ライフサイエンスコーパス: diffusible

1 The remaining diffusible actin concentration is orders of magnitude hi

2 Roughly a quarter of the diffusible actin pool is in filamentous form as diffusin

3 The diffusible actin transport, on the other hand, is global

4 andscape can heavily influence the effect of diffusible activators and should be more widely consider

5 nism for this phenomenon: confinement causes diffusible activators to accumulate locally and surpass

6 ide (LCO) Nod factors is well characterized, diffusible AM fungal signals were only recently identifi

7 intain chromosome content by generation of a diffusible anaphase inhibitor.

8 studies reveal that anaphase inhibitors are diffusible and active outside the confines of the mitoti

9 on deconvolved x-ray fluorescence imaging of diffusible and bound ions at native concentrations, with

10 onsistent with this perspective, the readily diffusible and broadly reactive (*)NO is increasingly ap

11 -cell signaling through the exchange of both diffusible and contact-dependent signals.

12 I and iNOS, whose metabolic products include diffusible and highly reactive peroxynitrites, the ultim

13 Both diffusible and surface-bound molecules are thought to in

14 opmental biologists have defined many of the diffusible and transcription factors that control muscle

15 However, bacteriocins are typically freely diffusible, and so of little value to planktonic cells i

16 ic glioma cells, vascular endothelial cells, diffusible angiogenic factors, and necrosis formation in

17 Unlike diffusible animal morphogens, which form a gradient acro

18 This shows that TA is the major M. xanthus-diffusible antibacterial agent against E. coli.

19 hemotaxis-driven aggregation - mediated by a diffusible attractant - is able to capture several quant

20 Nerve growth cone guidance by diffusible attractive and repulsive molecules is regulat

21 pinal cord, axons are initially attracted by diffusible attractive protein signals to approach and cr

22 ion device that is able to globally diminish diffusible autocrine signaling by applying continuous me

23 ed MAMPs-activated root defense, revealing a diffusible bacterial component that may regulate plant i

24 he ability of 4-hydroxy-2-nonenal (4-HNE), a diffusible breakdown product of omega-6 polyunsaturated

25 ects iPLA2beta-catalyzed BEL hydrolysis to a diffusible bromomethyl keto acid product that reacts wit

26 Here we describe a role for the diffusible C. elegans protein LECT-2, which is homologou

27 between calcium and the sAHP channels is the diffusible calcium sensor hippocalcin.

28 te intermediate could be formed, producing a diffusible carbonate radical upon reoxidation of copper.

29 s and sufficient for nuclear import of a non-diffusible cargo in permeabilized cells.

30 ellipodium and directional migration along a diffusible CCL19 gradient.

31 urified chromosomes catalytically generate a diffusible Cdc20 inhibitor or inhibit Cdc20 already boun

32 Bacteria use diffusible chemical messengers, termed pheromones, to co

33 In the dark, cells produce a diffusible chemical signal that diffuses into light regi

34 process termed quorum sensing, bacteria use diffusible chemical signals to coordinate cell density-d

35 cells often co-ordinate their behaviour via diffusible chemical signals.

36 g view that Ntn1 is an FP-derived long-range diffusible chemoattractant for CAs, but suggest a novel

37 line has been thought to act as a long-range diffusible chemoattractant for commissural axons (CAs).

38 ct from the floor plate (FP) as a long-range diffusible chemoattractant for commissural axons in the

39 d GFRalpha1 signaling in response to GDNF, a diffusible chemoattractant in the limb, indicating that

40 The first encodes a diffusible class 3 type semaphorin protein that is most

41 /Chondromodulin II acts as a muscle-derived, diffusible cofactor together with a skin-derived cell ad

42 During organogenesis, FGFs are diffusible communication signals that allow cells to coo

43 m hours to minutes compared to circuits with diffusible components.

