ライフサイエンスコーパス: digit

1 03(3) (brackets indicate uncertainty on last digit).

2 digits (e.g. lift a mug with three vs. five digits).

3 ion (i.e. the pattern) of joints within each digit.

4 h expanded apoptosis in the developing first digit.

5 ts and the positioning of joints within each digit.

6 polydactyly or syndactyly or missing a hand digit.

7 bstrate-based loading prior to the origin of digits.

8 vailable to bring these rates down to single digits.

9 strongly thickened relative to the inner two digits.

10 y on the Newcomb-Benford law for significant digits.

11 sis including varying numbers of significant digits.

12 anscoding numerals from dictation to written digits.

13 vasculature in the eye, and 50% have webbed digits.

14 neuron subtypes parallels the elaboration of digits.

15 that allows dexterous extension of the four digits.

16 me degree of coordinated control of multiple digits.

17 tics, requiring neural signals of individual digits.

18 ry refill time, alternating second and third digits.

19 s were modulated in a similar way across all digits.

20 gnal, then to a distal signal that organizes digits.

21 n the epithelium invaginates to separate the digits.

22 cipants were asked to memorize a sequence of digits (0-9), varying randomly in length between one, fo

23 hierarchically to initiate the formation of digit 1 by reducing Gli3 transcription and by enabling e

24 he loss of Hoxd13 expression, exclusively in digit 1 territory, correlates with increased Gli3 repres

25 t limbs does not extend into the presumptive digit 1 territory, which is therefore devoid of distal H

26 tanding the special morphology of the thumb (digit 1), the acquisition of which was an important adap

27 mouse mutant that specifically fail to form digit 1.

28 identified, including opposable movements of digits 1 and 2 (D1 and D2).

29 sensory input from just the opposing digits (digits 1-3) of one hand.

30 e conduction latency) and in the brain (i.e. digit 2/3 cortical separation distance).

31 o exhibits impaired visual awareness for the digits 2 to 9, and stimuli presented in close proximity

32 ex using vibrotactile stimulation over three digits (2, 3 and 5).

33 50 active site geometries matching 457 (2) 4-digit (3-digit) enzyme classification (E.C.) numbers, na

34 atic ductal adenocarcinoma (PDAC) has single-digit 5-year survival rates at <7%.

35 produced and evaluated in mice in vivo using Digit Abduction Score assays.

36 al hypotonia, epilepsy, developmental delay, digit abnormalities) to classify the condition.

37 al nervous system (CNS), cardiac, renal, and digit abnormalities.

38 neuron pools receive common input even when digit actions do not belong to a common behavioural repe

39 resulting in severe Shh loss of function and digit agenesis.

40 multiple digits, or of the first and second digits alone.

41 tterns of gene expression differentiation of digits, although the anterior-most digit of the pentadac

42 We show here, using the mouse digit amputation model, that SIRT3 deficiency has no imp

43 We previously discovered that treating digit amputation wounds with BMP2 in neonatal mice stimu

44 , and the origin of the highly derived first digit anatomy that facilitates these capabilities.

45 Our findings show that cooperation between DIGIT and BRD3 at regions of H3K18ac regulates the trans

46 ion between the long non-coding RNA (lncRNA) DIGIT and the bromodomain and extraterminal domain prote

47 lve rotational transitions to 11 significant digits and derive the rotational constant of (40)CaH(+)

48 sbar array optically images 1000 handwritten digits and electrically recognizes these imaged data wit

49 -limb transition was marked by the origin of digits and the loss of dermal fin rays.

50 e vertebrate limb include the positioning of digits and the positioning of joints within each digit.

51 r various image sets, including hand-written digits and through-wall body gestures, using a single ph

52 lex verbal stimuli (e.g. longer words versus digits); and (iii) it is involved in spontaneous retriev

53 sing cells contributed to the most posterior digit, and that inhibiting Shh-signaling inhibited Fgf8

54 ating patterns, such as hair follicles, limb digits, and intestinal villi, during development.

55 , which leads to flexion contractures of the digits, and is associated with other tissue-specific fib

56 s, including those involving the brain, eye, digits, and jaw.

