ

55 sequencing methods, because of the inherent difficulty in prioritizing candidate genes for diagnosti

56 nsity for precipitation, mainly owing to the difficulty in establishing causality.

57 amyotrophic lateral sclerosis, that lead to difficulty in detecting classical upper motor neuron sig

58 First, we illustrate the difficulty in evaluating classifiers after feature selec

59 nt for spinal cord injury is hindered by the difficulty in conducting clinical trials, which to date

60 ong patients with Alzheimer disease leads to difficulty in providing clinical counseling and diminish

61 lity to culture this species and the extreme difficulty in undertaking clinical research by experimen

62 In part, this is due to the difficulty in maintaining CNS neurons in vitro.

63 This difficulty in separating colorectal cancer from these ot

64 delayed hemolytic transfusion reactions and difficulty in finding compatible units, which can cause

65 be time consuming and tedious because of the difficulty in assembling completely accurate description

66 contributing factor to irreproducibility is difficulty in interpreting complex experimental methodol

67 A major difficulty in applying computational design methods to n

68 The difficulty in disentangling control and severity is high

69 early defined in larval zebrafish due to the difficulty in defining cytoarchitectonic nuclear boundar

70 distributions, researchers have experienced difficulty in integrating data across platforms.

71 have received much less attention given the difficulty in assessing detailed molecular-level informa

72 s been challenging to evaluate it due to the difficulty in obtaining detailed data on individual netw

73 One difficulty in measuring dicarboxylic acid emissions is t

74 g of such processes has been hindered by the difficulty in producing diffraction-quality crystals of

75 They also highlight the difficulty in disentangling direct checkpoint pathways f

76 reak during the simulation, highlighting the difficulty in sampling disordered states.

77 However, experimental methods have difficulty in solving disordered PPIs and existing prote

78 strand of M13 DNA, whereas gp5-C313S/trx has difficulty in synthesizing DNA through sites of secondar

79 remains challenging, in part because of the difficulty in implanting drug-eluting devices without su

80 The difficulty in treating drug addiction is compounded by t

81 (MD worse than -12 dB) loss, but had greater difficulty in detecting early (MD better than -6 dB) los

82 y the scarcity of available material and the difficulty in distinguishing early hematophages from non

83 ing to a number of characteristics including difficulty in establishing early diagnosis and the absen

84 dynamic nature of the oceans and continuing difficulty in managing ecosystem impacts of fisheries, i

85 havior remain unclear because of the extreme difficulty in tracking evolution of these notoriously co

86 Given the perceived difficulty in modifying extracellular matrix proteins to

87 Reading disability is a brain-based difficulty in acquiring fluent reading skills that affec

88 They also highlight the difficulty in using fMRI data for arbitrating between di

89 amily members with Alzheimer disease and the difficulty in slowing functional decline.

90 ion in humans remains elusive because of the difficulty in defining functionally important noncoding

91 w-listed barriers to an academic career were difficulty in obtaining funding and lower compensation.

92 cantly underdeveloped, partly because of the difficulty in applying genetics and common molecular app

93 e largely uncharacterized due in part to the difficulty in generating high-affinity, isoform-specific

94 single precious atom species has arisen from difficulty in synthesizing homogeneous and stable single

95 es have been conducted on this region due to difficulty in determining homology.

96 re Gram-negative vesicles originate, and the difficulty in envisioning how such a process could occur

97 unperturbed consciousness that fosters great difficulty in understanding how anesthetics alter this c

98 ystems for some important viruses and by the difficulty in conducting human clinical trials for disea

99 ing infection due to the cells' scarcity and difficulty in isolating in vivo.

100 This uncertainty emanates from the difficulty in measuring in situ soil N2 production and f

101 ian gene regulation has been hampered by the difficulty in measuring in vivo binding dynamics of larg

102 led remain unresolved because of the extreme difficulty in obtaining in vivo measurements.