44 Unexpectedly, diffusible cortical signals had the most potent effects

45 nitors to sense and respond appropriately to diffusible CSF-borne signals distributed widely througho

46 VD and FLP dendritic arbors and can act as a diffusible cue from a distance to shape dendritic arbors

47 A new study identifies a diffusible cue that mediates interactions with the epide

48 re we report the unexpected discovery that a diffusible cue, the axon guidance protein UNC-6 (Netrin)

49 linked coupling between regionally localized diffusible cues and cell adhesion can help axons navigat

50 Cell adhesion molecules and diffusible cues both regulate axon pathfinding, yet how

51 The expression patterns of the diffusible cues of the Slit family were altered in the f

52 ther the in-growing axons themselves produce diffusible cues to instruct target innervation remains u

53 on signaling pathways that are activated by diffusible cues, which shed light on synaptogenesis in t

54 emonstrated in mammalian myocytes, relies on diffusible cytoplasmic buffers, such as carnosine, homoc

55 ion of channels might be occurring through a diffusible cytoplasmic factor.

56 Simulations suggest that diffusible cytotoxic treatments, such as chemotherapy, m

57 ugh cAMP exhibits a strong spatial gradient, diffusible DARPP-32 facilitates the spread of PKA activi

58 nuclei play the role of traps that localize diffusible dpERK.

59 gical reconstructions, pharmacogenetics, and diffusible dye, calcium, and glutamate imaging, to direc

60 territories were labelled by co-injection of diffusible dye, radio-opaque substance and gelatin into

61 fish embryos, our analysis reveals a pool of diffusible Dystrophin and complexes bound at the fibre m

62 As a diffusible electrophile, HNE reacts extensively with cel

63 targeted locus, in a manner indicative of a diffusible epigenetic element.

64 e and its substrate tryptophan to synthesize diffusible exotoxins that kill the nematode Caenorhabdit

65 Since netrin-1 is a diffusible extracellular cue, the pathophysiology likely

66 n high expression of xynA, indicating that a diffusible extracellular xynA density factor is present

67 s mediated by a combination of Y-27632 and a diffusible factor (or factors) released by apoptotic fee

68 also show that EFN-4 probably functions as a diffusible factor because EFN-4 engineered to be soluble

69 rowth cone repellent factors (especially the diffusible factor Slit2) are required for CC development

70 indicate that mitotic centrosomes generate a diffusible factor, which we propose is activated Aurora

71 y cavity and acts non-cell autonomously as a diffusible factor.

72 states are dictated by the concentrations of diffusible factors (trans memory).

73 Both diffusible factors acting in trans and chromatin compone

74 reagents through the chip and for exchanging diffusible factors between cell chambers.

75 bition of spirochete motility by one or more diffusible factors elaborated by the feeding tick midgut

76 utput is the combined product of two inputs: diffusible factors in the cellular milieu acting in tran

77 Diffusible factors involved in patterning are reduced (F

78 ing is a complex process mediated in part by diffusible factors secreted from immune cells found at a

79 3-dimensional tissue culture system to assay diffusible factors that can limit proliferation in the c

80 the developing lung alters the regulation of diffusible factors that promote mesenchymal proliferatio

81 tting are the result of interactions between diffusible factors with antagonistic effects, morphogene

82 mal environment via physical interaction and diffusible factors.

83 ated, surface-bound molecules rather than by diffusible factors.

84 and promotes CIN in mammalian cells through diffusible factors.

85 ity in the patterning of immune responses by diffusible factors.

86 Incorporation of diffusible fluorescent labels into the viral membrane an

87 -bound FMN and between the bound FMNH2 and a diffusible FMN.

88 rane-bound Pref-1 to the biologically active diffusible form provides a new insight into Pref-1 funct

89 ain isoform, VEGF164, and expresses only the diffusible form, VEGF120.

90 Diffusible forms of Abeta, especially Abeta(42), decline

91 idence supports the hypothesis that soluble, diffusible forms of the amyloid beta-peptide (Abeta) are

92 hanism to convert ECM-bound VEGF into freely diffusible forms.

93 ly binding to cell membranes, and Slit2-C, a diffusible fragment.

94 eractions can occur in vivo, suggesting that diffusible germinants or other signals appear sufficient

95 uch as regulation of microtubule dynamics by diffusible gradients, spatially selective motor activiti

96 is comprised of extracellular matrix (ECM), diffusible growth factors, cytokines and a variety of no

97 Here, we show that netrin-1, a diffusible guidance cue expressed along the migratory ro

98 -dependent rapid endocytosis stimulated by a diffusible guidance cue.