57 % of all evoked movements in M1 involved the digits, and the majority of these consisted of finger fl

58 with individual tissue specificities in the digit anlagen, growth plates, skull sutures and fingerti

59 ic magnitude classification task with single-digit Arabic numbers.

60 e-examination of available data suggest that digits are actually patterned as evenly spaced spots, no

61 In crown group tetrapods, individual digits are homologized in relation to a pentadactyl grou

62 ubiquitin-binding motif uniformly developed digit arthritis with features common to psoriatic arthri

63 grees of freedom (DOFs), including wrist and digit artificial joints.

64 digm to predict movement action for all five digits as well as rotation of the thumb.

65 he baseline, and are even detected at single digit attomole (amole) range.

66 duce the Bitome, a matrix composed of binary digits (bits) representing the genomic positions of geno

67 critical role for the nail epithelium on the digit bone during homeostatic regeneration and show that

68 embryos, the IET moves normally between the digits but fails to bifurcate because of abnormal adhesi

69 les that manipulated the tarsometatarsus and digits, but the timing of these changes is unknown.

70 ently regulates more posterior Hoxd genes in digit cells.

71 dynamism in the gene expression profiles of digits, challenging the notion that five digits have con

72 Using RNA splicing prediction as well as digit classification as case studies, we demonstrate tha

73 urons, emphasizing the specialized status of digit control in the evolution of skilled motor behavior

74 y be attributed to their lack of independent digit control.

75 MRI, the cortical representations of the two digits costimulated above-resonance shifted closer, pote

76 classification tasks based on a hand-written digit dataset and by learning several Atari 2600 games s

77 stem is demonstrated in SPICE based on MNIST digit dataset, yielding 90% accuracy and no accuracy deg

78 a role that may be important in early-stage digit development.

79 Random digit dialing was used to recruit adult participants who

80 remove sensory input from just the opposing digits (digits 1-3) of one hand.

81 timuli presented in close proximity to these digits, due to perceptual distortion.

82 ) or its relation with involved effectors or digits (e.g. lift a mug with three vs. five digits).

83 site geometries matching 457 (2) 4-digit (3-digit) enzyme classification (E.C.) numbers, native acti

84 scles and elbow extensors, weak to wrist and digit extensors, and almost absent to the intrinsic musc

85 In the tetrapod limb, the digits (fingers or toes) are the elements most subject t

86 morphometry in skin biopsies from the third digit fingertip.

87 Wrist and digit flexor motoneurons sometimes inhibited the corresp

88 We selected the Achilles, forepaw digit flexor, patellar, and supraspinatus tendons due to

89 force production task consisting of uncommon digit force coordination patterns, we found that synapti

90 t for both prenatal (neural tube closure and digit formation) and postnatal development (hyaloid regr

91 13 (HOX13 hereafter), which are required for digit formation, and HOXA11, involved in forearm/leg dev

92 how several trends in the lineage leading to digited forms, including the consolidation of fin rays (

93 The murine digit has been used to study mammalian regeneration, whe

94 clude only the identity of the anterior-most digit has shifted position, suggesting a 1,3,4 digit ide

95 of digits, challenging the notion that five digits have conserved developmental identities across am

96 using WGS from 419 individuals to call eight-digit HLA types and RNA-seq data from matched iPSCs.

97 However, testing hypotheses of digit homology is challenging because it is unclear whet

98 ish Medical Birth Register using a unique 10-digit identifier assigned to all live births and new res

99 results suggested that Tbx5 is required for digit identity in a subset of limb mesenchymal cells.

100 In addition, Bmp2 also restores posterior digit identity in the absence of Shh signalling, thus in

101 git has shifted position, suggesting a 1,3,4 digit identity in the bird wing.

102 of NRG1-soaked beads rescued regeneration to digits in denervated limbs, and pharmacological inhibiti

103 d to an impairment of the independent use of digits in skilled manual actions, similar injuries in hu

104 Our findings suggest that the emergence of digits in the limb is matched by distinct mechanisms for

105 attern of MCs in the distal pads of all five digits in the macaque monkey (with hands similar to huma

106 Digits-in-noise (DIN), a widely used test of speech-in-n

107 bicipitale radii, and a robust second manual digit, indicating that it is a more derived avialan than

108 it remains unclear how the specification of digit-innervating motor neuron subtypes parallels the el