103 l size remain poorly understood owing to the difficulty in sizing individual bacteria over long perio

104 The difficulty in distinguishing infection by Zika virus (ZI

105 mportance of correct diagnosis and potential difficulty in treating infections.

106 However, due to the difficulty in characterizing/inferring different types o

107 cification of a number of parameters and has difficulty in extracting information on compounds that a

108 ther than research trials, patients may have difficulty in getting insurance coverage for genetic tes

109 for halide-adsorbed nanocrystals due to the difficulty in analysing interactions between metals and

110 tween these components is limited due to the difficulty in assaying interactions in the context of th

111 is challenging in oligomeric proteins is the difficulty in characterizing intermediate, singly bound

112 ads to underestimation of disease burden and difficulty in measuring interventions to control CDI.

113 inhibitory control by the prefrontal cortex, difficulty in controlling intrusive thoughts is also ass

114 One difficulty in using ion mobility (IM) mass spectrometry

115 mpound identification due to matrix effects, difficulty in separating isomer and isobaric ions, and l

116 ane-encoding exon 3 has been hindered by the difficulty in distinguishing it from the transmembrane i

117 been hampered by its slow growth in culture, difficulty in isolating it, and lack of commercial molec

118 s very important, yet there is a fundamental difficulty in understanding its mechanism: to measure an

119 This in turn has been because of the difficulty in conducting large clinical studies in an un

120 However, the difficulty in transferring large-scale data to clients a

121 The main difficulty in detecting larger network motifs in biologi

122 loping and optimizing these therapies is the difficulty in determining levels of GCase activity prese

123 ion efficiency, lack of reproducibility, and difficulty in providing linear quantification.

124 ing this selective failure is limited by the difficulty in obtaining live human neurons from affected

125 One difficulty in performing long-term FT-IR measurements on

126 The difficulty in accessing lung tissue and washes from indi

127 clinic; however, [(18)F]FDG-PET often faces difficulty in differentiating malignant tissues from cer

128 The difficulty in accessing mammalian nephrons in vivo hinde

129 maging is underused, in part, because of the difficulty in interpreting maps without an underlying ce

130 t abundant microbial cells in the ocean, but difficulty in cultivating marine Thaumarchaeota has hind

131 however, is severely limited because of the difficulty in finding matched donors.

132 It highlights the difficulty in differentiating melanoma from an EB nevus.

133 ate using experimental techniques due to the difficulty in crystallising membrane proteins embedded w

134 One difficulty in studying metastasis stems from the complex

135 Given our vast methane reserves and the difficulty in transporting methane without substantial l

136 nt of such gastroresident electronics is the difficulty in powering millimeter-sized electronics devi

137 facilitate unusual redox chemistry, but the difficulty in synthesizing MOFs with metal ions in reduc

138 This is a result of the difficulty in extracting molecular information from in v

139 The difficulty in treating mood disorders has brought about

140 deling these biases has been hindered by the difficulty in identifying mutated Ig sequences in vivo i

141 mentary mode has been challenging due to the difficulty in making n-type carbon nanotube transistors

142 tions have been limited by the extraordinary difficulty in obtaining n-type conductivity.

143 e not fully understood, partially due to the difficulty in obtaining native-like folded proteins in v

144 r is still speculative, owing to the extreme difficulty in recreating neutral matter-antimatter plasm

145 t due to slow tumbling of the system and the difficulty in identifying NOE interactions across protei

146 Since one reason for this is an inherent difficulty in obtaining nutrient-deficient conditions in

147 ies exist in these young children due to the difficulty in obtaining objective evidence of reversible

148 This approach not only eliminates the difficulty in screening of low-dose OP exposure (less th

149 ure of proteome quality is likely due to the difficulty in producing one, a problem that we have appr

150 but this could not be tested because of the difficulty in extracting only the cell-wall lipids.

151 Part of the difficulty in developing optimal therapies is the large

152 Dyspnea, difficulty in walking or climbing, fatigue/increased nee

153 r treatment and patient counseling given the difficulty in treating orbital schwannomatosis.