99 We found that diffusible guidance molecules caused membrane potential

100 the acidic zone via Ca(2+)/H(+) exchange on diffusible HDPs and ATP molecules, energized by the [H(+

101 rystal structures of non-rhodopsin GPCRs for diffusible hormones and neurotransmitters presents an un

102 n)-coupled receptors (GPCRs) that respond to diffusible hormones and neurotransmitters.

103 that VAP MSP domains are secreted and act as diffusible hormones for Eph receptors.

104 y, although NK cells kept moving over freely diffusible ICAM-1 on a lipid bilayer, they bound and spr

105 expression of several targets, including the diffusible IGF antagonist Igfbp3 in the dermal papilla.

106 is observed only as long as GAT107 is freely diffusible in solution, although the potentiating activi

107 obleaching, we show that Hsk1-Dfp1 is freely diffusible in the nucleus.

108 catalyzing the intramitotic production of a diffusible inhibitor of APC/C(Cdc20) (the anaphase-promo

109 ocalized activator that is antagonistic to a diffusible inhibitor was able to simulate the switch-lik

110 f additional fronts by generating long-range diffusible inhibitors or by sequestering essential polar

111 ngers and include the highly phosphorylated, diffusible inositol polyphosphates (InsPs) and inositol

112 stinct Ca(2+) signals, generated by a freely diffusible InsP3 message.

113 studies of a model enzyme, M8, showed that a diffusible intermediate preferentially reacted with argi

114 tercomplex electron transfer, which requires diffusible intermediates and the cytochrome b6f complex.

115 -ADP-ribosylation, which is mediated through diffusible intermediates.

116 tack, the eggs were coinjected with a freely diffusible internal fluorescent standard, rhodamine dext

117 e explained predominantly by modulation from diffusible intracellular factors, and not changes in cha

118 l protocols for microscopy, we observed that diffusible ions such as potassium and sodium were lost d

119 However, given that the BMP signal can be diffusible, it remains unclear how a local extracellular

120 Although nitric oxide is freely diffusible, its biological function can be controlled by

121 Netrin-1, a diffusible laminin-related protein, is highly expressed

122 However, because these diffusible LDEs can modify many targets [e.g., >700 cyst

123 receptors activates a heretofore unsuspected diffusible ligand that may work in conjunction with the

124 Overexpression of APP or Abeta-derived diffusible ligand treatment also led to mitochondrial fr

125 a direct response to an as yet unidentified diffusible ligand.

126 human G protein-coupled receptor bound to a diffusible ligand.

127 terestingly, oligomeric amyloid-beta-derived diffusible ligands (ADDLs) caused mitochondrial fragment

128 er soluble Abeta forms (amyloid beta-derived diffusible ligands (ADDLs)) were also suggested to form

129 oligomers, also referred to as Abeta-derived diffusible ligands (ADDLs), act as highly specific patho

130 for G protein-coupled receptors (GPCRs) with diffusible ligands have employed extensively mutated or

131 PGs do not act by transporting extracellular diffusible ligands or require leukocyte antigen-related

132 ) oligomers were distinct from Abeta-derived diffusible ligands which did not elicit significant THP-

133 eta) assemblies (also known as Abeta-derived diffusible ligands, or ADDLs) may represent a primary ne

134 s in the structural study of GPCRs that bind diffusible ligands.

135 site, allowing a potential entry pathway for diffusible ligands.

136 ially regulated in the GPCRs that respond to diffusible ligands?

137 of GPCR interaction could be well suited for diffusible linear peptide ligands and a common feature o

138 o allow directed movement towards the slowly diffusible lipid phosphatidylethanolamine (PE).

139 Mycolactone is a diffusible lipid secreted by the human pathogen Mycobact

140 or question about lipid signaling is whether diffusible lipids can selectively target specific protei

141 Gradients of diffusible long-range attractant and repellent proteins

142 iscussion of the current distinction between diffusible long-range versus substrate-bound short-range

143 gh the production, release, and reception of diffusible low molecular weight chemical signaling molec

144 ting at unattached kinetochores to produce a diffusible Mad2-Cdc20 intermediate and a diffusible step

145 l contact and is carried by an extracellular diffusible marker.

146 Planktonic P. aeruginosa diffusible material (PsaDM) induced stronger p38alpha MA

147 omycete strain CNQ-525 can reduce MnO2 via a diffusible mechanism.