109 We show that digit-innervating motor neurons can be defined by select

110 is sufficient to induce the specification of digit-innervating motor neurons, emphasizing the special

111 DIGIT is also enriched in regions of H3K18ac, and the de

112 Its foot, of which the third digit is much longer than the second and fourth digits,

113 s have proposed that the iterative series of digits is established by a Turing-like mechanism generat

114 it is much longer than the second and fourth digits, is distinct from those of all other currently re

115 crophages and T regulatory cells in skin and digit joints as well as by increased expression of matri

116 ported associations between second-to-fourth digit length ratio (2D:4D), a proxy for prenatal androge

117 unique derived morphology of the human fifth digit little work has investigated why humans alone disp

118 eletions that suggest a mode of evolutionary digit loss through expanded apoptosis in the developing

119 of musculoskeletal tissues following limb or digit loss.

120 judgments of sound location as a function of digit magnitude (1-9).

121 affinity (Ki = 38 pM), coupled with a single-digit micromolar activity against Trypanosoma brucei bru

122 We improved compound potency to the double-digit micromolar range.

123 demonstrate this by printing, within single-digit millisecond time scales, nanowires with widths sma

124 to two visual recognition tasks, handwritten digits (MNIST) and objects in small natural images (CIFA

125 on Test (beta = - 0.79, P < 0.01) and Symbol Digit Modalities Test (beta = -0.70, P = 0.02) at 15 yea

126 6.5; 95% CI=9.5 to 23.4; p<0.001) and Symbol Digit Modalities Test (beta=41.8; 95% CI=18.7 to 65.0; p

127 ory Serial Addition Test (R(2)=0.29), Symbol Digit Modalities Test (R(2)=0.31) and executive function

128 standard pen-and-paper tests, such as Symbol Digit Modalities Test (SDMT) and Montreal Cognitive Asse

129 S)) and information processing speed (Symbol Digit Modalities Test (SDMT)) compared with conventional

130 t Walk Test, 9-Hole Peg Test (9-HPT), Symbol Digit Modalities Test (SDMT), Brief Visuospatial Memory

131 anded Disability Status Scale and the Symbol Digit Modalities Test at baseline and 2-year follow-up.

132 The Symbol Digit Modalities Test can also be used in clinical trial

133 tor score, total functional capacity, symbol digit modalities test, and Stroop word test.

134 ty, reliability, and sensitivity, the Symbol Digit Modalities Test, or its computer-based analogues,

135 ced Auditory Serial Addition Test and Symbol Digit Modalities Test, respectively.

136 ced Auditory Serial Addition Test and Symbol Digit Modalities Test.

137 with subsequent decline in cognition (symbol-digit modality test r=-0.374, p<0.0001; Stroop word read

138 ional importance, the mechanisms controlling digit morphology remain poorly understood.

139 tromyographic (EMG) activity associated with digit movement at different wrist postures must also cha

140 t (p < 0.05, ANOVA) when performing the same digit movement in five different wrist postures.

141 igm-shifting approach for independent, multi-digit movement intent prediction based on multi-output,

142 show that adaptation acquired during single-digit movements transfers to the hand opening when subse

143 is a combination of two goal-directed single-digit movements, each directed at a specific position on

144 l changes such as coordination of individual digit movements, increased pronation/supination, and knu

145 on a combination of two goal-directed single-digit movements.

146 are potent Sirt2 inhibitors active at single-digit muM level by using the Sirt2 substrate alpha-tubul

147 ample from motoneurons innervating wrist and digit muscles to those controlling the shoulder and elbo

148 for specifying motor neurons that innervate digit muscles.

149 , the majority of individuals lack the fifth digit/nail hypoplasia phenotype, a hallmark of most SSRI

150 isability, coarse facial features, and fifth digit/nail hypoplasia that are caused by pathogenic vari

151 oscopy method called MINFLUX delivers single-digit nanometer-scale three-dimensional (3D) resolution

152 Single-digit nanometer-size layers of C forms were detected at

153 ture design, wafer-scale fabrication, single-digit nanometre channels, reliable fluidic sealing and l

154 hips with complex designs and down to single-digit nanometre dimensions over 200 mm wafer scale.

155 eparate inhibitor exhibiting at least single-digit nanomolar (or lower) potency and a broad spectrum.