154 ilding blocks remains a challenge due to the difficulty in preparing organic structural units of prec

155 This approach creates difficulty in parsing out the effects of adaptive behavi

156 fessionals highlighted internal factors, the difficulty in engaging people with negative symptoms in

157 f semantic representations is complicated by difficulty in disentangling perceptual and semantic infl

158 However, the difficulty in obtaining periodic crystal lattices which

159 isk management-driven control decisions, and difficulty in predicting pest outbreaks fuel present rel

160 as proved challenging, partly because of the difficulty in differentiating phenotypes that define hom

161 ing question in part because of the inherent difficulty in quantifying plutonic volumes.

162 However, past research evidences difficulty in disaggregating prenatal environmental infl

163 us protein complexes has been limited by the difficulty in obtaining pristine cell-derived assemblies

164 nging because of the malignant potential and difficulty in predicting prognosis.

165 terns during meiosis remain undefined due to difficulty in obtaining pure germ cell samples, especial

166 The difficulty in detecting rare infected cells immediately

167 ng of many adult epithelia is limited by the difficulty in maintaining relevant stem cell populations

168 ryo-injection, culture of primary cells, and difficulty in producing reliable reagents with a limited

169 ed symbiotic or parasitic lifestyle, but the difficulty in culturing representative members constrain

170 plexity of the cholinergic circuitry and the difficulty in comparing results from in vivo studies obt

171 e in tailed bacteriophages, highlighting the difficulty in generalizing results from bacteriophage in

172 on of susceptibles may explain, in part, the difficulty in identifying risk factors for knee osteoart

173 accessibility of the infected tissue and the difficulty in obtaining samples without contamination by

174 Study limitations include difficulty in confirming schizophrenia diagnoses indepen

175 This study highlights the difficulty in localizing seizures arising from the cingu

176 ered for integrated photonics because of the difficulty in coupling selectively to high-order modes,

177 ination in T cells, can create a fundamental difficulty in determining single-cell kinetics from cell

178 the maxillary sinus determine the degree of difficulty in performing sinus augmentation.

179 king-related behaviors, among them a greater difficulty in quitting smoking.

180 recise roles are often unresolved due to the difficulty in capturing "snapshots" during the export pa

181 onfirmed that loneliness was associated with difficulty in processing social cues.

182 er of the two patient groups had any special difficulty in producing spatial details.

183 and systemic diseases and conditions and the difficulty in determining specific causes of change in C

184 th cochlear implants, often experience great difficulty in understanding speech in noisy environments

185 However, to date, the difficulty in producing stable p-type ZnO is a bottlenec

186 gh-order stimulus representation rather than difficulty in sustaining stable activity patterns over t

187 mplicate that subjects with PTSD experienced difficulty in overcoming Stroop interference.

188 Results from this study also indicate the difficulty in correlating structural changes across scal

189 ems, however, remains challenging due to the difficulty in creating structurally controlled macromole

190 till poorly understood, in part owing to the difficulty in characterizing structure at the nanoscale,

191 The results highlight the difficulty in applying such models to realistic media un

192 The difficulty in eliciting such Abs by vaccination is parti

193 Until recently, the reasons for difficulty in inducing such bnAbs have been obscure.

194 The study demonstrates the difficulty in using such structures to infer a mechanism

195 bstacles to the use of (225)Ac have been the difficulty in finding suitable chelators to stably attac

196 due to the scarcity of clinical isolates and difficulty in performing susceptibility tests to determi

197 of the zebrafish is currently limited by the difficulty in obtaining systematic electrophysiological

198 re tool called Primer-BLAST to alleviate the difficulty in designing target-specific primers.