148 proinflammatory cytokine TNF-alpha acts as a diffusible mediator of the bystander effects induced by

149 Immune responses are regulated by diffusible mediators, the cytokines, which act at sub-na

150 ited a rapid drop in current upon removal of diffusible mediators.

151 ation genetics, in which a single species of diffusible, membrane-bound signalling molecules can self

152 A potent, diffusible messenger is hydrogen peroxide (H2O2), but it

153 The diffusible messenger NO plays multiple roles in neuropro

154 production of calcium influx factor (CIF), a diffusible messenger that can deliver the signal from th

155 argets for activity-dependent modulation via diffusible messengers NO and BDNF, which enhance and dep

156 c utility for monitoring reactions involving diffusible metabolites in other complex biological matri

157 diated by both direct cell-cell contacts and diffusible microparticles.

158 Lansky et al. now show that the diffusible microtubule crosslinker Ase1p can generate sl

159 ery to actively sort biosynthetic cargo from diffusible misfolded and resident ER proteins.

160 Two-color PALM shows that the freely diffusible mitochondrial matrix protein is largely exclu

161 dies revealed a significant reduction in the diffusible mobility of CypB(W128A)-GFP compared with Cyp

162 e order of 1 mm, greater than expected for a diffusible molecular cue.

163 ssically held views that NO acts as a freely diffusible molecule regulated primarily by concentration

164 a network when the local concentration of a diffusible molecule surpasses a critical threshold.

165 ich quenches oscillations and incorporates a diffusible molecule.

166 peroxide (H2 O2 ), which is a small, readily diffusible molecule.

167 does not rely exclusively on the exchange of diffusible molecules and energy carriers such as hydroge

168 th large eukaryotic cells: they employ small diffusible molecules and involve receptor subunits resem

169 ty, bacterial populations produce and detect diffusible molecules called autoinducers.

170 However, some of these diffusible molecules could have reversible effects on br

171 oral distributions of an extensive number of diffusible molecules drive a variety of complex function

172 Diffusible molecules extravasate, intravasate, are remov

173 We suggest that tension, rather than diffusible molecules generated or sequestered at the lea

174 ween blood flow and the extraction of freely diffusible molecules in tissue, was recently extended to

175 In this study, we sought to identify diffusible molecules produced during the HR that could i

176 row transplantation is not limited to freely diffusible molecules such as enzymes, but also large str

177 cognized that bacteria communicate via small diffusible molecules, a process termed quorum sensing.

178 e facing biologists is to relate the diverse diffusible molecules, control circuits, and gene regulat

179 chanism wherein P. aeruginosa secretes small diffusible molecules, specifically acyl homo serine lact

180 um sensing (QS) is a mechanism wherein small diffusible molecules, specifically acyl-homoserine lacto

181 ethodology to label, retain, and image small diffusible molecules, which can be transposable to other

182 e-spanning complexes, or indirectly, through diffusible molecules.

183 dapted for adsorption of nutrients and other diffusible molecules.

184 small changes in the local concentration of diffusible molecules.

185 om those of other known two-component flavin-diffusible monooxygenase family members, such as PheA2 a

186 genase belonging to the two-component flavin-diffusible monooxygenase family of reduced flavin-depend

187 o the newly established two-component flavin-diffusible monooxygenase family, were identified in the

188 hether FGF8 controls patterning as a classic diffusible morphogen has not been directly tested.

189 These observations support FGF8 as a classic diffusible morphogen in neocortex, thereby guiding futur

190 A "notch-drives-growth" model, in which a diffusible morphogen produced at each notch promotes spe

191 , whose DNA-binding affinity is modulated by diffusible N-acyl homoserine lactone (AHL) signalling mo

192 Despite its diffusible nature, NO modifies thiol groups of specific

193 axons target normally despite replacement of diffusible Netrin-B by membrane-tethered ligands.

194 troglial CNTF expression was not affected by diffusible neuronal molecules or by neurotransmitters.

195 The inclusion of a diffusible nutrient, supplied by the blood vessels, allo

196 oluble amyloid fibrils and the generation of diffusible oligomeric aggregates that are implicated as

197 However, formation of diffusible, oligomeric forms of Abeta, both on and off p

198 The recent recognition that small, diffusible oligomers may be the principal bioactive form

199 These results support the hypothesis that diffusible oligomers of Abeta initiate a synaptic dysfun

200 lls possessing foci had fewer (if any) small diffusible oligomers of Htt103Q.