156 found that this new variant exhibits single-digit nanomolar affinity for KRasGTP, confirming the com

157 and selective MMP-12 inhibitors with single-digit nanomolar affinity in vitro and in vivo efficacy.

158 Several compounds bound with one-digit nanomolar affinity to hCD80 and displaced CTLA-4 a

159 zes human integrin alphavbeta(6) with single-digit nanomolar affinity.

160 to major structural protein VP1 with single-digit nanomolar affinity.

161 Our initial macrocycles, which were double-digit nanomolar FXIa inhibitors, were further optimized

162 ular, compounds 46, 49, and 50 showed single-digit nanomolar IC50 values for in vitro inhibition of K

163 initial fragment screening hit led to double-digit nanomolar inhibitors of SPR with excellent ligand

164 and characterization of a novel class of one-digit nanomolar NAMPT inhibitors based on in vitro chara

165 cyclic pyridone inhibitors exhibiting single digit nanomolar potency in both biochemical and cell bas

166 growth of many tumor cell lines with single-digit nanomolar potency.

167 esulting compounds have Ki values in the two-digit nanomolar range, are not cytotoxic, and inhibit vi

168 ion (IC(50)) values in the single- or double-digit nanomolar range.

169 The decahydroquinoxalines 5-8 show single-digit nanomolar to subnanomolar kappa-opioid receptor af

170 hesized and found to act as very potent (two-digit nM range) irreversible AC inhibitors by reaction w

171 At present, a double-digit number of efforts are devoted to the development o

172 trength and genetically interact to regulate digit number, body patterning, and cardiac development.

173 rmation with growth and the determination of digit number.

174 d judged the probability of presence of each digit/object category in each image.

175 ted on large datasets of faces, hand-written digits, objects, newswire articles, sensor readings from

176 nsates of which the formation is promoted by DIGIT, occupies enhancers of endoderm transcription fact

177 Also note the nail striations in the second digit of the left hand (*).

178 iation of digits, although the anterior-most digit of the pentadactyl limb has a unique, conserved ex

179 ands shows generalized swelling of the third digit of the right hand, corresponding to dactylitis (ar

180 TIMEs connected to artificial sensors in the digits of a prosthesis to generate sensory feedback, whi

181 that are differentially expressed among the digits of amniote limbs; their spatial expression domain

182 s following a lesion that deafferented three digits of one hand.

183 nection between the fin rays of fish and the digits of tetrapods and suggest that digits originated v

184 was a (~30%) loss of MCs on the deafferented digits of the injured hand compared with the contralater

185 However, as four of the five digits of the mouse limb are morphologically similar in

186 Total folate was associated with 2.56 more digits on the DSST (95% CI: 0.82, 4.31; P-trend = 0.01).

187 was significantly associated with 3.92 more digits on the DSST (95% CI: 2.28, 5.55; P-trend < 0.01)

188 We costimulated two digits on the hand synchronously at, above, or below the

189 g magnitude, and loading distribution of all digits on the non-dominant hand of skilled flintknappers

190 (specialized for running), having only four digits on their forefeet.

191 research has been conducted into the role of digits one to three during these manual behaviours, and

192 f some intrinsic muscles associated with the digits or the acquisition of additional muscles that int

193 The fusion of digits or toes, syndactyly, can be part of complex syndr

194 nvolving flexions and extensions of multiple digits, or of the first and second digits alone.

195 and the digits of tetrapods and suggest that digits originated via the transition of distal cellular

196 n involved the co-option of the pre-existing digit patterning mechanism and therefore uncovers an emb

197 and water erosion can amount to up to double-digit percentages for major crops.

198 912 (14m) were discovered, which display two-digit picomolar affinities with K(i) values from 0.069 t

199 e transfer of prism adaptation during single-digit pointing movements to grasping movements.

200 ng, and assigned to participants' annual six-digit postal code addresses during follow-up.

201 Nevertheless, this still leads to single-digit ppt(v) limits of detection for protonated monomers

202 , 2) anthropometric measure completeness, 3) digit preference for height and age, 4) difference in me

203 Characteristics of their digits provide evidence of roosting behaviour, as in der

204 eras, that can detect the presence of single-digit pW of radiant flux intensity.

