ライフサイエンスコーパス: difluoromethylornithine

1 ment in cells grown in the presence of alpha-difluoromethylornithine.

2 re potent inhibitor of the enzyme than alpha-difluoromethylornithine.

3 xogenous putrescine in the presence of alpha-difluoromethylornithine.

4 y preventing putrescine formation with alpha-difluoromethylornithine.

5 on of Xenopus oocytes injected with 50 nl of difluoromethylornithine (5 mM) and methylglyoxal bis(gua

6 ivation is polyamine dependent because alpha-difluoromethylornithine, a specific inhibitor of ODC act

7 However, the addition of difluoromethylornithine, a specific ODC inhibitor, to th

8 Treatment with alpha-difluoromethylornithine, a specific ornithine decarboxyl

9 Furthermore, alpha-difluoromethylornithine, a suicide inhibitor of ODC, inh

10 The specific ODC inhibitor, alpha-difluoromethylornithine, abrogated all suppressive effec

11 dition, in vivo inhibition of ODC with alpha-difluoromethylornithine also exacerbated the colitis.

12 Treatment of gerbils with either alpha-difluoromethylornithine, an inhibitor of ODC, or MDL 725

13 Treatment of ZD:Wt mice with alpha-difluoromethylornithine, an inhibitor of ornithine decar

14 depletion of cellular polyamines with alpha-difluoromethylornithine, an inhibitor of ornithine decar

15 alpha-Difluoromethylornithine, an irreversible inhibitor of OD

16 Oral consumption of alpha-difluoromethylornithine, an irreversible specific inhibi

17 f cationic amino acid transport, or by alpha-difluoromethylornithine, an ornithine decarboxylase inhi

18 lbenzylamine and two chemopreventive agents, difluoromethylornithine and perillyl alcohol.

19 ine was inhibited by the ODC inhibitor alpha-difluoromethylornithine, and L-proline generation was bl

20 2-Difluoromethylornithine could also reactivate hair growt

21 The ODC inhibitor 2-difluoromethylornithine could prevent hair loss and part

22 Inhibiting ODC activity with alpha-difluoromethylornithine delayed DCVC-induced cell death.

23 Two compounds, difluoromethylornithine (DFMO) and 5-fluorouracil (5-FU)

24 We studied effects of the combination of difluoromethylornithine (DFMO) and sulindac on biomarker

25 DL-alpha-Difluoromethylornithine (DFMO) causes polyamines of the

26 toma (NB) cells with the ODC inhibitor alpha-difluoromethylornithine (DFMO) depleted polyamine pools

27 ibition of polyamine biosynthesis with alpha-difluoromethylornithine (DFMO) has been shown to inhibit

28 Depletion of cellular polyamines by DL-alpha-difluoromethylornithine (DFMO) induced levels of JunD mR

29 The Odc inhibitor alpha-difluoromethylornithine (DFMO) inhibited neuroblast prol

30 Alpha-difluoromethylornithine (DFMO) inhibits the proto-oncoge

31 L-Alpha-difluoromethylornithine (DFMO) is a chemopreventive agen

32 sms underlying the chemopreventive effect of difluoromethylornithine (DFMO) on the development of mam

33 eatment with the Odc suicide inhibitor alpha-difluoromethylornithine (DFMO) or Odc heterozygosity mar

34 We found that the inhibition of ODC by alpha-difluoromethylornithine (DFMO) resulted in a approximate

35 ty by RS1-Reg mutants and the ODC1 inhibitor difluoromethylornithine (DFMO) was measured in the absen

36 tion of the NO donor agents as well as alpha-difluoromethylornithine (DFMO), a known ODC inhibitor, w

37 of ODC/Ras double transgenic mice with alpha-difluoromethylornithine (DFMO), a specific inhibitor of

38 When K14-MEK mice were given alpha-difluoromethylornithine (DFMO), a suicide inactivator of

39 etermine the chemopreventive effect of alpha-difluoromethylornithine (DFMO), an enzyme-activated irre

40 by zinc deficiency can be inhibited by alpha-difluoromethylornithine (DFMO), an enzyme-activated, irr

41 amine levels in COS-7 cells induced by alpha-difluoromethylornithine (DFMO), an inhibitor of ornithin

42 cultured in the presence or absence of alpha-difluoromethylornithine (DFMO), an inhibitor of the poly

43 We administered alpha-difluoromethylornithine (DFMO), an irreversible inhibito

44 We administered alpha-difluoromethylornithine (DFMO), an irreversible inhibito

45 The use of alpha-difluoromethylornithine (DFMO), an irreversible inhibito

46 f cationic amino acid transport, or by alpha-difluoromethylornithine (DFMO), an ODC inhibitor.