201 tivity such as the mRNA and siRNA or nuclear diffusible oligonucleotide.

202 ts riboflavin and Rose Bengal as well as the diffusible one-electron oxidant Na2IrCl6.

203 sfer-based biosensors that are either freely diffusible or bound to A kinase anchoring proteins, we d

204 Cells communicate by sensing diffusible or surface-associated chemical signals, with

205 Mechanistic studies provide evidence for diffusible organic radicals and highlight the difference

206 ng from unattached kinetochores to produce a diffusible |P;wait anaphase|P' signal.

207 ally regulated; however, the function of the diffusible p75NTR ectodomain (p75ECD) after shedding rem

208 At each stage within such as a cascade, a diffusible particle is reversibly bound by immobile trap

209 elf-enhancing activator protein, HetR, and a diffusible pentapeptide inhibitor PatS-5 (RGSGR).

210 ane protein that can be cleaved to release a diffusible peptide.

211 lution containing orthophosphate reduced the diffusible phosphorus content in a concentration-depende

212 g axonal transport of CPs that have inherent diffusible pools and distinguish this transport modality

213 Cooperation through the sharing of diffusible products raises new questions about tumorigen

214 eptor and motor complexes are coupled by the diffusible protein CheY-P.

215 s, it is unclear whether gradients of freely diffusible proteins can form within bacterial cells give

216 membrane-bound elements and does not involve diffusible proteins or small molecules.

217 We assume that cooperators generate a diffusible public good, which can be absorbed by any cel

218 Nitric oxide (NO) is a diffusible radical gas produced from the activity of nit

219 ciency and stochasticity are the result of a diffusible, rate-limiting activator.

220 ng proteins shield the genetic material from diffusible reactive oxygen species by reacting with them

221 This freely diffusible reactive oxygen species is proposed as the ag

222 Small diffusible redox proteins facilitate electron transfer i

223 However, it is unclear how freely diffusible ROS dictate specific cellular responses.

224 y, treating larvae with hydrogen peroxide, a diffusible ROS that has been implicated as a signaling m

225 H2O2 has an important role as a diffusible second messenger [2], and mediates its effect

226 oxide (NO) functions widely as a transmitter/diffusible second messenger in the central nervous syste

227 These results strongly suggest that a key diffusible second messenger mediating the MOR-signaling

228 ratio-calcium-imaging methods, we describe a diffusible second messenger pathway stimulated by the MO

229 lysis and is therefore mediated by a readily diffusible second messenger.

230 pathway involves Gq/11 and is mediated by a diffusible second messenger.

231 gs suggest that local generation of a highly diffusible signal can regulate polarized cell growth, pr

232 e in gametophyte recognition and implicate a diffusible signal emanating from either gametophyte that

233 Signal molecules of the diffusible signal factor (DSF) family have been shown re

234 ll-cell communication system consisting of a diffusible signal factor (DSF) synthase, RpfF, and a DSF

235 Many bacterial pathogens produce diffusible signal factor (DSF)-type quorum sensing (QS)

236 chain fatty acid signaling molecules such as diffusible signal factor, which act as cell-to-cell comm

237 The release of OMVs was suppressed by the diffusible signal factor-dependent quorum-sensing system

238 It does this by generating a diffusible signal from free kinetochores into the cytopl

239 The diffusible signal molecule Slit and the neuronally expre

240 3D hydrogel by incorporating the sets of the diffusible signal molecules delivered through drug-relea

241 s communicate by releasing and sensing small diffusible signal molecules in a process commonly known

242 e gene expression collectively by exchanging diffusible signal molecules known as autoinducers.

243 Bacteria can communicate via diffusible signal molecules they generate and release to

244 argued that bacteria communicate using small diffusible signal molecules to coordinate, among other t

245 rocess coordinated by the mutual exchange of diffusible signal molecules.

246 e actions of one or more chemically distinct diffusible signal molecules.

247 generating the targeted spatial gradients of diffusible signal molecules.

248 ssion in many bacterial species, mediated by diffusible signal molecules.

249 so that only cells that sense light and the diffusible signal produce a positive output.