199 A fundamental difficulty in testing "targeted therapies" in acute myel

200 our study region, which highlights potential difficulty in detecting temporal responses of organism a

201 he heart in vivo is challenging owing to the difficulty in accessing the heart and the tissue motion

202 interest dynamics, partly due to the extreme difficulty in accessing the human mind from observations

203 itations due to the narrow dynamic range and difficulty in adapting the method for multi-point sensin

204 The difficulty in annotating the vast amounts of biological

205 natively spliced transcripts, as well as the difficulty in assessing the impact of small insertions/d

206 of methyl NMR has often been limited by the difficulty in assigning the methyl resonances.

207 plasm exist but are underutilized due to the difficulty in capturing the dynamic nature of physiologi

208 with promising anticancer activity, but the difficulty in characterizing the mechanism of action of

209 This finding highlights the difficulty in characterizing the structure-activity rela

210 herin function in mESCs is compounded by the difficulty in delineating the structural and signalling

211 n studying these binary oxide systems is the difficulty in describing the heterogeneities that occur

212 This is, in part, due to a difficulty in detecting the neural correlates of value u

213 rbon (CHC) blends of insects, as well as the difficulty in determining the absolute configurations of

214 h developing new biological therapies is the difficulty in determining the affinity with which protei

215 gress in the field has been inhibited by the difficulty in determining the energy levels of molecules

216 often are misdiagnosed with INH, leading to difficulty in determining the true prevalence of NICCD.

217 all task, even after repeated trials, is the difficulty in discriminating the different reinforcement

218 and is currently incurable due, in part, to difficulty in eliminating the leukemia cells protected b

219 complex nature of cellular processes and the difficulty in establishing the identity of individual me

220 iques is problematic, owing to the practical difficulty in establishing the initial conditions.

221 e brain-cognition mappings--for example, the difficulty in establishing the specificity of postulated

222 Pereira points out the difficulty in establishing the strength of the associati

223 genotyping have been hindered because of the difficulty in estimating the expansion size.

224 sion are not treated, perhaps because of the difficulty in explaining the benefits and risks of r-tPA

225 lem for existing theory which highlights the difficulty in explaining the spread and persistence of p

226 ouble predicting this history because of the difficulty in following the feedback of energy from stel

227 However, the difficulty in forming the unstable diazo compound partne

228 nsively studied at the tissue level, but the difficulty in imaging the endothelium with cellular reso

229 The main difficulty in improving the efficiency of PV energy conv

230 mercial development has been hindered due to difficulty in interpreting the change in impedance upon

231 daughter cells is unknown, partly due to the difficulty in interpreting the complex dynamic behavior

232 aviourally, participants experienced greater difficulty in judging the concreteness of multi-meaning

233 comparative epidemiological studies, and the difficulty in keeping the review up to date with the pac

234 The difficulty in maintaining the reconstituting capabilitie

235 e organisms, in part because of the inherent difficulty in measuring the intracellular Hg concentrati

236 r distortions due to the Kerr effect and the difficulty in modulating the optical field to effectivel

237 that in other parts of the world because of difficulty in obtaining the necessary generators and reg

238 s indicated on a 5-point scale the degree of difficulty in performing the following procedures: lesio

239 (i.e., number of free associates produced or difficulty in performing the free associate task).

240 ause of the following: dystonia resulting in difficulty in placing the patients in frame, patient's i

241 esolution of this issue has been hindered by difficulty in quantifying the fraction of woody cover in

242 The main difficulty in quantifying the spatial pattern of disease

243 l-carbon quaternary stereogenic center), the difficulty in reaching the desired adducts through asymm

244 c suppressors of this mutant suggests it has difficulty in releasing the N-terminal membrane targetin

245 th unresolved phylogenies, demonstrating the difficulty in resolving the evolutionary history of gene

246 rpose result in inefficient cell capture and difficulty in retrieving the captured cells.