205 The digit ratio (2D:4D) is said to be a potential marker of

206 We found that the digit ratios (the right 2D:4D, the left 2D:4D, and the r

207 Moreover, extension of the digit rays and the patterning of the joints occur simult

208 stripes, which then elongate into rod-shaped digit rays by incorporating new cells at their tips.

209 We perform a digit recognition task and simulate a multilayer network

210 highest subjective and objective scores on a digit recognition task, improving the intelligibility by

211 nnel junction) can be used to achieve spoken-digit recognition with an accuracy similar to that of st

212 ready be used for tasks, such as handwritten digit recognition.

213 enes with similar temporal patterns in mouse digit regeneration and axolotl blastema differentiation

214 Costimulation at-resonance did not shift the digit regions, but increased the functional coupling bet

215 edded in a cortical sheet, mimicking the two digit regions, were costimulated at different frequencie

216 is challenging because it is unclear whether digits represent distinct and conserved gene regulatory

217 nance frequencies, reproducing the spread of digit representations seen with fMRI.

218 The evolutionary emergence of digits represents a specialized adaptation of limb morph

219 in regions of H3K18ac, and the depletion of DIGIT results in decreased recruitment of BRD3 to these

220 and movements yet their absence of opposable digits results in relatively imprecise grasping actions

221 e. radius/ulna) and then autopod (i.e. wrist/digits) segments during limb development.

222 periderm allows the IET to bifurcate as the digits separate.

223 We found that in digit separation, the overlying epidermis forms a migrat

224 idermal developmental processes required for digit separation.

225 entify 25% more words in spoken sentences or digit sequences presented in high levels of background n

226 investigate the intersubject variability of digit somatotopy across participants and the stability o

227 (F-A-S), category fluency (animals/minute), digit span (direct and backwards) tests and the Hayling

228 ociated with performance on the Trails B and digit span backwards, mildly associated with Trails A pe

229 er (digit span forward, Trails A) or higher (digit span backwards, Trails B) executive demands, and l

230 tests than the group with normal vision: the digit span forward and backward tests (beta = -0.8 [95%

231 ed the relationship between glaucoma and the digit span forward test (P = 0.043; percentage of the to

232 Next, we assessed tasks with lower (digit span forward, Trails A) or higher (digit span back

233 e and was not associated with performance on digit span forwards.

234 t, and Wechsler Adult Intelligence Scale-III Digit Span Test Backward) were measured and age-adjusted

235 Word Association Test, Trail Making Test and Digit Span tests; whereas health-related quality of life

236 ecutive Function (Trail Making Test, Stroop, Digit Span), Processing Speed (Ruff 2 and 7 Test, Digit

237 ry dilation responses were recorded during a digit-span task with three-, six-, and nine-digit spans.

238 Nontrained near-transfer WM tests (Digit-Span, Spatial-Span), self-reported executive funct

239 digit-span task with three-, six-, and nine-digit spans.

240 the well-known association of HLA antigen (2-digit specificity) MMs with kidney graft survival, estim

241 eyond those MMs assessed at the antigenic (2-digit) specificity.

242 ent was released with a diagnosis of a fifth digit sprain.

243 Letter-digit substitution (HR, 1.59; 95% CI, 1.22-2.04), verbal

244 administered (Stroop color word test, letter-digit substitution, verbal fluency, and word learning) a

245 ental State Examination, Stroop Test, Letter-Digit-Substitution Test, Word Fluency Test), mood (Cente

246 Wechsler-Adult-Intelligence-Scale (WAIS)-III Digit Symbol (WAIS-IIIDS) and Symbol Search (WAIS-IIISS)

247 Object Learning Task), and processing speed (digit symbol coding task).

248 statistically significant correlations with Digit Symbol Coding Test score (r = 0.558, P = 0.001; an

249 and processing speed (Trail Making Test and Digit Symbol Coding).

250 tal State Examination (3MSE) 4 times and the Digit Symbol Substitution Test (DSST) 5 times.

251 Learning Test (RAVLT) for verbal memory, the Digit Symbol Substitution Test (DSST) for psychomotor sp

252 The NHANES measured Digit Symbol Substitution Test (DSST) score and relative

253 f scoring low on 1 of 4 cognitive tests: the Digit Symbol Substitution Test (DSST), the Consortium to

254 the Montreal Cognitive Assessment (MoCA) and Digit Symbol Substitution Test (DSST).