250 Thus, a diffusible signal that acts independent of local circuit

251 d as a concentration-dependent response to a diffusible signal, but the duration of morphogen signall

252 uced either by a concentration gradient of a diffusible signal, or by spontaneous symmetry breaking c

253 thogenic bacterium, mediated by a fatty acid Diffusible Signaling Factor (DSF), is required to coloni

254 The diffusible signaling factor (DSF)-based quorum sensing (

255 e neuroepithelium that function by releasing diffusible signaling factors.

256 cteria depends on release and detection of a diffusible signaling molecule (autoinducer) among a mult

257 stimulated by the secretion by fibroblast of diffusible signaling molecules, such as prostaglandin E2

258 nants that provide cell surface receptors or diffusible signalling chemicals to identify proximal cel

259 nd sense a fatty acid signal molecule called diffusible signalling factor (DSF, 2(Z)-11-methyldodecen

260 itecture in which both positive and negative diffusible signals act on stem and/or progenitor cells l

261 gh precise control in both space and time of diffusible signals and binding interactions.

262 Endothelial and pericyte diffusible signals from both regions differentially prom

263 l interactions involves plant recognition of diffusible signals from the fungus, including lipochitoo

264 mutual recognition involving the release of diffusible signals into the rhizosphere.

265 ory suggested that cAMP and other field-wide diffusible signals mediate tissue integration and termin

266 ion-diffusion system posits that interacting diffusible signals produced by static cells first define

267 g quorum sensing (QS), whereby cells secrete diffusible signals that generate phenotypic responses as

268 Our study identifies extracellular diffusible signals that modulate the Hippo pathway and a

269 The capability of diffusible signals to induce the formation of a fluid-fi

270 nsport phenomena and spatial distribution of diffusible signals, and we highlight the unmet need for

271 s well as regulation by internally generated diffusible signals.

272 uman gut microbiota are suspected to produce diffusible small molecules that modulate host signaling

273 The other strain produces diffusible small molecules: pyrrolnitrin, a known antifu

274 ccurs within an intracellular phagosome, but diffusible species can react with the neutrophil and sur

275 ive intermediates produced in RNA exposed to diffusible species such as hydroxyl radical.

276 e a diffusible Mad2-Cdc20 intermediate and a diffusible step in which that intermediate amplifies pro

277 Therefore, a diffusible strained form of NAD+ intermediate was propos

278 Diffusible stromal targets remained elevated in the abse

279 he active metabolite of F-araAMP to a highly diffusible substance capable of efficiently killing byst

280 ch communication through pheromones or other diffusible substances points to a nonindividual autonomo

281 the normal organization of RyRs and releases diffusible substances that control Ca(2+) spark properti

282 Cells in these colonies produced diffusible substances that markedly inhibited in vitro a

283 he sheath, the elastic properties that allow diffusible substrates to penetrate through expandable ho

284 even without the presence of freely membrane-diffusible substrates.

285 d by in vitro or in vivo administration of a diffusible synthetic ligand.

286 We have discovered that the diffusible TGFss-related factor Radar (Gdf6a) is necessa

287 ed to the mitotic spindle compartment or are diffusible throughout the cytoplasm.

288 not require contact between bacteria but are diffusible toxins released into the environment.

289 stent with the hypothesis that ATP acts as a diffusible trigger of calcium release waves, local eject

290 formation in which CV2 serves to concentrate diffusible Tsg/BMP4 complexes in the vertebral body cart

291 lacks this highly basic domain and is freely diffusible upon secretion.

292 ites of fenestration allowing for passage of diffusible vasoactive substances and interface of endoth

293 attern of site-specific phosphorylation than diffusible VEGF.

294 mus and inducing the synthesis of the freely diffusible volume-based transmitter NO, through the acti

295 Thus, we propose that the diffusible 'wait anaphase' signal could be the MCC itsel

296 through unattached kinetochores generating a diffusible 'wait anaphase' signal that inhibits the APC/

297 ll differences in the availability of freely diffusible water between inside and outside the cell gre

298 We show adhesion molecules are freely diffusible within the axon membrane and accumulate at fo

299 ociated with an aggregate rather than freely diffusible within the dense-body granule.

300 ating the sensitivity of specific neurons to diffusible Wnt ligands and thereby defines distinct patt