247 f SAXS profiles is nontrivial because of the difficulty in separating the scattering signals of each

248 rdinate motifs are extremely rare due to the difficulty in stabilizing the planar hypercoordinate con

249 bout simplified model systems because of the difficulty in studying the complex intestinal ecosystem

250 ith specific properties is often hindered by difficulty in tuning the material composition without sa

251 The difficulty in understanding the emergence of this large-

252 western hemisphere is a prime example of the difficulty in untangling the taxonomic complexity within

253 e had a redshift measurement, because of the difficulty in pinpointing their celestial coordinates.

254 igning peptide-based catalysts, but also the difficulty in predicting their accessible transition sta

255 iet were more likely to experience low or no difficulty in providing their patients with dietary advi

256 not been well documented due to the inherent difficulty in separating their effects.

257 lled by microemulsions, there is substantial difficulty in understanding their growth mechanism.

258 However, so does the difficulty in identifying them.

259 nctional devices is challenging owing to the difficulty in positioning them at specified sites on sur

260 AD per unit of (131)I activity elucidate the difficulty in achieving therapeutic efficacy for BMs whe

261 therapeutics for AD has been hampered by the difficulty in translating therapies that work in rodents

262 aggregation remains elusive due to the great difficulty in characterizing these complex and frequentl

263 ver, the use of the method is limited by the difficulty in deriving these groups.

264 Because of the difficulty in studying these microorganisms in both huma

265 The difficulty in understanding these functions can be at le

266 BB is key to treating S2 effectively and the difficulty in achieving this goal is likely to be a reas

267 One difficulty in addressing this is that GR function is inf

268 The key difficulty in articulating this relationship is that sha

269 The difficulty in calibrating this relation is compounded by

270 This is primarily due to the difficulty in characterizing this modification and due t

271 ent animal models are lacking because of the difficulty in deleting this large multigene family.

272 A fundamental difficulty in determining this action, however, is that

273 rly sensitive to ROS is discussed, as is the difficulty in exploiting this hypersensitivity to tiopro

274 The difficulty in predicting this property hampers, however,

275 of Candida osteomyelitis of 32% reflects the difficulty in treating this infection.

276 Previous studies attributed the notorious difficulty in treating this state to strong double excit

277 Owing to the difficulty in combating thrips vectors with insecticides

278 ng techniques suffer from low resolution and difficulty in imaging through the skull.

279 rogramming in plants has been impeded by the difficulty in obtaining tissue for analysis.

280 Developmental dyslexia, an unexplained difficulty in learning to read, has been associated with

281 ic of dyslexia and thought to be a basis for difficulty in learning to read.

282 Patients in both groups had difficulty in returning to their narratives after going

283 in interaction with MinD, suggesting it has difficulty in switching to the active form.

284 As the theory predicts, difficulty in rearranging trains depends on the numbers

285 Because of the difficulty in measuring tumor characteristics in patient

286 ercialized due to poor antigen stability and difficulty in obtaining unconventional release kinetics.

287 ailable deposition processes suffer from the difficulty in depositing uniform and reproducible coatin

288 Due to the difficulty in synthesizing very large BBCPs, the fidelit

289 Due to the difficulty in distinguishing viridans group streptococci

290 56-item draft scale, capturing the level of difficulty in performing vision-dependent activities.

291 understood, partly because of the technical difficulty in revealing weak association of coding ends

292 nuous positive airway pressure adherence and difficulty in achieving weight loss.

293 novel small alien fragments may explain the difficulty in developing well-adapted lines carrying Wsm

294 se intermediates is severely hampered by the difficulty in obtaining well-diffracting crystals of tra

295 The difficulty in identifying what behaviors qualify as new

296 in poorly understood, in part because of the difficulty in discerning where CaMKII binds in live cell

297 ative diseases is further complicated by the difficulty in determining whether the drug truly retards

298 e existence of 4 main DENV serotypes and the difficulty in defining which individuals have been expos

299 instead on local conditions and point to the difficulty in sustaining whole-ocean euxinia.

300 into consideration the infiltrative nature, difficulty in obtaining wide margins, high recurrence ra