255 g Test (TMT), Rey Auditory Learning Test and Digit Symbol Substitution Test before and after treatmen

256 Span), Processing Speed (Ruff 2 and 7 Test, Digit Symbol Substitution Test), and Verbal Memory (Verb

257 -Mental State Examination orientation items, Digit Symbol Substitution Test, and Category Naming Test

258 king Test Part B, the Mini-Cog test, and the Digit Symbol Substitution Test, determining each test's

259 on with the Trail Making Test Part B and the Digit Symbol Substitution test.

260 re of averaged Trailmaking A and B tests and digit symbol test [DST]) from >/=2 measurements.

261 NM-MRI)-and baseline slowing measured by the Digit Symbol test and a gait speed paradigm.

262 the Wechsler Adult Intelligence Scale (WAIS) digit symbol test.

263 The Trails B and Digit Symbol tests also performed reasonably well (AUCs,

264 Examination) and performance on subtests of Digit Symbol, Trail Making Test B, and Block Design, con

265 LT trials 1-5,CVLT delayed recall), Wechsler Digit Symbol, Trail-making Test parts A and B (TMT-A; TM

266 ts: the Delayed Word Recall Test (DWRT), the Digit-Symbol Substitution Test (DSST), and the Word Flue

267 al Memory delayed recall, Boston Naming, and Digit-Symbol Substitution.

268 tate bipedal locomotion, losing an opposable digit that grasped branches in favor of a longitudinal a

269 goal, we developed a software pipeline named digit that implements a novel measure of mapping ambigui

270 Dactylitis is diffuse swelling of the digits that is usually related to an underlying inflamma

271 ongation) and the motor dimension (number of digits) that are more strongly coded in ventral and dors

272 The fifth digit therefore appears key to >2 million years of stone

273 s (the "blastema") completely regenerate the digit tip after distal, but not proximal, amputation.

274 Innate regeneration following digit tip amputation is one of the few examples of epimo

275 Here, using the regenerating mouse digit tip as a mammalian model, we demonstrate that macr

276 By genetic lineage analyses, the digit tip blastema has been defined as a population of h

277 A sequencing of over 38,000 cells from mouse digit tip blastemas and unamputated control digit tips a

278 It has also been revealed that, during digit tip regeneration and in some non-mammalian vertebr

279 Overall, our results suggest that digit tip regeneration is controlled by a gene regulator

280 Digit tip regeneration is mediated by the blastema, the

281 an atlas of the cell types participating in digit tip regeneration.

282 Full digit tip was regenerated only in the MSX1/2 group and w

283 mBMSCs) to regenerate a proximally amputated digit tip.

284 digit tip blastemas and unamputated control digit tips and generate an atlas of the cell types parti

285 ological analyses indicated full regrowth of digit tips in the Msx-overexpressing groups, particularl

286 induced tissues can contribute to endogenous digit tissue after transplantation.

287 Our data reveal the fifth digit to be heavily and frequently recruited during all

288 perovskite solar cells have gone from single digits to a certified 22.1% in a few years' time.

289 The discovery of persistent digit topography of amputees' missing hand could be expl

290 the amino acid level to achieve 99-100% four-digit typing accuracy for both class I and II HLA genes,

291 We suggest that the elongated third digit was employed in a unique foraging strategy, highli

292 on was reported to disappear when the middle digit was lifted off the thermal stimulator, suggesting

293 t muscles as skeletal elements elongated and digits were lost, and yet the developmental mechanisms r

294 ndomly in length between one, four and seven digits, where EEG recordings for working memory load est

295 ells over-proliferate and form an additional digit, which can be prevented by applying Bmp2 or by inh

296 cortices coded preferentially the number of digits while ventral-stream and dorsal-stream regions co

297 esses of reading, as elicited by letters and digits whose level of ambiguity was parametrically manip

298 which allows dexterous control of individual digits with some degree of coordinated control of multip

299 rove the muscle's ability to maintain flexed digits without increasing energetic demands.

300 dences of linked individuals (centroids of 3-digit zip code).

301 When stratified by 5-digit ZIP code, the relative cash prices for generic dru