47 thout the ornithine decarboxylase inhibitor, difluoromethylornithine (DFMO), and induced to undergo a

48 lls were exposed to the specific ODC blocker difluoromethylornithine (DFMO), and ODC activity, intrac

49 the ornithine decarboxylase (ODC) inhibitor difluoromethylornithine (DFMO), beginning at the time th

50 N1,N11-diethylnorspermine (DENSPM) or alpha-difluoromethylornithine (DFMO), have synergistic effects

51 NO, like alpha-difluoromethylornithine (DFMO), interferes with cell pro

52 One of the currently used drugs, alpha-difluoromethylornithine (DFMO), is a suicide inhibitor o

53 (2) In combination with difluoromethylornithine (DFMO), P-S reduced tumor multip

54 on with the polyamine biosynthesis inhibitor difluoromethylornithine (DFMO), provides a method to tar

55 A specific inhibitor of the transgene, alpha-difluoromethylornithine (DFMO), reversibly blocked the a

56 PA, the irreversible inhibitor of ODC, alpha-difluoromethylornithine (DFMO), was used.

57 the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO).

58 tors N-hydroxy-nor-L-arginine (nor-NOHA) and difluoromethylornithine (DFMO).

59 e alone, dehydroepiandrosterone (DHEA), or 2-difluoromethylornithine (DFMO).

60 the ornithine decarboxylase (ODC) inhibitor difluoromethylornithine (DFMO).

61 ration of the suicide inhibitor of ODC alpha-difluoromethylornithine (DFMO, 0.5% w/v) in the drinking

62 f two molecules that alter polyamine levels: difluoromethylornithine (DFMO; also called eflornithine)

63 orrelated in diabetic and control rats given difluoromethylornithine (DFMO; Marion Merrell Dow, Cinci

64 nhibiting ornithine decarboxylase with alpha-difluoromethylornithine dramatically enhanced the cytopl

65 atment with the biosynthesis inhibitor alpha-difluoromethylornithine during tetracycline removal inte

66 and the pharmacological agents piroxicam and difluoromethylornithine each reduced intestinal adenoma

67 Arginase inhibitor alpha-difluoromethylornithine enhanced NO production/dilation

68 as, whereas the combination of piroxicam and difluoromethylornithine exerted a moderate effect.

69 on to that observed for putrescine and alpha-difluoromethylornithine in previous T. brucei ODC struct

70 ing ornithine decarboxylase (ODC) with alpha-difluoromethylornithine increased the levels of ATF-2 mR

71 Depletion of cellular polyamines by alpha-difluoromethylornithine induced levels of phosphorylated

72 Polyamine depletion with alpha-difluoromethylornithine inhibited the activities of RhoA

73 , the polyamine biosynthesis inhibitor alpha-difluoromethylornithine inhibits the ability of MTAP-def

74 the ornithine decarboxylase inhibitor alpha-difluoromethylornithine or the S-adenosylmethionine deca

75 ed either apoptosis in the basal epithelium (difluoromethylornithine) or both apoptosis and vacuolati

76 ated with the polyamine synthesis inhibitor, difluoromethylornithine, or the K(ATP) channel inhibitor

77 well as those grown in the presence of alpha-difluoromethylornithine plus putrescine.

78 Inhibition of ODC by difluoromethylornithine prevented basal and induced cell

79 stration of the suicidal ODC inhibitor alpha-difluoromethylornithine reduced UVB-induced BCCs in Ptch

80 interfering RNA or the competitive inhibitor difluoromethylornithine restored iNOS protein expression

81 he ornithine decarboxylase inhibitor L-alpha-difluoromethylornithine sensitized all of these leukemia

82 ptosis could be blocked by the ODC inhibitor difluoromethylornithine, the caspase inhibitors Z-VAD FM

83 m target of Akt, was also increased in alpha-difluoromethylornithine-treated cells, which was prevent

84 alpha-Difluoromethylornithine treatment of infected mice resto

85 vities in J774.1 cells using L-norvaline and difluoromethylornithine treatment, respectively.

86 The ODC inhibitor, alpha-difluoromethylornithine, was administered to H pylori-in

87 The "resurrection drug" eflornithine (difluoromethylornithine), which is used clinically to tr

88 reatment with the ODC enzyme inhibitor alpha-difluoromethylornithine, which results in regression of