ライフサイエンスコーパス: digestive vacuole

1 ozoin formation within lipid droplets in the digestive vacuole.

2 ligned hemozoin crystals within the parasite digestive vacuole.

3 embrane of the intra-erythrocytic parasite's digestive vacuole.

4 mediating the efflux of chloroquine from the digestive vacuole.

5 s is a vast process that occurs in an acidic digestive vacuole.

6 proteolysis of hemoglobin in the Plasmodium digestive vacuole.

7 omineralization within the malarial parasite digestive vacuole.

8 ing starvation, and the formation of central digestive vacuoles.

9 of hemozoin biosynthesis within the parasite digestive vacuoles.

10 stidine-rich protein II (HRP II) in purified digestive vacuoles.

11 te cytosol, HRPs are brought into the acidic digestive vacuole along with hemoglobin.

12 Hemoglobin degradation occurs in the acidic digestive vacuole and is essential for the survival of t

13 to its target ferriprotoporphyrin IX in the digestive vacuole and loss of verapamil reversibility of

14 on of PfA-M1 caused swelling of the parasite digestive vacuole and prevented proteolysis of hemoglobi

15 ations of material were detected in abnormal digestive vacuoles and aggregated at the parasite plasma

16 accumulation of quinolines in the plasmodium digestive vacuole, and suggest that a quinoline heme com

17 ve and -resistant parasites, causes enlarged digestive vacuoles, and renders chloroquine-resistant st

18 lobin by sequestering it within the parasite digestive vacuole as a polymer called hemozoin.

19 his probe localizes to the malarial parasite digestive vacuole (DV) during initial perfusion under ph

20 embrane-spanning domains and is found in the digestive vacuole (DV) membrane of intraerythrocytic par

21 e proton electrochemical gradient across the digestive vacuole (DV) membrane.

22 (triple-PM KO), and mutants lacking all four digestive vacuole (DV) plasmepsins (pfpm4, pfpm1, pfpm2

23 not only infective merozoites, but also the digestive vacuole (DV), a membrane-bounded organelle con

24 orientation of hemozoin crystals within the digestive vacuole (DV), as a signature of their nucleati

25 nsmembrane protein localizes to the parasite digestive vacuole (DV), the site of CQ action, where inc

26 the volume and pH regulation of the parasite digestive vacuole (DV), using the fluorescence imaging c

27 throcytes by selectively lysing the parasite digestive vacuole (DV).

28 ced rate of ATP-dependent CQ uptake into the digestive vacuole (DV).

29 ficult or impossible with hematin-containing digestive vacuoles from P. falciparum-infected erythrocy

30 inhibit hemozoin formation in the parasite's digestive vacuole in a manner similar to that of chloroq

31 ance mechanism operates at the P. falciparum digestive vacuole membrane in malaria.

32 is associated with multiple mutations in the digestive vacuole membrane protein PfCRT.

33 ide polymorphisms in pfmdr1, which encodes a digestive vacuole membrane-bound ATP-binding cassette tr

34 ISPR-Cas9-based gene editing, identified the digestive vacuole membrane-spanning transporter PfMDR1 (

35 functions as a transporter in the parasite's digestive vacuole membrane.

36 4, previously known only to function in the digestive vacuole of asexual blood stage Plasmodium, pla

37 e previously only known to be present in the digestive vacuole of asexual stage malaria parasites.

38 The digestive vacuole of Plasmodium falciparum is the site o

39 ation of protonated CQ as a weak base in the digestive vacuole of the erythrocyte-stage parasite, and

40 The maintenance of acidic pH in the digestive vacuole of the malaria parasite is thought to

41 Obtaining a definitive measurement of digestive vacuole pH has been surprisingly difficult.

42 tagged dyes as probes for the measurement of digestive vacuole pH has proved problematic, yet some su

43 is associated with an attenuated increase in digestive vacuole pH relative to CVIET pfcrt-carrying is

44 were identified as a novel class of malaria digestive vacuole plasmepsin inhibitors by using NMR-bas

45 The digestive vacuole plasmepsins PfPM1, PfPM2, PfPM4, and P

46 Mutations in a digestive vacuole protein encoded by a 13-exon gene, pfc

47 Mutations in both digestive vacuole-resident transporters are thought to d

48 to efflux chloroquine from the intracellular digestive vacuole, the site of drug action.

49 nthesizes insoluble hemozoin crystals in the digestive vacuole through polymerization of beta-hematin

50 lciparum is associated with mutations in the digestive vacuole transmembrane protein PfCRT.

51 ultiple amino acid mutations in the parasite digestive vacuole transmembrane protein PfCRT.

52 and pfmdr 1, which encode the P. falciparum digestive-vacuole transmembrane proteins PfCRT and Pgh1,

53 oin (Hz) produced within the living parasite digestive vacuole, under physiologic conditions.

54 cumulation of electron-dense vesicles in the digestive vacuole was observed upon disruption of PfPM4;

55 ort, and in association with hemozoin of the digestive vacuole, where chloroquine inhibits heme polym

56 -product of hemoglobin catabolism within the digestive vacuole, where heme is predominantly sequester